| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I N Mefford, A Foutz, N Noyce, S M Jurik, C Handen, W C Dement, J D Barcha. Distribution of norepinephrine, epinephrine, dopamine, serotonin, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindole-3-acetic acid in dog brain. Brain research. vol 236. issue 2. 1982-06-24. PMID:6175382. |
dopamine (da) and its major metabolites, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acids (hva), were localized primarily in basal ganglia with relatively high concentrations also found in amygdala, septum and substantia nigra. |
1982-06-24 |
2023-08-12 |
dog |
| S A Dolina, B M Kogan, G V Tananov. [Catecholamine levels in the striatum, hypothalamus, and adrenals of rats with genetic predisposition to epileptic seizures]. Biulleten' eksperimental'noi biologii i meditsiny. vol 93. issue 2. 1982-06-14. PMID:7066515. |
at the same time the concentration of dopamine in the basal ganglia and hypothalamus was far greater than that of the subsequent reaction products (noradrenaline, homovanillic and dioxyphenyl acetic acids), and the concentration of dopamine in the adrenals exceeded that of noradrenaline and adrenaline. |
1982-06-14 |
2023-08-12 |
rat |
| S A Dolina, B M Kogan, G V Tananov. [Catecholamine levels in the striatum, hypothalamus, and adrenals of rats with genetic predisposition to epileptic seizures]. Biulleten' eksperimental'noi biologii i meditsiny. vol 93. issue 2. 1982-06-14. PMID:7066515. |
excess dopamine in the basal ganglia seems likely to be the reason for the failure of caudate nucleus inhibitory function in km rats, thereby contributing to the increased sensitivity of the animals to convulsants. |
1982-06-14 |
2023-08-12 |
rat |
| B L Waszczak, D A Bergstrom, J R Walter. Single unit responses of substantia nigra and globus pallidus neurons to GABA agonist and antagonist drugs. Advances in biochemical psychopharmacology. vol 30. 1982-04-12. PMID:7331938. |
since reticulata and pallidal neurons seem at least as likely as dopamine neurons to be targets of this striatal gabaergic pathway, a much more expanded role for gaba within the basal ganglia might now be explored. |
1982-04-12 |
2023-08-12 |
Not clear |
| V P Barkhatova, E I Kandel', E G Demin. [Approaches to the study of dopamine metabolism in various extrapyramidal diseases]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 81. issue 7. 1981-12-21. PMID:6457476. |
a considerable lowering of the homovanillic acid (hva) concentration is demonstrated in patients with parkinsonism: this reflects the degeneration of the dopamine-containing pathways and the lowering of the dopamine synthesis in the basal ganglia in that disease. |
1981-12-21 |
2023-08-12 |
Not clear |
| A Ruffieux, W Schult. [Influence of dopamine on pars reticulata neurones of substantia nigra (author's transl)]. Journal de physiologie. vol 77. issue 1. 1981-07-09. PMID:7230051. |
7 the present results would support the concept that dendritically released dopamine not only affects other nigral dopamine neurones, but also influences non-dopaminergic nigral neurones, some of which project outside the basal ganglia. |
1981-07-09 |
2023-08-12 |
rat |
| V Cvejić, D V Mićić, B M Djuricić, B J Mrsulja, B B Mrsulj. Monoamines and related enzymes in cerebral cortex and basal ganglia following transient ischemia in gerbils. Acta neuropathologica. vol 51. issue 1. 1981-01-26. PMID:7435143. |
a rebound increase of norepinephrine and serotonin appeared in early stages (up to 1 h) of post-ischemia both in cerebral cortex and basal ganglia; a rebound increase of dopamine as found only in cerebral cortex. |
1981-01-26 |
2023-08-12 |
Not clear |
| D B Calne, J K Kebabia. Parkinson's disease: unanswered questions. Journal of neural transmission. Supplementum. issue 16. 1981-01-16. PMID:6933216. |
the role of the depletion of dopamine in parkinsonism is also unclear; we do not even know whether the impact of the deficit is more significant in the basal ganglia, or the substantia nigra. |
1981-01-16 |
2023-08-12 |
Not clear |
| Tardive dyskinesia: summary of a Task Force Report of the American Psychiatric Association. By the Task Force on Late Neurological Effects of Antipsychotic Drugs. The American journal of psychiatry. vol 137. issue 10. 1980-11-24. PMID:6106389. |
the casue is unknown, but increased sensitivity to dopamine in the basal ganglia may contribute to the pathophysiology. |
1980-11-24 |
2023-08-12 |
Not clear |
| R H Roth, N G Bacopoulos, G Bustos, D E Redmon. Antipsychotic drugs: differential effects on dopamine neurons in basal ganglia and mesocortex following chronic administration in human and nonhuman primates. Advances in biochemical psychopharmacology. vol 24. 1980-10-27. PMID:6105797. |
