| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mario Manto, Danielle Marmolin. Cerebellar disorders--at the crossroad of molecular pathways and diagnosis. Cerebellum (London, England). vol 8. issue 4. 2010-02-19. PMID:19859773. |
our understanding of the pathogenesis of cerebellar ataxias has started several decades ago and is continuously growing. |
2010-02-19 |
2023-08-12 |
Not clear |
| Joost H Heeroma, Christian Henneberger, Sanjeev Rajakulendran, Michael G Hanna, Stephanie Schorge, Dimitri M Kullman. Episodic ataxia type 1 mutations differentially affect neuronal excitability and transmitter release. Disease models & mechanisms. vol 2. issue 11-12. 2010-02-18. PMID:19779067. |
heterozygous mutations of kcna1, the gene encoding potassium channel kv1.1 subunits, cause episodic ataxia type 1 (ea1), which is characterized by paroxysmal cerebellar incoordination and interictal myokymia. |
2010-02-18 |
2023-08-12 |
human |
| Y L Lo, S Fook-Chong, L L Chan, W Y Ong, P Ratnagopa. Electrophysiological evidence of cerebellar fiber system involvement in the Miller Fisher syndrome. Journal of the neurological sciences. vol 288. issue 1-2. 2010-02-17. PMID:19863971. |
in the miller fisher syndrome (mfs), ataxia may be due involvement of ia afferents and the cerebellum. |
2010-02-17 |
2023-08-12 |
Not clear |
| Thomas Klockgethe. Sporadic ataxia with adult onset: classification and diagnostic criteria. The Lancet. Neurology. vol 9. issue 1. 2010-02-17. PMID:20083040. |
finally, patients might have a sporadic degenerative disease, such as multiple system atrophy of cerebellar type or sporadic adult-onset ataxia of unknown aetiology. |
2010-02-17 |
2023-08-12 |
Not clear |
| Hugo A Arroyo, Natalia Tringle. [Opsoclonus-myoclonus syndrome]. Medicina. vol 69. issue 1 Pt 1. 2010-02-05. PMID:19240003. |
an autoimmune mechanism would be responsible for the dysfunction of structures in brain stem and cerebellum thus explaining some of the cardinal symptoms such as opsoclonus, myoclonus and ataxia. |
2010-02-05 |
2023-08-12 |
Not clear |
| M Anheim, B Monga, M Fleury, P Charles, C Barbot, M Salih, J P Delaunoy, M Fritsch, L Arning, M Synofzik, L Schöls, J Sequeiros, C Goizet, C Marelli, I Le Ber, J Koht, J Gazulla, J De Bleecker, M Mukhtar, N Drouot, L Ali-Pacha, T Benhassine, M Chbicheb, A M'Zahem, A Hamri, B Chabrol, J Pouget, R Murphy, M Watanabe, P Coutinho, M Tazir, A Durr, A Brice, C Tranchant, M Koeni. Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients. Brain : a journal of neurology. vol 132. issue Pt 10. 2010-02-03. PMID:19696032. |
ataxia with oculomotor apraxia type 2 (aoa2) is an autosomal recessive disease due to mutations in the senataxin gene, causing progressive cerebellar ataxia with peripheral neuropathy, cerebellar atrophy, occasional oculomotor apraxia and elevated alpha-feto-protein (afp) serum level. |
2010-02-03 |
2023-08-12 |
Not clear |
| Yoshikazu Ugaw. [Basic mechanism of magnetic human cerebellar stimulation and its clinical application]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 10. 2010-01-19. PMID:19999142. |
in contrast, the suppression was normally elicited in patients with a lesion at pontine nucleus, middle cerebellar peduncle even though they had clinically definite ataxia. |
2010-01-19 |
2023-08-12 |
human |
| Yoshikazu Ugaw. [Basic mechanism of magnetic human cerebellar stimulation and its clinical application]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 10. 2010-01-19. PMID:19999142. |
based on these results, we concluded that the cerebellar electrical stimulation method was useful to differentiate cerebellar ataxia due to cerebellar efferent pathways lesions from other cerebellar ataxia and non-cerebellar ataxia. |
2010-01-19 |
2023-08-12 |
human |
| Yoshikazu Ugaw. [Basic mechanism of magnetic human cerebellar stimulation and its clinical application]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 10. 2010-01-19. PMID:19999142. |
these all results supported the proposal that the magnetic stimulation over the cerebellum can enable us to differentiate the cerebellar efferent ataxia from other cerebellar ataxia and non-cerebellar ataxia. |
2010-01-19 |
2023-08-12 |
human |
| Seika Nakamura, Reika Wate, Akiyo Shinde, Shinya Asayama, Satoshi Nakano, Hirofumi Kusak. [A case of cerebellar syndrome associated with HIV infection]. Rinsho shinkeigaku = Clinical neurology. vol 49. issue 10. 2010-01-19. PMID:19999147. |
we could not establish the exact pathogenesis of ataxia in this patient it could have been primary cerebellar degeneration caused by hiv, or the other viruses detected (ebv, jcv) or autoimmune mechanisms caused by these viruses. |
