| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hassan Mitwally, Mohamed Omar Saad, Dania Alkhiyami, Amr Mohamed Fahmi, Sara Mahmoud, Eman Al Hmoud, Rasha El Enany, Hassan Younis, Shaban Mohammed, Palli Abdul Rouf, Binny Thomas, Moza Al Hai. Risk of serotonin syndrome in acutely ill patients receiving linezolid and opioids concomitantly: a retrospective cohort study. IJID Regions (Online). vol 5. 2022-11-03. PMID:36324824. |
combining linezolid with serotonergic agents may increase serotonin syndrome (ss) risk.linezolid is recommended in patients with suspected or confirmed resistant gram-positive bacterial infections, especially if vancomycin cannot be used. |
2022-11-03 |
2023-08-14 |
Not clear |
| Paul W Andrews, Catherine Bosyj, Luke Brenton, Laura Green, Paul J Gasser, Christopher A Lowry, Virginia M Picke. All the brain's a stage for serotonin: the forgotten story of serotonin diffusion across cell membranes. Proceedings. Biological sciences. vol 289. issue 1986. 2022-11-02. PMID:36321487. |
this failure has limited our understanding of a key regulator of serotonergic neurotransmission, impeded research on the potential intracellular actions of serotonin in post-synaptic neurons and glial cells, and may have impeded our understanding of the mechanism by which antidepressant medications reduce depressive symptoms. |
2022-11-02 |
2023-08-14 |
Not clear |
| Esther Silk, Mustansir Diwan, Thallita Rabelo, Hailey Katzman, Ana Carolina P Campos, Flavia Venetucci Gouveia, Peter Giacobbe, Nir Lipsman, Clement Haman. Serotonin 5-HT Psychopharmacology. 2022-10-25. PMID:36282287. |
in rodents, vmpfc dbs reduces raphe cell firing and increases serotonin (5-ht) release and the expression of serotonergic receptors in different brain regions. |
2022-10-25 |
2023-08-14 |
Not clear |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Sai Dheeraj Gutlapalli, Vamsi Krishna Lavu, Rana Abdelwahab Mohamed, Ruimin Huang, Shanthi Potla, Sushen Bhalla, Yousif Al Qabandi, Savitri Aninditha Nandula, Chinmayi Sree Boddepalli, Pousette Hami. The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine. Cureus. vol 14. issue 9. 2022-10-19. PMID:36258960. |
venlafaxine is a second line anti-depressant and the most commonly used in the treatment of selective serotonin reuptake inhibitor nonresponders in major depression; due to its effects on the noradrenergic and serotonergic systems as a serotonin and norepinephrine reuptake inhibitor, there has been considerable apprehension regarding its use in patients with cardiovascular diseases, particularly post-myocardial infarction depression, some of the feared adverse effects include qt prolongation, arrhythmias including torsades de pointes and sudden cardiac death. |
2022-10-19 |
2023-08-14 |
Not clear |
| Adam Schindzielor. Increased Sensitivity to Serotonin Syndrome in Cerebral Palsy. Case reports in psychiatry. vol 2022. 2022-10-17. PMID:36247225. |
the syndrome is typically induced by the combination of two or more serotonergic agents; however, there have been instances of serotonin syndrome occurring while a patient is on a single medication. |
2022-10-17 |
2023-08-14 |
Not clear |
| Daisuke Ib. Role of interaction of mGlu2 and 5-HT Pharmacology, biochemistry, and behavior. 2022-10-16. PMID:36244526. |
role of interaction of mglu2 and 5-ht the serotonergic and glutamatergic neurotransmitter systems have been implicated in the pathophysiology of schizophrenia, and increasing evidence shows that they interact functionally. |
2022-10-16 |
2023-08-14 |
Not clear |
| Hugo Martin, Sébastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Pénicaud, Sophie Layé, Bruno P Guiard, Xavier Fioramont. Insulin modulates emotional behavior through a serotonin-dependent mechanism. Molecular psychiatry. 2022-10-07. PMID:36207585. |
