| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Haroon, C C Fleischer, J C Felger, X Chen, B J Woolwine, T Patel, X P Hu, A H Mille. Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Molecular psychiatry. vol 21. issue 10. 2017-09-05. PMID:26754953. |
these data indicate that increased inflammation in major depression may lead to increased glutamate in the basal ganglia in association with glial dysfunction and suggest that therapeutic strategies targeting glutamate may be preferentially effective in depressed patients with increased inflammation as measured by crp. |
2017-09-05 |
2023-08-13 |
Not clear |
| Ariana Q Farrand, Rebecca A Gregory, Cristina M Bäckman, Kristi L Helke, Heather A Boge. Altered glutamate release in the dorsal striatum of the MitoPark mouse model of Parkinson's disease. Brain research. vol 1651. 2017-07-28. PMID:27659966. |
a potential mechanism involved in the formation of lid is greater glutamate release into the dorsal striatum as a result of altered basal ganglia neurocircuitry due to reduced nigrostriatal da neurotransmission. |
2017-07-28 |
2023-08-13 |
mouse |
| Sarah Beggiato, Maria Cristina Tomasini, Andrea Celeste Borelli, Dasiel Oscar Borroto-Escuela, Kjell Fuxe, Tiziana Antonelli, Sergio Tanganelli, Luca Ferrar. Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:27127992. |
in this study, the functional role of individual striatal receptors for adenosine (a2ar), dopamine (d2r), and the metabotropic glutamate receptor mglu5r in regulating rat basal ganglia activity was characterized in vivo using dual-probe microdialysis in freely moving rats. |
2017-06-23 |
2023-08-13 |
rat |
| Sarah Beggiato, Maria Cristina Tomasini, Andrea Celeste Borelli, Dasiel Oscar Borroto-Escuela, Kjell Fuxe, Tiziana Antonelli, Sergio Tanganelli, Luca Ferrar. Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:27127992. |
using dual-probe microdialysis, we characterized the functional role of striatal adenosine a2a receptor (a2ar), dopamine d2 receptor (d2r), and metabotropic glutamate receptor 5 (mglur5) interactions in regulating rat basal ganglia activity. |
2017-06-23 |
2023-08-13 |
rat |
| Ebrahim Haroon, Andrew H Mille. Inflammation Effects on Brain Glutamate in Depression: Mechanistic Considerations and Treatment Implications. Current topics in behavioral neurosciences. vol 31. 2017-06-20. PMID:27830574. |
in addition, the administration of the inflammatory cytokine interferon-alpha has been shown to increase brain glutamate in the basal ganglia and dorsal anterior cingulate cortex as measured by magnetic resonance spectroscopy (mrs). |
2017-06-20 |
2023-08-13 |
human |
| Ebrahim Haroon, Andrew H Mille. Inflammation Effects on Brain Glutamate in Depression: Mechanistic Considerations and Treatment Implications. Current topics in behavioral neurosciences. vol 31. 2017-06-20. PMID:27830574. |
moreover, mrs studies in patients with major depressive disorder have revealed that increased markers of inflammation including c-reactive protein correlate with increased basal ganglia glutamate, which in turn was associated with anhedonia and psychomotor retardation. |
2017-06-20 |
2023-08-13 |
human |
| Sudie E Back, Jenna L McCauley, Kristina J Korte, Daniel F Gros, Virginia Leavitt, Kevin M Gray, Mark B Hamner, Stacia M DeSantis, Robert Malcolm, Kathleen T Brady, Peter W Kaliva. A Double-Blind, Randomized, Controlled Pilot Trial of N-Acetylcysteine in Veterans With Posttraumatic Stress Disorder and Substance Use Disorders. The Journal of clinical psychiatry. vol 77. issue 11. 2017-05-25. PMID:27736051. |
this study explored the efficacy of n-acetylcysteine in the treatment of posttraumatic stress disorder (ptsd), which frequently co-occurs with sud and shares impaired prefrontal cortex regulation of basal ganglia circuitry, in particular at glutamate synapses in the nucleus accumbens. |
2017-05-25 |
2023-08-13 |
Not clear |
| Fernando Caravaggio, Shinichiro Nakajima, Eric Plitman, Philip Gerretsen, Jun Ku Chung, Yusuke Iwata, Ariel Graff-Guerrer. The effect of striatal dopamine depletion on striatal and cortical glutamate: A mini-review. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26334687. |
however, it is unclear a priori how alterations in striatal dopamine should modulate glutamate concentrations in the basal ganglia. |
2016-09-14 |
2023-08-13 |
human |
| Fernando Caravaggio, Shinichiro Nakajima, Eric Plitman, Philip Gerretsen, Jun Ku Chung, Yusuke Iwata, Ariel Graff-Guerrer. The effect of striatal dopamine depletion on striatal and cortical glutamate: A mini-review. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26334687. |
the review concludes that chronic dopamine depletion (>4months) produces decreases in striatal glutamate levels which are consistent with the classical model of the basal ganglia. |
2016-09-14 |
2023-08-13 |
human |
| Balázs Gulyás, Judit Sovago, Baltazar Gomez-Mancilla, Zhisheng Jia, Csaba Szigeti, Károly Gulya, Martin Schumacher, Ralph Paul Maguire, Fabrizio Gasparini, Christer Halldi. Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease: a preliminary investigation in the postmortem human brain. Brain structure & function. vol 220. issue 5. 2016-08-19. PMID:24969128. |
