| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nathan Gock, Jordan Follett, Gordon L Rintoul, Timothy V Beischlag, Frank J S Le. Endosomal recycling and dopamine neurotransmission: Exploring the links between the retromer and Parkinson's disease. Synapse (New York, N.Y.). 2022-01-26. PMID:35080780. |
the involvement of the retromer complex in dopamine neurobiology is further underscored by its links to parkinson's disease, a neurodegenerative disorder of the dopamine system. |
2022-01-26 |
2023-08-13 |
Not clear |
| Przemysław Cieśla. Glutamate receptors in the dopamine system – function and role in reinforcement learning Postepy biochemii. vol 67. issue 3. 2021-12-11. PMID:34894387. |
glutamate receptors in the dopamine system – function and role in reinforcement learning midbrain dopamine neurons along with the major target of their projections, dopaminoceptive neurons in striatum, regulate reinforcement learning and motivation. |
2021-12-11 |
2023-08-13 |
mouse |
| Ping Zhong, Luye Qin, Zhen Ya. Dopamine Differentially Regulates Response Dynamics of Prefrontal Cortical Principal Neurons and Interneurons to Optogenetic Stimulation of Inputs from Ventral Tegmental Area. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 8. 2021-11-29. PMID:32236403. |
these results have revealed a role of dopamine in regulating the temporal dynamics of excitation/inhibition balance in vta-pfc circuit, which provides insights into the functional consequence of activating dopamine system in the mesocortical system. |
2021-11-29 |
2023-08-13 |
Not clear |
| Sotiria Maria Iliopoulou, Stergios Tsartsalis, Stefan Kaiser, Philippe Millet, Benjamin B Tournie. Dopamine and Neuroinflammation in Schizophrenia - Interpreting the Findings from Translocator Protein (18kDa) PET Imaging. Neuropsychiatric disease and treatment. vol 17. 2021-11-26. PMID:34819729. |
further studies are needed to combine tspo and dopamine imaging to study the association between microglial activation and dopamine system function. |
2021-11-26 |
2023-08-13 |
human |
| Guillermo Goode-Romero, Laura Dominguez, Ana Martíne. Electron Donor-Acceptor Properties of Different Muscarinic Ligands: On the Road to Control Schizophrenia. Journal of chemical information and modeling. vol 61. issue 10. 2021-11-22. PMID:34555904. |
the current treatments are mainly focused on the dopamine system, but the so-named dopamine hypothesis of schizophrenia fails to explain all the symptoms. |
2021-11-22 |
2023-08-13 |
Not clear |
| Claire J Ciampa, Jourdan H Parent, Molly R Lapoint, Kaitlin N Swinnerton, Morgan M Taylor, Victoria R Tennant, A J Whitman, William J Jagust, Anne S Berr. Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging. Cerebral cortex (New York, N.Y. : 1991). 2021-11-19. PMID:34718454. |
aging is associated with declines in multiple components of the dopamine system including loss of dopamine-producing neurons, atrophy of the dopamine system's cortical targets, and reductions in the density of dopamine receptors. |
2021-11-19 |
2023-08-13 |
Not clear |
| Andrew Kayse. Dopamine and Gambling Disorder: Prospects for Personalized Treatment. Current addiction reports. vol 6. issue 2. 2021-11-17. PMID:31728265. |
to address variation in the severity of gambling disorder, this review evaluates the contribution of mesocorticolimbic dopamine neurons to potential behavioral endophenotypes, the influence of individual differences in the dopamine system on gambling and related behaviors, and the possible role for dopaminergic medications in the treatment of gambling disorder. |
2021-11-17 |
2023-08-13 |
Not clear |
| Masamichi Yokokura, Kiyokazu Takebasashi, Akiyo Takao, Kyoko Nakaizumi, Etsuji Yoshikawa, Masami Futatsubashi, Katsuaki Suzuki, Kazuhiko Nakamura, Hidenori Yamasue, Yasuomi Ouch. In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32439845. |
alterations in the cortical dopamine system and microglial activation have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (adhd), one of neurodevelopmental disorders that can be conventionally treated with a dopamine enhancer (methylphenidate) albeit unsatisfactorily. |
2021-11-15 |
2023-08-13 |
human |
| Manuel A Fernandez-Parrilla, David Reyes-Corona, Yazmin M Flores-Martinez, Rasajna Nadella, Michael J Bannon, Lourdes Escobedo, Minerva Maldonado-Berny, Jaime Santoyo-Salazar, Luis O Soto-Rojas, Claudia Luna-Herrera, Jose Ayala-Davila, Juan A Gonzalez-Barrios, Gonzalo Flores, Maria E Gutierrez-Castillo, Armando J Espadas-Alvarez, Irma A Martínez-Dávila, Porfirio Nava, Daniel Martinez-Fon. Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472486. |
overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system, a hallmark in parkinson's disease. |
2021-11-10 |
2023-08-13 |
human |
| Jessica M Illenberger, Steven B Harrod, Charles F Mactutus, Kristen A McLaurin, Asha Kallianpur, Rosemarie M Booz. HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 4. 2021-10-20. PMID:32533296. |
