| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Volodymyr I Dzhala, Kevin J Stale. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629188. |
we assessed the effect of endogenous gaba on ictal activity and neuronal firing rate in hippocampal slices from postnatal day 1 (p1) to p30. |
2003-03-24 |
2023-08-12 |
rat |
| Volodymyr I Dzhala, Kevin J Stale. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 5. 2003-03-24. PMID:12629188. |
thus, the propensity of the developing hippocampus for ictal activity is highly correlated with the effect of gaba on action potential probability and reversed by gaba(a) antagonists, indicating that gaba-mediated excitation is causally linked to ictal activity in this developmental window. |
2003-03-24 |
2023-08-12 |
rat |
| Tae Cheon Kang, Sung Jin An, Seung Kook Park, In Koo Hwang, Jae Chun Bae, Moo Ho Wo. Changed vesicular GABA transporter immunoreactivity in the gerbil hippocampus following spontaneous seizure and vigabatrin administration. Neuroscience letters. vol 335. issue 3. 2003-03-21. PMID:12531468. |
changed vesicular gaba transporter immunoreactivity in the gerbil hippocampus following spontaneous seizure and vigabatrin administration. |
2003-03-21 |
2023-08-12 |
Not clear |
| Tae Cheon Kang, Sung Jin An, Seung Kook Park, In Koo Hwang, Jae Chun Bae, Moo Ho Wo. Changed vesicular GABA transporter immunoreactivity in the gerbil hippocampus following spontaneous seizure and vigabatrin administration. Neuroscience letters. vol 335. issue 3. 2003-03-21. PMID:12531468. |
these results suggest that decreased vgat expression in the ss gerbil hippocampus may affect epileptogenesis in this animal, and that the subsequent alteration in its expression induced by seizure and the administration of gvg may reflect a modulation of gaba release to alleviate seizure activity. |
2003-03-21 |
2023-08-12 |
Not clear |
| Nicholas Brandon, Jasmina Jovanovic, Stephen Mos. Multiple roles of protein kinases in the modulation of gamma-aminobutyric acid(A) receptor function and cell surface expression. Pharmacology & therapeutics. vol 94. issue 1-2. 2003-03-13. PMID:12191597. |
moreover, changes in the efficacy of synaptic inhibition mediated by gaba(a) receptors are believed to be play central roles in certain forms of synaptic plasticity, including rebound potentiation in the cerebellum, and hippocampal long-term potentiation. |
2003-03-13 |
2023-08-12 |
Not clear |
| Katarzyna Mercik, Ewa D Zarnowska, Maria Mandat, Jerzy W Mozrzyma. Saturation and self-inhibition of rat hippocampal GABA(A) receptors at high GABA concentrations. The European journal of neuroscience. vol 16. issue 12. 2003-03-12. PMID:12492419. |
saturation and self-inhibition of rat hippocampal gaba(a) receptors at high gaba concentrations. |
2003-03-12 |
2023-08-12 |
rat |
| Katarzyna Mercik, Ewa D Zarnowska, Maria Mandat, Jerzy W Mozrzyma. Saturation and self-inhibition of rat hippocampal GABA(A) receptors at high GABA concentrations. The European journal of neuroscience. vol 16. issue 12. 2003-03-12. PMID:12492419. |
current responses to ultrafast gamma-aminobutyric acid (gaba) applications were recorded from excised patches in rat hippocampal neurons to study the gating properties of gaba(a) receptors at gaba concentrations close to saturating ones and higher. |
2003-03-12 |
2023-08-12 |
rat |
| Massimo Avoli, Margherita D'Antuono, Jacques Louvel, Rüdiger Köhling, Giuseppe Biagini, René Pumain, Giovanna D'Arcangelo, Virginia Tancred. Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Progress in neurobiology. vol 68. issue 3. 2003-03-05. PMID:12450487. |
these data indicate that in control animals: (i) prolonged, nmda receptor-dependent epileptiform discharges, resembling electrographic limbic seizures, originate in the entorhinal cortex from where they propagate to the hippocampus via the perforant path-dentate gyrus route; (ii) the initiation and maintenance of these ictal discharges is paradoxically contributed by gaba (mainly type a) receptor-mediated mechanisms; and (iii) ca3 outputs, which relay a continuous pattern of interictal discharge at approximately 1hz, control rather than sustain ictal discharge generation in entorhinal cortex. |
2003-03-05 |
2023-08-12 |
Not clear |
| W-N Zhang, T Bast, J Feldo. Prepulse inhibition in rats with temporary inhibition/inactivation of ventral or dorsal hippocampus. Pharmacology, biochemistry, and behavior. vol 73. issue 4. 2003-03-04. PMID:12213540. |
bilateral ventral or dorsal hippocampal infusions of the gamma-aminobutyric acid a (gaba(a)) receptor agonist muscimol (1 microg/side) or the sodium-channel blocker tetrodotoxin (ttx, 10 ng/side) reduced ppi. |
2003-03-04 |
2023-08-12 |
human |
| Tae Cheon Kang, Seung Kook Park, In Koo Hwang, Sung Jin An, Jae Hoon Bahn, Dae Won Kim, Soo Young Choi, Oh Shin Kwon, Nam In Baek, Hyeon Yong Lee, Moo Ho Wo. Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure. Brain research. vol 957. issue 2. 2003-02-25. PMID:12445966. |
