| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Ting Huang, Po-See Chen, Yu-Min Kuo, Shun-Fen Tzen. Intermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice. Journal of neuroinflammation. vol 17. issue 1. 2021-03-31. PMID:32450884. |
high-fat diet (hfd) intake has been reported to stimulate the activation of astrocytes and microglia in the arcuate nucleus (arc) of the hypothalamus in obese rodents and humans. |
2021-03-31 |
2023-08-13 |
mouse |
| Candace M Marsters, Dinushan Nesan, Rena Far, Natalia Klenin, Quentin J Pittman, Deborah M Kurrasc. Embryonic microglia influence developing hypothalamic glial populations. Journal of neuroinflammation. vol 17. issue 1. 2021-03-18. PMID:32375817. |
here, we examined the influence of embryonic microglia on gliogenesis within the developing tuberal hypothalamus, a region later important for energy balance, reproduction, and thermoregulation. |
2021-03-18 |
2023-08-13 |
Not clear |
| Martin Valdearcos, Martin G Myers, Suneil K Koliwa. Hypothalamic microglia as potential regulators of metabolic physiology. Nature metabolism. vol 1. issue 3. 2021-01-19. PMID:32694719. |
more recently, microglia, 'cns macrophages', have been shown to accumulate and undergo activation in response to dietary excess in the mediobasal hypothalamus (mbh), and early studies have implicated these cells as injury-responsive mediators of hypothalamic dysfunction. |
2021-01-19 |
2023-08-13 |
Not clear |
| Sayani Mukherjee, Miguel A Cabrera, Nadka I Boyadjieva, Gregory Berger, Bénédicte Rousseau, Dipak K Sarka. Alcohol Increases Exosome Release from Microglia to Promote Complement C1q-Induced Cellular Death of Proopiomelanocortin Neurons in the Hypothalamus in a Rat Model of Fetal Alcohol Spectrum Disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 41. 2021-01-19. PMID:32887744. |
alcohol increases exosome release from microglia to promote complement c1q-induced cellular death of proopiomelanocortin neurons in the hypothalamus in a rat model of fetal alcohol spectrum disorders. |
2021-01-19 |
2023-08-13 |
rat |
| Sayani Mukherjee, Miguel A Cabrera, Nadka I Boyadjieva, Gregory Berger, Bénédicte Rousseau, Dipak K Sarka. Alcohol Increases Exosome Release from Microglia to Promote Complement C1q-Induced Cellular Death of Proopiomelanocortin Neurons in the Hypothalamus in a Rat Model of Fetal Alcohol Spectrum Disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 41. 2021-01-19. PMID:32887744. |
microglia, a type of cns immune cell, have been shown to contribute to ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (pomc) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. |
2021-01-19 |
2023-08-13 |
rat |
| Seemaab Ali, Anthony G Mansour, Wei Huang, Nicholas J Queen, Xiaokui Mo, Jacqueline M Anderson, Quais N Hassan, Ripal S Patel, Ryan K Wilkins, Michael A Caligiuri, Lei Ca. CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. Aging. vol 12. issue 3. 2021-01-13. PMID:32007953. |
chronic plx treatment depleted 75% of microglia from the hypothalamus and reduced markers of inflammation without affecting brain-derived neurotrophic factor levels induced by ee. |
2021-01-13 |
2023-08-13 |
mouse |
| Michael J Butler, Alexis A Perrini, Lisa A Ecke. Estradiol treatment attenuates high fat diet-induced microgliosis in ovariectomized rats. Hormones and behavior. vol 120. 2020-12-21. PMID:31923417. |
four days of hfd consumption promoted microgliosis, as measured via an increase in the number of microglia in the arcuate nucleus (arc) of the hypothalamus and nucleus of the solitary tract (nts), and a decrease in microglial branching in the arc, nts, lateral hypothalamus (lh), and ventromedial hypothalamus. |
2020-12-21 |
2023-08-13 |
rat |
| Jérémy Terrien, Isabelle Seugnet, Bolaji Seffou, Maria J Herrero, James Bowers, Lamis Chamas, Stéphanie Decherf, Evelyne Duvernois-Berthet, Chakib Djediat, Bertrand Ducos, Barbara A Demeneix, Marie-Stéphanie Clerget-Froidevau. Reduced central and peripheral inflammatory responses and increased mitochondrial activity contribute to diet-induced obesity resistance in WSB/EiJ mice. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31873127. |
hfd induced increased body weight gain, circulating levels of leptin, cholesterol, hdl and ldl in c57bl/6j whereas wsb/eij mice displayed a lower inflammatory status, both peripherally (lower levels of circulating cytokines) and centrally (less activated microglia in the hypothalamus) as well as more reactive mitochondria in the hypothalamus. |
2020-11-09 |
2023-08-13 |
mouse |
| Zsuzsanna Winkler, Dániel Kuti, Ágnes Polyák, Balázs Juhász, Krisztina Gulyás, Nikolett Lénárt, Ádám Dénes, Szilamér Ferenczi, Krisztina J Kovác. Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:30996341. |
bolus insulin administration to fasted mice resulted in hypoglycemia, which increased hypothalamo-pituitary-adrenal (hpa) axis- and sympathetic activity, increased transcription of neuropeptide y (npy) and agouti-related peptide (agrp) in the hypothalamic arcuate nucleus and activated iba1+ microglia in the hypothalamus. |
2020-10-20 |
2023-08-13 |
mouse |