group 1 metabotropic glutamate subtype 5 receptors (mglur5) contribute to the control of motor behavior by regulating the balance between excitation and inhibition of outputs in the basal ganglia. |
2016-08-19 |
2023-08-13 |
human |
| Vincent A Jourdain, Nicolas Morin, Laurent Grégoire, Marc Morissette, Thérèse Di Paol. Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy. Journal of neurosurgery. vol 123. issue 6. 2016-03-28. PMID:25932606. |
the subthalamic nucleus (stn) is the sole glutamatergic nucleus within the basal ganglia, and its lesion may produce changes in glutamate receptors in various areas of the basal ganglia. |
2016-03-28 |
2023-08-13 |
monkey |
| Vincent A Jourdain, Nicolas Morin, Laurent Grégoire, Marc Morissette, Thérèse Di Paol. Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy. Journal of neurosurgery. vol 123. issue 6. 2016-03-28. PMID:25932606. |
the authors aimed to investigate the biochemical changes in glutamate receptors in striatal and pallidal regions of the basal ganglia after lesion of the stn in parkinsonian macaque monkeys. |
2016-03-28 |
2023-08-13 |
monkey |
| Hanna Iderberg, Natallia Maslava, Analisa D Thompson, Michael Bubser, Colleen M Niswender, Corey R Hopkins, Craig W Lindsley, P Jeffrey Conn, Carrie K Jones, M Angela Cenc. Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist. Neuropharmacology. vol 95. 2016-03-08. PMID:25749357. |
metabotropic glutamate receptor 4 (mglu4) negatively modulates gaba and glutamate release in the 'indirect pathway' of the basal ganglia, and has thus been proposed as a potential target to treat motor symptoms in parkinson's disease. |
2016-03-08 |
2023-08-13 |
rat |
| Christopher B Divito, Kathy Steece-Collier, Daniel T Case, Sean-Paul G Williams, Jennifer A Stancati, Lianteng Zhi, Maria E Rubio, Caryl E Sortwell, Timothy J Collier, David Sulzer, Robert H Edwards, Hui Zhang, Rebecca P Sea. Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 45. 2016-02-22. PMID:26558771. |
the vesicular glutamate transporter 3 (vglut3) is expressed by striatal cholinergic interneurons (cins) and is thus well positioned to regulate dopamine (da) signaling and locomotor activity, a canonical measure of basal ganglia output. |
2016-02-22 |
2023-08-13 |
mouse |
| Ebrahim Haroon, Jennifer C Felger, Bobbi J Woolwine, Xiangchuan Chen, Samir Parekh, James R Spivey, Xiaoping P Hu, Andrew H Mille. Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25500218. |
age-related increases in basal ganglia glutamate are associated with tnf, reduced motivation and decreased psychomotor speed during ifn-alpha treatment: preliminary findings. |
2016-02-04 |
2023-08-13 |
human |
| Ebrahim Haroon, Jennifer C Felger, Bobbi J Woolwine, Xiangchuan Chen, Samir Parekh, James R Spivey, Xiaoping P Hu, Andrew H Mille. Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25500218. |
data by our group have shown increased glutamate as measured by magnetic resonance spectroscopy (mrs) in basal ganglia and dorsal anterior cingulate cortex of patients administered the inflammatory cytokine interferon (ifn)-alpha. |
2016-02-04 |
2023-08-13 |
human |
| Ebrahim Haroon, Jennifer C Felger, Bobbi J Woolwine, Xiangchuan Chen, Samir Parekh, James R Spivey, Xiaoping P Hu, Andrew H Mille. Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25500218. |
older patients treated with ifn-alpha exhibited a significantly greater increase in glutamate from visit 1 to visit 2 as reflected by the glutamate/creatine ratio (glu/cr) in left basal ganglia compared to older controls and younger ifn-alpha-treated and untreated subjects. |
2016-02-04 |
2023-08-13 |
human |
| Marianne Amalri. Targeting metabotropic glutamate receptors (mGluRs) in Parkinson's disease. Current opinion in pharmacology. vol 20. 2015-09-28. PMID:25462289. |
the interplay between dopamine and glutamate in the basal ganglia regulate critical aspects of motor and cognitive behavior. |
2015-09-28 |
2023-08-13 |
Not clear |
| Nicolas Morin, Marc Morissette, Laurent Grégoire, Thérèse Di Paol. Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25046277. |
our aim was to investigate the long-term effect of the prototypal metabotropic glutamate 5 (mglu5) receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (mpep) with l-dopa on basal ganglia sert, 5-ht(1a) and 5-ht(2a) receptor levels in monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2015-07-31 |
2023-08-13 |
monkey |
| Thierry Paillard, Yves Rolland, Philipe de Souto Barret. Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review. Journal of clinical neurology (Seoul, Korea). vol 11. issue 3. 2015-07-16. PMID:26174783. |
exercise limits the alteration in dopaminergic neurons in the substantia nigra and contributes to optimal functioning of the basal ganglia involved in motor commands and control by adaptive mechanisms involving dopamine and glutamate neurotransmission. |
2015-07-16 |
2023-08-13 |
Not clear |