| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Mitsumura, Nobutake Hosoi, Nobuhiko Furuya, Hirokazu Hira. Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice. The Journal of physiology. vol 589. issue Pt 13. 2012-04-13. PMID:21558162. |
staggerer mutant mice have functional loss of a transcription factor, retinoid-related orphan receptor α (rorα), which is abundantly expressed in purkinje cells (pcs) of the cerebellum.homozygous staggerer (sg/sg)mice show cerebellar hypoplasia and congenital ataxia. |
2012-04-13 |
2023-08-12 |
mouse |
| Xianghong Kuang, Mingshan Yan, Joanne M Ajmo, Virginia L Scofield, George Stoica, Paul K Y Won. Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species. Biochemical and biophysical research communications. vol 418. issue 2. 2012-04-09. PMID:22260947. |
ataxia telangiectasia (a-t) is an inherited disease, the most prominent feature of which is ataxia caused by degeneration of cerebellar neurons and synapses. |
2012-04-09 |
2023-08-12 |
mouse |
| C Napon, J Kabor. [Painful ophthalmoplegia in a woman from Burkina Faso: cerebral venous thrombosis (CVT) of the cavernous sinus]. Medecine tropicale : revue du Corps de sante colonial. vol 70. issue 4. 2012-04-05. PMID:22368942. |
one month later, clinical symptoms had progressed to asymmetric muscle weakness in all four limbs, right cerebellum ataxia and involvement of the trigeminal ophthalmic branch. |
2012-04-05 |
2023-08-12 |
Not clear |
| S Vermeer, B P C van de Warrenburg, M A A P Willemsen, M Cluitmans, H Scheffer, B P Kremer, N V A M Knoer. Autosomal recessive cerebellar ataxias: the current state of affairs. Journal of medical genetics. vol 48. issue 10. 2012-03-15. PMID:21856962. |
autosomal recessive cerebellar ataxias: the current state of affairs. |
2012-03-15 |
2023-08-12 |
Not clear |
| S Vermeer, B P C van de Warrenburg, M A A P Willemsen, M Cluitmans, H Scheffer, B P Kremer, N V A M Knoer. Autosomal recessive cerebellar ataxias: the current state of affairs. Journal of medical genetics. vol 48. issue 10. 2012-03-15. PMID:21856962. |
among the hereditary ataxias, autosomal recessive cerebellar ataxias (arcas) encompass a diverse group of rare neurodegenerative disorders in which a cerebellar syndrome is the key clinical feature. |
2012-03-15 |
2023-08-12 |
Not clear |
| Daniel J Bonthiu. Ataxia and the cerebellum. Seminars in pediatric neurology. vol 18. issue 2. 2012-03-15. PMID:22036481. |
ataxia and the cerebellum. |
2012-03-15 |
2023-08-12 |
Not clear |
| Daniel J Bonthiu. Ataxia and the cerebellum. Seminars in pediatric neurology. vol 18. issue 2. 2012-03-15. PMID:22036481. |
while ataxia may be due to lesions in a variety of locations throughout the peripheral and central nervous systems, it is most commonly due to dysfunction of the cerebellum. |
2012-03-15 |
2023-08-12 |
Not clear |
| Mathieu Anheim, Christine Tranchant, Michel Koeni. The autosomal recessive cerebellar ataxias. The New England journal of medicine. vol 366. issue 7. 2012-02-24. PMID:22335741. |
the autosomal recessive cerebellar ataxias. |
2012-02-24 |
2023-08-12 |
Not clear |
| Alfredo Damasceno, Marcondes C França, Fernando Cendes, Anamarli Nucc. Cerebellar atrophy is infrequently [corrected] associated with non-paraneoplastic sensory neuronopathy. Arquivos de neuro-psiquiatria. vol 69. issue 4. 2012-02-09. PMID:21877027. |
despite the evidence of a defective proprioceptive sensory input in sn,the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum. |
2012-02-09 |
2023-08-12 |
Not clear |
| A Gimenez-Cassina, R Wade-Martins, S Gomez-Sebastian, J-C Corona, F Lim, J Diaz-Nid. Infectious delivery and long-term persistence of transgene expression in the brain by a 135-kb iBAC-FXN genomic DNA expression vector. Gene therapy. vol 18. issue 10. 2012-01-30. PMID:21490681. |
to develop gene therapy strategies for friedreich's ataxia (frda), we have examined the persistence of transgene expression in the brain in vivo provided by the entire 135 kb fxn genomic dna locus delivered as an infectious bacterial artificial chromosome (ibac) herpes simplex virus type 1 (hsv-1)-based vector injected in the adult mouse cerebellum. |
