| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rujin Tian, Xiaoping Wu, Tracy L Hagemann, Alexandre A Sosunov, Albee Messing, Guy M McKhann, James E Goldma. Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes. Journal of neuropathology and experimental neurology. vol 69. issue 4. 2010-05-21. PMID:20448479. |
a knock-in mouse model of axd also shows significant reduction of glutamate transporter 1 in the hippocampus. |
2010-05-21 |
2023-08-12 |
mouse |
| Yan Lou, Wei-ping Wang, Pan Li, Rui-sheng Duan, Lin Pe. [Interrelationship between change of cAMP responsive element binding protein (CREB) or N-methyl-D-aspartate receptor (NR1) expressing in hippocampus and impairment of learning and memory after epilepsy]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 38. issue 6. 2010-05-20. PMID:18095593. |
the changes of transcription factors creb and glutamate receptor n-methyl-d-aspartate (nmda) receptor subtype nr1 expressing in hippocampus and the relationship between creb or nr1 expression change and learning or memory deficit after epilepsy. |
2010-05-20 |
2023-08-12 |
Not clear |
| Wei He, Zhenyong Cheng, Gang Fu, Xulin Xu, Qing Lu, Lianjun Gu. ZD7288-induced suppression of long-term potentiation was attenuated by exogenous NMDA at the Schaffer collateral-CA1 synapse in the rat in vivo. European journal of pharmacology. vol 631. issue 1-3. 2010-05-17. PMID:20064502. |
in the present study, we investigated the effect of zd7288 on synaptic transmission and high frequency stimulation (hfs)-induced ltp in the schaffer collateral-ca1 synapse of rat hippocampus in vivo, and examined the possible relations between activation of n-methyl-d-aspartate (nmda) type of glutamate receptor and hcn channels for induction of ltp. |
2010-05-17 |
2023-08-12 |
rat |
| Pan-Yue Deng, Zhaoyang Xiao, Archana Jha, David Ramonet, Toshimitsu Matsui, Michael Leitges, Hee-Sup Shin, James E Porter, Jonathan D Geiger, Saobo Le. Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392936. |
whereas cck has been shown to increase glutamate concentration in the perfusate of hippocampal slices and in purified rat hippocampal synaptosomes, the cellular and molecular mechanisms whereby cck modulates glutamatergic function remain unexplored. |
2010-05-14 |
2023-08-12 |
rat |
| Izumi Maezawa, Lee-Way Ji. Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392956. |
hippocampal neurons treated with cm from mecp2-null microglia showed an abnormal stunted and beaded dendritic morphology, and signs of microtubule disruption and damage of postsynaptic glutamatergic components within 24 h. we identified that the toxic factor in the cm is glutamate, because (1) mecp2-null microglia released a fivefold higher level of glutamate, (2) blockage of microglial glutamate synthesis by a glutaminase inhibitor abolished the neurotoxic activity, (3) blockage of microglial glutamate release by gap junction hemichannel blockers abolished the neurotoxic activity, and (4) glutamate receptor antagonists blocked the neurotoxicity of the mecp2-null microglia cm. |
2010-05-14 |
2023-08-12 |
Not clear |
| Bernadette M Cortese, Todd R Mitchell, Matthew P Galloway, Kristen E Prevost, Jidong Fang, Gregory J Moore, Thomas W Uhd. Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior. Physiology & behavior. vol 99. issue 4. 2010-05-12. PMID:20006966. |
additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. |
2010-05-12 |
2023-08-12 |
rat |
| Bernadette M Cortese, Todd R Mitchell, Matthew P Galloway, Kristen E Prevost, Jidong Fang, Gregory J Moore, Thomas W Uhd. Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior. Physiology & behavior. vol 99. issue 4. 2010-05-12. PMID:20006966. |
an inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the epm and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. |
2010-05-12 |
2023-08-12 |
rat |
| Aven Lee, Barbara E Lingwood, S Tracey Bjorkman, Stephanie M Miller, Philip Poronnik, Nigel L Barnett, Paul Colditz, David V Po. Rapid loss of glutamine synthetase from astrocytes in response to hypoxia: implications for excitotoxicity. Journal of chemical neuroanatomy. vol 39. issue 3. 2010-05-11. PMID:20034557. |
glutamine synthetase (gs), a key enzyme in the detoxification of glutamate and ammonia, was rapidly lost from astrocytes in regions susceptible to damage, including the ca1 of hippocampus and various cortical regions. |
2010-05-11 |
2023-08-12 |
Not clear |
| Feng Guo, Feng Sun, Jun-Ling Yu, Qing-Hua Wang, Da-Yu Tu, Xiao-Yuan Mao, Rui Liu, Kun-Can Wu, Ni Xie, Li-Ying Hao, Ji-Qun Ca. Abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus. Brain research bulletin. vol 81. issue 4-5. 2010-05-06. PMID:19853022. |
abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus. |
2010-05-06 |
2023-08-12 |
rat |
| Feng Guo, Feng Sun, Jun-Ling Yu, Qing-Hua Wang, Da-Yu Tu, Xiao-Yuan Mao, Rui Liu, Kun-Can Wu, Ni Xie, Li-Ying Hao, Ji-Qun Ca. Abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus. Brain research bulletin. vol 81. issue 4-5. 2010-05-06. PMID:19853022. |
the present study was undertaken to detect eaats (glast, glt-1 and eaac-1) and group i metabotropic glutamate receptors (mglur1) in ser hippocampus from both the level of mrna and protein in sers hippocampus compared with control wistar rats. |
2010-05-06 |
2023-08-12 |
rat |
