| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Lee, M J Crouche. Actions of Group I and Group II metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission. Neuroscience. vol 117. issue 3. 2003-05-05. PMID:12617971. |
the failure of (s)-mcpg alone to modify cortical 5-ht release suggests that group ii mglu receptors do not tonically modulate serotonergic neurotransmission in the cerebral cortex but this does not preclude an important functional role for these receptors during pathological conditions when endogenous neurotransmitter levels become excessively elevated. |
2003-05-05 |
2023-08-12 |
human |
| Andreas Reif, Klaus-Peter Lesc. Toward a molecular architecture of personality. Behavioural brain research. vol 139. issue 1-2. 2003-05-02. PMID:12642172. |
in recent years, molecular genetics has begun to identify specific genes coding in particular for components of the serotonergic and dopaminergic neurotransmitter systems representing quantitative trait loci (qtls) for behavioral traits. |
2003-05-02 |
2023-08-12 |
Not clear |
| A Birthelmer, A Ehret, F Amtage, S Förster, O Lehmann, H Jeltsch, J-C Cassel, R Jackisc. Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Brain research bulletin. vol 59. issue 5. 2003-03-17. PMID:12507688. |
neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. |
2003-03-17 |
2023-08-12 |
rat |
| Manolis Markianos, John Hatzimanolis, Lefteris Lykoura. Relationship between prolactin responses to ECT and dopaminergic and serotonergic responsivity in depressed patients. European archives of psychiatry and clinical neuroscience. vol 252. issue 4. 2003-02-24. PMID:12242577. |
the prolactin (prl) increases in plasma, induced by the electrical stimulus during electroconvulsive therapy (ect), is a consistent finding that can be studied in order to obtain information about its actions on the brain neurotransmitter systems, the most probable candidates being the serotonergic and the dopaminergic system. |
2003-02-24 |
2023-08-12 |
human |
| Reidun Ursi. Serotonin and sleep. Sleep medicine reviews. vol 6. issue 1. 2003-02-14. PMID:12531142. |
serotonergic activity may be accompanied by waking or sleep depending on the brain area and receptor type involved in the response, on the current behavioural state and on the concomitant agonism/antagonism of other neurotransmitter systems. |
2003-02-14 |
2023-08-12 |
Not clear |
| Luca Santarelli, Gabriella Gobbi, Pierre Blier, René He. Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1). The Journal of clinical psychiatry. vol 63 Suppl 11. 2003-02-11. PMID:12562138. |
experimental studies of these affective disorders to date have largely focused on the neurotransmitter pathways with well-established pathophysiologic roles, such as serotonergic, noradrenergic, and gamma-aminobutyric acid (gaba)-ergic systems; agents modulating the activity of these pathways are known to be clinically effective. |
2003-02-11 |
2023-08-12 |
mouse |
| Kathelijne Peremans, Kurt Audenaert, Peter Blanckaert, Filip Jacobs, Frank Coopman, Francis Verschooten, Henri Van Bree, Cornelis Van Heeringen, John Mertens, Guido Slegers, Rudi Dierck. Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 7-8. 2003-01-27. PMID:12502029. |
normal aging is associated with a decrease in number and size of neurons, loss of synapses and neuronal branching and with a reduced functioning neurotransmitter systems, such as the serotonergic system. |
2003-01-27 |
2023-08-12 |
dog |
| Peter J Morgane, David J Mokler, Janina R Galle. Effects of prenatal protein malnutrition on the hippocampal formation. Neuroscience and biobehavioral reviews. vol 26. issue 4. 2002-11-22. PMID:12204193. |
since this involves particular attention to the gabaergic interneurons we have examined the complex interneuronal networks of the hippocampal formation and their neurotransmitter afferent inputs, particularly the serotonergic system from the midbrain raphé nuclei. |
2002-11-22 |
2023-08-12 |
Not clear |
| Erica L Unger, Pascale Mazzola-Pomietto, Dennis L Murphy, Anne M Andrew. 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine]. The Journal of pharmacology and experimental therapeutics. vol 303. issue 2. 2002-11-22. PMID:12388632. |
moreover, this study clearly shows that 2'-nh(2)-mptp can be utilized in rats as a tool to study the serotonergic and noradrenergic neurotransmitter systems. |
2002-11-22 |
2023-08-12 |
mouse |
| Csaba Juhász, Harry T Chugani, Otto Muzik, Diane C Chugan. Hypotheses from functional neuroimaging studies. International review of neurobiology. vol 49. 2002-11-06. PMID:12040903. |
