| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L Sherwi. Neuroactive amino acids in focally epileptic human brain: a review. Neurochemical research. vol 24. issue 11. 1999-11-24. PMID:10555779. |
glutamate decarboxylase (gad), responsible for gaba synthesis, is diminished in interneurons in discrete regions of epileptogenic cortex and hippocampus. |
1999-11-24 |
2023-08-12 |
human |
| A L Sherwi. Neuroactive amino acids in focally epileptic human brain: a review. Neurochemical research. vol 24. issue 11. 1999-11-24. PMID:10555779. |
gaba in contrast, exhibits a delayed and feeble rise in the epileptic hippocampus possibly due to a reduction in the number and/or efficiency of gaba transporters. |
1999-11-24 |
2023-08-12 |
human |
| M F Jackson, B Esplin, R Cape. Activity-dependent enhancement of hyperpolarizing and depolarizing gamma-aminobutyric acid (GABA) synaptic responses following inhibition of GABA uptake by tiagabine. Epilepsy research. vol 37. issue 1. 1999-11-22. PMID:10515172. |
the effects of the 7-aminobutyric acid (gaba) uptake blocker tiagabine on isolated inhibitory postsynaptic potentials (ipsps) were examined in ca1 pyramidal cells of the rat hippocampal slice preparation. |
1999-11-22 |
2023-08-12 |
rat |
| D E Pellegrini-Giampietro, F Peruginelli, E Meli, A Cozzi, S Albani-Torregrossa, R Pellicciari, F Moron. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms. Neuropharmacology. vol 38. issue 10. 1999-11-22. PMID:10530822. |
neuroprotection was also observed when aida was added to the hippocampal perfusion fluid in microdialysis experiments, and this effect was associated with an increase in the basal output of gaba. |
1999-11-22 |
2023-08-12 |
rat |
| W Löscher, D Hönack, M Grame. Effect of depth electrode implantation with or without subsequent kindling on GABA turnover in various rat brain regions. Epilepsy research. vol 37. issue 2. 1999-11-19. PMID:10510976. |
compared to naive controls, prolonged electrode implantation in the amygdala induced a significant reduction of aoaa-induced gaba accumulation in amygdala, hippocampus, piriform cortex, olfactory bulb, frontal cortex, striatum, hypothalamus, tectum, and cerebellar cortex. |
1999-11-19 |
2023-08-12 |
rat |
| S Smirnov, P Paalasmaa, M Uusisaari, J Voipio, K Kail. Pharmacological isolation of the synaptic and nonsynaptic components of the GABA-mediated biphasic response in rat CA1 hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 21. 1999-11-19. PMID:10531429. |
high-frequency stimulation (hfs) applied to stratum radiatum of a rat hippocampal slice in the presence of ionotropic glutamate receptor antagonists evokes a biphasic gaba(a) receptor-dependent response in ca1 pyramidal neurons, with a brief hyperpolarizing ipsp (hipsp) followed by a long-lasting depolarization. |
1999-11-19 |
2023-08-12 |
rat |
| M Kneussel, J H Brandstätter, B Laube, S Stahl, U Müller, H Bet. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 21. 1999-11-19. PMID:10531433. |
both in brain sections and cultured hippocampal neurons derived from geph -/- mice, synaptic gaba(a) receptor clusters containing either the gamma2 or the alpha2 subunit were absent, whereas glutamate receptor subunits were normally localized at postsynaptic sites. |
1999-11-19 |
2023-08-12 |
mouse |
| H M Haughey, J M Brown, A E Fleckenstein, G R Hanso. Oxygen radicals differentially affect Na+/Cl(-)-dependent transporters. European journal of pharmacology. vol 379. issue 1. 1999-11-15. PMID:10499378. |
to determine whether environmental differences between the striatum and hippocampus contributed to this lack of oxidative effect on norepinephrine transporters, synaptosomal gamma-aminobutyric acid (gaba) uptake was assessed in both regions. |
1999-11-15 |
2023-08-12 |
rat |
| H M Haughey, J M Brown, A E Fleckenstein, G R Hanso. Oxygen radicals differentially affect Na+/Cl(-)-dependent transporters. European journal of pharmacology. vol 379. issue 1. 1999-11-15. PMID:10499378. |
xanthine oxidase similarly decreased [3h]gaba uptake in both the striatum and hippocampus, supporting the conclusion that environmental differences did not account for the lack of effect on norepinephrine transport. |
1999-11-15 |
2023-08-12 |
rat |
| X Leinekugel, I Khalilov, H McLean, O Caillard, J L Gaiarsa, Y Ben-Ari, R Khazipo. GABA is the principal fast-acting excitatory transmitter in the neonatal brain. Advances in neurology. vol 79. 1999-11-03. PMID:10514814. |
in the neonatal rat hippocampus, gaba, acting via gabaa receptors, activates voltage-gated sodium and calcium channels and potentiates the activity of n-methyl-d-aspartate (nmda) receptors by reducing their voltage-dependent mg2+ block. |
