| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tim S Heistek, Marta Ruiperez-Alonso, A Jaap Timmerman, Arjen B Brussaard, Huibert D Mansvelde. α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations. The Journal of physiology. vol 591. issue 4. 2013-08-06. PMID:23109109. |
it is unknown which gaba(a) receptor α subunit controls hippocampal oscillations and where these receptors are expressed. |
2013-08-06 |
2023-08-12 |
mouse |
| Tim S Heistek, Marta Ruiperez-Alonso, A Jaap Timmerman, Arjen B Brussaard, Huibert D Mansvelde. α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations. The Journal of physiology. vol 591. issue 4. 2013-08-06. PMID:23109109. |
to address these questions we used transgenic mice expressing gaba(a) receptor α1 and/or α2 subunits with point mutations (h101r) that render these receptors insensitive to allosteric modulation at the benzodiazepine binding site, and tested how increased or decreased function of α subunits affects hippocampal oscillations. |
2013-08-06 |
2023-08-12 |
mouse |
| Tim S Heistek, Marta Ruiperez-Alonso, A Jaap Timmerman, Arjen B Brussaard, Huibert D Mansvelde. α2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations. The Journal of physiology. vol 591. issue 4. 2013-08-06. PMID:23109109. |
these findings suggest that α2-containing gaba(a) receptors expressed in the ca3 region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations. |
2013-08-06 |
2023-08-12 |
mouse |
| W Saskia van der Hel, Pieter van Eijsden, Ineke W M Bos, Robin A de Graaf, Kevin L Behar, Onno van Nieuwenhuizen, Pierre N E de Graan, Kees P J Brau. In vivo MRS and histochemistry of status epilepticus-induced hippocampal pathology in a juvenile model of temporal lobe epilepsy. NMR in biomedicine. vol 26. issue 2. 2013-08-01. PMID:22806932. |
four and eight weeks after se, in vivo (1) h and γ-aminobutyric acid (gaba)-edited mrs of the hippocampus was performed in combination with dedicated ex vivo immunohistochemistry for the interpretation and validation of mrs findings. |
2013-08-01 |
2023-08-12 |
rat |
| F McLeod, R Ganley, L Williams, J Selfridge, A Bird, S R Cob. Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome. Neuroscience. vol 231. 2013-07-25. PMID:23238573. |
brain slices challenged with the gaba(a)-receptor antagonist bicuculline (0.1-10 μm) and the potassium channel blocker 4-aminopyridine (1-50 μm) also revealed differences between genotypes with hippocampal circuits from mecp2(stop/y) mouse slices showing enhanced epileptiform burst duration and frequency. |
2013-07-25 |
2023-08-12 |
mouse |
| Behnam Yousefi, Meisam Farjad, Mohammad Nasehi, Mohammad Reza Zarrindas. Involvement of the CA1 GABAA receptors in ACPA-induced impairment of spatial and non-spatial novelty detection in mice. Neurobiology of learning and memory. vol 100. 2013-07-23. PMID:23231965. |
this study investigates the effects of dorsal hippocampal (ca1) gaba(a) receptors on spatial and non-spatial novelty detection deficit, induced by a selective cb1 receptor agonist (acpa), during a non-associative task. |
2013-07-23 |
2023-08-12 |
mouse |
| Pierangelo Cifelli, Eleonora Palma, Cristina Roseti, Gianluca Verlengia, Michele Simonat. Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy. Frontiers in cellular neuroscience. vol 7. 2013-07-22. PMID:23874269. |
in particular, the repetitive activation of gabaa receptors produces a use-dependent decrease (rundown) of the evoked currents (i gaba), which is markedly enhanced in the hippocampus and cortex of drug-resistant mtle patients. |
2013-07-22 |
2023-08-12 |
human |
| Pierangelo Cifelli, Eleonora Palma, Cristina Roseti, Gianluca Verlengia, Michele Simonat. Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy. Frontiers in cellular neuroscience. vol 7. 2013-07-22. PMID:23874269. |
this phenomenon has been also observed in the pilocarpine model, where the increased i gaba rundown is observed in the hippocampus at the time of the first spontaneous seizure, then extends to the cortex and remains constant in the chronic phase of the disease. |
2013-07-22 |
2023-08-12 |
human |
| Christopher B Ransom, Wucheng Tao, Yuanming Wu, William J Spain, George B Richerso. Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons. Journal of neurophysiology. vol 109. issue 3. 2013-07-16. PMID:23114210. |
rapid regulation of tonic gaba currents in cultured rat hippocampal neurons. |
2013-07-16 |
2023-08-12 |
human |
| Christopher B Ransom, Wucheng Tao, Yuanming Wu, William J Spain, George B Richerso. Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons. Journal of neurophysiology. vol 109. issue 3. 2013-07-16. PMID:23114210. |
