| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qianshuo Mao, Jinjia Wang, Zihan Yang, Ruidong Ding, Shuangyu Lv, Xinying J. The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders. Depression and anxiety. vol 2024. 2025-04-14. PMID:40226675. |
ghrelin can affect the onset of psychosis by regulating neurotransmitters such as dopamine, γ-aminobutyric acid (gaba), and 5-hydroxytryptamine (5-ht) through the hypothalamus-pituitary-adrenal (hpa) axis, brain-gut axis, the mesolimbic dopamine system, and other ways. |
2025-04-14 |
2025-04-16 |
Not clear |
| Peter Manza, Dardo Tomasi, Şükrü Barış Demiral, Ehsan Shokri-Kojori, Christina Lildharrie, Esther Lin, Gene-Jack Wang, Nora D Volko. Neural basis for individual differences in the attention-enhancing effects of methylphenidate. Proceedings of the National Academy of Sciences of the United States of America. vol 122. issue 13. 2025-03-24. PMID:40127280. |
here, we extensively characterized the brain dopamine system with positron emission tomography (pet) imaging (including striatal dopamine d1 and d2/3 receptor availability and mp-induced dopamine increases) and measured attention task-evoked fmri brain activity in two separate sessions (placebo and 60 mg oral mp; single-blind, counterbalanced) in 37 healthy adults. |
2025-03-24 |
2025-03-27 |
Not clear |
| Sandor Szunyogh, Emily Carroll, Richard Wade-Martin. Recent developments in gene therapy for Parkinson's disease. Molecular therapy : the journal of the American Society of Gene Therapy. 2025-03-23. PMID:40121531. |
in this review we explore various gene therapy strategies currently being developed targeting key aspects of pd pathogenesis: the restoration of the dopamine system by delivering genes involved in dopamine biosynthesis; reinforcing the inhibitory signalling pathways through glutamic acid decarboxylase (gad) delivery to increase gaba production; enhancing neuronal survival and development by introducing various neurotrophic factors; delivery of genes to complement recessive familial pd mutations to correct mitochondrial dysfunction; restoring lysosomal function through delivery of gba1 to increase glucocerebrosidase (gcase) activity; and reducing alpha-synuclein levels by reducing or silencing snca expression. |
2025-03-23 |
2025-03-26 |
Not clear |
| Jianjie Chen, Mengyan Xu, Lijuan Li, Yuting Lu, Yongju Luo, Jinling Ca. Chronic fluoride induces neurotoxicity in zebrafish through the gut-brain axis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2025-02-26. PMID:40010531. |
fluoride significantly reduced dopamine content and dopamine pathway related gene expression in brain. |
2025-02-26 |
2025-03-01 |
zebrafish |
| Jianjie Chen, Mengyan Xu, Lijuan Li, Yuting Lu, Yongju Luo, Jinling Ca. Chronic fluoride induces neurotoxicity in zebrafish through the gut-brain axis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2025-02-26. PMID:40010531. |
fluoride significantly decreased the dopamine content in the intestine, disturbed the gene expression of dopamine pathway related genes. |
2025-02-26 |
2025-03-01 |
zebrafish |
| Anna Loftén, Davide Cadeddu, Klara Danielsson, Rosita Stomberg, Louise Adermark, Bo Söderpalm, Mia Ericso. Reduced Alcohol Consumption Following Ablation of Cholinergic Interneurons in the Nucleus Accumbens of Wistar Rats. Addiction biology. vol 30. issue 2. 2025-02-12. PMID:39936333. |
alcohol activates the mesolimbic dopamine system leading to an increase of extracellular dopamine (da) in the nucleus accumbens, an event that is associated with the reinforcing effects of alcohol. |
2025-02-12 |
2025-02-14 |
rat |
| Kurt M Fraser, Val Collins, Amy R Wolff, David J Ottenheimer, Kaisa N Bornhoft, Fiona Pat, Bridget J Chen, Patricia H Janak, Benjamin T Saunder. Contextual cues facilitate dynamic value encoding in the mesolimbic dopamine system. Current biology : CB. 2025-01-24. PMID:39855205. |
together, these results help refine notions of dopamine function, revealing a prominent contribution of the mesolimbic dopamine system to the rapid revaluation of motivation. |
2025-01-24 |
2025-01-28 |
rat |
| Maurizio Marchesini, Giulia Topi, Cesare Bonezzi, Laura Demartin. Amitriptyline-perphenazine therapy for persistent idiopathic facial pain: translational perspectives from a retrospective study. Journal of anesthesia, analgesia and critical care. vol 4. issue 1. 2024-12-19. PMID:39695777. |
recent insights into the role of dopamine in facial pain suggest that a novel therapeutic approach could target the dopamine system. |
2024-12-19 |
2024-12-21 |
Not clear |
| Haley Krupa, Ashley N Gearhardt, Anne Lewandowski, Nicole M Aven. Food Addiction. Brain sciences. vol 14. issue 10. 2024-10-26. PMID:39451967. |
the brain adapts to addiction by way of the mesolimbic dopamine system, endogenous opioids and receptors, acetylcholine and dopamine balance, and adaptations of serotonin in neuroanatomy. |
2024-10-26 |
2024-10-28 |
Not clear |
| F Gregory Ashby, Heidi A Zetzer, Collie W Conoley, Alan D Pickerin. Just do it: A neuropsychological theory of agency, cognition, mood, and dopamine. Journal of experimental psychology. General. vol 153. issue 6. 2024-06-17. PMID:38884963. |
a novel theory proposes that increases in agency disinhibit the dopamine system and thereby increase the number of tonically active dopamine neurons in the ventral tegmental area. |
2024-06-17 |
2024-06-19 |
human |
