| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miwako Katagi, Yuki Nakae, Junko Okano, Kazunori Fujino, Tomoki Tanaka, Itsuko Miyazawa, Natsuko Ohashi, Takahiko Nakagawa, Hideto Kojim. Aberrant bone marrow-derived microglia in the hypothalamus may dysregulate appetite in diabetes. Biochemical and biophysical research communications. vol 682. 2023-10-08. PMID:37806251. |
bone marrow derived cells (bmdcs) migrate into the hypothalamus, where those cells give rise to microglia to regulate food intake. |
2023-10-08 |
2023-10-15 |
mouse |
| Yang Tae Kim, Byong Seo Park, Hye Rim Yang, Se On Yi, Il Seong Nam-Goong, Jae Geun Ki. Exploring the potential hypothalamic role in mediating cisplatin-induced negative energy balance. Chemico-biological interactions. 2023-09-28. PMID:37769865. |
in addition, we observed activation of microglia and inflammation in the hypothalamus following treatment with cisplatin. |
2023-09-28 |
2023-10-07 |
mouse |
| Vaibhave Ubba, Serene Joseph, Olubusayo Awe, Dustin Jones, Milan K Dsilva, Mingxiao Feng, Junjiang Wang, Xiaomin Fu, Razeen J Akbar, Brittany H Bodnar, Wenhui Hu, Hong Wang, Xiaofeng Yang, Ling Yang, Peixin Yang, Rexford Ahima, Sara Divall, Sheng W. Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess. Endocrinology. 2023-09-22. PMID:37738624. |
western blot studies show that markers of inflammation and microglia activation, such as nf-kb p-65 and iba1, increased in the hypothalamus of con-dht mice compared to con-veh. |
2023-09-22 |
2023-10-07 |
mouse |
| Emily Ortiz Nazario, Carla M Denton Ortiz, Lawry D M Soto Escobar, Zaira Mateo Mayol, Maria Colon Romero, Anixa Hernandez Lopez, James T Porte. Sex-dependent effects of angiotensin II type 1 receptor blocker on molecular and behavioral changes induced by single prolonged stress. Behavioural brain research. 2023-08-31. PMID:37652238. |
recent preclinical studies demonstrate that activation of the angiotensin type 1 receptor (at1r) in the paraventricular region of the hypothalamus (pvr) promotes anxiety-like behaviors and enables microglia proliferation. |
2023-08-31 |
2023-09-07 |
Not clear |
| Mohammed Z Rizwan, Romy Kerbus, Kaj Kamstra, Pramuk Keerthisinghe, Alexander Tup. Dietary wheat gluten induces astro- and microgliosis in the hypothalamus of male mice. Journal of neuroendocrinology. 2023-08-03. PMID:37534400. |
gluten regardless of whether it was added to lfd or hfd led to a profound increase in the number of microglia and astrocytes in the arcuate nucleus of the hypothalamus, as detected by immunohistochemistry for ionised calcium binding adaptor molecule 1 (iba-1) and glial fibrillary acidic protein (gfap), respectively. |
2023-08-03 |
2023-08-14 |
mouse |
| Bárbara Juacy Rodrigues Costa-de-Santana, Raul Manhães-de-Castro, Henrique José Cavalcanti Bezerra Gouveia, Eliesly Roberto Silva, Marcos Antônio da Silva Araújo, Diego Cabral Lacerda, Omar Guzmán-Quevedo, Luz Torner, Ana Elisa Toscan. Motor deficits are associated with increased glial cell activation in the hypothalamus and cerebellum of young rats subjected to cerebral palsy. Brain research. 2023-06-10. PMID:37301423. |
there was also found to be an increase in astrocyte and microglia activation in the cerebellum and hypothalamus (arcuate nucleus, arc) of animals subjected to cp. |
2023-06-10 |
2023-08-14 |
rat |
| Lareb Hassan, Zainab Ahsan, Hunniya Bint E Ria. An Unusual Case of Blackout in a COVID-19 Patient: COVID-19 Brain Fog. Cureus. vol 15. issue 3. 2023-04-19. PMID:37073192. |
this in turn, triggers the release of mediators that activate microglia, causing inflammation in the hypothalamus. |
2023-04-19 |
2023-08-14 |
Not clear |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
our results show that the dorsomedial hypothalamus and hippocampal ca2 region of adult male mice undergo increased microglia volume, territory, and endpoints following social isolation, whereas females exhibit this increase in the hypothalamus only. |
2023-03-15 |
2023-08-14 |
