| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christiaan H Vinkers, Ruud van Oorschot, S Mechiel Korte, Berend Olivier, Lucianne Groenin. 5-HT1A receptor blockade reverses GABA(A) receptor alpha3 subunit-mediated anxiolytic effects on stress-induced hyperthermia. Psychopharmacology. vol 211. issue 2. 2010-09-24. PMID:20535452. |
stress-related disorders are associated with dysfunction of both serotonergic and gabaergic pathways, and clinically effective anxiolytics act via both neurotransmitter systems. |
2010-09-24 |
2023-08-12 |
Not clear |
| Marie-Eve Tremblay, Mustapha Riad, Ania Majewsk. Preparation of mouse brain tissue for immunoelectron microscopy. Journal of visualized experiments : JoVE. issue 41. 2010-09-14. PMID:20689505. |
combined with tem, pre-embedding immunocytochemistry allows the discrimination of cellular elements with few distinctive features and identification criteria (e.g., microglial perikarya and processes, when using an antibody against the microglia-specific marker iba1 (ionized calcium binding adaptor molecule 1; as presented here)), identifying the neurotransmitter contents of cellular elements (e.g., serotonergic) and their ultrastructural localization of soluble or membrane-bound proteins (e.g., 5 ht1a and epha4 receptors). |
2010-09-14 |
2023-08-12 |
mouse |
| S M O'Mahony, D C Bulmer, A-M Coelho, P Fitzgerald, C Bongiovanni, K Lee, W Winchester, T G Dinan, J F Crya. 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 5. 2010-07-15. PMID:20003079. |
the serotonergic neurotransmitter system has been strongly implicated as a key player in the manifestation of ibs symptomatology including visceral hypersensitivity. |
2010-07-15 |
2023-08-12 |
rat |
| Feng Wei, Ronald Dubner, Shiping Zou, Ke Ren, Guang Bai, Dong Wei, Wei Gu. Molecular depletion of descending serotonin unmasks its novel facilitatory role in the development of persistent pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 25. 2010-07-15. PMID:20573908. |
although 5-ht-containing neurons in the rostral ventromedial medulla (rvm) provide the major descending serotonergic projection to the spinal cord, it is not clear whether the neurotransmitter 5-ht itself released from rvm-spinal neurons contributes to descending pain modulation. |
2010-07-15 |
2023-08-12 |
rat |
| Gil D Rabinovici, Bruce L Mille. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS drugs. vol 24. issue 5. 2010-06-25. PMID:20369906. |
current pharmacotherapy for ftld focuses on manipulating serotonergic or dopaminergic neurotransmitter systems to ameliorate behavioural or motor symptoms. |
2010-06-25 |
2023-08-12 |
Not clear |
| Susann Scherag, Johannes Hebebrand, Anke Hinne. Eating disorders: the current status of molecular genetic research. European child & adolescent psychiatry. vol 19. issue 3. 2010-06-14. PMID:20033240. |
candidate gene studies have initially focused on the serotonergic and other central neurotransmitter systems and on genes involved in body weight regulation. |
2010-06-14 |
2023-08-12 |
Not clear |
| N Herrmann, K L Lancto. The management of behavioural disturbances in dementia: the role of serotonergic therapies. IDrugs : the investigational drugs journal. vol 1. issue 2. 2010-06-09. PMID:18465534. |
recent research has focused on alterations in central serotonergic dysfunction as an important factor in the etiology of many of these disturbances, though numerous other neurotransmitter systems are also likely to be involved. |
2010-06-09 |
2023-08-12 |
Not clear |
| Andreas Altenburger, Andreas Wanninge. Neuromuscular development in Novocrania anomala: evidence for the presence of serotonin and a spiralian-like apical organ in lecithotrophic brachiopod larvae. Evolution & development. vol 12. issue 1. 2010-05-25. PMID:20156279. |
our data are the first direct proof for the presence of an immunoreactive neurotransmitter in lecithotrophic brachiopod larvae and demonstrate the existence of flask-shaped serotonergic cells in the brachiopod larval apical organ, thus significantly increasing the probability that this cell type was part of the bauplan of the larvae of the last common lophotrochozoan ancestor. |
2010-05-25 |
2023-08-12 |
Not clear |
| Niklas Nordquist, Lars Orelan. Serotonin, genetic variability, behaviour, and psychiatric disorders--a review. Upsala journal of medical sciences. vol 115. issue 1. 2010-05-25. PMID:20187845. |
in this review we explore, based on recent research, the hypothesis that the dual role of serotonin as a neurotransmitter and a neurotrophic factor has a significant impact on behaviour and risk for neuropsychiatric disorders through altered development of limbic neurocircuitry involved in emotional processing, and development of the serotonergic neurons, during early brain development. |
2010-05-25 |
2023-08-12 |
monkey |
| Ted Reichborn-Kjenneru. The genetic epidemiology of personality disorders. Dialogues in clinical neuroscience. vol 12. issue 1. 2010-04-26. PMID:20373672. |
molecular genetic studies of pds, mostly candidate gene association studies, indicate that genes linked to neurotransmitter pathways, especially in the serotonergic and dopaminergic systems, are involved. |
