| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nader N Youssef, Carlo Di Lorenz. Pediatric gastrointestinal motility--future directions and challenges. Digestive diseases (Basel, Switzerland). vol 24. issue 3-4. 2006-10-17. PMID:16849858. |
experiments studying polymorphisms in serotonin transporter gene (sert) and different therapeutic responses to serotonergic agents in adults with irritable bowel syndrome need to be carried out in children with functional bowel disorders. |
2006-10-17 |
2023-08-12 |
Not clear |
| G B García, C Konjuh, R O Duffard, A M Evangelista de Duffar. Dopamine-beta-hydroxylase immunohistochemical study in the locus coeruleus of neonate rats exposed to 2,4-dichlorophenoxyacetic acid through mother's milk. Drug and chemical toxicology. vol 29. issue 4. 2006-10-12. PMID:16931444. |
as tyrosine hydroxylase levels in the lc are regulated by serotonin and in a previous study we demonstrated that this neurotransmitter was increased in 2,4-d-exposed pups, an indirect effect through serotonergic inhibition could be involved in the decreased dbetah synthesis in the lc of these pups. |
2006-10-12 |
2023-08-12 |
rat |
| Philippe Girard, Marie-Claude Coppé, Danielle Verniers, Yannick Pansart, Jean-Marie Gillardi. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacological research. vol 54. issue 3. 2006-10-05. PMID:16750379. |
in vitro binding assays yielded the following measures of affinity (ic(50)): serotonergic 5-ht(2c) (1.4 microm), 5-ht(2a) (5.1 microm), 5-ht(3) (22.3 microm), 5-ht(1b) (41.7 microm), 5-ht(1a) (64.9 microm), adrenergic alpha(1) (15.0 microm) and dopaminergic d(1) (100 microm). |
2006-10-05 |
2023-08-12 |
mouse |
| Philippe Girard, Marie-Claude Coppé, Danielle Verniers, Yannick Pansart, Jean-Marie Gillardi. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacological research. vol 54. issue 3. 2006-10-05. PMID:16750379. |
pretreatments with adrenergic alpha(1) (prazosin) and alpha(2) (yohimbine), and serotonergic 5-ht(1b) (gr127935) receptor antagonists significantly increased the nefopam ed(50) in the writhing test. |
2006-10-05 |
2023-08-12 |
mouse |
| Philippe Girard, Marie-Claude Coppé, Danielle Verniers, Yannick Pansart, Jean-Marie Gillardi. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacological research. vol 54. issue 3. 2006-10-05. PMID:16750379. |
the serotonergic 5-ht(2c) (rs102221) and the dopaminergic d(2) (sulpiride) receptor antagonists inhibited nefopam antinociception in the formalin test. |
2006-10-05 |
2023-08-12 |
mouse |
| Philippe Girard, Marie-Claude Coppé, Danielle Verniers, Yannick Pansart, Jean-Marie Gillardi. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacological research. vol 54. issue 3. 2006-10-05. PMID:16750379. |
however, in both tests, nefopam analgesic activity was not modified by the following receptor antagonists: dopaminergic d(1) (sch23390), serotonergic 5-ht(1a) (nan-190, way100635), 5-ht(2a) (r96544, ketanserin), 5-ht(3) (tropisetron), and 5-ht(4) (sdz205557). |
2006-10-05 |
2023-08-12 |
mouse |
| Philippe Girard, Marie-Claude Coppé, Danielle Verniers, Yannick Pansart, Jean-Marie Gillardi. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacological research. vol 54. issue 3. 2006-10-05. PMID:16750379. |
in conclusion, nefopam analgesic activity could be modulated by the adrenergic alpha(1) and alpha(2) receptors, the dopaminergic d(2) receptors, and the serotonergic 5-ht(1b) and 5-ht(2c) receptor subtypes. |
2006-10-05 |
2023-08-12 |
mouse |
| R L Cowan, E Haga, B deB Frederick, M S Dietrich, R L P Vimal, S E Lukas, P F Rensha. MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16782178. |
previous animal studies have demonstrated that 3,4-methylenedioxymethamphetamine (mdma) exposure causes serotonin axotomy that is greatest in occipital cortex (including primary visual cortex) where serotonergic axons innervate neurons and blood vessels. |
2006-10-05 |
2023-08-12 |
human |
| Sunmee Wee, William L Woolverto. Self-administration of mixtures of fenfluramine and amphetamine by rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 84. issue 2. 2006-10-05. PMID:16828855. |
the present experiment was designed to examine the relationship between the serotonergic activity and efficacy as a reinforcer by allowing rhesus monkeys (n=5) to self-administer amphetamine mixed with a serotonin releaser, fenfluramine. |
2006-10-05 |
2023-08-12 |
monkey |
| Miguel Esteve. Invertebrate modeling of a migraine channelopathy. Headache. vol 46 Suppl 1. 2006-10-05. PMID:16927961. |
although the importance of serotonin to migraine tendency suggests a link between serotonergic signaling and cacna1a function, the nature of this connection remains unclear in vertebrate studies. |
2006-10-05 |
2023-08-12 |
human |
