| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergiy Sylantyev, Leonid P Savtchenko, Nathanael O'Neill, Dmitri A Rusako. Extracellular GABA waves regulate coincidence detection in excitatory circuits. The Journal of physiology. vol 598. issue 18. 2021-02-15. PMID:32667048. |
rapid changes in neuronal network activity trigger widespread waves of extracellular gaba in hippocampal neuropil. |
2021-02-15 |
2023-08-13 |
Not clear |
| Vikram Babu Kasaragod, Anabel Pacios-Michelena, Natascha Schaefer, Fang Zheng, Nicole Bader, Christian Alzheimer, Carmen Villmann, Hermann Schindeli. Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 52. 2021-02-10. PMID:33318193. |
electrophysiological recordings from hippocampal slices and activity measurements of glutamic acid decarboxylase (gad), a plp-dependent enzyme synthesizing the neurotransmitter γ-aminobutyric acid (gaba), define how artemisinins also interfere presynaptically with gabaergic signaling. |
2021-02-10 |
2023-08-13 |
Not clear |
| Michelle Guignet, Amanda Campbell, H Steve Whit. Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action? Epilepsia. vol 61. issue 11. 2021-02-03. PMID:33063849. |
cbm's preclinical performance in tests, including the mouse 6-hz model of treatment-resistant seizures, the chemoconvulsant seizure models of generalized epilepsy, and the rat hippocampal kindling model of focal epilepsy, was distinct from other voltage-gated sodium channel blockers and gaba |
2021-02-03 |
2023-08-13 |
mouse |
| Kenichi Adachi, Daisuke Kato, Tomoaki Kahyo, Tomokazu Konishi, Toyohiro Sato, Yuta Madokoro, Masayuki Mizuno, Hiroyasu Akatsu, Mitsutoshi Setou, Noriyuki Matsukaw. Possible correlated variation of GABA Biochemical and biophysical research communications. vol 542. 2021-02-02. PMID:33503541. |
possible correlated variation of gaba cholinergic neural activation from the medial septal nucleus to hippocampus plays a crucial role in episodic memory as a regulating system for glutamatergic neural activation in the hippocampus. |
2021-02-02 |
2023-08-13 |
mouse |
| P Timothy Doughty, Imran Hossain, Chenggong Gong, Kayla A Ponder, Sandipan Pati, Prabhu U Arumugam, Teresa A Murra. Novel microwire-based biosensor probe for simultaneous real-time measurement of glutamate and GABA dynamics in vitro and in vivo. Scientific reports. vol 10. issue 1. 2021-01-13. PMID:32728074. |
we measured real-time dynamics of glu and gaba in rat hippocampal slices and observed a significant, nonlinear shift in the e/i ratio from excitatory to inhibitory dominance as electrical stimulation frequency increased from 10 to 140 hz, suggesting that gaba release is a component of a homeostatic mechanism in the hippocampus to prevent excitotoxic damage. |
2021-01-13 |
2023-08-13 |
rat |
| Fumiko Arima-Yoshida, Matthieu Raveau, Atsushi Shimohata, Kenji Amano, Akihiro Fukushima, Masashi Watanave, Shizuka Kobayashi, Satoko Hattori, Masaya Usui, Haruhiko Sago, Nobuko Mataga, Tsuyoshi Miyakawa, Kazuhiro Yamakawa, Toshiya Manab. Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA Scientific reports. vol 10. issue 1. 2021-01-11. PMID:32843708. |
in electrophysiological analyses using hippocampal slices, we found that the later phase of the depolarization during tetanic stimulation, which was regulated by gaba |
2021-01-11 |
2023-08-13 |
mouse |
| Christopher K Salmon, Horia Pribiag, Claire Gizowski, W Todd Farmer, Scott Cameron, Emma V Jones, Vivek Mahadevan, Charles W Bourque, David Stellwagen, Melanie A Woodin, Keith K Mura. Depolarizing GABA Transmission Restrains Activity-Dependent Glutamatergic Synapse Formation in the Developing Hippocampal Circuit. Frontiers in cellular neuroscience. vol 14. 2021-01-10. PMID:32161521. |