2010-01-19 |
2023-08-12 |
Not clear |
| Hristelina Ilieva, Magdalini Polymenidou, Don W Clevelan. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. The Journal of cell biology. vol 187. issue 6. 2010-01-15. PMID:19951898. |
damage to a specific set of key partner cells as well as to vulnerable neurons may account for the selective susceptibility of neuronal subtypes in many human neurodegenerative diseases, including huntington's disease (hd), parkinson's disease (pd), prion disease, the spinal cerebellar ataxias (scas), and alzheimer's disease (ad). |
2010-01-15 |
2023-08-12 |
human |
| Christine Tranchant, Mathieu Anhei. [Autosomal recessive cerebellar ataxias]. Presse medicale (Paris, France : 1983). vol 38. issue 12. 2009-12-30. PMID:19442480. |
[autosomal recessive cerebellar ataxias]. |
2009-12-30 |
2023-08-12 |
Not clear |
| W Ilg, M Synofzik, D Brötz, S Burkard, M A Giese, L Schöl. Intensive coordinative training improves motor performance in degenerative cerebellar disease. Neurology. vol 73. issue 22. 2009-12-22. PMID:19864636. |
in this study, we examined the effectiveness of a 4-week intensive coordinative training for 16 patients with progressive ataxia due to cerebellar degeneration (n = 10) or degeneration of afferent pathways (n = 6). |
2009-12-22 |
2023-08-12 |
Not clear |
| Henry L Paulso. The spinocerebellar ataxias. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. vol 29. issue 3. 2009-12-07. PMID:19726947. |
slowly progressive ataxia accompanied by cerebellar degeneration is often genetic in origin. |
2009-12-07 |
2023-08-12 |
Not clear |
| Katrin Bürk, Ulrike Mälzig, Stefanie Wolf, Suzette Heck, Konstantinos Dimitriadis, Tanja Schmitz-Hübsch, Sascha Hering, Tobias M Lindig, Verena Haug, Dagmar Timmann, Ingrid Degen, Bernd Kruse, Jan-Markus Dörr, Susanne Ratzka, Anja Ivo, Ludger Schöls, Sylvia Boesch, Thomas Klockgether, Thomas Klopstock, Jörg B Schul. Comparison of three clinical rating scales in Friedreich ataxia (FRDA). Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 12. 2009-12-04. PMID:19562766. |
although originally developed for the use in dominantly inherited ataxias, which are primarily ataxias of the cerebellar type, sara can also be used successfully to assess afferent ataxia, which is the predominant form in frda. |
2009-12-04 |
2023-08-12 |
Not clear |
| Masaoki Iwanami, Masaaki Odaka, Toshiki Nakamura, Koichi Hirat. [Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome associated with anti P/Q-type voltage-gated calcium channel antibody in a patient with primary double lung cancer]. Brain and nerve = Shinkei kenkyu no shinpo. vol 61. issue 9. 2009-12-03. PMID:19803409. |
neurological examination revealed diplopia, mild ptosis, bilateral horizontal gaze-evoked nystagmus, and cerebellar limb and truncal ataxia. |
2009-12-03 |
2023-08-12 |
Not clear |
| Susan E Tomlinson, Michael G Hanna, Dimitri M Kullmann, S Veronica Tan, David Burk. Clinical neurophysiology of the episodic ataxias: insights into ion channel dysfunction in vivo. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 120. issue 10. 2009-11-17. PMID:19734086. |
the genetic episodic ataxias are a group of disorders with heterogeneous phenotype and genotype, but share in common the feature of intermittent cerebellar dysfunction. |
2009-11-17 |
2023-08-12 |
Not clear |
| Corinna Lappe-Siefke, Sven Loebrich, Wulf Hevers, Oliver B Waidmann, Michaela Schweizer, Susanne Fehr, Jean-Marc Fritschy, Ivan Dikic, Jens Eilers, Scott M Wilson, Matthias Kneusse. The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS genetics. vol 5. issue 9. 2009-11-17. PMID:19759851. |
ataxia represents a pathological coordination failure that often involves functional disturbances in cerebellar circuits. |
2009-11-17 |
2023-08-12 |
mouse |
| Antonio García, Silvia Alvarez, Jon Infante, José Bercian. Masseter reflex in the study of spinocerebellar ataxia type 2 and type 3. Muscle & nerve. vol 40. issue 4. 2009-11-16. PMID:19618433. |
in this investigation we assess the utility of the masseter reflex for diagnostic purposes in autosomal dominant cerebellar ataxias. |
2009-11-16 |
2023-08-12 |
Not clear |
| Rolf H Joho, Edward C Hurloc. The role of Kv3-type potassium channels in cerebellar physiology and behavior. Cerebellum (London, England). vol 8. issue 3. 2009-11-09. PMID:19247732. |
behavioral phenotypes in kv3-null mutant mice such as ataxia with prominent hypermetria and heightened alcohol sensitivity are characteristic of cerebellar dysfunction. |
2009-11-09 |
2023-08-12 |
mouse |