2012-01-30 |
2023-08-12 |
mouse |
| Yi-chung Lee, Yi-chu Liao, Po-shan Wang, I-Hui Lee, Kon-ping Lin, Bing-wen Soon. Comparison of cerebellar ataxias: A three-year prospective longitudinal assessment. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 11. 2012-01-27. PMID:21626567. |
comparison of cerebellar ataxias: a three-year prospective longitudinal assessment. |
2012-01-27 |
2023-08-12 |
Not clear |
| Marius Krauthausen, Sally L Ellis, Julian Zimmermann, Maria Sarris, Denis Wakefield, Michael T Heneka, Iain L Campbell, Marcus Mülle. Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12. The American journal of pathology. vol 179. issue 5. 2012-01-24. PMID:21925471. |
gf-il12 mice develop ataxia because of severe cerebellar inflammation but have little overt ocular disease. |
2012-01-24 |
2023-08-12 |
mouse |
| Conceição Bettencourt, Cristina Santos, Paula Coutinho, Patrizia Rizzu, João Vasconcelos, Teresa Kay, Teresa Cymbron, Mafalda Raposo, Peter Heutink, Manuela Lim. Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3): a two-case report. BMC neurology. vol 11. 2012-01-23. PMID:22023810. |
mjd presents extrapyramidal motor signs, namely parkinsonism, more frequently than the other subtypes of autosomal dominant cerebellar ataxias. |
2012-01-23 |
2023-08-12 |
Not clear |
| Namik Kaya, Hesham Aldhalaan, Banan Al-Younes, Dilek Colak, Taghreed Shuaib, Fahad Al-Mohaileb, Abdulaziz Al-Sugair, Michael Nester, Suad Al-Yamani, Albandary Al-Bakheet, Nadia Al-Hashmi, Moeen Al-Sayed, Brian Meyer, Heinz Jungbluth, Mohammed Al-Owai. Phenotypical spectrum of cerebellar ataxia associated with a novel mutation in the CA8 gene, encoding carbonic anhydrase (CA) VIII. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 7. 2012-01-17. PMID:21812104. |
ca8 involvement should be considered in the differential diagnosis of other genetically unresolved autosomal recessive cerebellar ataxias. |
2012-01-17 |
2023-08-12 |
Not clear |
| Arnulf H Koeppen, Ashley N Davis, Jennifer A Morra. The cerebellar component of Friedreich's ataxia. Acta neuropathologica. vol 122. issue 3. 2012-01-10. PMID:21638087. |
the cerebellar component of friedreich's ataxia. |
2012-01-10 |
2023-08-12 |
Not clear |
| Michael Strup. Cerebellar ataxias: news on genetics and the excitability of affected neurons. Journal of neurology. vol 258. issue 3. 2012-01-09. PMID:21347867. |
cerebellar ataxias: news on genetics and the excitability of affected neurons. |
2012-01-09 |
2023-08-12 |
Not clear |
| José L Pedroso, Pedro Braga-Neto, André C Felício, Camila C H Aquino, Lucila B Fernandes do Prado, Gilmar Fernandes do Prado, Orlando G P Barsottin. Sleep disorders in cerebellar ataxias. Arquivos de neuro-psiquiatria. vol 69. issue 2A. 2011-12-16. PMID:21537570. |
sleep disorders in cerebellar ataxias. |
2011-12-16 |
2023-08-12 |
Not clear |
| José L Pedroso, Pedro Braga-Neto, André C Felício, Camila C H Aquino, Lucila B Fernandes do Prado, Gilmar Fernandes do Prado, Orlando G P Barsottin. Sleep disorders in cerebellar ataxias. Arquivos de neuro-psiquiatria. vol 69. issue 2A. 2011-12-16. PMID:21537570. |
cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. |
2011-12-16 |
2023-08-12 |
Not clear |
| José L Pedroso, Pedro Braga-Neto, André C Felício, Camila C H Aquino, Lucila B Fernandes do Prado, Gilmar Fernandes do Prado, Orlando G P Barsottin. Sleep disorders in cerebellar ataxias. Arquivos de neuro-psiquiatria. vol 69. issue 2A. 2011-12-16. PMID:21537570. |
in this review, we highlight the main sleep disorders related to cerebellar ataxias focusing on rem sleep behavior disorder (rbd), restless legs syndrome (rls), periodic limb movement in sleep (plms), excessive daytime sleepiness (eds), insomnia and sleep apnea. |
2011-12-16 |
2023-08-12 |
Not clear |
| Matthis Synofzik, Jana Godau, Tobias Lindig, Ludger Schöls, Daniela Ber. Transcranial sonography reveals cerebellar, nigral, and forebrain abnormalities in Friedreich's ataxia. Neuro-degenerative diseases. vol 8. issue 6. 2011-12-07. PMID:21659723. |
transcranial sonography reveals cerebellar, nigral, and forebrain abnormalities in friedreich's ataxia. |
2011-12-07 |
2023-08-12 |
Not clear |