here we hypothesized that insulin modulates the serotonergic (5-ht) system to control emotional behavior and that insulin resistance in 5-ht neurons contributes to the development of mood disorders in t2d. |
2022-10-07 |
2023-08-14 |
Not clear |
| Anissa Dudde, Loc Phi Van, Lars Schrader, Arnd J Obert, E Tobias Kraus. Brain gain-Is the cognitive performance of domestic hens affected by a functional polymorphism in the serotonin transporter gene? Frontiers in psychology. vol 13. 2022-10-03. PMID:36186393. |
the serotonin transporter (5-htt) plays an important role in regulating serotonergic transmission |
2022-10-03 |
2023-08-14 |
Not clear |
| Peyman Sahbaie, Karen-Amanda Irvine, Xiao-You Shi, J David Clar. Monoamine control of descending pain modulation after mild traumatic brain injury. Scientific reports. vol 12. issue 1. 2022-09-29. PMID:36175479. |
the intrathecal injection of ondansetron showed that loss of dnic was not due to excess serotonergic signaling through 5-ht |
2022-09-29 |
2023-08-14 |
mouse |
| Mu Li, Qingyang Chen, Yuan-Wei Zhan. Determining Ligand and Ion-Induced Conformational Changes in Serotonin Transporter with Its Fluorescent Substrates. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142837. |
the serotonin transporter (sert) catalyzes reuptake of the neurotransmitter serotonin after its release by serotonergic neurons and is the molecular target for antidepressant drugs and psychostimulants. |
2022-09-23 |
2023-08-14 |
Not clear |
| Nikola Fritz, Sabrina Berens, Yuanjun Dong, Cristina Martínez, Stefanie Schmitteckert, Lesley A Houghton, Miriam Goebel-Stengel, Verena Wahl, Maria Kabisch, Dorothea Götze, Mauro D'Amato, Tenghao Zheng, Ralph Röth, Hubert Mönnikes, Jonas Tesarz, Felicitas Engel, Annika Gauss, Martin Raithel, Viola Andresen, Jutta Keller, Thomas Frieling, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Paul J Kennedy, John F Cryan, Timothy G Dinan, Eamonn M M Quigley, Robin Spiller, Caroll Beltrán, Ana María Madrid, Verónica Torres, Emeran A Mayer, Gregory Sayuk, Maria Gazouli, George Karamanolis, Mariona Bustamante, Xavier Estivil, Raquel Rabionet, Per Hoffmann, Markus M Nöthen, Stefanie Heilmann-Heimbach, Börge Schmidt, André Franke, Wolfgang Lieb, Wolfgang Herzog, Guy Boeckxstaens, Mira M Wouters, Magnus Simrén, Gudrun A Rappold, Maria Vicario, Javier Santos, Rainer Schaefert, Justo Lorenzo-Bermejo, Beate Niesle. The serotonin receptor 3E variant is a risk factor for female IBS-D. Journal of molecular medicine (Berlin, Germany). 2022-09-19. PMID:36121467. |
evidence of disturbed serotonergic function in ibs accumulated for the 5-ht |
2022-09-19 |
2023-08-14 |
Not clear |
| Giulia Braccagni, Simona Scheggi, Marco Bortolat. Elevated levels of serotonin 5-HT European archives of psychiatry and clinical neuroscience. 2022-09-12. PMID:36094569. |
tissues were processed for immunoblotting analyses on eight key serotonergic targets: tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of brain serotonin synthesis; serotonin transporter (sert), the primary carrier for serotonin uptake; monoamine oxidase a (maoa), the primary enzyme for serotonin catabolism; and five serotonin receptors previously shown to influence social behavior: 5-ht |
2022-09-12 |
2023-08-14 |
human |
| Samyukta Varma, Sona Xavier, Saral Desai, Syed Al. A Case of Serotonin Syndrome Precipitated by Quetiapine in a Middle-Aged Female on Trazodone and Sertraline. Cureus. vol 14. issue 8. 2022-09-08. PMID:36072169. |
serotonin syndrome (ss) is a potentially life-threatening condition caused by drugs that act on serotonergic receptors or alter serotonin metabolism. |