pet is also able to investigate developmental abnormalities of serotonergic and gabaergic neurotransmitter systems in vivo. |
2002-11-06 |
2023-08-12 |
human |
| S Z East, P W J Burnet, R W Kerwin, P J Harriso. An RT-PCR study of 5-HT(6) and 5-HT(7) receptor mRNAs in the hippocampal formation and prefrontal cortex in schizophrenia. Schizophrenia research. vol 57. issue 1. 2002-10-30. PMID:12165372. |
regional decreases in 5-ht(6)r and 5-ht(7)r expression in schizophrenia may contribute to the overall serotonergic alterations which occur in the disorder, in part through their interactions with other neurotransmitter systems including glutamate and acetylcholine. |
2002-10-30 |
2023-08-12 |
human |
| M J Arranz, D Collier, R W Kerwi. Pharmacogenetics for the individualization of psychiatric treatment. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 1. issue 1. 2002-09-18. PMID:12173312. |
these include the dopaminergic and serotonergic receptors, neurotransmitter transporters and other receptors and enzymes involved in psychiatric disorders. |
2002-09-18 |
2023-08-12 |
Not clear |
| David J Bur. Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 17. issue 3. 2002-09-16. PMID:12112190. |
dysfunction of multiple neurotransmitter systems, including the serotonergic system, may be involved. |
2002-09-16 |
2023-08-12 |
Not clear |
| S Muchimapura, A J Fulford, R Mason, C A Marsde. Isolation rearing in the rat disrupts the hippocampal response to stress. Neuroscience. vol 112. issue 3. 2002-09-06. PMID:12074911. |
isolation rearing in the rat alters hippocampal function, including the serotonergic system, leading to changes in neurotransmitter systems in other brain areas. |
2002-09-06 |
2023-08-12 |
human |
| Christo Goridis, Hermann Rohre. Specification of catecholaminergic and serotonergic neurons. Nature reviews. Neuroscience. vol 3. issue 7. 2002-07-12. PMID:12094209. |
here, we review our current knowledge of the regulatory circuits that direct neurotransmitter choice, and discuss the development of well-studied types of catecholaminergic and serotonergic neurons. |
2002-07-12 |
2023-08-12 |
Not clear |
| Toshihiko Morimoto, Kenji Hashimoto, Hiroshi Yasumatsu, Hiroshi Tanaka, Masatake Fujimura, Makoto Kuriyama, Koreichi Kimura, Shuzo Takehara, Keiji Yamagam. Neuropharmacological profile of a novel potential atypical antipsychotic drug Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)- 6H-[1]benzothieno[2,3-b][1,5] benzodiazepine maleate). Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 4. 2002-05-09. PMID:11927170. |
similar to clozapine and olanzapine, y-931 interacted with multiple neurotransmitter receptors such as dopaminergic, serotonergic, alpha-adrenergic, muscarinic and histaminergic receptors. |
2002-05-09 |
2023-08-12 |
rat |
| David Kahne, Alina Tudorica, Alice Borella, Lee Shapiro, Fabian Johnstone, Wei Huang, Patricia M Whitaker-Azmiti. Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism. Physiology & behavior. vol 75. issue 3. 2002-04-30. PMID:11897268. |
the current work is aimed at producing such a model by treating developing rat pups with a serotonergic agonist, 5-methoxytryptamine (5-mt; 1 mg/kg) during development (from gestational age 12 days to postnatal day 20), thus mimicking one of the hallmark neurochemical features of the illness-increases in the neurotransmitter, serotonin. |
2002-04-30 |
2023-08-12 |
human |
| B Dea. Understanding the pathology of schizophrenia: recent advances from the study of the molecular architecture of postmortem CNS tissue. Postgraduate medical journal. vol 78. issue 917. 2002-04-18. PMID:11884695. |
recent findings have shown changes in markers in a number of neurotransmitter systems in the brains of subjects with schizophrenia which include the dopaminergic, serotonergic, cholinergic, glutamatergic, and gabaergic systems of the cns. |
2002-04-18 |
2023-08-12 |
human |
| J Thome, W Retz, M Baader, B Pesold, M Hu, M Cowen, N Durany, G Adler, F A Henn, M Rösle. Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725820. |
in order to identify gene variants related to the serotonergic neurotransmitter system that possibly represent a hereditary risk factor for sporadic alzheimer's disease (ad), patients suffering from ad and non-demented psychiatric inpatients without symptoms of dementia were genotyped for polymorphisms of htr6 (267c/t) and htr2a (-1438g/a). |
2002-04-16 |
2023-08-12 |
Not clear |
| J Thome, W Retz, M Baader, B Pesold, M Hu, M Cowen, N Durany, G Adler, F A Henn, M Rösle. Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725820. |
however, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in ad. |
2002-04-16 |
2023-08-12 |
Not clear |