| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amrita Madhusudan, Corinne Sidler, Irene Knuese. Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging. The European journal of neuroscience. vol 30. issue 6. 2009-11-17. PMID:19735296. |
here, we report that these age-related neuropathological changes in hippocampus, entorhinal and piriform cortices of aged wild-type mice are accompanied by abnormal axonal varicosities and altered expression profiles of calcium-binding proteins in plaque-dense areas, as well as a significant reduction in the number of parvalbumin-positive gamma-aminobutyric acid (gaba)ergic projection neurons in basal forebrain areas, including medial septum (ms), ventral and horizontal diagonal band of broca (vdb/hdb) and substantia innominata (si), compared with young subjects. |
2009-11-17 |
2023-08-12 |
mouse |
| Bernard Da. Angelman syndrome: current understanding and research prospects. Epilepsia. vol 50. issue 11. 2009-11-12. PMID:19874386. |
recent findings in animal models demonstrated altered dendritic spine formation as well as both synaptic [including gamma-aminobutyric acid (gaba)(a) and n-methyl-d-aspartate (nmda) transmission] and nonsynaptic (including gap junction) influences in various brain regions, including hippocampus and cerebellar cortex. |
2009-11-12 |
2023-08-12 |
Not clear |
| Aihua Wang, Zhaofu Chi, Shengjun Wang, Shuhua Wang, Qinjian Su. Calcineurin-mediated GABA(A) receptor dephosphorylation in rats after kainic acid-induced status epilepticus. Seizure. vol 18. issue 7. 2009-11-02. PMID:19497770. |
taken together, our data suggest that down-regulation in inhibition of gaba(a)r 2/3 by can activity contributes to an elevation in neuronal excitability of hippocampus, which may be involved in development of chronic processes of seizures. |
2009-11-02 |
2023-08-12 |
rat |
| Masahiko Iwakiri, Katsuyoshi Mizukami, Milos D Ikonomovic, Masanori Ishikawa, Eric E Abrahamson, Steven T DeKosky, Takashi Asad. An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 29. issue 3. 2009-10-19. PMID:19019179. |
an immunohistochemical study of gaba a receptor gamma subunits in alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. |
2009-10-19 |
2023-08-12 |
human |
| Masahiko Iwakiri, Katsuyoshi Mizukami, Milos D Ikonomovic, Masanori Ishikawa, Eric E Abrahamson, Steven T DeKosky, Takashi Asad. An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 29. issue 3. 2009-10-19. PMID:19019179. |
immunohistochemical characterization of the distribution of gaba(a) receptor subunits gamma1/3 and 2 in the hippocampus relative to neurofibrillary tangle (nft) pathology staging was performed in cognitively normal subjects (braak stage i/ii, n = 4) and two groups of alzheimer's disease (ad) patients (braak stage iii/iv, n = 4; braak stage v/vi, n = 8). |
2009-10-19 |
2023-08-12 |
human |
| Simo S Oja, Pirjo Saransaar. Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia. Neurochemical research. vol 34. issue 9. 2009-10-19. PMID:19343493. |
the basal and k(+)-evoked release of the neuroactive endogenous amino acids gaba, glycine, taurine, l-glutamate and l-aspartate was now studied in slices from the hippocampus and brain stem from 7-day-old and 3-month-old mice under control and ischemic conditions. |
2009-10-19 |
2023-08-12 |
mouse |
| Simo S Oja, Pirjo Saransaar. Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia. Neurochemical research. vol 34. issue 9. 2009-10-19. PMID:19343493. |
gaba release was much greater in 3-month-old than in 7-day-old mice, whereas with taurine the situation was the opposite, in the hippocampus in particular. |
2009-10-19 |
2023-08-12 |
mouse |
| Simo S Oja, Pirjo Saransaar. Release of endogenous amino acids from the hippocampus and brain stem from developing and adult mice in ischemia. Neurochemical research. vol 34. issue 9. 2009-10-19. PMID:19343493. |
ischemia enhanced the release of all neuroactive amino acids in both brain regions, the effects being relatively most pronounced in the case of gaba, aspartate and glutamate in the hippocampus in 3-month-old mice, and taurine in 7-day-old and glycine in 3-month-old mice in the brain stem. |
2009-10-19 |
2023-08-12 |
mouse |
| Fereshteh Pourabdolhossein, Asghar Ghasemi, Ameneh Shahroukhi, Mohammad Amin Sherafat, Ali Khoshbaten, Alireza Asgar. In vitro assessment of paraoxon effects on GABA uptake in rat hippocampal synaptosomes. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 5. 2009-10-13. PMID:19460429. |
in vitro assessment of paraoxon effects on gaba uptake in rat hippocampal synaptosomes. |
2009-10-13 |
2023-08-12 |
rat |
| Fereshteh Pourabdolhossein, Asghar Ghasemi, Ameneh Shahroukhi, Mohammad Amin Sherafat, Ali Khoshbaten, Alireza Asgar. In vitro assessment of paraoxon effects on GABA uptake in rat hippocampal synaptosomes. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 5. 2009-10-13. PMID:19460429. |
the present investigation studied the potential interactions between paraoxon and gaba uptake in hippocampal synaptosomes. |
2009-10-13 |
2023-08-12 |
rat |
| Fereshteh Pourabdolhossein, Asghar Ghasemi, Ameneh Shahroukhi, Mohammad Amin Sherafat, Ali Khoshbaten, Alireza Asgar. In vitro assessment of paraoxon effects on GABA uptake in rat hippocampal synaptosomes. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 5. 2009-10-13. PMID:19460429. |