| Erik Lauterbach, Jürgen Brunner, Barbara Hawellek, Ute Lewitzka, Marcus Ising, Brigitta Bondy, Marie Luise Rao, Christine Frahnert, Dan Rujescu, Bruno Müller-Oerlinghausen, Jürgen Schley, Isabella Heuser, Wolfgang Maier, Fritz Hohagen, Werner Felber, Thomas Bronisc. Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior. Journal of affective disorders. vol 91. issue 1. 2006-10-04. PMID:16412522. |
abnormalities in the serotonergic (5-ht) system have been implicated in the pathogenesis of suicidal behavior. |
2006-10-04 |
2023-08-12 |
Not clear |
| Jun Li, Yufeng Wang, Rulun Zhou, Bing Wang, Haobo Zhang, Li Yang, Stephen V Faraon. Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16563621. |
to further investigate the role of other genes of the serotonergic pathway in adhd, the current study examined variants of the serotonin 4 receptor gene in a relatively large sample of adhd nuclear families. |
2006-09-28 |
2023-08-12 |
human |
| R Díez-Alarcia, F Pilar-Cuéllar, M A Paniagua, J J Meana, A Fernández-Lópe. Pharmacological characterization and autoradiographic distribution of alpha2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain. Neuroscience. vol 141. issue 1. 2006-09-28. PMID:16697114. |
rx 821002, serotonin (5-ht) and 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] competition assays, and competition binding assays performed in the presence of serotonin demonstrated that [(3)h]rx 821002 binds with higher affinity to a serotonergic component, probably 5-ht(1a) receptors, than to the alpha(2)-adrenoceptors. |
2006-09-28 |
2023-08-12 |
rat |
| Lydia Schiller, Monika Jähkel, Jochen Oehle. The influence of sex and social isolation housing on pre- and postsynaptic 5-HT1A receptors. Brain research. vol 1103. issue 1. 2006-09-28. PMID:16814751. |
serotonergic (5-ht) receptors are crucial for different brain functions and play an important role in several pathological conditions. |
2006-09-28 |
2023-08-12 |
mouse |
| Paul J Gasser, Christopher A Lowry, Miles Orchini. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928864. |
these data support the hypothesis that corticosterone-induced inhibition of oct3 mediates stress-induced accumulation of 5-ht in the dmh and suggest that corticosterone may acutely modulate physiological and behavioral responses to stressors by altering serotonergic neurotransmission in this brain region. |
2006-09-28 |
2023-08-12 |
rat |
| P Ken Gillma. A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action. Biological psychiatry. vol 59. issue 11. 2006-09-27. PMID:16460699. |
the spectrum concept formulates st as a continuum of serotonergic effects, mediated by the degree of elevation of intrasynaptic serotonin. |
2006-09-27 |
2023-08-12 |
Not clear |
| Raquel Garcia, Lurdes Gano, Leonor Maria, António Paulo, Isabel Santos, Hartmut Spie. Synthesis and biological evaluation of tricarbonyl Re(I) and Tc(I) complexes anchored by poly(azolyl)borates: application on the design of radiopharmaceuticals for the targeting of 5-HT1A receptors. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 11. issue 6. 2006-09-27. PMID:16823553. |
using 4a as the lead structure, we have synthesized the functionalized complexes fac-[m{kappa(3)-h(mu-h)b(tim(bu-pip))(2)}(co)(3)] [m is re (8), (99m)tc (8a); tim(bu-pip) is methyl[4-((2-methoxyphenyl)-1-piperazinyl)butyl](2-mercapto-1-methylimidazol-5-yl)methanamide] and fac-[m{kappa (3)-h(mu-h)b(tim(me))(tim(bu-pip))}(co)(3)] [m is re (9), (99m)tc (9a)] and evaluated their potential as radioactive probes for the targeting of brain 5-ht(1a) serotonergic receptors. |
2006-09-27 |
2023-08-12 |
mouse |
| Fuad Lechin, Bertha van der Dijs, Gerardo Hernández-Adriá. Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 4. 2006-09-25. PMID:16436311. |
monoaminergic neurons located in the central nervous system (cns) are organized into complex circuits which include noradrenergic (na), adrenergic (ad), dopaminergic (da), serotonergic (5-ht), histaminergic (h), gaba-ergic and glutamatergic systems. |
2006-09-25 |
2023-08-12 |
Not clear |
| Sîan M J Hemmings, Craig J Kinnear, Christine Lochner, Soraya Seedat, Valerie A Corfield, Johanna C Moolman-Smook, Dan J Stei. Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population. The Israel journal of psychiatry and related sciences. vol 43. issue 2. 2006-09-22. PMID:16910371. |
there is some evidence that both disorders (ocd and ttm) are mediated by serotonergic (5-ht) and dopaminergic pathways. |
2006-09-22 |
2023-08-12 |
Not clear |
| Eszter Kirilly, Anita Benko, Linda Ferrington, Romeo D Ando, Paul A T Kelly, Gyorgy Bagd. Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats. The international journal of neuropsychopharmacology. vol 9. issue 1. 2006-09-19. PMID:16060968. |
mdma causes selective depletion of serotonergic terminals in experimental animals and the consequent decrease in synaptic 5-ht may, inter alia, increase impulsivity. |
2006-09-19 |
2023-08-12 |
rat |