depolarizing gaba transmission restrains activity-dependent glutamatergic synapse formation in the developing hippocampal circuit. |
2021-01-10 |
2023-08-13 |
Not clear |
| Gemma Modinos, Fatma Şimşek, Matilda Azis, Matthijs Bossong, Ilaria Bonoldi, Carly Samson, Beverly Quinn, Jesus Perez, Matthew R Broome, Fernando Zelaya, David J Lythgoe, Oliver D Howes, James M Stone, Anthony A Grace, Paul Allen, Philip McGuir. Correction: Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 13. 2021-01-09. PMID:30279560. |
correction: prefrontal gaba levels, hippocampal resting perfusion and the risk of psychosis. |
2021-01-09 |
2023-08-13 |
Not clear |
| Eve Mon Oo, Katesirin Ruamyod, Ladawan Khowawisetsut, Chairat Turbpaiboon, Vipavadee Chaisuksunt, Panapat Uawithya, Nanthanit Pholphana, Nuchanart Rangkadilok, Supin Chompoopon. Germinated Brown Rice Attenuates Cell Death in Vascular Cognitive Impaired Mice and Glutamate-Induced Toxicity In HT22 Cells. Journal of agricultural and food chemistry. vol 68. issue 18. 2021-01-05. PMID:32275827. |
like pure gaba, gbr decreased cognitive deficits in memory behavioral tests and significantly attenuated hippocampal neuronal cell death at |
2021-01-05 |
2023-08-13 |
mouse |
| Kelsey Prena, Hu Cheng, Sharlene D Newma. Hippocampal Neurotransmitter Inhibition Suppressed During Gaming Explained by Skill Rather Than Gamer Status. Frontiers in human neuroscience. vol 14. 2020-12-31. PMID:33364929. |
goal-directed spatial decision making video games combine spatial mapping, memory, and reward; all of which can involve hippocampal excitation through suppression of an inhibitory neurotransmitter, γ-aminobutyric acid (gaba). |
2020-12-31 |
2023-08-13 |
human |
| Kelsey Prena, Hu Cheng, Sharlene D Newma. Hippocampal Neurotransmitter Inhibition Suppressed During Gaming Explained by Skill Rather Than Gamer Status. Frontiers in human neuroscience. vol 14. 2020-12-31. PMID:33364929. |
in this study, gaba was measured before and after 30 min of video game play within a voxel around the hippocampus. |
2020-12-31 |
2023-08-13 |
human |
| Kelsey Prena, Hu Cheng, Sharlene D Newma. Hippocampal Neurotransmitter Inhibition Suppressed During Gaming Explained by Skill Rather Than Gamer Status. Frontiers in human neuroscience. vol 14. 2020-12-31. PMID:33364929. |
it was predicted that all participants would experience a decrease in gaba during gaming as a result of in-game rewards; and, those who were most competitive with the goal-directed spatial decision making game would display lower hippocampal gaba concentrations after gaming. |
2020-12-31 |
2023-08-13 |
human |
| Kelsey Prena, Hu Cheng, Sharlene D Newma. Hippocampal Neurotransmitter Inhibition Suppressed During Gaming Explained by Skill Rather Than Gamer Status. Frontiers in human neuroscience. vol 14. 2020-12-31. PMID:33364929. |
those who were not competitive, because they were too skilled or not skilled enough, would demonstrate higher hippocampal gaba concentrations after gaming. |
2020-12-31 |
2023-08-13 |
human |
| Kelsey Prena, Hu Cheng, Sharlene D Newma. Hippocampal Neurotransmitter Inhibition Suppressed During Gaming Explained by Skill Rather Than Gamer Status. Frontiers in human neuroscience. vol 14. 2020-12-31. PMID:33364929. |
