| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter V Rabins, David B Arciniega. Pathophysiology of involuntary emotional expression disorder. CNS spectrums. vol 12. issue 4 Suppl 5. 2007-10-04. PMID:17426671. |
this network includes specific cerebral, cerebellar, and brainstem areas and their multiple projections/pathways, with activity modulated through serotonergic, dopaminergic, glutamatergic, and possibly sigma receptor neurotransmitter systems. |
2007-10-04 |
2023-08-12 |
human |
| B A Luellen, L E Bianco, L M Schneider, A M Andrew. Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice. Genes, brain, and behavior. vol 6. issue 5. 2007-09-19. PMID:17156118. |
it is not known, however, whether age-accelerated loss of serotonergic innervation in bdnf(+/-) mice occurs in other brain regions, advances beyond 18 months or is associated with alterations in other neurotransmitter systems. |
2007-09-19 |
2023-08-12 |
mouse |
| J-E Lim, J Pinsonneault, W Sadee, D Saffe. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Molecular psychiatry. vol 12. issue 5. 2007-06-26. PMID:17453063. |
tryptophan hydroxylase isoform 2 (tph2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. |
2007-06-26 |
2023-08-12 |
human |
| Vivienne Ann Russel. Neurobiology of animal models of attention-deficit hyperactivity disorder. Journal of neuroscience methods. vol 161. issue 2. 2007-06-12. PMID:17275916. |
however, evidence obtained from some animal models suggests that the noradrenergic and serotonergic neurotransmitter systems may be the target of drugs that ameliorate adhd symptoms. |
2007-06-12 |
2023-08-12 |
mouse |
| L Charles Murrin, Jeff D Sanders, David B Bylun. Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults. Biochemical pharmacology. vol 73. issue 8. 2007-05-31. PMID:17316571. |
comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults. |
2007-05-31 |
2023-08-12 |
Not clear |
| L Charles Murrin, Jeff D Sanders, David B Bylun. Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults. Biochemical pharmacology. vol 73. issue 8. 2007-05-31. PMID:17316571. |
we review here the development of the noradrenergic and serotonergic nervous systems, both in terms of neurotransmitter system markers and function. |
2007-05-31 |
2023-08-12 |
Not clear |
| Charles B Nemerof. Recent advances in the neurobiology of depression. Psychopharmacology bulletin. vol 36 Suppl 2. 2007-05-03. PMID:12490820. |
substantial evidence has accrued, including changes in neurotransmitter and neurotransmitter metabolite concentrations, reuptake sites, and receptors, to support the hypothesis that alteration in neuronal serotonergic and noradrenergic function occurs in the central nervous system of patients with major depression. |
2007-05-03 |
2023-08-12 |
Not clear |
| Lei Wang, Lan Yu, Guang He, Jing Zhang, Ai-Ping Zhang, Jing Du, Rui-Qi Tang, Xin-Zhi Zhao, Jie Ma, Jie-Kun Xuan, Yue Xiao, Niu-Fan Gu, Guo-Ying Feng, Ming-Qing Xu, Qing-He Xing, Lin H. Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients. Neuroscience letters. vol 414. issue 1. 2007-04-27. PMID:17287080. |
serotonin transporter (5-htt) is a key component of the serotonergic neurotransmitter system. |
2007-04-27 |
2023-08-12 |
Not clear |
| Anne-Kathrin Ettl, Jochen Holzschuh, Wolfgang Drieve. The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus. Anatomy and embryology. vol 211 Suppl 1. 2007-04-05. PMID:17024299. |
the effects of the mutation appear not to be restricted to dopaminergic neurons, as development of other neurotransmitter systems (serotonergic and cholinergic) is impaired as well. |
2007-04-05 |
2023-08-12 |
zebrafish |
| Xiaohui Xu, Keeley Brookes, Chih-Ken Chen, Yu-Shu Huang, Yu-Yu Wu, Philip Asherso. Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples. BMC psychiatry. vol 7. 2007-03-19. PMID:17328795. |
molecular genetic and pharmacological studies suggest the involvement of the dopaminergic, serotonergic and noradrenergic neurotransmitter systems in the pathogenesis of adhd. |
2007-03-19 |
2023-08-12 |
Not clear |
| Richard S Jope, Myoung-Sun Ro. Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Current drug targets. vol 7. issue 11. 2007-01-04. PMID:17100582. |
several intracellular signaling cascades converge on gsk3 to modulate its activity, and several neurotransmitter systems also regulate gsk3, including serotonergic, dopaminergic, cholinergic, and glutamatergic systems. |
