| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alena O Burnyasheva, Natalia A Stefanova, Nataliya G Kolosova, Darya V Telegin. Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer's Disease Signs Development. Biochemistry. Biokhimiia. vol 88. issue 12. 2024-03-10. PMID:38462444. |
here we analyzed the age-related alterations of the levels of glutamate, gaba, as well as enzymes that synthesize them (glutaminase, glutamine synthetase, gaba-t, and gad67), transporters (glast, glt-1, and gat1), and relevant receptors (glua1, nmdar1, nmda2b, and gabaar1) in the whole hippocampus of the wistar rats and of the senescence-accelerated oxys rats, a model of the most common (> 95%) sporadic ad. |
2024-03-10 |
2024-03-14 |
rat |
| Alena O Burnyasheva, Natalia A Stefanova, Nataliya G Kolosova, Darya V Telegin. Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer's Disease Signs Development. Biochemistry. Biokhimiia. vol 88. issue 12. 2024-03-10. PMID:38462444. |
our results suggest that there is a decline in glutamate and gaba signaling with age in hippocampus of the both rat strains. |
2024-03-10 |
2024-03-14 |
rat |
| Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyü. Gender-related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model. Synapse (New York, N.Y.). vol 78. issue 2. 2024-03-04. PMID:38436644. |
gender-related variation expressions of neuroplastin traf6, glua1, gaba(a) receptor, and pmca in cortex, hippocampus, and brainstem in an experimental epilepsy model. |
2024-03-04 |
2024-03-06 |
rat |
| Züleyha Doğanyiğit, Aslı Okan, Seher Yılmaz, A Cihangir Uğuz, Enes Akyü. Gender-related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model. Synapse (New York, N.Y.). vol 78. issue 2. 2024-03-04. PMID:38436644. |
it was observed that neuroplastin and related proteins tnf receptor-associated factor 6 (traf6), gamma amino butyric acid type a receptors [(gaba(a)], and plasma membrane ca2+ atpase (pmca) protein immunoreactivity levels increased especially in the male hippocampus, and only ampa receptor subunit type 1 (glua1) immunoreactivity decreased, unlike other proteins. |
2024-03-04 |
2024-03-06 |
rat |
| Mani Surya Kumar Palepu, Siva Nageswara Rao Gajula, Malleshwari K, Rajesh Sonti, Manoj P Dandeka. SCFAs Supplementation Rescues Anxiety- and Depression-like Phenotypes Generated by Fecal Engraftment of Treatment-Resistant Depression Rats. ACS chemical neuroscience. 2024-02-21. PMID:38382546. |
administration of scfas (acetate, propionate, and butyrate at 67.5, 25, and 40 mm, respectively) for 7 days exerted robust antidepressant and antianxiety effects by restoring the levels of scfas in plasma and fecal samples, and proinflammatory cytokines (tnf-α and il-6), serotonin, gaba, norepinephrine, and dopamine in the hippocampus and/or frontal cortex of trd and trd-fmt animals. |
2024-02-21 |
2024-02-24 |
rat |
| Jennifer A Cale, Ethan J Chauhan, Joshua J Cleaver, Anthoio R Fusciardi, Sophie McCann, Hannah C Waters, Juš Žavbi, Madeleine V Kin. GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. Molecular neurobiology. 2024-02-16. PMID:38363536. |
we recently showed that male lister-hooded rats exposed to pcp-iso exhibit reduced hippocampal expression of the gaba interneuron marker calbindin. |
2024-02-16 |
2024-02-18 |
rat |
| Jennifer A Cale, Ethan J Chauhan, Joshua J Cleaver, Anthoio R Fusciardi, Sophie McCann, Hannah C Waters, Juš Žavbi, Madeleine V Kin. GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. Molecular neurobiology. 2024-02-16. PMID:38363536. |
the current study expanded on this by investigating changes to additional populations of gabaergic interneurons in frontal cortical and hippocampal tissue from the same animals (by immunohistochemistry) as well as levels of gaba itself (via elisa). |
2024-02-16 |
2024-02-18 |