the over-expression of plk in the hippocampus of pre-seizure ss gerbils suggests that plp play an important role in the modulation of gad activity and gaba reuptake as mediated by membrane transporter via neurons. |
2003-02-25 |
2023-08-12 |
Not clear |
| Matthew I Banks, Jason B Hardie, Robert A Pearc. Development of GABA(A) receptor-mediated inhibitory postsynaptic currents in hippocampus. Journal of neurophysiology. vol 88. issue 6. 2003-02-25. PMID:12466433. |
development of gaba(a) receptor-mediated inhibitory postsynaptic currents in hippocampus. |
2003-02-25 |
2023-08-12 |
Not clear |
| Peter A Goldstein, Frank P Elsen, Shui-Wang Ying, Carolyn Ferguson, Gregg E Homanics, Neil L Harriso. Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit. Journal of neurophysiology. vol 88. issue 6. 2003-02-25. PMID:12466441. |
prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the gaba(a) receptor alpha1 subunit. |
2003-02-25 |
2023-08-12 |
mouse |
| Tae-Cheon Kang, Seung-Kook Park, In Koo Hwang, Sung-Jin An, Soo Young Choi, Oh-Shin Kwon, Nam-In Baek, Hyeon Yong Lee, Moo Ho Wo. The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation. Neurochemistry international. vol 42. issue 3. 2003-02-13. PMID:12427478. |
the altered expression of gaba shunt enzymes in the gerbil hippocampus before and after seizure generation. |
2003-02-13 |
2023-08-12 |
Not clear |
| Tae-Cheon Kang, Seung-Kook Park, In Koo Hwang, Sung-Jin An, Soo Young Choi, Oh-Shin Kwon, Nam-In Baek, Hyeon Yong Lee, Moo Ho Wo. The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation. Neurochemistry international. vol 42. issue 3. 2003-02-13. PMID:12427478. |
in the present study, the distribution of succinic semialdehyde dehydrogenase (ssadh) and succinic semialdehyde reductase (ssar) in the hippocampus of the mongolian gerbil and its association with various sequelae of spontaneous seizure were investigated in order to identify the roles of gaba shunt in the epileptogenesis and the recovery mechanisms in these animals. |
2003-02-13 |
2023-08-12 |
Not clear |
| Thomas R Minor, Aimee M Hunte. Stressor controllability and learned helplessness research in the United States: sensitization and fatigue processes. Integrative physiological and behavioral science : the official journal of the Pavlovian Society. vol 37. issue 1. 2003-02-06. PMID:12069365. |
we propose that this process eventually depletes gaba, thus removing an important form of inhibition on excitatory glutamate transmission in the amygdala, hippocampus, and frontal cortex. |
2003-02-06 |
2023-08-12 |
rat |
| Koji Tominaga, Mamiko Kai, Atsushi Yamauchi, Shinya Dohgu, Kayoko Toda, Ryozo Oishi, Yasufumi Kataok. Subchronic treatment with cyclosporin A decreases the binding properties of the GABAA receptor in ovariectomized rats. Life sciences. vol 72. issue 4-5. 2003-01-27. PMID:12467883. |
in this study, we investigated the effect of cyclosporin a on the binding properties of the gabaa receptor in the hippocampus, known to be responsible for the induction of seizures, to clarify the mechanism of cyclosporin a-inhibited gaba neurotransmission in ovariectomized rats, as a climacterium model. |
2003-01-27 |
2023-08-12 |
rat |
| Koji Tominaga, Mamiko Kai, Atsushi Yamauchi, Shinya Dohgu, Kayoko Toda, Ryozo Oishi, Yasufumi Kataok. Subchronic treatment with cyclosporin A decreases the binding properties of the GABAA receptor in ovariectomized rats. Life sciences. vol 72. issue 4-5. 2003-01-27. PMID:12467883. |
this study supports the hypothesis that ovariectomy elevates the susceptibility to cyclosporin a-induced convulsions by accelerating the inhibitory actions of cyclosporin a on gaba neurotransmission in the hippocampus. |
2003-01-27 |
2023-08-12 |
rat |
| Yuko Fujisaki, Atsushi Yamauchi, Shinya Dohgu, Kazuyuki Sunada, Chozaburou Yamaguchi, Ryozo Oishi, Yasufumi Kataok. Cyclosporine A-increased nitric oxide production in the rat dorsal hippocampus mediates convulsions. Life sciences. vol 72. issue 4-5. 2003-01-27. PMID:12467895. |
these findings suggest that csa stimulates no production and induces convulsions as a result of an interaction between no and the gamma-aminobutyric acid (gaba) system in the hippocampus. |
2003-01-27 |
2023-08-12 |
mouse |
| Hideaki Noguchi, Kazuhiro Kitazumi, Megumi Mori, Toshiharu Shib. Effect of zaleplon on learning and memory in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 366. issue 2. 2003-01-24. PMID:12122506. |
these results suggest that zaleplon is characterized by a reduced amnesic liability, which may be due to its low affinity for the benzodiazepine site of the gaba(a) receptor in the hippocampus. |
2003-01-24 |
2023-08-12 |
rat |
| Shu P Li, Moon S Park, Jong Y Bahk, Myeong O Ki. Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. Neuroscience letters. vol 334. issue 2. 2003-01-24. PMID:12435490. |
chronic nicotine and smoking exposure decreases gaba(b1) receptor expression in the rat hippocampus. |
2003-01-24 |
2023-08-12 |
rat |