| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Placheta, E Singer, W Sieghart, M Karobat. Properties of [3H]taurine release from crude synaptosomal fractions of rat cerebral cortex. Neurochemical research. vol 4. issue 6. 1980-07-28. PMID:120936. |
the release of previously accumulated [3h]taurine and [14c]gaba from crude synaptosomal (p2) fractions isolated from rat cerebral cortex was studied using a superfusion system. |
1980-07-28 |
2023-08-11 |
rat |
| U C Sábato, S Fiszer de Plazas, E De Roberti. The convulsant drugs 3-mercaptopropionate and methionine sulfoximine inhibit L-glutamate and L-aspartate binding to a hydrophobic protein fraction from rat cerebral cortex. Neurochemical research. vol 4. issue 6. 1980-07-28. PMID:545163. |
the action of the convulsant drugs, methionine sulfoximine (mso), 3-mercaptopropionate (3-mp), megimide (mg), and allylglycine on the binding of l-[14c]aspartate, l-[14c]glutamate and [14c]gaba to a hydrophobic protein fraction isolated from rat cerebral cortex was studied. |
1980-07-28 |
2023-08-11 |
rat |
| M M Robin, M G Palfreyman, M M Zraika, P J Schechte. An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin. European journal of pharmacology. vol 62. issue 4. 1980-07-22. PMID:6445277. |
using the degree of enzyme inhibition in various brain areas as a measure of drug distribution following intrastriatal administration of gamma-acetylenic gaba and gamma-vinyl gaba, there was found considerable retrodiffusion via the needle tract to the overlying cortex. |
1980-07-22 |
2023-08-12 |
rat |
| M Abe, M Matsud. Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions. Journal of nutritional science and vitaminology. vol 25. issue 6. 1980-06-16. PMID:541751. |
the effects of administration of dl-penicillamine (pea), thiosemicarbazide (tsc), semicarbazide-hcl (sc) as convulsants and pyridoxine (pn) as anticonvulsant on gamma-aminobutyric acid (gaba) content, glutamic acid decarboxylase (gad) and gamma-aminobutyric acid transaminase (gaba-t) activities in cerebral cortex, striatum, diencephalon, mesencephalon, cerebellum and pons/medulla were investigated. |
1980-06-16 |
2023-08-11 |
mouse |
| C Pfister, H Danne. [Notes on the transmitter histochemistry of the cortex cerebelli of rat]. Acta histochemica. vol 65. issue 2. 1980-05-30. PMID:120097. |
the cortex cerebelli of the normal, adult rat was investigated fluorescence histochemically by means of the paraformaldehyde method according to falck and hillarp (1962) for visualization of catecholamines and a modified ninhydrin-reaction for the demonstration of gaba (pfister and gorne 1978), respectively. |
1980-05-30 |
2023-08-11 |
rat |
| S Govoni, M Memo, L Saiani, P F Spano, M Trabucch. Impairment of brain neurotransmitter receptors in aged rats. Mechanisms of ageing and development. vol 12. issue 1. 1980-04-23. PMID:6243729. |
on the other hand, [3h] gaba binding is significantly decreased in substantia nigra and hypothalamus of aged rats, while it is unmodified in cerebral cortex, cerebellum, striatum and nucleus accumbens. |
1980-04-23 |
2023-08-12 |
rat |
| J A Assumpção, N Bernardi, J Brown, T W Ston. Selective antagonism by benzodiazepines of neuronal responses to excitatory amino acids in the cerebral cortex. British journal of pharmacology. vol 67. issue 4. 1980-03-27. PMID:42460. |
after intravenous diazepam, responses to gaba and taurine were reduced on 3 cells and unchanged on 11.3 on purkinje cells in the cerebellum a number of cells (5 of 16) exhibited a substantial increase in responses to gaba and taurine following intravenous or iontophoretic application of benzodiazepines.4 it is suggested that the highly selective reduction of excitatory amino acid responses in the cerebral cortex may be of particular relevance to the behavioural effects of benzodiazepines. |
1980-03-27 |
2023-08-11 |
rat |
| G G Yarbrough, M Williams, D R Haubric. The neuropharmacology of a novel gamma-aminobutyric acid analog, kojic amine. Archives internationales de pharmacodynamie et de therapie. vol 241. issue 2. 1980-03-17. PMID:118713. |
iontophoretically applied ka exerted a pronounced (comparable to gaba on the basis of ejection currents)i inhibition of the firing of cerebellar purkinje cells and spontaneously active or glutamate-activated neurons in the cerebral cortex. |
1980-03-17 |
2023-08-11 |
rat |
| S Sarhan, N Seile. Metabolic inhibitors and subcellular distribution of GABA. Journal of neuroscience research. vol 4. issue 5-6. 1980-03-17. PMID:392122. |
two irreversible gaba-t inhibitors, vinyl gaba and acetylenic gaba, two gad inhibitors, 3-mercaptopropionic acid and pyridoxal phosphate glutamyl-gamma-hydrazone, and di-n propylacetate, a clinically useful anticonvulsant, have been studied to determine their effects on gaba compartmentalization in mouse brain cortex. |
