| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-juan Guan, Jun-ling Wang, Bei-sha Tan. [Recent advance in genetic study of hereditary autosomal recessive cerebellar ataxia]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 29. issue 6. 2013-04-03. PMID:23225047. |
autosomal recessive cerebellar ataxias (arca) are a highly heterogeneous group of rare neurodegenerative diseases affecting both central and peripheral nervous systems. |
2013-04-03 |
2023-08-12 |
Not clear |
| John E Greenle. Treatment of paraneoplastic cerebellar degeneration. Current treatment options in neurology. vol 15. issue 2. 2013-04-01. PMID:23315179. |
paraneoplastic cerebellar degeneration is an uncommon autoimmune disorder characterized clinically by progressive, ultimately incapacitating ataxia and pathologically by destruction of cerebellar purkinje cells, with variable loss of other cell populations. |
2013-04-01 |
2023-08-12 |
Not clear |
| Adebimpe W Kasumu, Charlotte Hougaard, Frederik Rode, Thomas A Jacobsen, Jean Marc Sabatier, Birgitte L Eriksen, Dorte Strøbæk, Xia Liang, Polina Egorova, Dasha Vorontsova, Palle Christophersen, Lars Christian B Rønn, Ilya Bezprozvann. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chemistry & biology. vol 19. issue 10. 2013-03-26. PMID:23102227. |
we conclude that sk2 channels constitute a therapeutic target for sca2 treatment and that the developed selective sk2/3 modulator ns13001 holds promise as a potential therapeutic agent for treatment of sca2 and possibly other cerebellar ataxias. |
2013-03-26 |
2023-08-12 |
mouse |
| Catherine Lemaire-Vieille, Yannick Bailly, Paul Erlich, Corinne Loeuillet, Jacques Brocard, Anne-Marie Haeberlé, Guy Bombarde, Camille Rak, Valérie Demais, Chantal Dumestre-Pérard, Jean Gagnon, Jean-Yves Cesbro. Ataxia with cerebellar lesions in mice expressing chimeric PrP-Dpl protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 4. 2013-03-20. PMID:23345215. |
ataxia with cerebellar lesions in mice expressing chimeric prp-dpl protein. |
2013-03-20 |
2023-08-12 |
mouse |
| Fatemeh Rahimi Shourmasti, Iran Goudarzi, Taghi Lashkarbolouki, Kataneh Abrari, Mahmoud Elahdadi Salmani, Afsaneh Goudarz. Effects of riluzole on harmaline induced tremor and ataxia in rats: biochemical, histological and behavioral studies. European journal of pharmacology. vol 695. issue 1-3. 2013-03-19. PMID:22975288. |
thus, we aimed to investigate the therapeutic effects of riluzole on harmaline-induced tremor and ataxia in rat, and determining whether riluzole exerts its effect through modulation of glutamate levels in cerebellum. |
2013-03-19 |
2023-08-12 |
rat |
| Dandan Jia, Beisha Tang, Zhao Chen, Yuting Shi, Zhanfang Sun, Li Zhang, Junling Wang, Kun Xia, Hong Jian. Spinocerebellar ataxia type 28 (SCA28) is an uncommon cause of dominant ataxia among Chinese kindreds. The International journal of neuroscience. vol 122. issue 10. 2013-02-26. PMID:22563911. |
autosomal dominant cerebellar ataxias (adcas) are a clinically and genetically heterogeneous group of neurodegenerative disorders primarily affecting the cerebellum. |
2013-02-26 |
2023-08-12 |
Not clear |
| R Paudel, J Hardy, T Revesz, J L Holton, H Houlde. Review: genetics and neuropathology of primary pure dystonia. Neuropathology and applied neurobiology. vol 38. issue 6. 2013-02-22. PMID:22897341. |
neuropathology has been the key to understanding the aetiology of many neurological disorders such as alzheimer's disease, parkinson's disease, frontotemporal degeneration and cerebellar ataxias. |
2013-02-22 |
2023-08-12 |
Not clear |
| Sang Seok Yeo, Sung Ho Jan. Delayed neural degeneration following gamma knife radiosurgery in a patient with an arteriovenous malformation: a diffusion tensor imaging study. NeuroRehabilitation. vol 31. issue 2. 2013-02-07. PMID:22951706. |
a 43-year-old male patient was diagnosed with an intraventricular hemorrhage (ivh) due to rupture of an avm in the right middle cerebellar peduncle, and exhibited cognitive impairment, quadriparesis, and ataxia after ivh onset. |
2013-02-07 |
2023-08-12 |
Not clear |
| Natalie Winter, Peter Kovermann, Christoph Fahlk. A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents. Brain : a journal of neurology. vol 135. issue Pt 11. 2013-02-04. PMID:23107647. |
episodic ataxia is a human genetic disease characterized by paroxysmal cerebellar incoordination. |
2013-02-04 |
2023-08-12 |
human |
| Xingzhi Chang, Yu Huang, Hongdi Meng, Yuwu Jiang, Ye Wu, Hui Xiong, Shuang Wang, Jiong Qi. Clinical study in Chinese patients with late-infantile form neuronal ceroid lipofuscinoses. Brain & development. vol 34. issue 9. 2013-01-28. PMID:22245569. |
