| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Chun He, Shuang-Long Hou, Kai-Bin Wang, Ning Xu, Ke Li, Ting Xiong, Jing Lu. Treadmill running on neuropathic pain: via modulation of neuroinflammation. Frontiers in molecular neuroscience. vol 17. 2024-07-11. PMID:38989156. |
treadmill exercise can alleviate neuropathic pain mainly by regulating neuroinflammation, including inhibiting the activity of pro-inflammatory factors and over activation of microglia in the dorsal horn, regulating the expression of mu opioid receptor expression in the rostral ventromedial medulla and levels of γ-aminobutyric acid to activate the descending pain modulatory system and the overexpression of brain-derived neurotrophic factor. |
2024-07-11 |
2024-07-13 |
Not clear |
| Wulin Liang, Tianrui Zhang, Mingqian Zhang, Jiahui Gao, Rikang Huang, Xiyan Huang, Jianhua Chen, Lu Cheng, Liyuan Zhang, Zhishan Huang, Qiling Tan, Zhanhong Jia, Shuofeng Zhan. Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931456. |
the activation of microglia in the spinal dorsal horn was measured via immunofluorescence staining. |
2024-06-27 |
2024-06-29 |
rat |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |
| Shan-Ming Yang, Yuan-Bo Li, Hua-Xing Si, Yi Wei, Fu-Juan Ma, Jian Wang, Tao Chen, Kun Che. C-176 reduces inflammation-induced pain by blocking the cGAS-STING pathway in microglia. The International journal of neuroscience. 2024-05-13. PMID:38738512. |
our research results suggested that the cgas-sting pathway had a function in the inflammation mediated by microglia in the spinal cord dorsal horn. |
2024-05-13 |
2024-05-27 |
mouse |
| Serena Boccella, Michela Perrone, Antimo Fusco, Roozbe Bonsale, Rosmara Infantino, Silvia Nuzzo, Giovanni Pecoraro, Federica Ricciardi, Andrea Maria Morace, Gianluca Petrillo, Ilaria Leone, Monica Franzese, Vito de Novellis, Francesca Guida, Marco Salvatore, Sabatino Maione, Livio Luong. Spinal neuronal activity and neuroinflammatory component in a mouse model of CFA-induced vestibulodynia. Brain, behavior, and immunity. 2024-04-18. PMID:38636564. |
furthermore, we examined microglia activation in the l6-s1 dorsal horn using immunofluorescence, unveiling hypertrophic phenotypes indicative of neuroinflammation in the spinal cord. |
2024-04-18 |
2024-04-21 |
mouse |
| Zhehao Xu, Yue Wang, Changcheng Jiang, Zhengwei Wang, Yongfeng Chen, Manli Fa. The Regulation of the PD-1/PD-L1 Pathway in Imiquimod-Induced Chronic Psoriasis Itch and Itch Sensitization in Mouse. Molecular pain. 2024-04-17. PMID:38631843. |
during this period, there was a significant increase in pd-1 receptor expression in both the imiquimod-treated skin and the spinal dorsal horn in mice, accompanied by significant activation of microglia in the spinal dorsal horn. |
2024-04-17 |
2024-04-20 |
mouse |
| Wanxiang Qin, Yuping Li, Jian Cui, Bao Yu, Lehua Yu, Congwen Yan. Neutrophil extracellular traps as a unique target in the treatment of inflammatory pain. Biochemical and biophysical research communications. vol 710. 2024-04-11. PMID:38604072. |
we investigated the pathological importance of peripheral nets formation in inflammatory pain and its influence on the activation of spinal dorsal horn microglia. |
2024-04-11 |
2024-04-14 |
mouse |
| Peter A Smit. BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended. Neuroscience. 2024-02-28. PMID:38417539. |
these transform the phenotype of dorsal horn microglia such that they express p2x4 purinoceptors. |
2024-02-28 |
2024-03-02 |
Not clear |
| Heng Zhang, Ruifen Gu, Jisheng Luo, Chuanhua Zhong, Jinhong Pa. Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain. In vivo (Athens, Greece). vol 38. issue 2. 2024-02-28. PMID:38418142. |
this study aimed to investigate the role of notch receptor 1 (notch1)-mediated activation of microglia in the l5-s2 spinal dorsal horn in chronic prostatitis pain. |
2024-02-28 |
2024-03-02 |
Not clear |
| Ri Chen, Xueru Xu, Youfen Yu, Yanqin Chen, Chun Lin, Rongguo Li. High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI. Scientific reports. vol 14. issue 1. 2024-02-24. PMID:38402335. |
four different voltages (45 v, 65 v, 85 v, and 100 v) of prf on drg significantly alleviated the sni-induced nep, reduced the levels of activating transcription factor 3 (atf3) in drg, improved the ultrastructure of drg, and promoted autophagy in spinal microglia to varying degrees and partially reversed the increased expression of tnf-α and the reduced expression of il-10 in spinal cord dorsal horn (scdh). |
2024-02-24 |
2024-02-27 |
rat |