1980-03-17 |
2023-08-11 |
mouse |
| D A Primros. Treatment of self-injurious behaviour with a GABA (gamma-aminobutyric acid) analogue. Journal of mental deficiency research. vol 23. issue 3. 1980-02-26. PMID:390158. |
gaba, in addition to being a muscle relaxant, is also a major inhibitor in many areas of the brain, including the cortex and basal ganglia (callingham, 1972) andit was presumed by the author that some severely subnormal defectives have damage in these areas and hence might be deficient in this inhibitor. |
1980-02-26 |
2023-08-11 |
Not clear |
| A Schousbo. Effects of GABA-analogues on the high-affinity uptake of GABA in astrocytes in primary cultures. Advances in experimental medicine and biology. vol 123. 1980-02-15. PMID:42281. |
beta-proline was a selective inhibitor of gaba transport in astrocytes, whereas r-trans-4-methyl-4-aminocrotonic acid and s-nipecotic acid seemed to be selective inhibitors of neuronal gaba transport, as studied using very thin slices ("prisms") of brain cortex. |
1980-02-15 |
2023-08-11 |
Not clear |
| R J Reiffenstei. Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex. Canadian journal of physiology and pharmacology. vol 57. issue 8. 1980-01-24. PMID:497893. |
the hypothesis that the seizure susceptibility of chronically denervated cortex is due to interruption of recurrent inhibitory pathways was tested by examining the release of 3h-labeled gamma-aminobutyric acid ([3h]gaba) from chronic slabs and normal cortex of cats. |
1980-01-24 |
2023-08-11 |
cat |
| R J Reiffenstei. Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex. Canadian journal of physiology and pharmacology. vol 57. issue 8. 1980-01-24. PMID:497893. |
when methacholine was used to evoke seizure activity, [3h]gaba release was depressed in both normal and epileptic cortex, suggesting that the mechanism of seizure genesis by cholinomimetics involves suppression of inhibitory neuron activity. |
1980-01-24 |
2023-08-11 |
cat |
| R J Reiffenstei. Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex. Canadian journal of physiology and pharmacology. vol 57. issue 8. 1980-01-24. PMID:497893. |
pentylenetetrazol-induced seizures evoked a small, equal increase in [3h]gaba efflux from epileptic and normal cortex. |
1980-01-24 |
2023-08-11 |
cat |
| R J Reiffenstei. Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex. Canadian journal of physiology and pharmacology. vol 57. issue 8. 1980-01-24. PMID:497893. |
preseizure efflux of [3h]gaba was the same from chronic slabs and normal cortex in all experiments. |
1980-01-24 |
2023-08-11 |
cat |
| A I Balakleevsky, N P Bobrova, N V Shevtchenk. Regulation of gamma-aminobutyric acid metabolism in different brain structures by cholinergic and adrenergic drugs. Annali dell'Istituto superiore di sanita. vol 14. issue 1. 1979-12-29. PMID:756168. |
minor changes in gaba metabolism are observed in cerebral cortex and cerebellum. |
1979-12-29 |
2023-08-11 |
mouse |
| G G Collin. Evidence of a neurotransmitter role for aspartate and gamma-aminobutyric acid in the rat olfactory cortex. The Journal of physiology. vol 291. 1979-11-29. PMID:225475. |
when slices from the unoperated side were exposed to solutions containing 25 mm-k+ or stimulated with electrodes placed directly on the cortex enclosed by the cup there was a ca(2+)-dependent release of aspartate and gaba accompanied by a ca(2+)-independent release of taurine. |
1979-11-29 |
2023-08-11 |
rat |
| T H Chiu, H C Rosenber. GABA receptor-mediated modulation of 3H-diazepam binding in rat cortex. European journal of pharmacology. vol 56. issue 4. 1979-11-28. PMID:225180. |
gaba receptor-mediated modulation of 3h-diazepam binding in rat cortex. |
1979-11-28 |
2023-08-11 |
rat |
| T H Chiu, H C Rosenber. GABA receptor-mediated modulation of 3H-diazepam binding in rat cortex. European journal of pharmacology. vol 56. issue 4. 1979-11-28. PMID:225180. |
three membrane preparations of rat cortex were used to examine the effects of gaba, bicuculline and bicucine on specific 3h-diazepam binding. |
1979-11-28 |
2023-08-11 |
rat |
| E Kunert, E L Dovedov. [Effect of light deprivation on GABA metabolism in subcellular fractions of the rabbit visual system]. Voprosy meditsinskoi khimii. vol 25. issue 4. 1979-10-24. PMID:473689. |
specific activity of glutamate decarboxylase was decreased in subfractions of light and heavy synaptosomes, and gamma-aminobutyric acid (gaba) transaminase activity--also in subfractions of free mitochondria, isolated from visual zone of brain cortex and of anterior mesencephalon but not from locomotive region of brain cortex of the light-deprived rabbits. |
1979-10-24 |
2023-08-11 |
rabbit |