| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David P Stirlin. Potential physiological and pathological roles for axonal ryanodine receptors. Neural regeneration research. vol 18. issue 4. 2022-10-07. PMID:36204832. |
clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and glia. |
2022-10-07 |
2023-08-14 |
Not clear |
| Xiaolong Zheng, Wei Wan. Astrocyte transplantation for repairing the injured spinal cord: a mini-review. Journal of biomedical research. 2022-09-03. PMID:36056564. |
astrocytes, the major glia supporting the normal function of neurons in the spinal cord, become active and form glial scars after sci, which has long been regarded as a barrier for axon regeneration. |
2022-09-03 |
2023-08-14 |
human |
| Souptik Basu, Indra N Choudhury, Jia Yu Peppermint Lee, Anu Chacko, Jenny A K Ekberg, James A St Joh. Macrophages Treated with VEGF and PDGF Exert Paracrine Effects on Olfactory Ensheathing Cell Function. Cells. vol 11. issue 15. 2022-08-12. PMID:35954252. |
glial cell transplantation using olfactory ensheathing cells (oecs) holds a promising approach for treating spinal cord injury (sci). |
2022-08-12 |
2023-08-14 |
Not clear |
| Sarah V Donato, Matthew K Vickaryou. Radial Glia and Neuronal-like Ependymal Cells Are Present within the Spinal Cord of the Trunk (Body) in the Leopard Gecko ( Journal of developmental biology. vol 10. issue 2. 2022-06-23. PMID:35735912. |
radial glia and neuronal-like ependymal cells are present within the spinal cord of the trunk (body) in the leopard gecko ( as is the case for many lizards, leopard geckos ( |
2022-06-23 |
2023-08-14 |
Not clear |
| Ting Xiang, Jia-Heng Li, Han-Yu Su, Kun-Hong Bai, Shuang Wang, Richard J Traub, Dong-Yuan Ca. Spinal CCK1 receptors contribute to somatic pain hypersensitivity induced by malocclusion via a reciprocal neuron-glial signaling cascade. The journal of pain. 2022-06-12. PMID:35691467. |
these findings indicate that the signaling transduction between neurons and glia at the spinal cord level contributes to the descending pain facilitation through cck1 receptors during the development of the comorbidity of tmd and fms. |
2022-06-12 |
2023-08-14 |
Not clear |
| Zhenpeng Li, Jintao Fang, Jiantao Yang, Bengang Qin, Wenting He, Jian Qi, Qingtang Zhu, Honggang Wang, Liqiang G. Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model. Pain research & management. vol 2022. 2022-04-04. PMID:35371367. |
this study aimed to evaluate whether the site of c7 neurotomy affects spinal cord glial cell activation and pain-related behavior on the paralyzed side in a rat stroke model. |
2022-04-04 |
2023-08-13 |
rat |
| Rajeshwar Kumar Yadav, Sidharth Mehan, Rakesh Sahu, Sumit Kumar, Andleeb Khan, Hafiz Antar Makeen, Mohammed Al Bratt. Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats. Human & experimental toxicology. vol 41. 2022-04-04. PMID:35373622. |
mehg increases oligodendrocyte death, glial cell activation, and motor neuron demyelination in the motor cortex and spinal cord. |
2022-04-04 |
2023-08-13 |
rat |
| Danny Mortensen, Maria Soendergaard Thoefner, Joergen Steen Agerholm, Lasse Slumstrup, Troels Staehelin Jensen, Ole Jannik Bjerrum, Mette Berendt, Jens Randel Nyengaar. Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching. Pain. 2022-03-30. PMID:35353770. |
this histopathological study used spinal cords from ckcs with syringomyelia to investigate: 1) whether specific structural cervical spinal cord entities involved in nociception are affected by loss of neuroparenchyma or other pathological changes in ckcs with pain-related behaviour and phantom scratching, 2) if pain related behaviour or phantom scratching correlated with loss of a specific anatomical entity or upregulation of glia cells, and 3) if syringomyelia-related lesions affected specific functional spinal cord units of nociception.spinal cord segments c1-c8 from ckcs with mri-confirmed syringomyelia and clinical signs of pain and phantom scratch (n=8) were compared to ckcs without syringomyelia (n=4). |
2022-03-30 |
2023-08-13 |
Not clear |
| Nicolas Stoflet Lavoie, Vincent Truong, Dane Malone, Thomas Pengo, Nandadevi Patil, James R Dutton, Ann M Par. Human induced pluripotent stem cells integrate, create synapses and extend long axons after spinal cord injury. Journal of cellular and molecular medicine. 2022-03-08. PMID:35257489. |
twelve weeks later, cells derived from the transplanted snpcs survived and differentiated into neurons and glia that filled the lesion cavity and produced a thoracic spinal cord transcriptional program in vivo. |
2022-03-08 |
2023-08-13 |
human |
| Jing Wang, Feng Zhou, Susu Zhang, Mao Mao, Shanwu Feng, Xian Wan. Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain. Neuroscience letters. 2022-02-12. PMID:35149198. |
furthermore, dul (20 mg/kg/day) for 5 days markedly ameliorated ptx-induced trpv1, cgrp, and sp upregulation in the drg and sdh, and mitigated ptx-induced spinal cord glia activation and tnf-α expression. |