2022-09-08 |
2023-08-14 |
Not clear |
| Shu-Hsien Sheu, Srigokul Upadhyayula, Vincent Dupuy, Song Pang, Fei Deng, Jinxia Wan, Deepika Walpita, H Amalia Pasolli, Justin Houser, Silvia Sanchez-Martinez, Sebastian E Brauchi, Sambashiva Banala, Melanie Freeman, C Shan Xu, Tom Kirchhausen, Harald F Hess, Luke Lavis, Yulong Li, Séverine Chaumont-Dubel, David E Clapha. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell. vol 185. issue 18. 2022-09-02. PMID:36055200. |
using a cilia-targeted serotonin sensor, we show that opto- and chemogenetic stimulation of serotonergic axons releases serotonin onto cilia. |
2022-09-02 |
2023-08-14 |
Not clear |
| Michael J Schu. Chronic Serotonin Toxicity in the Older Patient With Polypharmacy. The Senior care pharmacist. vol 37. issue 9. 2022-08-30. PMID:36038994. |
pharmacogenomic (pgx) testing can provide added insight into a potentially iatrogenic cause for serotonin toxicity, because testing can elucidate how well an individual patient may metabolize serotonergic medications. |
2022-08-30 |
2023-08-14 |
Not clear |
| Margaret R MacLean, Barry Fanburg, Nicolas Hill, Howard M Lazarus, Thomas F Pack, Michelle Palacios, Krishna C Penumatsa, Stephen A Wrin. Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho. Comprehensive Physiology. vol 12. issue 4. 2022-08-29. PMID:36036567. |
the "serotonin hypothesis of pulmonary hypertension" arose when serotonin was associated with pah induced by diet pills such as fenfluramine, aminorex, and chlorphentermine; these act as indirect serotonergic agonists causing the release of serotonin from platelets and cells through the sert. |
2022-08-29 |
2023-08-14 |
Not clear |
| Robertas Strumila, Aiste Lengvenyte, Emilie Olie, Philippe Courtet, Sebastien Guillaum. Escitalopram should be investigated in anorexia nervosa: Rationale and review of mechanisms. Journal of psychopharmacology (Oxford, England). 2022-08-25. PMID:36003008. |
as studies have shown decreased serotonergic and increased dopaminergic transmission in an, we hypothesized that an ideal drug for an management should boost serotonin levels to increase serotonergic and decrease dopaminergic transmission, the two main features of escitalopram action. |
2022-08-25 |
2023-08-14 |
Not clear |
| Isadora Braga Contreiras Carneiro, Ana Elisa Toscano, Marcela de Sá Barreto da Cunha, Diego Cabral Lacerda, Paula Brielle Pontes, Raul Manhães de Castro, Tereza Cristina Bonfim de Jesus Deiró, Jairza Maria Barreto Medeiro. Serotonergic mechanisms associated with experimental models of hypoxia: a systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-08-23. PMID:35996828. |
the aim of this systematic review was to explore and discuss the literature concerning the effects of hypoxia or anoxia during the perinatal period on the serotoninergic network in rodents, through mechanisms that lead to changes in serotonergic neurons, serotonin(5-ht) and 5-hydroxyindole amino acid (5-hiaa) levels, segments of central nervous system affected, 5-ht transporter and 5-ht receptor. |
2022-08-23 |
2023-08-14 |
Not clear |
| Wenfei Wang, Yichun Wang, Qiuting Guo, Huiting Li, Zhaoqiang Wang, Jia Li, Taotao Li, Tiantian Tang, Yujiao Wang, Yanzhuo Jia, Yao Wang, Junbo Zou, Yajun Shi, Dongyan Guo, Ming Yang, Xiaofei Zhang, Jing Su. Valerian essential oil for treating insomnia Frontiers in nutrition. vol 9. 2022-08-22. PMID:35990355. |
following pathway activation, we propose that the core gene protein kinase pka activates the serotonergic synapse signal pathway to increase the expression of 5-ht and gaba, thus improving insomnia symptoms and alleviating anxiety. |
2022-08-22 |
2023-08-14 |
rat |