| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wendy Rockhill, Jennifer L Kirkman, Martha M Bosm. Spontaneous activity in the developing mouse midbrain driven by an external pacemaker. Developmental neurobiology. vol 69. issue 11. 2009-10-29. PMID:19449313. |
anatomical analysis of the development of the serotonergic axons that carry sa from the hindbrain to the midbrain indicates that their increasing elongation during development may control the onset of sa in the midbrain. |
2009-10-29 |
2023-08-12 |
mouse |
| Ilona Klejbor, Aaron Kucinski, Scott R Wersinger, Thomas Corso, Jan H Spodnik, Jerzy Dziewiatkowski, Janusz Moryś, Renae A Hesse, Kenner C Rice, Robert Miletich, Ewa K Stachowiak, Michal K Stachowia. Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. Schizophrenia research. vol 113. issue 2-3. 2009-10-29. PMID:19570652. |
we show in th(tk-)/th(tk-) mice that hypoplastic development of da systems induces serotonergic hyperinnervation of midbrain da nuclei, demonstrating the co-developmental relationship between da and 5-ht systems. |
2009-10-29 |
2023-08-12 |
mouse |
| Karen Sugden, Ales Tichopad, Nadeem Khan, Ian W Craig, Ursula M D'Souz. Genes within the serotonergic system are differentially expressed in human brain. BMC neuroscience. vol 10. 2009-08-17. PMID:19445671. |
in this study, we report expression patterns of five serotonergic genes (tph1, tph2, 5-ht2a, 5-ht2c, 5-htt) in seven different human post-mortem brain regions (superior frontal gyrus, superior temporal gyrus, striatum, cerebellum, hippocampus, midbrain and thalamus) using taqman real-time quantitative pcr. |
2009-08-17 |
2023-08-12 |
human |
| M W Hale, A Hay-Schmidt, J D Mikkelsen, B Poulsen, J A Bouwknecht, A K Evans, C E Stamper, A Shekhar, C A Lowr. Exposure to an open-field arena increases c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex. Neuroscience. vol 157. issue 4. 2009-04-15. PMID:18951955. |
treatment effects on c-fos expression in serotonergic and non-serotonergic cells in the midbrain raphe nuclei were determined 2 h following open-field exposure or home cage control (co) conditions. |
2009-04-15 |
2023-08-12 |
rat |
| M W Hale, A Hay-Schmidt, J D Mikkelsen, B Poulsen, J A Bouwknecht, A K Evans, C E Stamper, A Shekhar, C A Lowr. Exposure to an open-field arena increases c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex. Neuroscience. vol 157. issue 4. 2009-04-15. PMID:18951955. |
rats tested under both light conditions responded with increases in c-fos expression in serotonergic neurons within subdivisions of the midbrain raphe nuclei compared with co rats. |
2009-04-15 |
2023-08-12 |
rat |
| Suzanne N Haber, Justin L Brucke. Cognitive and limbic circuits that are affected by deep brain stimulation. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273166. |
additional integral parts of the network include, the amygdala, the midbrain dopamine cells and the serotonergic neurons. |
2009-04-07 |
2023-08-12 |
Not clear |
| Kaia Kala, Maarja Haugas, Kersti Lilleväli, Jordi Guimera, Wolfgang Wurst, Marjo Salminen, Juha Partane. Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons. Development (Cambridge, England). vol 136. issue 2. 2009-03-18. PMID:19088086. |
using tissue-specific inactivation and ectopic expression, we show that gata2 regulates gabaergic neuron development in the mouse midbrain, but not in rhombomere 1, where it is needed in the serotonergic lineage. |
2009-03-18 |
2023-08-12 |
mouse |
| Paul Gacek, Tamlin S Conner, Howard Tennen, Henry R Kranzler, Jonathan Covaul. Tryptophan hydroxylase 2 gene and alcohol use among college students. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18782386. |
tryptophan hydroxylase (tph2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. |
2009-03-05 |
2023-08-12 |
human |
| Anna Castañé, Francesc Artigas, Analía Bortolozz. The absence of 5-HT(1A) receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex. Psychopharmacology. vol 200. issue 2. 2009-01-29. PMID:18594799. |
projection pyramidal neurons and local gabaergic interneurons in mpfc express 5-ht(1a) receptors, whose activation modulates dopaminergic (da) and serotonergic (5-ht) activity in midbrain and the cortical release of both monoamines. |
2009-01-29 |
2023-08-12 |
mouse |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
depressed suicide patients have elevated expression of neuronal tryptophan hydroxylase 2 (tph2) mrna and protein in midbrain serotonergic neurons, as well as increases in brain serotonin turnover. |
2009-01-23 |
2023-08-12 |
Not clear |
