All Relations between microglial cell and spinal cord posterior horn

Publication Sentence Publish Date Extraction Date Species
Jing Wang, Wei Song, Yujiao Zhang, Jian Wang, Yongqiang Wang, Jiangang Song, Yalan Zho. Electroacupuncture Alleviates Pain by Suppressing P2Y12R-Dependent Microglial Activation in Monoarthritic Rats. Neurochemical research. 2024-02-10. PMID:38337134. if analysis further revealed that most p2y12r was expressed in microglia in the spinal dorsal horn. 2024-02-10 2024-02-12 rat
Lunhao Chen, Chao Jiang, Qian Xu, Jiale Jin, Sigen A, Xi Wang, Xiaolin Li, Yaling Hu, Huankun Sun, Xuan Lu, Shumin Duan, Zhihua Gao, Wenxin Wang, Yue Wan. Biphasic release of betamethasone from an injectable HA hydrogel implant for alleviating lumbar disc herniation induced sciatica. Acta biomaterialia. 2024-01-20. PMID:38244658. in a mouse model of ldh, the epidural administration of bd/bp@ha efficiently alleviated ldh-induced sciatica for at least 10 days by inhibiting the activation of macrophages and microglia in dorsal root ganglion and spinal dorsal horn, respectively. 2024-01-20 2024-01-23 mouse
Zuoxia Zhang, Yanting Mao, Simin Huang, Rui Xu, Yulin Huang, Shuming Li, Yu'e Sun, Xiaoping Gu, Zhengliang M. Microglia Promote Inhibitory Synapse Phagocytosis in the Spinal Cord Dorsal Horn and Modulate Pain-Like Behaviors in a Murine Cancer-Induced Bone Pain Model. Anesthesia and analgesia. 2024-01-19. PMID:38241681. microglia promote inhibitory synapse phagocytosis in the spinal cord dorsal horn and modulate pain-like behaviors in a murine cancer-induced bone pain model. 2024-01-19 2024-01-22 mouse
Karen M Fisher, Joseph P Garner, Corinna Darian-Smit. Chronic Adaptations in the Dorsal Horn Following a Cervical Spinal Cord Injury in Primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 3. 2024-01-17. PMID:38233220. microglia density also increased in the affected dorsal horn at 4-6 months and then decreased, but did not return to baseline by 1 year, suggesting refinement continues beyond this time. 2024-01-17 2024-01-20 monkey
Leyan Shan, Kangtai Xu, Luyao Ji, Qian Zeng, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang, Zilong Wan. Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, behavior, and immunity. 2024-01-08. PMID:38190982. injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. 2024-01-08 2024-01-10 mouse
Leyan Shan, Kangtai Xu, Luyao Ji, Qian Zeng, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang, Zilong Wan. Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, behavior, and immunity. 2024-01-08. PMID:38190982. here we report that injured sensory neurons-derived galectin-3 (gal3) activates and reprograms microglia in the spinal dorsal horn (sdh) and contributes to neuropathic pain. 2024-01-08 2024-01-10 mouse
Xuan Zhu, Siyi Liu, Lixia Tian, Xiang Li, Rongrong Yao, Yunhan Zhao, Zihao Gao, Xue-Ru Liu, Xin-Qi Liu, Fu-Quan Huo, Lingli Lian. Spinal interleukin-16 mediates inflammatory pain via promoting glial activation. International immunopharmacology. vol 127. 2023-12-19. PMID:38113689. in addition, cd4 expression was upregulated in the spinal dorsal horn after cfa injection and cd4 was present in microglia and in contact with astrocytes and activated spinal neurons. 2023-12-19 2023-12-23 mouse
Xuan Zhu, Siyi Liu, Lixia Tian, Xiang Li, Rongrong Yao, Yunhan Zhao, Zihao Gao, Xue-Ru Liu, Xin-Qi Liu, Fu-Quan Huo, Lingli Lian. Spinal interleukin-16 mediates inflammatory pain via promoting glial activation. International immunopharmacology. vol 127. 2023-12-19. PMID:38113689. taken together, these results suggest that enhanced il-16-cd4 signaling triggers pain and activates microglia and astrocytes in the spinal dorsal horn, thus contributing to inflammatory pain. 2023-12-19 2023-12-23 mouse
Yajing Xu, Stephanie C Koch, Alexander Chamessian, Qianru He, Mayya Sundukova, Paul Heppenstall, RuRong Ji, Maria Fitzgerald, Simon Begg. Microglial refinement of A-fibre projections in the postnatal spinal cord dorsal horn is required for normal maturation of dynamic touch. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-11-21. PMID:37989592. thus, functional microglia are necessary for the normal postnatal development of dorsal horn sensory circuits. 2023-11-21 2023-11-29 mouse