the patients have onset age of 2-3.5 years, and most of them initially present partial seizure, and then progressed to deteriorated mental function, refractory myoclonic seizures, impaired vision, and ataxia with cerebellar atrophy. |
2013-01-28 |
2023-08-12 |
Not clear |
| Almundher Al-Maawali, Susan Blaser, Grace Yoo. Diagnostic approach to childhood-onset cerebellar atrophy: a 10-year retrospective study of 300 patients. Journal of child neurology. vol 27. issue 9. 2013-01-23. PMID:22764178. |
hereditary ataxias associated with cerebellar atrophy are a heterogeneous group of disorders. |
2013-01-23 |
2023-08-12 |
Not clear |
| Almundher Al-Maawali, Susan Blaser, Grace Yoo. Diagnostic approach to childhood-onset cerebellar atrophy: a 10-year retrospective study of 300 patients. Journal of child neurology. vol 27. issue 9. 2013-01-23. PMID:22764178. |
neuroimaging is a crucial initial investigation in the diagnostic evaluation of ataxia in childhood, and the presence of cerebellar atrophy helps guide further investigations. |
2013-01-23 |
2023-08-12 |
Not clear |
| Claire N Ashley, Kelly D Hoang, David R Lynch, Susan L Perlman, Bernard L Mari. Childhood ataxia: clinical features, pathogenesis, key unanswered questions, and future directions. Journal of child neurology. vol 27. issue 9. 2013-01-23. PMID:22859693. |
childhood ataxia is characterized by impaired balance and coordination primarily because of cerebellar dysfunction. |
2013-01-23 |
2023-08-12 |
Not clear |
| J Schwabova, F Zahalka, V Komarek, T Maly, P Hrasky, T Gryc, O Cakrt, A Zumrov. Uses of the postural stability test for differential diagnosis of hereditary ataxias. Journal of the neurological sciences. vol 316. issue 1-2. 2013-01-22. PMID:22336696. |
posturography is attested to as a useful method for differential diagnosis of hereditary ataxias and provides neurophysiological findings in cerebellar and sensoric ataxias. |
2013-01-22 |
2023-08-12 |
Not clear |
| Peter K Jackso. TTBK2 kinase: linking primary cilia and cerebellar ataxias. Cell. vol 151. issue 4. 2013-01-16. PMID:23141531. |
ttbk2 kinase: linking primary cilia and cerebellar ataxias. |
2013-01-16 |
2023-08-12 |
mouse |
| Emmanuelle Apartis, Anne Blancher, Wassilios G Meissner, Lucie Guyant-Maréchal, David Maltête, Thomas De Broucker, André-Pierre Legrand, Hichem Bouzenada, Hung Tran Thanh, Magali Sallansonnet-Froment, Adrien Wang, François Tison, Carole Roué-Jagot, Frédéric Sedel, Perrine Charles, Sandra Whalen, Delphine Héron, Stéphane Thobois, Alice Poisson, Gaetan Lesca, Anne-Marie Ouvrard-Hernandez, Valérie Fraix, Stephane Palfi, Marie-Odile Habert, Bertrand Gaymard, Jean-Claude Dussaule, Pierre Pollak, Marie Vidailhet, Alexandra Durr, Jean-Claude Barbot, Véronique Gourlet, Alexis Brice, Mathieu Anhei. FXTAS: new insights and the need for revised diagnostic criteria. Neurology. vol 79. issue 18. 2013-01-14. PMID:23077007. |
fragile x-associated tremor ataxia syndrome (fxtas) is defined by fmr1 premutation, cerebellar ataxia, intentional tremor, and middle cerebellar peduncle (mcp) hyperintensities. |
2013-01-14 |
2023-08-12 |
Not clear |
| Alessandro Didonna, Joshua Sussman, Federico Benetti, Giuseppe Legnam. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. vol 6. issue 3. 2013-01-02. PMID:22561161. |
whereas prp (c) is highly expressed in the central nervous system (cns), dpl is detected mostly in testes and its ectopic expression in the cns leads to ataxia as well as purkinje and granule cell degeneration in the cerebellum. |
2013-01-02 |
2023-08-12 |
mouse |
| Joshua Hersheson, Andrea Haworth, Henry Houlde. The inherited ataxias: genetic heterogeneity, mutation databases, and future directions in research and clinical diagnostics. Human mutation. vol 33. issue 9. 2012-12-13. PMID:22689585. |
the inherited cerebellar ataxias are a diverse group of clinically and genetically heterogeneous neurodegenerative disorders. |
2012-12-13 |
2023-08-12 |
human |
| Adebimpe Kasumu, Ilya Bezprozvann. Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum (London, England). vol 11. issue 3. 2012-12-11. PMID:20480274. |
scas are generally characterized by progressive ataxia and cerebellar atrophy. |
2012-12-11 |
2023-08-12 |
Not clear |
| Adebimpe Kasumu, Ilya Bezprozvann. Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias. Cerebellum (London, England). vol 11. issue 3. 2012-12-11. PMID:20480274. |
it is not currently understood how mutations in these 17 proteins lead to the cerebellar atrophy and ataxia. |
2012-12-11 |
2023-08-12 |
Not clear |