we measured endogenous tonic gaba currents from cultured rat hippocampal neurons to evaluate how they are affected by 1) transient increases in extracellular gaba concentration ([gaba]), 2) transient postsynaptic depolarization, and 3) depolarization of presynaptic cells. |
2013-07-16 |
2023-08-12 |
human |
| Christopher B Ransom, Wucheng Tao, Yuanming Wu, William J Spain, George B Richerso. Rapid regulation of tonic GABA currents in cultured rat hippocampal neurons. Journal of neurophysiology. vol 109. issue 3. 2013-07-16. PMID:23114210. |
nonvesicular gaba release due to gat1 reversal also occurred in acute hippocampal brain slices. |
2013-07-16 |
2023-08-12 |
human |
| Krzysztof Tokarski, Bartosz Bobula, Małgorzata Grzegorzewska-Hiczwa, Magdalena Kusek, Grzegorz Hes. Stress- and antidepressant treatment-induced modifications of 5-HT₇ receptor functions in the rat brain. Pharmacological reports : PR. vol 64. issue 6. 2013-07-16. PMID:23406741. |
these studies demonstrated that 5-ht(7) receptors play an important role in the modulation of the activity of the hippocampal network by regulating the excitability of pyramidal cells of the ca1 area, as well as via their effect on gaba and glutamatergic transmission. |
2013-07-16 |
2023-08-12 |
rat |
| Mario Marchi, Stefania Zappettini, Guendalina Olivero, Anna Pittaluga, Massimo Grill. Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes. Neurochemistry international. vol 60. issue 6. 2013-07-11. PMID:22417725. |
the effect of chronic nicotine treatment on the release of endogenous glutamate (glu), aspartate (asp) and gaba evoked in vitro by kcl, 4-aminopyridine (4ap) and nicotinic agonists in synaptosomes of rat hippocampus was investigated. |
2013-07-11 |
2023-08-12 |
rat |
| Maria Summa, Silvia Di Prisco, Massimo Grilli, Cesare Usai, Mario Marchi, Anna Pittalug. Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology. vol 66. 2013-07-02. PMID:22564442. |
presynaptic mglu7 receptors control gaba release in mouse hippocampus. |
2013-07-02 |
2023-08-12 |
mouse |
| Maria Summa, Silvia Di Prisco, Massimo Grilli, Cesare Usai, Mario Marchi, Anna Pittalug. Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology. vol 66. 2013-07-02. PMID:22564442. |
mouse hippocampal synaptosomes were preloaded with [(3)h]d-γ-aminobutyric acid ([(3)h]gaba) and then exposed in superfusion to 12 mm kcl. |
2013-07-02 |
2023-08-12 |
mouse |
| Maria Summa, Silvia Di Prisco, Massimo Grilli, Cesare Usai, Mario Marchi, Anna Pittalug. Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology. vol 66. 2013-07-02. PMID:22564442. |
mouse hippocampal synaptosomal plasmamembranes posses mglu7 receptor proteins; confocal microscopy analysis unveiled that mglu7 proteins colocalize with syntaxin-1a (stx-1a), with vesicular gaba transporter (vgat)-proteins and with gaba(b) receptor subunit proteins. |
2013-07-02 |
2023-08-12 |
mouse |
| Maria Summa, Silvia Di Prisco, Massimo Grilli, Cesare Usai, Mario Marchi, Anna Pittalug. Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology. vol 66. 2013-07-02. PMID:22564442. |
we propose that presynaptic inhibitory mglu7 heteroreceptors, negatively coupled to ac-dependent intraterminal pathway, exist in mouse hippocampal gaba-containing terminals, where they colocalize, but do not functionally cross-talk, with gaba(b) autoreceptors. |
2013-07-02 |
2023-08-12 |
mouse |
| Timothy J Schoenfeld, Pedro Rada, Pedro R Pieruzzini, Brian Hsueh, Elizabeth Goul. Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637169. |
we further showed that running enhances local inhibitory mechanisms in the hippocampus, including increases in stress-induced activation of hippocampal interneurons, expression of vesicular gaba transporter (vgat), and extracellular gaba release during cold water swim stress. |
2013-07-01 |
2023-08-12 |
mouse |
| Sam A Booker, Anna Gross, Daniel Althof, Ryuichi Shigemoto, Bernhard Bettler, Michael Frotscher, Matthew Hearing, Kevin Wickman, Masahiko Watanabe, Ákos Kulik, Imre Vid. Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637187. |
in this study, we have combined high-resolution immunoelectron microscopy, whole-cell patch-clamp recording, and computational modeling to investigate the subcellular distribution and effects of gaba(b)rs and their postsynaptic effector kir3 channels in rat hippocampal pvis. |
2013-07-01 |
2023-08-12 |
rat |
| Sam A Booker, Anna Gross, Daniel Althof, Ryuichi Shigemoto, Bernhard Bettler, Michael Frotscher, Matthew Hearing, Kevin Wickman, Masahiko Watanabe, Ákos Kulik, Imre Vid. Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637187. |
furthermore, these data provide evidence for a compartment-specific molecular divergence of hippocampal pvi subtypes, suggesting that activation of gaba(b)rs may shift the balance between perisomatic and dendritic inhibition. |
2013-07-01 |
2023-08-12 |
rat |