Dongxia Duan, Lian Wang, Yueyang Feng, Daiyu Hu, Donghong Cu. Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission. Canadian journal of physiology and pharmacology. 2023-11-17. PMID:37976472. picroside Ⅱ (pⅡ) attenuated neuropathic pain by inhibiting the neuroinflammation of the spinal dorsal horn, however, how it engaged in the cross-talk between microglia and neurons remained ambiguous. 2023-11-17 2023-11-20 rat
Fumihiro Saika, Yohji Fukazawa, Shiroh Kishioka, Norikazu Kiguch. Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis. Journal of pharmacological sciences. vol 153. issue 4. 2023-11-16. PMID:37973215. ablation of itch-related sensory neurons using resiniferatoxin decreased itch-related scratching behavior and the number of hypertrophic microglia in the spinal dorsal horn. 2023-11-16 2023-11-20 mouse
Siyuan Wang, Chao Jiang, Kelei Cao, Run Li, Zhihua Gao, Yue Wan. HK2 in microglia and macrophages contribute to the development of neuropathic pain. Glia. 2023-11-01. PMID:37909251. however, selective ablation of hk2 in microglia reduced microgliosis in the spinal dorsal horn (sdh) with little analgesic effects. 2023-11-01 2023-11-08 Not clear
Zhe-Hao Xu, Jing-Cheng Zhang, Ke Chen, Xuan Liu, Xian-Zhi Li, Ming Yuan, Yue Wang, Jing-Yu Tia. Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. European journal of pharmacology. 2023-10-22. PMID:37866747. intrathecal pd-l1 (1 μg, 4 times a week for 1 week) suppressed the activation of the microglia in the spinal dorsal horn to relieve the chronic itch that was elicited by imiquimod-induced psoriasis and dnfb-induced allergic contact dermatitis. 2023-10-22 2023-11-08 mouse
Zhe-Hao Xu, Jing-Cheng Zhang, Ke Chen, Xuan Liu, Xian-Zhi Li, Ming Yuan, Yue Wang, Jing-Yu Tia. Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. European journal of pharmacology. 2023-10-22. PMID:37866747. although the activation of the microglia in the spinal dorsal horn was not detected in the aew-treated mice, intrathecal pd-l1 still reduced the number of scratches that were elicited by aew. 2023-10-22 2023-11-08 mouse
Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. in particular, ag490 treatment inhibited both microglial and astrocyte activation in the lumbar (l) 4-5 dorsal horn and significantly decreased levels of p-p38mapk, p-erk and p-jnk, which are known to be activated in microglia (p-p38mapk and p-erk) and astrocyte (p-jnk). 2023-10-20 2023-11-08 rat
Ryan W Castro, Mikayla C Lopes, Lindsay M De Biase, Gregorio Valde. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses. Glia. 2023-09-22. PMID:37737058. however, aging causes microglia in the ventral but not dorsal horn to lose their spatial organization. 2023-09-22 2023-10-07 mouse
Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Me. Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model. Neural regeneration research. vol 19. issue 3. 2023-09-18. PMID:37721302. in this study, we established a sprague-dawley rat model of spared nerve injury-induced neuropathic pain and found that gpr39 expression was significantly decreased in neurons and microglia in the spinal dorsal horn compared with sham-operated rats. 2023-09-18 2023-10-07 rat
Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T Supura. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia. European journal of medicinal chemistry. vol 260. 2023-09-07. PMID:37678143. by means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1 mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in cd-1 mice, as well as astrocyte and microglia activation in the dorsal horn of the lumbar spinal cord. 2023-09-07 2023-10-07 mouse
Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. moreover, sni-induced microglia activation and upregulation of p2x7r in spinal dorsal horn could be markedly inhibited by prf + drg. 2023-08-14 2023-08-16 Not clear
Ying Liang, Shuotao Zhong, Honghua Wang, Danlei Wu, Qingjuan Gon. Comparisons of the analgesic effect of different pulsed radiofrequency targets in SNI-induced neuropathic pain. Neuroreport. 2023-08-14. PMID:37577901. the results suggest that the analgesic effect of prf + drg increased with time whereas the other two not and microglia and p2x7r in the ipsilateral spinal dorsal horn may be involved in the process. 2023-08-14 2023-08-16 Not clear