antipsychotic drugs: differential effects on dopamine neurons in basal ganglia and mesocortex following chronic administration in human and nonhuman primates. |
1980-10-27 |
2023-08-12 |
human |
| E D Bir. Chemical pathology of Huntington's disease. Annual review of pharmacology and toxicology. vol 20. 1980-08-28. PMID:6446256. |
there are decreased concentrations of the neuroinhibitory transmitter gamma aminobutyric acid and this is associated with increased concentrations of dopamine and serotonin in the basal ganglia. |
1980-08-28 |
2023-08-12 |
Not clear |
| T Ashizawa, B M Patten, J Jankovi. Meige's syndrome. Southern medical journal. vol 73. issue 7. 1980-08-28. PMID:7384844. |
we think that biochemical abnormalities in the basal ganglia are responsible for the dyskinesias and submit data suggesting a reduction of dopamine turnover in the central nervous system of one patient. |
1980-08-28 |
2023-08-12 |
Not clear |
| N G Bacopoulos, D E Redmond, J Baulu, R H Rot. Chronic haloperidol or fluphenazine: effects on dopamine metabolism in brain, cerebrospinal fluid and plasma of Cercopithecus aethiops (vervet monkey). The Journal of pharmacology and experimental therapeutics. vol 212. issue 1. 1980-03-24. PMID:6766186. |
it is concluded that chronically increased dopamine metabolite production in the basal ganglia but not in cortex is reflected by increases in the hva level of cerebrospinal fluid and plasma and is accompanied by severe extrapyramidal side effects. |
1980-03-24 |
2023-08-12 |
monkey |
| M Stachowiak, J Białowas, M K Jurkowski, J Miros. Hunger induced changes in the noradrenaline and dopamine contents in various nuclei of the limbic system in rats. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:316524. |
teh effect of 48 hr food deprivation on noradrenaline (na) and dopamine (da) content in the dorsomedial, ventromedial and arcuate hypothalamic nuclei, in the anterior and posterior part of medial forebrain bundle, in the medial preoptic region, nucleus of diagonal band (septum), and in the central, medial and basal nuclei of the amygdaloid complex was investigated by radioenzymatic assay. |
1980-03-17 |
2023-08-11 |
rat |
| E S Tolosa, C La. Meige disease: striatal dopaminergic preponderance. Neurology. vol 29. issue 8. 1979-09-27. PMID:379689. |
dysfunction of the basal ganglia, characterized by a state of striatal dopamine preponderance, probably underlies the dystonic spasms in meige disease. |
1979-09-27 |
2023-08-11 |
Not clear |
| J D Parke. Bromocriptine in the treatment of parkinsonism. Drugs. vol 17. issue 5. 1979-09-17. PMID:37066. |
changes in movement are accompanied by biochemical changes in the central nervous system, consistent with the idea that bromocriptine has a dopamine agonist action in the basal ganglia and also in the mesolimbic system and hypothalamus. |
1979-09-17 |
2023-08-11 |
Not clear |
| G Curzo. The biochemistry of the basal ganglia and Parkinson's disease. Postgraduate medical journal. vol 53. issue 626. 1978-04-17. PMID:24209. |
while dopamine synthesis in the basal ganglia is defective in this condition, abnormalities of other transmitters occur, and their possible significance is discussed. |
1978-04-17 |
2023-08-11 |
Not clear |
| D Tarsy, R J Baldessarin. The pathophysiologic basis of tardive dyskinesia. Biological psychiatry. vol 12. issue 3. 1977-08-12. PMID:194633. |
a currently popular hypothesis is that there may be a functional excess in the activity of dopamine (da) as a synaptic neurotransmitter in the basal ganglia. |
1977-08-12 |
2023-08-11 |
Not clear |
| K Izumi, T Motomatsu, M Chrétie. Beta-endorphin induced akinesia in rats: effect of apomorhine and alpha-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia. Life sciences. vol 20. issue 7. 1977-05-27. PMID:557716. |
beta-endorphin induced akinesia in rats: effect of apomorhine and alpha-methyl-p-tyrosine and related modifications of dopamine turnover in the basal ganglia. |
1977-05-27 |
2023-08-11 |
rat |
| J Gerlac. Relationship between tardive dyskinesia, L-Dopa-induced hyperkinesia and parkinsonism. Psychopharmacology. vol 51. issue 3. 1977-05-20. PMID:403541. |
it is concluded that the irreversible neurotoxic effect of neuroleptic drugs may be associated with age-related changes in the oral somatotopic region of the basal ganglia (to be given consideration in any future search for the pathogenetic process underlying irreversible tardive dyskinesia), and that the pathophysiology of involuntary hyperkinesia in neuroleptic-treated psychiatric patients and in l-dopatreated parkinson patients may consist of a primary dopamine deficiency (pharmacological or structural), and a secondary relative hyperactivity in the dopaminergic system ("dopaminergic hypersensitivity") possibly corresponding to hypoactivity in the cholinergic system. |
1977-05-20 |
2023-08-11 |
Not clear |