rat |
| Kavitha Ukkirapandian, Kayalvizhi Elumalai, Karthika Priyadharshini Udaykumar, Sundaravadivel Vp, Muthulakshmi Rangasm. Behavioral and Biochemical Assays for Autism Models of Wistar Rats. Cureus. vol 16. issue 1. 2024-02-13. PMID:38344592. |
the estimation of antioxidant profile (malondialdehyde {mda}, glutathione {gsh}, catalase (cat), and superoxide dismutase {sod}), proinflammatory markers (tumor necrosis factor {tnf} alpha, transforming growth factor {tgf} beta, interleukin {il} 6, and il-1 beta), neurotransmitters (gamma-aminobutyric acid {gaba} and serotonin), and brain-derived neurotrophic factor (bdnf) in the hippocampal region was done. |
2024-02-13 |
2024-02-15 |
rat |
| Navneet Dhaliwal, Jatinder Dhaliwal, Kanwaljit Chopr. 7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia. Neurochemical research. 2024-02-01. PMID:38300457. |
p-akt, p-creb, bdnf, and neurotransmitter (nt) (glu, gaba, and ach) levels were also analyzed in the hippocampus of 2-vo rats. our results show that 7,8-dhf effectively improved memory performance and cholinergic dysfunction in 2-vo model rats. |
2024-02-01 |
2024-02-03 |
rat |
| Takashi Iwai, Rei Mishima, Shigeto Hirayama, Honoka Nakajima, Misa Oyama, Shun Watanabe, Hideaki Fujii, Mitsuo Tanab. SYK-623, a δ Opioid Receptor Inverse Agonist, Mitigates Chronic Stress-Induced Behavioral Abnormalities and Disrupted Neurogenesis. Journal of clinical medicine. vol 13. issue 2. 2024-01-26. PMID:38276114. |
in addition, the number of parvalbumin-positive gaba neurons, which play a crucial role in neurogenesis, was reduced in the hippocampus, and western blot analysis showed decreased glutamic acid decarboxylase protein levels. |
2024-01-26 |
2024-01-28 |
mouse |
| Chao Zhang, Kaihua Zhang, Xin Hu, Xianyun Cai, Yufan Chen, Fei Gao, Guangbin Wan. Regional GABA levels modulate abnormal resting-state network functional connectivity and cognitive impairment in multiple sclerosis. Cerebral cortex (New York, N.Y. : 1991). 2024-01-25. PMID:38271282. |
for this purpose, we used a combination of magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging to study gamma-aminobutyric acid and glutamate concentrations in the posterior cingulate cortex, medial prefrontal cortex and left hippocampus, and inter-network functional connectivity in 29 relapsing-remitting multiple sclerosis patients and 34 matched healthy controls. |
2024-01-25 |
2024-01-28 |
Not clear |
| Chao Zhang, Kaihua Zhang, Xin Hu, Xianyun Cai, Yufan Chen, Fei Gao, Guangbin Wan. Regional GABA levels modulate abnormal resting-state network functional connectivity and cognitive impairment in multiple sclerosis. Cerebral cortex (New York, N.Y. : 1991). 2024-01-25. PMID:38271282. |
moreover, mediation analyses indicated that decremented hippocampus gamma-aminobutyric acid levels in relapsing-remitting multiple sclerosis patients mediated the association between inter-network functional connectivity in various components of default mode network and verbal memory deficits. |
2024-01-25 |
2024-01-28 |
Not clear |
| Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Marzena Maćkowiak, Krystyna Gołembiowsk. Limbic System Response to Psilocybin and Ketamine Administration in Rats: A Neurochemical and Behavioral Study. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203271. |
both drugs influenced glutamate and gaba release in the nucleus accumbens, hippocampus and amygdala and increased ach levels in the hippocampus. |
2024-01-11 |
2024-01-13 |
rat |
| Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Rasajna Nadella, Aurora Del Carmen Sánchez-García, Laura Mireya Zavala-Flores, Daniel Hernandez-Baltaza. Gliosis induction on locus coeruleus in a living liver donor experimental model: A brief review. Iranian journal of basic medical sciences. vol 27. issue 1. 2024-01-02. PMID:38164479. |