1999-11-03 |
2023-08-12 |
rat |
| X Leinekugel, I Khalilov, H McLean, O Caillard, J L Gaiarsa, Y Ben-Ari, R Khazipo. GABA is the principal fast-acting excitatory transmitter in the neonatal brain. Advances in neurology. vol 79. 1999-11-03. PMID:10514814. |
the temporal window when gaba exerts excitatory actions coincides with a particular pattern of activity of hippocampal neuronal network that is characterized by periodical giant depolarizing potentials (gdps) reminiscent of interictal-like epileptiform discharges. |
1999-11-03 |
2023-08-12 |
rat |
| J W Swann, M G Pierson, K L Smith, C L Le. Developmental neuroplasticity: roles in early life seizures and chronic epilepsy. Advances in neurology. vol 79. 1999-11-03. PMID:10514815. |
however, as the hippocampus and neocortex enter the critical period of enhanced seizure susceptibility, inhibitory gaba systems mature rapidly. |
1999-11-03 |
2023-08-12 |
Not clear |
| K Nakamura, M Shiran. Activation of the reticulothalamic cholinergic pathway by the major metabolites of aniracetam. European journal of pharmacology. vol 380. issue 2-3. 1999-11-01. PMID:10513566. |
among the metabolites of aniracetam, local perfusion of n-anisoyl-gamma-aminobutyric acid (gaba, 0.1 and/or 1 microm) and p-anisic acid (1 microm) into the nucleus reticularis thalami, dorsal hippocampus and prefrontal cortex of shrsp produced a significant but delayed increase of acetylcholine release. |
1999-11-01 |
2023-08-12 |
rat |
| G Hoogland, M Blomenröhr, H Dijstelbloem, M de Wit, H A Spierenburg, C W van Veelen, P C van Rijen, A C van Huffelen, W H Gispen, P N de Graa. Characterization of neocortical and hippocampal synaptosomes from temporal lobe epilepsy patients. Brain research. vol 837. issue 1-2. 1999-10-21. PMID:10433988. |
(3) neocortical and hippocampal synaptosomes from tle patients contained 20-50% of the glutamate and gamma-aminobutyric acid (gaba) contents of rat cortical synaptosomes. |
1999-10-21 |
2023-08-12 |
human |
| A M Thomson, A Destexh. Dual intracellular recordings and computational models of slow inhibitory postsynaptic potentials in rat neocortical and hippocampal slices. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426478. |
dual intracellular recordings in slices of adult rat neocortex and hippocampus investigated slow, putative gaba(b) receptor-mediated inhibitory postsynaptic potentials. |
1999-10-08 |
2023-08-12 |
rat |
| A M Thomson, A Destexh. Dual intracellular recordings and computational models of slow inhibitory postsynaptic potentials in rat neocortical and hippocampal slices. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426478. |
thus some inhibitory connections in neocortex and hippocampus appear mediated solely by fast gaba(a) receptors, while others appear mediated solely by slow, non-ionotropic, possibly gaba(b) receptors. |
1999-10-08 |
2023-08-12 |
rat |
| S Chen, X Huang, X J Zeng, W Sieghart, E I Tiet. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430468. |
benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 gaba(a) receptor subunit proteins in the rat brain hippocampus and cortex. |
1999-10-08 |
2023-08-12 |
rat |
| S Chen, X Huang, X J Zeng, W Sieghart, E I Tiet. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430468. |
prolonged flurazepam exposure regulates the expression of selected (alpha1, beta2, beta3) gaba(a) receptor subunit messenger rnas in specific regions of the hippocampus and cortex with a time-course consistent with benzodiazepine tolerance both in vivo and in vitro. |
1999-10-08 |
2023-08-12 |
rat |
| S Chen, X Huang, X J Zeng, W Sieghart, E I Tiet. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430468. |
in this report, the immunostaining density of six specific gaba(a) receptor subunit (alpha1, beta2, beta1-3 and gamma2) antibodies was measured in the hippocampus and cortex, among other brain areas, in slide-mounted brain sections from flurazepam-treated and control rats using quantitative computer-assisted image analysis techniques. |
1999-10-08 |
2023-08-12 |
rat |
| S Chen, X Huang, X J Zeng, W Sieghart, E I Tiet. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430468. |
the selective changes in gaba(a) receptor subunit antibody immunostaining density in the hippocampus suggested that a change in the composition of gaba(a) receptors involving specific subunits (alpha1 and beta3) may be one mechanism underlying benzodiazepine anticonvulsant tolerance. |
1999-10-08 |
2023-08-12 |
rat |