2010-04-26 |
2023-08-12 |
Not clear |
| Hana Kovaru, Marek Pav, Frantisek Kovaru, Jiri Raboch, Anna Fiserov. Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells. Neuro endocrinology letters. vol 30. issue 4. 2010-03-08. PMID:20010506. |
depression is associated with abnormalities in the noradrenergic, serotonergic and dopaminergic neurotransmitter systems and reductions in the level of their precursors and metabolic turnover. |
2010-03-08 |
2023-08-12 |
human |
| Judit Lazary, Aron Lazary, Xenia Gonda, Anita Benko, Eszter Molnar, Laszlo Hunyady, Gabriella Juhasz, Gyorgy Bagd. Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotype. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 8. 2010-02-23. PMID:19725030. |
experimental data suggest that the ecs can modulate several neurotransmitter systems, including the serotonergic system, which itself plays a significant role in anxiety. |
2010-02-23 |
2023-08-12 |
Not clear |
| Rodney C Samaco, Caleigh Mandel-Brehm, Hsiao-Tuan Chao, Christopher S Ward, Sharyl L Fyffe-Maricich, Jun Ren, Keith Hyland, Christina Thaller, Stephen M Maricich, Peter Humphreys, John J Greer, Alan Percy, Daniel G Glaze, Huda Y Zoghbi, Jeffrey L Neu. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 51. 2010-02-18. PMID:20007372. |
deleting mecp2 from either th-positive dopaminergic and noradrenergic neurons or pet1-positive serotonergic neurons in mice decreased corresponding neurotransmitter concentration and specific phenotypes, likely through mecp2 regulation of rate-limiting enzymes involved in aminergic neurotransmitter production. |
2010-02-18 |
2023-08-12 |
mouse |
| Philip J Meas. Further strategies for treating fibromyalgia: the role of serotonin and norepinephrine reuptake inhibitors. The American journal of medicine. vol 122. issue 12 Suppl. 2010-01-27. PMID:19962496. |
preclinical studies using animal models of chronic pain have shown that pharmacologic agents that combine serotonergic and noradrenergic reuptake inhibition, thus augmenting the function of these neurotransmitters, have stronger analgesic effects than agents that inhibit reuptake of either neurotransmitter alone. |
2010-01-27 |
2023-08-12 |
Not clear |
| Winfried G Rossmanith, Wiebke Ruebberd. What causes hot flushes? The neuroendocrine origin of vasomotor symptoms in the menopause. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 25. issue 5. 2010-01-21. PMID:19903037. |
the lack of estrogens alters neurotransmitter activity, especially in the serotonergic and noradrenergic pathways. |
2010-01-21 |
2023-08-12 |
Not clear |
| Adolfo Sequeira, Firoza Mamdani, Carl Ernst, Marquis P Vawter, William E Bunney, Veronique Lebel, Sonia Rehal, Tim Klempan, Alain Gratton, Chawki Benkelfat, Guy A Rouleau, Naguib Mechawar, Gustavo Tureck. Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PloS one. vol 4. issue 8. 2010-01-19. PMID:19668376. |
while it seems clear that serotonergic alterations play a role in the pathogenesis of these major public health problems, dysfunction in additional neurotransmitter systems and other molecular alterations may also be implicated. |
2010-01-19 |
2023-08-12 |
Not clear |
| Patrik Roser, Beate Della, Christine Norra, Georg Juckel, Idun Uh. No association between chronic cannabis use and loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission. Neuroscience letters. vol 465. issue 2. 2010-01-14. PMID:19766579. |
it is suggested that cannabis use induces changes in neurotransmitter systems involved in the pathogenesis of depressive disorders, particularly in the serotonergic system. |
2010-01-14 |
2023-08-12 |
Not clear |
| D Armbruster, A Mueller, D A Moser, K P Lesch, B Brocke, C Kirschbau. Interaction effect of D4 dopamine receptor gene and serotonin transporter promoter polymorphism on the cortisol stress response. Behavioral neuroscience. vol 123. issue 6. 2010-01-05. PMID:20001112. |
the dopaminergic and the serotonergic neurotransmitter system have been found to modulate the amygdala-connected circuitries that are crucial in emotional modulation and response to fearful stimuli. |
2010-01-05 |
2023-08-12 |
Not clear |
| Courtney A Ficks, Irwin D Waldma. Gene-environment interactions in attention-deficit/hyperactivity disorder. Current psychiatry reports. vol 11. issue 5. 2010-01-04. PMID:19785980. |
genetic associations with adhd have been found in the dopaminergic, serotonergic, and noradrenergic neurotransmitter systems, but findings are inconsistent across studies. |
2010-01-04 |
2023-08-12 |
Not clear |
| Susan H Fox, Rosalind Chuang, Jonathan M Brotchi. Serotonin and Parkinson's disease: On movement, mood, and madness. Movement disorders : official journal of the Movement Disorder Society. vol 24. issue 9. 2009-10-21. PMID:19412960. |
the multitude of subtypes of 5-ht receptors in the brain and an increased understanding of the potential function 5-ht may play in modulating other neurotransmitter systems, including dopamine, gaba, and glutamate, have meant an expansion in efforts to develop potential serotonergic drugs for both motor and nonmotor symptoms in pd. |
2009-10-21 |
2023-08-12 |
Not clear |