however, chronic exposure to drugs or hiv-1 leads to dysregulation of the dopamine system as a result of fronto-striatal adaptations to oppose the effects of repeated instances of transiently increased dopamine. |
2021-10-20 |
2023-08-13 |
Not clear |
| Ja-Hyun Bai. Stress and the dopaminergic reward system. Experimental & molecular medicine. vol 52. issue 12. 2021-10-13. PMID:33257725. |
stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system. |
2021-10-13 |
2023-08-13 |
Not clear |
| Per A Al. Stuttering: A Disorder of Energy Supply to Neurons? Frontiers in human neuroscience. vol 15. 2021-10-12. PMID:34630054. |
(6) lastly, there are indications of interactions between the metabolic system and the dopamine system: for example, it is known that acute hypoxia results in an elevated tonic level of dopamine in the synapses. |
2021-10-12 |
2023-08-13 |
Not clear |
| Michelle Corkrum, Alfonso Araqu. Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34253855. |
astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling. |
2021-09-16 |
2023-08-13 |
Not clear |
| Michelle Corkrum, Alfonso Araqu. Astrocyte-neuron signaling in the mesolimbic dopamine system: the hidden stars of dopamine signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34253855. |
the present review will examine evidence revealing that astrocytes respond to dopamine and modulate information processing in the primary brain regions implicated in the mesolimbic dopamine system. |
2021-09-16 |
2023-08-13 |
Not clear |
| P Read Montague, Kenneth T Kishida, Rosalyn J Moran, Terry M Lohren. An efficiency framework for valence processing systems inspired by soft cross-wiring. Current opinion in behavioral sciences. vol 11. 2021-09-09. PMID:28191489. |
here, we present a model where the counterfactual part of these striatal dopamine fluctuations originates in another valuation system that shadows the dopamine system by acting as its near-antipode in terms of spike-rate encoding yet co-releases dopamine alongside its own native neurotransmitter. |
2021-09-09 |
2023-08-13 |
human |
| Anne L Collins, Benjamin T Saunder. Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking. Journal of neuroscience research. vol 98. issue 6. 2021-08-20. PMID:32056298. |
here, we review that work to synthesize current understanding of dopamine system heterogeneity across three levels, anatomical organization, functions in behavior, and modes of action, wherein we focus on signaling profiles and local mechanisms for modulation of dopamine release. |
2021-08-20 |
2023-08-13 |
Not clear |
| Polina Kosillo, Helen S Bateu. Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models. Frontiers in neural circuits. vol 15. 2021-08-17. PMID:34366796. |
overall, we find considerable support for the idea that the dopamine system may be dysregulated in syndromic asds; however, there does not appear to be a consistent signature and some models show increased dopaminergic function, while others have deficient dopamine signaling. |
2021-08-17 |
2023-08-13 |
mouse |
| Alessandro Tozzi, Miriam Sciaccaluga, Vittorio Loffredo, Alfredo Megaro, Ada Ledonne, Antonella Cardinale, Mauro Federici, Laura Bellingacci, Silvia Paciotti, Elena Ferrari, Antonino La Rocca, Alessandro Martini, Nicola B Mercuri, Fabrizio Gardoni, Barbara Picconi, Veronica Ghiglieri, Elvira De Leonibus, Paolo Calabres. Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit. Brain : a journal of neurology. 2021-07-23. PMID:34297092. |
in an additional set of experiments, we were able to rescue α-synuclein-induced alterations of motor function, striatal synaptic plasticity, and increased spontaneous excitatory synaptic currents by a sub-chronic treatment with l-dopa, a precursor of dopamine widely used in the therapy of parkinson's disease, clearly demonstrating that a dysfunctional dopamine system plays a critical role in the early phases of the disease. |
2021-07-23 |
2023-08-13 |
Not clear |
| Han Zhou, Tao Hou, Zhenhua Gao, Xiujie Guo, Chaoran Wang, Jixia Wang, Yanfang Liu, Xinmiao Lian. Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays. Journal of ethnopharmacology. vol 278. 2021-07-19. PMID:34139281. |
dopamine receptors are long-standing primary targets in the treatment of mental diseases and there is growing evidence that suggests relationships between obesity and the dopamine system, especially dopamine d1 and d2 receptors. |
2021-07-19 |
2023-08-13 |
Not clear |
| Cherie N Barnes, Conner W Wallace, Brielle S Jacobowitz, Steve C Fordah. Reduced phasic dopamine release and slowed dopamine uptake occur in the nucleus accumbens after a diet high in saturated but not unsaturated fat. Nutritional neuroscience. 2021-07-10. PMID:31914869. |
mounting evidence shows that saturated fat impacts dopamine neurons and their terminal fields, but little is known about the effect a diet high in unsaturated fat has on the dopamine system. |
2021-07-10 |
2023-08-13 |
mouse |