| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beatriz Godínez-Chaparro, Maria Cristina Rodríguez-Ramos, María Guadalupe Martínez-Lorenzana, Estefanía González-Morales, Karen Pamela Pérez-Ruíz, Antonio Espinosa de Los Monteros-Zuñiga, Felipe Mendoza-Pérez, Miguel Condes-Lar. Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 247. 2024-12-18. PMID:39675389. |
l4-l6 spinal cord dorsal horn astrocytes and microglia were active in these 6-ohda-lesioned rats. |
2024-12-18 |
2024-12-21 |
rat |
| Beatriz Godínez-Chaparro, Maria Cristina Rodríguez-Ramos, María Guadalupe Martínez-Lorenzana, Estefanía González-Morales, Karen Pamela Pérez-Ruíz, Antonio Espinosa de Los Monteros-Zuñiga, Felipe Mendoza-Pérez, Miguel Condes-Lar. Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 247. 2024-12-18. PMID:39675389. |
moreover, ppx (1 and 3 mg/kg, i.p./10 days, n = 10 per group) inhibited the bilateral mechanical hypersensitivity, and ppx (3 mg/kg/i.p./10 days) reduced 6-ohda-induced astrocyte and microglia activation, as well as reduced nf-κb/p-p65 expression only in astrocytes of dorsal horn spinal cord in the l5-l6. |
2024-12-18 |
2024-12-21 |
rat |
| Beatriz Godínez-Chaparro, Maria Cristina Rodríguez-Ramos, María Guadalupe Martínez-Lorenzana, Estefanía González-Morales, Karen Pamela Pérez-Ruíz, Antonio Espinosa de Los Monteros-Zuñiga, Felipe Mendoza-Pérez, Miguel Condes-Lar. Pramipexole decreases allodynia and hyperalgesia via NF-κB in astrocytes in rats with Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 247. 2024-12-18. PMID:39675389. |
these findings suggest that ppx could alleviate pain by decreasing the activation of microglia and astrocytes through the nf-κb/p-p65 pathway in the dorsal horn spinal cord. |
2024-12-18 |
2024-12-21 |
rat |
| Wencui Zhang, Bo Jiao, Shangchen Yu, Kaiwen Zhang, Jiaoli Sun, Baowen Liu, Xianwei Zhan. Spinal AT1R contributes to neuroinflammation and neuropathic pain via NOX2-dependent redox signaling in microglia. Free radical biology & medicine. 2024-12-05. PMID:39638264. |
increased at1r and nox2 expression were observed in activated dorsal horn microglia following sni. |
2024-12-05 |
2024-12-08 |
rat |
| Mingqiong Yu, Fengrui Wang, Ke Ha. Silencing of SH3BP2 Inhibits Microglia Activation Via the JAK/STAT Signaling in Spinal Cord Injury Models. Inflammation. 2024-11-16. PMID:39546158. |
the expression of sh3bp2 was increased in the spinal dorsal horn tissues of sci rats and lps-induced microglia. |
2024-11-16 |
2024-11-18 |
rat |
| Soichiro Tokeshi, Miyako Suzuki-Narita, Ikuko Tajiri, Kazuhide Inage, Jun Takeuchi, Takahito Arai, Yuya Kawarai, Hiroakira Terakawa, Seiji Ohtori, Sumihisa Orit. Comparison of effects of intra-articular diclofenac etalhyaluronate and hyaluronic acid in a monoiodoacetate rat osteoarthritis model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2024-11-11. PMID:39528346. |
the percentage of iba-1 positive microglia in the spinal dorsal horn and of fg + cgrp-labeled cells among fg-positive cells in the dorsal root ganglion were evaluated by immunohistochemical staining. |
2024-11-11 |
2024-11-17 |
rat |
| Yu Tian, YanFang Liu, Chang Liu, SaiSai Huan. NPD1 Relieves Neuropathic Pain and Accelerates the Recovery of Motor Function After Peripheral Nerve Injury. Pain research & management. vol 2024. 2024-11-08. PMID:39512892. |
immunohistochemistry analyses revealed that administering npd1 to pni mice decreased the spinal microglia and astrocyte activation and decreased the inflammatory factor expression in the spinal dorsal horn. |
2024-11-08 |
2024-11-16 |
mouse |
| Kazuhide Inou. Microglia in Neuropathic Pain. Advances in neurobiology. vol 37. 2024-08-29. PMID:39207704. |
in 2003, a breakthrough strategy for inducing np was proposed in which microglia of the spinal dorsal horn (sdh) are activated after peripheral nerve injury (pni) to overexpress p2x4 receptor (p2x4r) and play an important role in inducing tactile allodynia. |
2024-08-29 |
2024-09-04 |
Not clear |
| Shevon N Alexander, Olivia A Reed, Michael D Burto. Spinal cord microglia drive sex differences in ethanol-mediated PGE2-induced allodynia. Brain, behavior, and immunity. 2024-08-15. PMID:39147173. |
we also observed a significant female-specific shift to pro-inflammatory phenotype and morphological changes in microglia of the lumbar dorsal horn. |
2024-08-15 |
2024-08-18 |
mouse |
| Wei-Chun He, Shuang-Long Hou, Kai-Bin Wang, Ning Xu, Ke Li, Ting Xiong, Jing Lu. Treadmill running on neuropathic pain: via modulation of neuroinflammation. Frontiers in molecular neuroscience. vol 17. 2024-07-11. PMID:38989156. |
