| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bart Scholtissen, Ronald Deumens, Albert F G Leentjens, Christoph Schmitz, Arjan Blokland, Harry W M Steinbusch, Jos Prickaert. Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats. Pharmacology, biochemistry, and behavior. vol 83. issue 2. 2006-08-14. PMID:16504275. |
in parkinson's disease (pd), several neurotransmitter systems, such as the dopaminergic and serotonergic system, show signs of degeneration. |
2006-08-14 |
2023-08-12 |
rat |
| Goutam Chandra, Prasanta K Gangopadhyay, Karuppagounder S Senthil Kumar, Kochupurackal P Mohanakuma. Acute intranigral homocysteine administration produces stereotypic behavioral changes and striatal dopamine depletion in Sprague-Dawley rats. Brain research. vol 1075. issue 1. 2006-07-31. PMID:16487496. |
neurotransmitter levels in the serotonergic perikarya or terminals were unaltered 19 days following intraraphe infusion of homocysteine, which suggested the specificity of its action to dopaminergic neurons. |
2006-07-31 |
2023-08-12 |
rat |
| Hiroki Imbe, Yasutomo Iwai-Liao, Emiko Senb. Stress-induced hyperalgesia: animal models and putative mechanisms. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-27. PMID:16720304. |
the dysfunction of the hypothalamo-pituitary-adrenocortical axis (hpa axis) and multiple neurotransmitter systems in the central nervous system (cns), including endogenous opioid, serotonergic and noradrenergic systems, has been reported. |
2006-06-27 |
2023-08-12 |
Not clear |
| Falk Kiefer, Karl Man. New achievements and pharmacotherapeutic approaches in the treatment of alcohol dependence. European journal of pharmacology. vol 526. issue 1-3. 2006-05-25. PMID:16266700. |
the development of alcohol dependence seems to involve adaptive changes in amino acid neurotransmitter systems, stimulation of dopamine and opioid peptide systems, and changes in serotonergic activity. |
2006-05-25 |
2023-08-12 |
Not clear |
| Beth A Luellen, Matthew E Szapacs, Christopher K Materese, Anne M Andrew. The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF. Neuropharmacology. vol 50. issue 3. 2006-05-24. PMID:16288930. |
these results, in conjunction with previous findings, demonstrate that 2'-nh2-mptp causes degeneration of serotonergic axons innervating the cortex and hippocampus on par with depletions in neurotransmitter levels. |
2006-05-24 |
2023-08-12 |
mouse |
| Scott F Stoltenberg, Jennifer M Glass, Steven T Chermack, Heather A Flynn, Sheng Li, Margaret E Weston, Margit Burmeiste. Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene. Psychiatric genetics. vol 16. issue 1. 2006-05-18. PMID:16395128. |
converging evidence implicates the serotonergic neurotransmitter system in response inhibition circuitry. |
2006-05-18 |
2023-08-12 |
Not clear |
| Byung-Joo Ham, Min-Soo Lee, Heon-Jeong Lee, Rhee-Hun Kang, Chang-Su Han, Myoung-Jin Choi, Seung-Hwan Lee, Seung-Ho Ry. No association between the tryptophan hydroxylase gene polymorphism and major depressive disorders and antidepressant response in a Korean population. Psychiatric genetics. vol 15. issue 4. 2006-04-14. PMID:16314762. |
the serotonergic neurotransmitter system has been implicated in major depressive disorder (mdd) and appears to be the target of a variety of antidepressants. |
2006-04-14 |
2023-08-12 |
Not clear |
| Takuya Shinjo, Masakuni Okad. [Olanzapine use in cancer patients for refractory vomiting]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 33. issue 3. 2006-04-03. PMID:16531716. |
olanzapine,indicated for schizophrenia in japan, has an affinity for multiple neurotransmitter receptors including dopaminergic, serotonergic, histaminergic, adrenergic and muscarinic receptors. |
2006-04-03 |
2023-08-12 |
Not clear |
| B E Leonar. The HPA and immune axes in stress: the involvement of the serotonergic system. European psychiatry : the journal of the Association of European Psychiatrists. vol 20 Suppl 3. 2006-03-21. PMID:16459240. |
the impact of acute and chronic stress on the hypothalamic-pituitary-adrenal (hpa) axis is reviewed and evidence presented that corticotrophin releasing factor (crf) is the stress neurotransmitter which plays an important role in the activation of the central sympathetic and serotonergic systems. |
2006-03-21 |
2023-08-12 |
Not clear |
| Tsuri Lifschytz, Ronen Segman, Galit Shalom, Bernard Lerer, Eitan Gur, Tanya Golzer, Michael E Newma. Basic mechanisms of augmentation of antidepressant effects with thyroid hormone. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475961. |
the effects of t3, alone and together with the ssri fluoxetine, on mrna levels for the 5-ht1a and 5-ht1b autoreceptors, which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing(somatodendritic 5-ht1a autoreceptors) and neurotransmitter release (nerve terminal 5-ht1b autoreceptors) were also determined. |
2006-03-10 |
2023-08-12 |
human |