| Yoshihiro Takeuch. [Neurotransmission in developmental disorders]. No to hattatsu = Brain and development. vol 40. issue 6. 2009-01-07. PMID:19039985. |
furthermore, serotonergic neurons exert an inhibitory effect on midbrain dopamine cell bodies, and they have an influence on dopamine release in terminal regions. |
2009-01-07 |
2023-08-12 |
Not clear |
| Hyo-Jin Jeong, David Chenu, Emma E Johnson, Mark Connor, Christopher W Vaugha. Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Molecular pain. vol 4. 2008-12-17. PMID:19014464. |
in the present study we examined the serotonergic modulation of gabaergic and glutamatergic synaptic transmission in rat midbrain pag slices in vitro. |
2008-12-17 |
2023-08-12 |
rat |
| Prem Prakash Tripathi, Luca Giovanni Di Giovannantonio, Alessandro Viegi, Wolfgang Wurst, Antonio Simeone, Yuri Bozz. Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784307. |
mutant mice, in which otx2 was conditionally inactivated by a cre recombinase expressed under the transcriptional control of the engrailed1 (en1) gene (en1(cre/+); otx2(flox/flox)), show a reduced number of dopaminergic neurons and an increased number of serotonergic neurons in the ventral midbrain. |
2008-11-03 |
2023-08-12 |
mouse |
| Jin-Xia Dai, Ze-Lan Hu, Ming Shi, Chao Guo, Yu-Qiang Din. Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system. The Journal of comparative neurology. vol 509. issue 4. 2008-09-02. PMID:18512225. |
lmx1b was observed in dopaminergic neurons in the midbrain and serotonergic neurons in the hindbrain, as determined by double labeling with specific markers. |
2008-09-02 |
2023-08-12 |
mouse |
| Pablo Torterolo, Patricia Lagos, Sharon Sampogna, Michael H Chas. Melanin-concentrating hormone (MCH) immunoreactivity in non-neuronal cells within the raphe nuclei and subventricular region of the brainstem of the cat. Brain research. vol 1210. 2008-08-26. PMID:18410908. |
the mch+ cells in the midbrain raphe nuclei were closely related to neuronal processes of serotonergic neurons. |
2008-08-26 |
2023-08-12 |
cat |
| Sarven Sabunciyan, Robert Yolken, Christina M Ragan, James B Potash, Vishwajit L Nimgaonkar, Faith Dickerson, Ida C Llenos, Serge Wei. Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 8. 2008-02-05. PMID:17541950. |
the disruption of this gene results in cortical malformations and causes serotonergic and dopaminergic cells in the midbrain to be expressed in aberrant locations. |
2008-02-05 |
2023-08-12 |
Not clear |
| Kohtarou Konno, Machiko Matsumoto, Hiroko Togashi, Taku Yamaguchi, Takeshi Izumi, Masahiko Watanabe, Toshihiko Iwanaga, Mitsuhiro Yoshiok. Early postnatal stress affects the serotonergic function in the median raphe nuclei of adult rats. Brain research. vol 1172. 2008-01-09. PMID:17825274. |
the present study was undertaken to elucidate whether early postnatal stress affects rat brain development and influences the serotonergic function in the midbrain median raphe nuclei (mrn) and dorsal raphe nuclei (drn) in the adult, focusing on the response to unconditioned fear stress. |
2008-01-09 |
2023-08-12 |
rat |
| Yong Ren, Jian Fen. Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17587308. |
here we show that rotenone also selectively killed serotonergic neurons in midbrain neuronal cultures. |
2007-11-07 |
2023-08-12 |
Not clear |
| Daniel D Lam, Lora K Heisle. Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert reviews in molecular medicine. vol 9. issue 5. 2007-10-09. PMID:17316471. |
in the brain, serotonergic fibres from midbrain raphe nuclei project to key feeding centres, where serotonin acts on specific receptors to modulate the activity of various downstream neuropeptide systems and autonomic pathways and thus affects ingestive behaviour and energy expenditure. |
2007-10-09 |
2023-08-12 |
Not clear |
| Murray Esler, Elisabeth Lambert, Marlies Alvarenga, Florentia Socratous, Jeff Richards, David Barton, Ciaran Pier, Celia Brenchley, Tye Dawood, Jacqueline Hastings, Ling Guo, Deepak Haikerwal, David Kaye, Garry Jennings, Victor Kalff, Michael Kelly, Glen Wiesner, Gavin Lamber. Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: reduction by a selective serotonin reuptake inhibitor. Stress (Amsterdam, Netherlands). vol 10. issue 3. 2007-10-02. PMID:17613943. |
serotonin transporter genotyping suggested that increased whole brain serotonin turnover most likely derived not from impaired serotonin reuptake, but from increased firing in serotonergic midbrain raphe neurons projecting to both subcortical brain regions and the cerebral cortex. |
2007-10-02 |
2023-08-12 |
human |