treadmill exercise can alleviate neuropathic pain mainly by regulating neuroinflammation, including inhibiting the activity of pro-inflammatory factors and over activation of microglia in the dorsal horn, regulating the expression of mu opioid receptor expression in the rostral ventromedial medulla and levels of γ-aminobutyric acid to activate the descending pain modulatory system and the overexpression of brain-derived neurotrophic factor. |
2024-07-11 |
2024-07-13 |
Not clear |
| Wulin Liang, Tianrui Zhang, Mingqian Zhang, Jiahui Gao, Rikang Huang, Xiyan Huang, Jianhua Chen, Lu Cheng, Liyuan Zhang, Zhishan Huang, Qiling Tan, Zhanhong Jia, Shuofeng Zhan. Daphnetin Ameliorates Neuropathic Pain via Regulation of Microglial Responses and Glycerophospholipid Metabolism in the Spinal Cord. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931456. |
the activation of microglia in the spinal dorsal horn was measured via immunofluorescence staining. |
2024-06-27 |
2024-06-29 |
rat |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |
| Shan-Ming Yang, Yuan-Bo Li, Hua-Xing Si, Yi Wei, Fu-Juan Ma, Jian Wang, Tao Chen, Kun Che. C-176 reduces inflammation-induced pain by blocking the cGAS-STING pathway in microglia. The International journal of neuroscience. 2024-05-13. PMID:38738512. |
our research results suggested that the cgas-sting pathway had a function in the inflammation mediated by microglia in the spinal cord dorsal horn. |
2024-05-13 |
2024-05-27 |
mouse |
| Serena Boccella, Michela Perrone, Antimo Fusco, Roozbe Bonsale, Rosmara Infantino, Silvia Nuzzo, Giovanni Pecoraro, Federica Ricciardi, Andrea Maria Morace, Gianluca Petrillo, Ilaria Leone, Monica Franzese, Vito de Novellis, Francesca Guida, Marco Salvatore, Sabatino Maione, Livio Luong. Spinal neuronal activity and neuroinflammatory component in a mouse model of CFA-induced vestibulodynia. Brain, behavior, and immunity. 2024-04-18. PMID:38636564. |
furthermore, we examined microglia activation in the l6-s1 dorsal horn using immunofluorescence, unveiling hypertrophic phenotypes indicative of neuroinflammation in the spinal cord. |
2024-04-18 |
2024-04-21 |
mouse |
| Zhehao Xu, Yue Wang, Changcheng Jiang, Zhengwei Wang, Yongfeng Chen, Manli Fa. The Regulation of the PD-1/PD-L1 Pathway in Imiquimod-Induced Chronic Psoriasis Itch and Itch Sensitization in Mouse. Molecular pain. 2024-04-17. PMID:38631843. |
during this period, there was a significant increase in pd-1 receptor expression in both the imiquimod-treated skin and the spinal dorsal horn in mice, accompanied by significant activation of microglia in the spinal dorsal horn. |
2024-04-17 |
2024-04-20 |
mouse |
| Wanxiang Qin, Yuping Li, Jian Cui, Bao Yu, Lehua Yu, Congwen Yan. Neutrophil extracellular traps as a unique target in the treatment of inflammatory pain. Biochemical and biophysical research communications. vol 710. 2024-04-11. PMID:38604072. |
we investigated the pathological importance of peripheral nets formation in inflammatory pain and its influence on the activation of spinal dorsal horn microglia. |
2024-04-11 |
2024-04-14 |
mouse |
| Peter A Smit. BDNF in Neuropathic Pain; the Culprit that Cannot be Apprehended. Neuroscience. 2024-02-28. PMID:38417539. |
these transform the phenotype of dorsal horn microglia such that they express p2x4 purinoceptors. |
2024-02-28 |
2024-03-02 |
Not clear |
| Heng Zhang, Ruifen Gu, Jisheng Luo, Chuanhua Zhong, Jinhong Pa. Involvement of NOTCH1-mediated Microglia Activation in Neuromodulation of Chronic Prostatitis-related Pain. In vivo (Athens, Greece). vol 38. issue 2. 2024-02-28. PMID:38418142. |
this study aimed to investigate the role of notch receptor 1 (notch1)-mediated activation of microglia in the l5-s2 spinal dorsal horn in chronic prostatitis pain. |
2024-02-28 |
2024-03-02 |
Not clear |
| Ri Chen, Xueru Xu, Youfen Yu, Yanqin Chen, Chun Lin, Rongguo Li. High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI. Scientific reports. vol 14. issue 1. 2024-02-24. PMID:38402335. |
four different voltages (45 v, 65 v, 85 v, and 100 v) of prf on drg significantly alleviated the sni-induced nep, reduced the levels of activating transcription factor 3 (atf3) in drg, improved the ultrastructure of drg, and promoted autophagy in spinal microglia to varying degrees and partially reversed the increased expression of tnf-α and the reduced expression of il-10 in spinal cord dorsal horn (scdh). |
2024-02-24 |
2024-02-27 |
rat |
| Jing Wang, Wei Song, Yujiao Zhang, Jian Wang, Yongqiang Wang, Jiangang Song, Yalan Zho. Electroacupuncture Alleviates Pain by Suppressing P2Y12R-Dependent Microglial Activation in Monoarthritic Rats. Neurochemical research. 2024-02-10. PMID:38337134. |
if analysis further revealed that most p2y12r was expressed in microglia in the spinal dorsal horn. |
2024-02-10 |
2024-02-12 |
rat |