| William Slikker, Z Alex Xu, Edward D Levin, Theodore A Slotki. Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine. Critical reviews in toxicology. vol 35. issue 8-9. 2006-02-08. PMID:16417037. |
other events include an initial increase followed by a decrease in adenyl cyclase activity, as well as effects on the noradrenergic, dopaminergic, and serotonergic neurotransmitter systems. |
2006-02-08 |
2023-08-12 |
human |
| Jeanine I H Keuker, Jan N Keijser, Csaba Nyakas, Paul G M Luiten, Eberhard Fuch. Aging is accompanied by a subfield-specific reduction of serotonergic fibers in the tree shrew hippocampal formation. Journal of chemical neuroanatomy. vol 30. issue 4. 2006-01-13. PMID:16169187. |
although the effects of aging on various neurotransmitter systems in the hippocampus have been extensively investigated, it is not entirely clear whether or how the hippocampal serotonergic innervation changes during aging. |
2006-01-13 |
2023-08-12 |
rat |
| Filip Scheperjans, Nicola Palomero-Gallagher, Christian Grefkes, Axel Schleicher, Karl Zille. Transmitter receptors reveal segregation of cortical areas in the human superior parietal cortex: relations to visual and somatosensory regions. NeuroImage. vol 28. issue 2. 2005-12-22. PMID:16054841. |
regional distributions of ligand binding sites of 12 different neurotransmitter receptors (glutamatergic: ampa, kainate, nmda; gabaergic: gaba(a), gaba(b); cholinergic: muscarinic m2, nicotinic; adrenergic: alpha1, alpha2; serotonergic: 5-ht1a, 5-ht2; dopaminergic: d1) were studied in human postmortem brains by means of quantitative receptor autoradiography. |
2005-12-22 |
2023-08-12 |
human |
| Kenny J Simansk. NIH symposium series: ingestive mechanisms in obesity, substance abuse and mental disorders. Physiology & behavior. vol 86. issue 1-2. 2005-12-15. PMID:16129461. |
the presentations and discussion from this symposium (1) identified changes in neurotransmitter dynamics and gene expression in brain "reward circuits" accompanying learning of behaviors to obtain palatable foods or drugs of abuse; (2) analyzed behavioral findings in animals and humans, and neuroimaging data in humans, supporting treatment with gaba(b) agonists to reduce craving for drugs of abuse and possibly for highly rewarding foods; and (3) used neuroimaging data in humans to establish novel serotonergic targets for normalizing reward processes and impulse control in anorexia nervosa and bulimia. |
2005-12-15 |
2023-08-12 |
human |
| Paul A Sykes, Barry G Condro. Development and sensitivity to serotonin of Drosophila serotonergic varicosities in the central nervous system. Developmental biology. vol 286. issue 1. 2005-12-07. PMID:16122730. |
we tested the sensitivity of serotonergic varicosities to serotonin by adding neurotransmitter at various stages to isolated larval ventral nerve cords. |
2005-12-07 |
2023-08-12 |
drosophila_melanogaster |
| Teresa M du Bois, Chao Deng, Xu-Feng Huan. Membrane phospholipid composition, alterations in neurotransmitter systems and schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:16005134. |
this review addresses the relationship between modifications in membrane phospholipid composition (mpc) and alterations in dopaminergic, serotonergic and cholinergic neurotransmitter systems in schizophrenia. |
2005-10-27 |
2023-08-12 |
rat |
| Berend Olivie. Serotonergic mechanisms in aggression. Novartis Foundation symposium. vol 268. 2005-10-27. PMID:16206880. |
the serotonergic system in the cns has complex interactions with many, if not all other neurotransmitter systems in the brain. |
2005-10-27 |
2023-08-12 |
Not clear |
| Raphael J Le. Chronic pain and comorbid depression. Current treatment options in neurology. vol 7. issue 5. 2005-10-14. PMID:16079044. |
although antidepressants offer advantages in simultaneously producing pain relief and mitigating depression, not all antidepressants share equal efficacy; those with noradrenergic and serotonergic influences seem to fare better than agents with single neurotransmitter influences. |
2005-10-14 |
2023-08-12 |
Not clear |
| Debby Van Dam, Bart Marescau, Sebastiaan Engelborghs, Thomas Cremers, Jan Mulder, Matthias Staufenbiel, Peter Paul De Dey. Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models. Neurochemistry international. vol 46. issue 5. 2005-06-10. PMID:15737439. |
significant changes in compounds of the noradrenergic and serotonergic system were observed, as well as alterations in levels of the inhibitory neurotransmitter glycine and systemic amino acids. |
2005-06-10 |
2023-08-12 |
mouse |
| Jennifer L Kirwin, Jessica L Göre. Duloxetine: a dual serotonin-norepinephrine reuptake inhibitor for treatment of major depressive disorder. Pharmacotherapy. vol 25. issue 3. 2005-05-18. PMID:15843287. |
duloxetine, approved by the u.s. food and drug administration for the treatment of mdd, is a reuptake inhibitor at serotonergic and noradrenergic neurons and appears to have low affinity for other neurotransmitter systems. |
2005-05-18 |
2023-08-12 |
Not clear |