hippocampal synaptosomes were prepared and incubated with [(3)h] gaba in the presence of different doses of paraoxon for 10 min at 37 degrees c; and were then layered in chambers of a superfusion system and the [(3)h] gaba uptake was measured. |
2009-10-13 |
2023-08-12 |
rat |
| Fereshteh Pourabdolhossein, Asghar Ghasemi, Ameneh Shahroukhi, Mohammad Amin Sherafat, Ali Khoshbaten, Alireza Asgar. In vitro assessment of paraoxon effects on GABA uptake in rat hippocampal synaptosomes. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 5. 2009-10-13. PMID:19460429. |
in conclusion, micromolar concentrations of paraoxon were shown to interfere with gaba uptake in hippocampal synaptosomes, which indicates the gaba transporters may play a role in organophosphate-induced convulsions. |
2009-10-13 |
2023-08-12 |
rat |
| Piotr Maciejak, Janusz Szyndler, Danuta Turzyńska, Alicja Sobolewska, Ewa Taracha, Anna Skórzewska, Małgorzata Lehner, Andrzej Bidziński, Adam Hamed, Aleksandra Wisłowska-Stanek, Adam Płaźni. The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration. Brain research. vol 1282. 2009-10-09. PMID:19481536. |
we also examined the concentration of the amino acid glutamate, gaba, alanine and taurine in the hippocampus of rats using a microdialysis technique. |
2009-10-09 |
2023-08-12 |
rat |
| Piotr Maciejak, Janusz Szyndler, Danuta Turzyńska, Alicja Sobolewska, Ewa Taracha, Anna Skórzewska, Małgorzata Lehner, Andrzej Bidziński, Adam Hamed, Aleksandra Wisłowska-Stanek, Adam Płaźni. The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration. Brain research. vol 1282. 2009-10-09. PMID:19481536. |
we demonstrated that the baseline concentrations of glutamate, gaba, alanine, taurine, and the glutamine/gaba ratio were elevated in the hippocampus of fully kindled rats. |
2009-10-09 |
2023-08-12 |
rat |
| Kai Diederich, Sevgi Sevimli, Henrike Dörr, Evelin Kösters, Maike Hoppen, Lars Lewejohann, Rainer Klocke, Jens Minnerup, Stefan Knecht, Sigrid Nikol, Norbert Sachser, Armin Schneider, Ali Gorji, Clemens Sommer, Wolf-Rüdiger Schäbit. The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 37. 2009-10-02. PMID:19759304. |
the impact of g-csf deficiency on the structural integrity of the hippocampus was evaluated by analyzing the generation of doublecortin-expressing cells, the amount of bromodeoxyurine-labeled cells, the dendritic complexity in hippocampal neurons, the binding densities of nmda and gaba(a) receptors and the induction of long-term potentiation (ltp). |
2009-10-02 |
2023-08-12 |
mouse |
| Hervé Fiorentino, Nicola Kuczewski, Diabe Diabira, Nadine Ferrand, Menelas N Pangalos, Christophe Porcher, Jean-Luc Gaiars. GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 37. 2009-10-02. PMID:19759312. |
using whole-cell patch-clamp recordings on newborn mouse hippocampi lacking functional gaba(b) receptors (gaba(b)-rs) and time-lapse fluorescence imaging on cultured hippocampal neurons expressing gfp-tagged brain-derived neurotrophic factor (bdnf), we found that activation of metabotropic gaba(b) receptors (gaba(b)-rs) triggers secretion of bdnf and promotes the development of perisomatic gabaergic synapses in the newborn mouse hippocampus. |
2009-10-02 |
2023-08-12 |
mouse |
| Hervé Fiorentino, Nicola Kuczewski, Diabe Diabira, Nadine Ferrand, Menelas N Pangalos, Christophe Porcher, Jean-Luc Gaiars. GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 37. 2009-10-02. PMID:19759312. |
because activation of gaba(b)-rs occurs during the characteristic ongoing physiological network-driven synaptic activity present in the developing hippocampus, our results reveal a new mechanism by which synaptic activity can modulate the development of local gabaergic synaptic connections in the developing brain. |
2009-10-02 |
2023-08-12 |
mouse |
| Li Zhou, Yu-Wei Liu, Robert W Peoples, Min Yang, Xiang Tian, Yong-Xun Ai, Yuan-Ping Pang, Zhi-Wang Li, Yi-Fan Han, Chao-Ying L. Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons. Neuropharmacology. vol 57. issue 1. 2009-10-01. PMID:19393253. |
in the present study we investigated the mechanism of bis(7)-tacrine inhibition of gaba(a) receptor function using whole-cell patch-clamp recording in cultured rat hippocampal neurons. |
2009-10-01 |
2023-08-12 |
rat |
| Sabina Berretta, Barbara Gisabella, Francine M Bene. A rodent model of schizophrenia derived from postmortem studies. Behavioural brain research. vol 204. issue 2. 2009-09-25. PMID:19539659. |
additionally, currents associated with hyperpolarization-activated cationic channels (ih), which help to control neuronal firing rates of gaba cells in the hippocampus, were also increased. |
2009-09-25 |
2023-08-12 |
rat |
| Daniel L Jones, Scott C Baraba. Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice. Journal of neurophysiology. vol 102. issue 2. 2009-09-24. PMID:19515951. |
we analyzed inhibitory inputs, mediated by gamma-aminobutyric acid (gaba), to hippocampal interneurons in a mouse model of type 1 lissencephaly, a neurological disorder linked with severe seizures and brain malformation. |
2009-09-24 |
2023-08-12 |
mouse |