in addition, studies have shown that phx decreases gaba and 5-ht2a receptors, promotes loss of dendritic spines, and favors microgliosis in rat hippocampus. |
2024-01-02 |
2024-01-05 |
rat |
| Xiang Wu, Jian Liu, Yanping Hui, Zhongheng Wu, Ling Wang, Yixuan Wang, Yihua Bai, Jing Li, Lei Zhang, Yue Xi, Qiaojun Zhang, Libo L. Long-term intermittent theta burst stimulation enhanced hippocampus-dependent memory by regulating hippocampal theta oscillation and neurotransmitter levels in healthy rats. Neurochemistry international. 2023-12-29. PMID:38157888. |
however, it remains largely unknown whether this effect is achieved by regulating hippocampal theta oscillation and neurotransmitters gamma-aminobutyric acid (gaba) and glutamate, which are strongly related to memory. |
2023-12-29 |
2024-01-05 |
rat |
| Xiang Wu, Jian Liu, Yanping Hui, Zhongheng Wu, Ling Wang, Yixuan Wang, Yihua Bai, Jing Li, Lei Zhang, Yue Xi, Qiaojun Zhang, Libo L. Long-term intermittent theta burst stimulation enhanced hippocampus-dependent memory by regulating hippocampal theta oscillation and neurotransmitter levels in healthy rats. Neurochemistry international. 2023-12-29. PMID:38157888. |
thus, we investigated the effect of 14 days of itbs on hippocampus-dependent memory and further explored the roles of hippocampal theta oscillation and neurotransmitters gaba and glutamate in this effect. |
2023-12-29 |
2024-01-05 |
rat |
| Hong-Kun Wang, Jin-Ming He, Yue-Heng Yan, Zi-Hao Wang, Ruo-Xuan Li, Yan-Yan Wan. [Effect of Suanzaoren Decoction on expression of ionotropic glutamate receptors and synaptic plasticity in hippocampus of anxiety rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114151. |
enzyme-linked immunosorbent assay(elisa) was used to measure the levels of glutamate(glu) and γ-aminobutyric acid(gaba) in the rat hippocampus. |
2023-12-19 |
2023-12-23 |
mouse |
| Hong-Kun Wang, Jin-Ming He, Yue-Heng Yan, Zi-Hao Wang, Ruo-Xuan Li, Yan-Yan Wan. [Effect of Suanzaoren Decoction on expression of ionotropic glutamate receptors and synaptic plasticity in hippocampus of anxiety rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 20. 2023-12-19. PMID:38114151. |
elisa results showed that compared with the model group, the suanzaoren decoction group exhibited significantly reduced levels of glu, glu/gaba ratio(p<0.01), and significantly increased levels of gaba(p<0.01) in the rat hippocampus. |
2023-12-19 |
2023-12-23 |
mouse |
| Deepika Shukla, Anshika Goel, Pravat K Mandal, Shallu Joon, Khushboo Punjabi, Yashika Arora, Rajnish Kumar, Veer Singh Mehta, Padam Singh, Joseph C Maroon, Rishu Bansal, Kanika Sandal, Rimil Guha Roy, Avantika Samkaria, Shallu Sharma, Sandhya Sandhilya, Shradha Gaur, S Parvathi, Mallika Josh. Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson's Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study. ACS chemical neuroscience. 2023-12-05. PMID:38050970. |
in the current study, we have investigated the impact of os in pd by measuring the antioxidant glutathione (gsh) levels from the substantia nigra (sn), left hippocampus (lh) and neurotransmitter γ-amino butyric acid (gaba) levels from sn region. |
2023-12-05 |
2023-12-10 |
Not clear |
| Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatol. Interleukin-15 alters hippocampal synaptic transmission and impairs episodic memory formation in mice. Brain, behavior, and immunity. vol 115. 2023-11-24. PMID:37992787. |
acute exposure of hippocampal slices to il-15 enhances gamma-aminobutyricacid (gaba) release and reduces glutamatergic currents, while chronic treatment with il-15 increases the frequency of hippocampal miniature inhibitory synaptic transmission and impairs memory formation in the novel object recognition (nor) test. |
2023-11-24 |
2023-11-28 |
mouse |