| Feng Guo, Feng Sun, Jun-Ling Yu, Qing-Hua Wang, Da-Yu Tu, Xiao-Yuan Mao, Rui Liu, Kun-Can Wu, Ni Xie, Li-Ying Hao, Ji-Qun Ca. Abnormal expressions of glutamate transporters and metabotropic glutamate receptor 1 in the spontaneously epileptic rat hippocampus. Brain research bulletin. vol 81. issue 4-5. 2010-05-06. PMID:19853022. |
in this study, the glutamate concentration in sers hippocampus was increased compared with that of control rats by high performance liquid chromatography; the mrna expressions of glast and mglur1 in sers hippocampus were significantly lower than those in control rats hippocampus, whereas an abundant increase in mrna for glt-1 was observed by rt-pcr; eaac-1 and mglur1 protein in sers and control rats were localized widely in the hippocampus including ca1, ca3 and dentate gyrus regions by immunohistochemistry; the number of glast and mglur1-positive cells in the hippocampus of sers were less than those in control rats, especially for ca3 and dg region; the protein expression of glt-1 was up-regulated, but the protein expressions of glast and mglur1 were down-regulated in ser hippocampus by western blot. |
2010-05-06 |
2023-08-12 |
rat |
| Harald D Müller, Christian Berger, Stefan Schwab, Clemens Somme. Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition. Brain research. vol 1316. 2010-05-06. PMID:20026313. |
this complexity could easily be unraveled when focusing on the balance between excitatory glutamate and inhibitory gaba(a) receptors, in which case only the increase of hippocampal [(3)h]muscimol ligand binding 6 hours after the first application of pravastatin was accompanied by a net shift towards inhibition. |
2010-05-06 |
2023-08-12 |
rat |
| Detlef Balschun, Diederik Moechars, Zsuzsanna Callaerts-Vegh, Ben Vermaercke, Nathalie Van Acker, Luc Andries, Rudi D'Hoog. Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 3. 2010-05-04. PMID:19574394. |
vesicular glutamate transporter vglut1 has a role in hippocampal long-term potentiation and spatial reversal learning. |
2010-05-04 |
2023-08-12 |
mouse |
| Daisuke Ibi, Atsumi Nitta, Kumiko Ishige, Xiaobo Cen, Tomohiro Ohtakara, Toshitaka Nabeshima, Yoshihisa It. Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19766155. |
taken together, these results indicate that piccolo plays a pivotal role in synaptic plasticity in area ca1 and in hippocampus-dependent learning in mice, and that the extracellular levels of glutamate in the hippocampus under stimulated conditions are controlled by piccolo. |
2010-05-04 |
2023-08-12 |
mouse |
| Sonia Piccinin, Carlo Cinque, Laura Calò, Gemma Molinaro, Giuseppe Battaglia, Laura Maggi, Ferdinando Nicoletti, Daniela Melchiorri, Fabrizio Eusebi, Peter V Massey, Zafar I Bashi. Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 8. 2010-05-04. PMID:20181581. |
interaction between ephrins and mglu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus. |
2010-05-04 |
2023-08-12 |
rat |
| Sonia Piccinin, Carlo Cinque, Laura Calò, Gemma Molinaro, Giuseppe Battaglia, Laura Maggi, Ferdinando Nicoletti, Daniela Melchiorri, Fabrizio Eusebi, Peter V Massey, Zafar I Bashi. Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 8. 2010-05-04. PMID:20181581. |
we applied the group-i metabotropic glutamate (mglu) receptor agonist, 3,5-dihydroxyphenylglycine (dhpg), to neonatal or adult rat hippocampal slices at concentrations (10 microm) that induced a short-term depression (std) of excitatory synaptic transmission at the schaffer collateral/ca1 synapses. |
2010-05-04 |
2023-08-12 |
rat |
| Alan M Roloff, Garret R Anderson, Kirill A Martemyanov, Stanley A Thaye. Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 8. 2010-05-04. PMID:20181604. |
at hippocampal excitatory synapses, endocannabinoids (ecbs) mediate two forms of retrograde synaptic inhibition that are induced by postsynaptic depolarization or activation of metabotropic glutamate receptors (mglurs). |
2010-05-04 |
2023-08-12 |
Not clear |
| My Andersson, Eric Hans. Astrocytes impose postburst depression of release probability at hippocampal glutamate synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 16. 2010-05-04. PMID:20410129. |
astrocytes impose postburst depression of release probability at hippocampal glutamate synapses. |
2010-05-04 |
2023-08-12 |
rat |
| Eun Ok Lee, Hee Ju Park, Jihee Lee Kang, Hye-Sun Kim, Young Hae Chon. Resveratrol reduces glutamate-mediated monocyte chemotactic protein-1 expression via inhibition of extracellular signal-regulated kinase 1/2 pathway in rat hippocampal slice cultures. Journal of neurochemistry. vol 112. issue 6. 2010-04-30. PMID:20050970. |
in this study, we assessed the potential molecular basis for the role of glutamate in hippocampal inflammation by determining its effects on mcp-1 induction. |
2010-04-30 |
2023-08-12 |
rat |
| David Bouvier, Marie-Eve Tremblay, Mustapha Riad, Amadou T Corera, Diane Gingras, Katherine E Horn, Maryam Fotouhi, Martine Girard, Keith K Murai, Timothy E Kennedy, Peter S McPherson, Elena B Pasquale, Edward A Fon, Guy Douce. EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. Journal of neurochemistry. vol 113. issue 1. 2010-04-30. PMID:20067584. |
in vivo and in dissociated cultures, epha4 was localized by immunoelectron microscopy in vesicular glutamate transporter 1-positive terminals of hippocampal neurons. |
2010-04-30 |
2023-08-12 |
mouse |