| Wan-Yu Zhao, Ji-You Tan. [Research Progress in the Correlation Between Dopamine and Clinical Characterization of Narcolepsy]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 46. issue 2. 2024-04-30. PMID:38686723. |
dopamine,a neurotransmitter ubiquitous in the body fluids,blood,and urine of mammals and humans,is responsible for regulating their functions and metabolism.the dopamine system is involved in the neurobiological mechanisms of narcolepsy in animals and humans.however,researchers have drawn different or even opposite conclusions when measuring the dopamine level in the cerebrospinal fluid of narcolepsy patients.studies have confirmed that the occurrence of narcolepsy is related to the irreversible loss of orexins.the autoimmune reaction caused by the interactions of environmental factors with genetic factors destroys the hypothalamic orexin neurons and reduces orexin secretion,thereby lowering the level of arousal.we introduce the research progress and current status of dopamine and clinical characterization of narcolepsy by reviewing more than 40 articles published from 1982 to 2023,aiming to provide a reference for studying the relationship between the dopamine level and clinical characterization of narcolepsy and searching for the biomarkers of type 2 narcolepsy. |
2024-04-30 |
2024-05-03 |
Not clear |
| Bo Söderpalm, Mia Ericso. Alcohol and the dopamine system. International review of neurobiology. vol 175. 2024-03-30. PMID:38555117. |
ethanol, like most addictive drugs, acutely activates the mesolimbic dopamine system and releases dopamine, and ethanol-associated stimuli also appear to trigger dopamine release. |
2024-03-30 |
2024-04-02 |
Not clear |
| Paige M Estave, Steven E Albertson, Anushree N Karkhanis, Sara R Jone. Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Scientific reports. vol 14. issue 1. 2024-03-19. PMID:38499566. |
co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. |
2024-03-19 |
2024-03-21 |
rat |
| Patrick R Melugin, Suzanne O Nolan, Evelyn Kandov, Carson F Ferrara, Zahra Z Farahbakhsh, Cody A Sicilian. Medial prefrontal dopamine dynamics reflect allocation of selective attention. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496533. |
the mesocortical dopamine system is comprised of midbrain dopamine neurons that predominantly innervate the medial prefrontal cortex (mpfc) and exert a powerful neuromodulatory influence over this region |
2024-03-18 |
2024-03-20 |
Not clear |
| Jillian L Seiler, Xiaowen Zhuang, Alexandra B Nelson, Talia N Lerne. Dopamine across timescales and cell types: Relevance for phenotypes in Parkinson's disease progression. Experimental neurology. 2024-01-19. PMID:38242300. |
here, we review recent conceptual advances in our basic understanding of the dopamine system - including our rapidly advancing knowledge of dopamine neuron heterogeneity - with special attention to their importance for understanding pd. |
2024-01-19 |
2024-01-22 |
Not clear |
| Pengyu Zeng, Tiantian Wang, Lisan Zhang, Fang Gu. Exploring the causes of augmentation in restless legs syndrome. Frontiers in neurology. vol 14. 2023-10-16. PMID:37840917. |
dysfunction of the dopamine system highly possibly plays a role in the development of rls augmentation, as dopamine agonists improve desensitization of dopamine receptors, disturb receptor interactions within or outside the dopamine receptor family, and interfere with the natural regulation of dopamine synthesis and release in the neural system. |
2023-10-16 |
2023-11-08 |
Not clear |
| Anthony A Grace, Daniela L Ulian. Insights into the Mechanism of Action of Antipsychotic Drugs Derived from Animal Models: Standard of Care versus Novel Targets. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569748. |
therapeutic intervention for schizophrenia relies on blockade of dopamine d2 receptors in the associative striatum; however, there is little evidence for baseline overdrive of the dopamine system. |
2023-08-12 |
2023-08-16 |
Not clear |
| Deepika Suri, Giulia Zanni, Darshini Mahadevia, Nao Chuhma, Rinki Saha, Stephen Spivack, Nicolò Pini, Gregory S Stevens, Annette Ziolkowski-Blake, Eleanor H Simpson, Peter Balsam, Stephen Rayport, Mark S Ansorg. Dopamine transporter blockade during adolescence increases adult dopamine function, impulsivity, and aggression. Molecular psychiatry. 2023-08-02. PMID:37532798. |
the dopamine system is pivotal in controlling and shaping adolescent behaviors, and it undergoes heightened plasticity during that time, such that interference with dopamine signaling can have long-lasting behavioral consequences. |
2023-08-02 |
2023-08-14 |
mouse |
| Dillon J McGovern, Abigail M Polter, Emily D Prévost, Annie Ly, Connor J McNulty, Bodhi Rubinstein, David H Roo. Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-07-05. PMID:37407648. |
this vta glutamate to vta dopamine pathway regulated dopamine release to the nucleus accumbens through mu-opioid receptor activity in vivo. |
2023-07-05 |
2023-08-14 |
mouse |
| Sam Z Bacharach, David A Martin, Cassie A Stapf, Fangmiao Sun, Yulong Li, Joseph F Cheer, Donna J Cal. Decreased ventral tegmental area CB1R signaling reduces sign-tracking and shifts cue-outcome dynamics in rat nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-19. PMID:37208179. |
here, we examine a critical regulator of the dopamine system; endocannabinoids, which bind the cannabinoid receptor-1 (cb1r) in the ventral tegmental area (vta) to control cue-evoked striatal dopamine levels. |
2023-05-19 |
2023-08-14 |
rat |