while there were no significant differences in hippocampal gaba before and after gaming for gamers and non-gamers alike, there was a significant quadratic regression between performance on a spatial working memory task and post-gaming hippocampal gaba concentrations. |
2020-12-31 |
2023-08-13 |
human |
| Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mor. Behavioral and neurochemical characterization of the spontaneous mutation tremor, a new mouse model of audiogenic seizures. Epilepsy & behavior : E&B. vol 105. 2020-12-29. PMID:32109856. |
comparing with wild type (wt) mice, the tremor mice showed higher hippocampal gene expression of egr3 and gabra1 and increased concentrations of noradrenalin (nor; p = .0012), serotonin (5ht; p = .0083), 5-hydroxyindoleacetic acid (5-hiaa; p = .0032), γ-amino butyric acid (gaba; p = .0123), glutamate (p = .0217) and aspartate (p = .0124). |
2020-12-29 |
2023-08-13 |
mouse |
| H Scott, T J Phillips, Y Sze, A Alfieri, M F Rogers, V Volpato, C P Case, P J Brunto. Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior. Neurobiology of stress. vol 13. 2020-12-22. PMID:33344732. |
blocking oxidative stress using an antioxidant prevented the prenatal stress-induced anxiety phenotype in the male offspring, and prevented sex-specific neurobiological changes, specifically a reduction in dendrite lengths in the hippocampus, as well as reductions in the number of parvalbumin-positive neurons and gaba receptor subunits in the hippocampus and basolateral amygdala of the male offspring. |
2020-12-22 |
2023-08-13 |
rat |
| Raquel García-García, Juan F Guerrero, Manuel Lavilla-Miyasato, Jose R Magdalena, Juan F Ordoño, Marta Llansola, Carmina Montoliu, Vicent Teruel-Martí, Vicente Felip. Hyperammonemia alters the mismatch negativity in the auditory evoked potential by altering functional connectivity and neurotransmission. Journal of neurochemistry. vol 154. issue 1. 2020-12-04. PMID:31840253. |
hyperammonemia also alters membrane expression of glutamate and gaba receptors in hippocampus and reduces the changes in extracellular gaba and glutamate induced by the mmn paradigm of auditory stimulus in hippocampus of control rats. |
2020-12-04 |
2023-08-13 |
rat |
| Benjamin Spurny, Rene Seiger, Philipp Moser, Thomas Vanicek, Murray B Reed, Eva Heckova, Paul Michenthaler, Alim Basaran, Gregor Gryglewski, Manfred Klöbl, Siegfried Trattnig, Siegfried Kasper, Wolfgang Bogner, Rupert Lanzenberge. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage. vol 204. 2020-11-27. PMID:31606475. |
hippocampal gaba levels correlate with retrieval performance in an associative learning paradigm. |
2020-11-27 |
2023-08-13 |
human |
| Benjamin Spurny, Rene Seiger, Philipp Moser, Thomas Vanicek, Murray B Reed, Eva Heckova, Paul Michenthaler, Alim Basaran, Gregor Gryglewski, Manfred Klöbl, Siegfried Trattnig, Siegfried Kasper, Wolfgang Bogner, Rupert Lanzenberge. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage. vol 204. 2020-11-27. PMID:31606475. |
changes of gaba and glutamate were compared to retrieval success in the hippocampus, insula and thalamus. |
2020-11-27 |
2023-08-13 |
human |
| Benjamin Spurny, Rene Seiger, Philipp Moser, Thomas Vanicek, Murray B Reed, Eva Heckova, Paul Michenthaler, Alim Basaran, Gregor Gryglewski, Manfred Klöbl, Siegfried Trattnig, Siegfried Kasper, Wolfgang Bogner, Rupert Lanzenberge. Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm. NeuroImage. vol 204. 2020-11-27. PMID:31606475. |
however, baseline hippocampal gaba levels were significantly correlated with initial retrieval success (p |
2020-11-27 |
2023-08-13 |
human |