| Jing Wang, Wei Song, Yujiao Zhang, Jian Wang, Yongqiang Wang, Jiangang Song, Yalan Zho. Electroacupuncture Alleviates Pain by Suppressing P2Y12R-Dependent Microglial Activation in Monoarthritic Rats. Neurochemical research. 2024-02-10. PMID:38337134. |
if analysis further revealed that most p2y12r was expressed in microglia in the spinal dorsal horn. |
2024-02-10 |
2024-02-12 |
rat |
| Lunhao Chen, Chao Jiang, Qian Xu, Jiale Jin, Sigen A, Xi Wang, Xiaolin Li, Yaling Hu, Huankun Sun, Xuan Lu, Shumin Duan, Zhihua Gao, Wenxin Wang, Yue Wan. Biphasic release of betamethasone from an injectable HA hydrogel implant for alleviating lumbar disc herniation induced sciatica. Acta biomaterialia. 2024-01-20. PMID:38244658. |
in a mouse model of ldh, the epidural administration of bd/bp@ha efficiently alleviated ldh-induced sciatica for at least 10 days by inhibiting the activation of macrophages and microglia in dorsal root ganglion and spinal dorsal horn, respectively. |
2024-01-20 |
2024-01-23 |
mouse |
| Zuoxia Zhang, Yanting Mao, Simin Huang, Rui Xu, Yulin Huang, Shuming Li, Yu'e Sun, Xiaoping Gu, Zhengliang M. Microglia Promote Inhibitory Synapse Phagocytosis in the Spinal Cord Dorsal Horn and Modulate Pain-Like Behaviors in a Murine Cancer-Induced Bone Pain Model. Anesthesia and analgesia. 2024-01-19. PMID:38241681. |
microglia promote inhibitory synapse phagocytosis in the spinal cord dorsal horn and modulate pain-like behaviors in a murine cancer-induced bone pain model. |
2024-01-19 |
2024-01-22 |
mouse |
| Karen M Fisher, Joseph P Garner, Corinna Darian-Smit. Chronic Adaptations in the Dorsal Horn Following a Cervical Spinal Cord Injury in Primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 44. issue 3. 2024-01-17. PMID:38233220. |
microglia density also increased in the affected dorsal horn at 4-6 months and then decreased, but did not return to baseline by 1 year, suggesting refinement continues beyond this time. |
2024-01-17 |
2024-01-20 |
monkey |
| Leyan Shan, Kangtai Xu, Luyao Ji, Qian Zeng, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang, Zilong Wan. Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, behavior, and immunity. 2024-01-08. PMID:38190982. |
injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. |
2024-01-08 |
2024-01-10 |
mouse |
| Leyan Shan, Kangtai Xu, Luyao Ji, Qian Zeng, Yaqi Liu, Yifei Wu, Yiming Chen, Yitong Li, Qiaodan Hu, Jiawei Wu, Yuanfan Xu, Yuhui Luo, Changlin Li, Chaoran Wu, Changyu Jiang, Zilong Wan. Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn. Brain, behavior, and immunity. 2024-01-08. PMID:38190982. |
here we report that injured sensory neurons-derived galectin-3 (gal3) activates and reprograms microglia in the spinal dorsal horn (sdh) and contributes to neuropathic pain. |
2024-01-08 |
2024-01-10 |
mouse |
| Xuan Zhu, Siyi Liu, Lixia Tian, Xiang Li, Rongrong Yao, Yunhan Zhao, Zihao Gao, Xue-Ru Liu, Xin-Qi Liu, Fu-Quan Huo, Lingli Lian. Spinal interleukin-16 mediates inflammatory pain via promoting glial activation. International immunopharmacology. vol 127. 2023-12-19. PMID:38113689. |
in addition, cd4 expression was upregulated in the spinal dorsal horn after cfa injection and cd4 was present in microglia and in contact with astrocytes and activated spinal neurons. |
2023-12-19 |
2023-12-23 |
mouse |
| Xuan Zhu, Siyi Liu, Lixia Tian, Xiang Li, Rongrong Yao, Yunhan Zhao, Zihao Gao, Xue-Ru Liu, Xin-Qi Liu, Fu-Quan Huo, Lingli Lian. Spinal interleukin-16 mediates inflammatory pain via promoting glial activation. International immunopharmacology. vol 127. 2023-12-19. PMID:38113689. |
taken together, these results suggest that enhanced il-16-cd4 signaling triggers pain and activates microglia and astrocytes in the spinal dorsal horn, thus contributing to inflammatory pain. |
2023-12-19 |
2023-12-23 |
mouse |
| Yajing Xu, Stephanie C Koch, Alexander Chamessian, Qianru He, Mayya Sundukova, Paul Heppenstall, RuRong Ji, Maria Fitzgerald, Simon Begg. Microglial refinement of A-fibre projections in the postnatal spinal cord dorsal horn is required for normal maturation of dynamic touch. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-11-21. PMID:37989592. |
thus, functional microglia are necessary for the normal postnatal development of dorsal horn sensory circuits. |
2023-11-21 |
2023-11-29 |
mouse |
| Dongxia Duan, Lian Wang, Yueyang Feng, Daiyu Hu, Donghong Cu. Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission. Canadian journal of physiology and pharmacology. 2023-11-17. PMID:37976472. |
picroside Ⅱ (pⅡ) attenuated neuropathic pain by inhibiting the neuroinflammation of the spinal dorsal horn, however, how it engaged in the cross-talk between microglia and neurons remained ambiguous. |
2023-11-17 |
2023-11-20 |
rat |