2022-02-12 |
2023-08-13 |
rat |
| Souptik Basu, Indra N Choudhury, Lynn Nazareth, Anu Chacko, Todd Shelper, Marie-Laure Vial, Jenny A K Ekberg, James A St Joh. In vitro modulation of Schwann cell behavior by VEGF and PDGF in an inflammatory environment. Scientific reports. vol 12. issue 1. 2022-01-14. PMID:35027585. |
peripheral glial cell transplantation with schwann cells (scs) is a promising approach for treating spinal cord injury (sci). |
2022-01-14 |
2023-08-13 |
rat |
| Jean-Christophe Perez, Yannick N Gerber, Florence E Perri. Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury. Frontiers in aging neuroscience. vol 13. 2021-12-13. PMID:34899275. |
the glial scar that forms after traumatic spinal cord injury (sci) is mostly composed of microglia, ng2 glia, and astrocytes and plays dual roles in pathophysiological processes induced by the injury. |
2021-12-13 |
2023-08-13 |
Not clear |
| Dan Luo, Xing Li, Yonghui Hou, Yu Hou, Jiyao Luan, Jiaxian Weng, Jiheng Zhan, Dingkun Li. Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo. Drug development research. 2021-11-29. PMID:34842291. |
spinal cord injury (sci) leads to microvascular damage and the destruction of the blood spinal cord barrier (bscb), which can progress into secondary injuries, such as apoptosis and necrosis of neurons and glia, culminating in permanent neurological deficits. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tingting Ye, Yifei Cheng, Chao L. Adaptor Protein Complex 1 Sigma 3 Is Highly Expressed in Glioma and Could Enhance Its Progression. Computational and mathematical methods in medicine. vol 2021. 2021-11-24. PMID:34367317. |
glioma is the widely occurring deadly neoplasm induced by glial cell canceration in the central nervous system, including the brain and spinal cord. |
2021-11-24 |
2023-08-13 |
Not clear |
| Håkan Aldskogius, Elena N Kozlov. Dorsal Root Injury-A Model for Exploring Pathophysiology and Therapeutic Strategies in Spinal Cord Injury. Cells. vol 10. issue 9. 2021-11-19. PMID:34571835. |
at the same time, a lesion at this interface creates a localized injury of the spinal cord itself, but with an initial neuronal injury affecting only the axons of dorsal root ganglion neurons, and still a glial cell response closely resembling the one seen after direct spinal cord injury. |
2021-11-19 |
2023-08-13 |
Not clear |
| Miho Shiratori-Hayashi, Makoto Tsud. Spinal glial cells in itch modulation. Pharmacology research & perspectives. vol 9. issue 6. 2021-11-17. PMID:34677000. |
studies have shown that astrocytes, a type of glial cell, are activated in the spinal cord in response to skin inflammation and contribute to the exacerbation of chronic itch. |
2021-11-17 |
2023-08-13 |
Not clear |
| Alexandru Tatomir, Austin Beltrand, Vinh Nguyen, Jean-Paul Courneya, Dallas Boodhoo, Cornelia Cudrici, Dafin F Muresanu, Violeta Rus, Tudor C Badea, Horea Ru. RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis. Frontiers in immunology. vol 12. 2021-11-08. PMID:34394104. |
we showed recently that spinal cord astrocytes in mice lacking rgc-32 display an immature phenotype reminiscent of progenitors and radial glia, with an overall elongated morphology, increased proliferative capacity, and increased expression of progenitor markers when compared to their wild-type (wt) counterparts that make them incapable of undergoing reactive changes during the acute phase of experimental autoimmune encephalomyelitis (eae). |
2021-11-08 |
2023-08-13 |
mouse |
| Kimberly Howard-Quijano, Tomoki Yamaguchi, Fei Gao, Yuki Kuwabara, Stephanie Puig, Eevanna Lundquist, Siamak Salavatian, Bradley Taylor, Aman Mahaja. Spinal Cord Stimulation Reduces Ventricular Arrhythmias by Attenuating Reactive Gliosis and Activation of Spinal Interneurons. JACC. Clinical electrophysiology. vol 7. issue 10. 2021-10-28. PMID:34454884. |
this study investigated spinal cord neuronal and glial cell activation during cardiac ischemia-reperfusion (ir)-triggered ventricular arrhythmias and neuromodulation therapy by spinal cord stimulation (scs). |
2021-10-28 |
2023-08-13 |
Not clear |
| Junxuan Ma, Vaibhav Patil, Abhay Pandit, Leo R Quinlan, David P Finn, Sibylle Grad, Mauro Alini, Marianna Perogli. In Vitro Model to Investigate Communication between Dorsal Root Ganglion and Spinal Cord Glia. International journal of molecular sciences. vol 22. issue 18. 2021-10-28. PMID:34575886. |
in vitro model to investigate communication between dorsal root ganglion and spinal cord glia. |
2021-10-28 |
2023-08-13 |
rat |
| Junxuan Ma, Vaibhav Patil, Abhay Pandit, Leo R Quinlan, David P Finn, Sibylle Grad, Mauro Alini, Marianna Perogli. In Vitro Model to Investigate Communication between Dorsal Root Ganglion and Spinal Cord Glia. International journal of molecular sciences. vol 22. issue 18. 2021-10-28. PMID:34575886. |
in this study, an in vitro model was used to evaluate the communication between drg and spinal cord glia. |
2021-10-28 |
2023-08-13 |
rat |