2007-01-04 |
2023-08-12 |
Not clear |
| H G M Westenberg, C Sandne. Tolerability and safety of fluvoxamine and other antidepressants. International journal of clinical practice. vol 60. issue 4. 2006-12-04. PMID:16620364. |
the highly specific actions of ssris of enhancing serotonergic neurotransmission appears to explain their benefit, while lack of direct actions on other neurotransmitter systems is responsible for their superior safety profile compared with tricyclic antidepressants. |
2006-12-04 |
2023-08-12 |
Not clear |
| Robert B Raffa, Gregory W Stagliano, Ronald J Tallarid. Subadditive withdrawal from cocaine/kappa-opioid agonist combinations in Planaria. Brain research. vol 1114. issue 1. 2006-11-28. PMID:16914122. |
planaria are particularly valuable for these studies because of their permeable exteriors and their relevant neurotransmitter systems (e.g., dopaminergic, opioid, and serotonergic). |
2006-11-28 |
2023-08-12 |
Not clear |
| Bart Scholtissen, Frans R J Verhey, Jos J Adam, Wim Weber, Albert F G Leentjen. Challenging the serotonergic system in Parkinson disease patients: effects on cognition, mood, and motor performance. Clinical neuropharmacology. vol 29. issue 5. 2006-11-14. PMID:16960473. |
multiple neurotransmitter systems, including the serotonergic system, are involved in the pathophysiology of this disease. |
2006-11-14 |
2023-08-12 |
Not clear |
| John P Dahl, Joseph F Cubells, Riju Ray, Andrew E Weller, Falk W Lohoff, Thomas N Ferraro, David W Oslin, Kyle M Kampman, Charles Dackis, Yilang Tang, Joel Gelernter, Henry R Kranzler, Charles P O'Brien, Wade H Berrettin. Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. Addiction biology. vol 11. issue 1. 2006-11-09. PMID:16759340. |
while the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. |
2006-11-09 |
2023-08-12 |
human |
| Rainald Mössner, Seong-Wook Yun, Klaus-Peter Lesch, Manfred Gerlach, Michael A Klein, Peter Riedere. Unaltered susceptibility to scrapie in serotonin transporter deficient mice. Neurochemistry international. vol 49. issue 5. 2006-10-18. PMID:16730863. |
specifically, hyperactivity of the serotonergic system in prion diseases is suggested by an increase in the turnover rate of the neurotransmitter serotonin (5-hydroxytryptamine, 5-ht) in human and experimental prion diseases. |
2006-10-18 |
2023-08-12 |
mouse |
| G B García, C Konjuh, R O Duffard, A M Evangelista de Duffar. Dopamine-beta-hydroxylase immunohistochemical study in the locus coeruleus of neonate rats exposed to 2,4-dichlorophenoxyacetic acid through mother's milk. Drug and chemical toxicology. vol 29. issue 4. 2006-10-12. PMID:16931444. |
as tyrosine hydroxylase levels in the lc are regulated by serotonin and in a previous study we demonstrated that this neurotransmitter was increased in 2,4-d-exposed pups, an indirect effect through serotonergic inhibition could be involved in the decreased dbetah synthesis in the lc of these pups. |
2006-10-12 |
2023-08-12 |
rat |
| M Eriksson, U Berggren, C Fahlke, J Engel, J Balldi. Platelet monoamine oxidase B (MAO-B) activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 1. 2006-09-15. PMID:15959855. |
the results support the notion that the peripheral marker platelet mao-b activity is related to the function of the central serotonergic neurotransmitter system as assessed by the prolactin response to 60 mg dl-fenfluramin. |
2006-09-15 |
2023-08-12 |
human |
| B Scholtissen, F R J Verhey, H W M Steinbusch, A F G Leentjen. Serotonergic mechanisms in Parkinson's disease: opposing results from preclinical and clinical data. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 1. 2006-09-15. PMID:16252066. |
however, other neurotransmitter systems also show signs of degeneration, among which the serotonergic system. |
2006-09-15 |
2023-08-12 |
human |
| Caroline H Williams-Gray, Thomas Foltynie, Simon J G Lewis, Roger A Barke. Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options. CNS drugs. vol 20. issue 6. 2006-09-05. PMID:16734499. |
deficits in neurotransmitter systems provide more obvious therapeutic targets and dysfunction of dopaminergic, cholinergic, noradrenergic and serotonergic systems have all been implicated; these may each underlie different features of parkinson's disease dementia, perhaps explaining some of the heterogeneity of the syndrome. |
2006-09-05 |
2023-08-12 |
Not clear |