| Felipe Macedo, Lucas Souza Dos Santos, Isaias Glezer, Fernanda Marques da Cunh. Brain Innate Immune Response in Diet-Induced Obesity as a Paradigm for Metabolic Influence on Inflammatory Signaling. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31068773. |
the activation of brain immune cells in the hypothalamus, which are represented by microglia and brain macrophages, is associated with obesity and has been the focus of intense research. |
2020-09-30 |
2023-08-13 |
Not clear |
| T C Peixoto, E G Moura, E Oliveira, V Younes-Rapozo, P N Soares, V S T Rodrigues, M A Torsoni, A S Torsoni, A C Manhães, P C Lisbo. Hypothalamic Neuropeptides Expression and Hypothalamic Inflammation in Adult Rats that Were Exposed to Tobacco Smoke during Breastfeeding: Sex-Related Differences. Neuroscience. vol 418. 2020-09-24. PMID:31487543. |
to understand the central mechanisms underlying the obese phenotype of adult rats that were directly and indirectly exposed to cigarette smoke during lactation, we investigated leptin signaling, orexigenic and anorexigenic neuropeptides expression, as well as astrocyte and microglia markers in hypothalamus. |
2020-09-24 |
2023-08-13 |
rat |
| Matthew C Valdez, Danielle Freeborn, Joseph M Valdez, Andrew F M Johnstone, Samantha J Snow, Alan H Tennant, Urmila P Kodavanti, Prasada Rao S Kodavant. Mitochondrial Bioenergetics in Brain Following Ozone Exposure in Rats Maintained on Coconut, Fish and Olive Oil-Rich Diets. International journal of molecular sciences. vol 20. issue 24. 2020-04-28. PMID:31847143. |
microglial morphology and gfap immunoreactivity were assessed across diet groups; results indicated that fish oil consistently decreased reactive microglia in the hypothalamus and hippocampus. |
2020-04-28 |
2023-08-13 |
rat |
| David F Barnard, Kristin M Gabella, Adam C Kulp, Austin D Parker, Patrick B Dugan, John D Johnso. Sex differences in the regulation of brain IL-1β in response to chronic stress. Psychoneuroendocrinology. vol 103. 2020-04-23. PMID:30711897. |
additional studies revealed that metyrapone significantly increases norepinephrine turnover in the hypothalamus and medial prefrontal cortex in male rats and that microglia appear to be the cell type contributing to the production of il-1β. |
2020-04-23 |
2023-08-13 |
rat |
| Luke Harrison, Katrin Pfuhlmann, Sonja C Schriever, Paul T Pfluge. Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice. Molecular metabolism. vol 24. 2020-04-15. PMID:30979678. |
obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (rg) of astrocytes and microglia. |
2020-04-15 |
2023-08-13 |
mouse |
| Lucy G Chastain, Tina Franklin, Omkaram Gangisetty, Miguel A Cabrera, Sayani Mukherjee, Pallavi Shrivastava, Shaima Jabbar, Dipak K Sarka. Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 9. 2020-03-17. PMID:30737481. |
in addition, there were significantly more microglia present in the hypothalamus of adult af animals, and their hypothalamic microglia showed more cluster of differentiation molecule 11b (cd11b) activation, tnf-α expression, and il-6 expression in response to lps. |
2020-03-17 |
2023-08-13 |
human |
| Jessica M Rosin, Deborah M Kurrasc. Emerging roles for hypothalamic microglia as regulators of physiological homeostasis. Frontiers in neuroendocrinology. vol 54. 2020-03-02. PMID:31059719. |
recent evidence has shown that microglia are also responsive to external stressors and can influence both the development and function of the hypothalamus in a sex-dependent manner. |
2020-03-02 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Deborah M Kurrasc. Emerging roles for hypothalamic microglia as regulators of physiological homeostasis. Frontiers in neuroendocrinology. vol 54. 2020-03-02. PMID:31059719. |
in this review, we briefly outline how the hypothalamus regulates physiological homeostasis and then describe how this literature overlaps with our understanding of microglia's role in the cns. |
2020-03-02 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Deborah M Kurrasc. Emerging roles for hypothalamic microglia as regulators of physiological homeostasis. Frontiers in neuroendocrinology. vol 54. 2020-03-02. PMID:31059719. |
we also outline the current literature demonstrating how microglia loss or activation affects the hypothalamus, and ultimately homeostasis. |
2020-03-02 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Deborah M Kurrasc. Emerging roles for hypothalamic microglia as regulators of physiological homeostasis. Frontiers in neuroendocrinology. vol 54. 2020-03-02. PMID:31059719. |
we conclude by proposing how microglia could be key regulators of homeostatic processes by sensing cues external to the cns and transmitting them through the hypothalamus. |
2020-03-02 |
2023-08-13 |
Not clear |
| Limin Mao, Danielle Hochstetter, Liyun Yao, Yueling Zhao, Jihong Zhou, Yuefei Wang, Ping X. Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) Attenuates Neuroinflammation in Palmitic Acid-Stimulated BV-2 Microglia and High-Fat Diet-Induced Obese Mice. International journal of molecular sciences. vol 20. issue 20. 2020-02-26. PMID:31614951. |
obesity is closely associated with neuroinflammation in the hypothalamus, which is characterized by over-activated microglia and excessive production of pro-inflammatory cytokines. |
2020-02-26 |
2023-08-13 |
mouse |