mouse |
| Alex P Vu, David Lam, Cayla Denney, Kelly V Lee, Jason R Plemel, Jesse Jackso. Social isolation produces a sex and brain-region specific alteration of microglia state. The European journal of neuroscience. 2023-03-15. PMID:36918398. |
males exhibited decreases in the phagocytic-lysosomal marker cd68 in microglia in these regions, whereas females showed an increase in cd68 in the hypothalamus suggesting sexually dimorphic and brain region specific change in microglia state in response to social isolation. |
2023-03-15 |
2023-08-14 |
mouse |
| Sosorburam Batsukh, Seyeon Oh, Kyoungmin Rheu, Bae-Jin Lee, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byu. Rice Germ Ameliorated Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior by Reducing Neuroinflammation. Nutrients. vol 14. issue 24. 2022-12-23. PMID:36558541. |
in the hypothalamus, cums elevated m1-type microglia markers of cd86 and nf-κb, whereas rg lowered these levels. |
2022-12-23 |
2023-08-14 |
mouse |
| Moonseok Choi, Dongsoo Kim, Young-Jin Youn, Junghwa Ryu, Yun Ha Jeon. Effect of Obesity and High-Density Lipoprotein Concentration on the Pathological Characteristics of Alzheimer's Disease in High-Fat Diet-Fed Mice. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293147. |
the reactivity of astrocytes and microglia in the dentate gyrus of the hippocampus and fornix of the hypothalamus in 5xfad mice was decreased in the transgenic (tg)-hfd high group. |
2022-10-27 |
2023-08-14 |
mouse |
| Ken-Yu Hironao, Hitoshi Ashida, Yoko Yamashit. Black soybean seed coat polyphenol ameliorates the abnormal feeding pattern induced by high-fat diet consumption. Frontiers in nutrition. vol 9. 2022-10-27. PMID:36299984. |
in the present study, we found that polyphenols derived from black soybean seed coat (be) significantly ameliorated the accumulation of activated microglia and pro-inflammatory cytokine expression in the arcuate nucleus of the hypothalamus of hfd-fed mice, and restored their feeding pattern to one comparable to that of standard diet-fed mice, thereby ameliorating dio. |
2022-10-27 |
2023-08-14 |
mouse |
| Tracy Butler, Lidia Glodzik, Xiuyuan Hugh Wang, Ke Xi, Yi Li, Hong Pan, Liangdong Zhou, Gloria Chia-Yi Chiang, Simon Morim, Nimmi Wickramasuriya, Emily Tanzi, Thomas Maloney, Patrick Harvey, Xiangling Mao, Qolamreza Ray Razlighi, Henry Rusinek, Dikoma C Shungu, Mony de Leon, Craig S Atwood, P David Mozle. Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women. Scientific reports. vol 12. issue 1. 2022-08-03. PMID:35922659. |
we used positron emission tomography (pet) with a radiotracer sensitive to the translocator protein (tspo) expressed by activated microglia, to assess correlations between age and regional brain tspo in a group of healthy subjects (n = 43, 19 female, aged 23-78), focusing on hypothalamus. |
2022-08-03 |
2023-08-14 |
human |
| Muhammad S Aldhshan, Gursagar Jhanji, Nicole J Poritsanos, Tooru M Mizun. Glucose Stimulates Glial Cell Line-Derived Neurotrophic Factor Gene Expression in Microglia through a GLUT5-Independent Mechanism. International journal of molecular sciences. vol 23. issue 13. 2022-07-09. PMID:35806073. |
we hypothesized that an increased local glucose concentration stimulates gdnf expression while inhibiting manf expression in the hypothalamus and microglia via glut5. |
2022-07-09 |
2023-08-14 |
Not clear |
| Caitlin R Coker, Melissa White, Aneesh Singal, Sarah S Bingaman, Anirban Paul, Amy C Arnold, Yuval Silberma. Minocycline Reduces Hypothalamic Microglia Activation and Improves Metabolic Dysfunction in High Fat Diet-Induced Obese Mice. Frontiers in physiology. vol 13. 2022-07-05. PMID:35784876. |
ramified (resting) and non-ramified (active) microglia were quantified in the hypothalamus following immunohistochemical staining of ionized calcium-binding adaptor 1 (iba-1) and further assessed by rnaseq. |
2022-07-05 |
2023-08-14 |
mouse |
| María Del Mar Fernández-Arjona, Ana León-Rodríguez, Jesús M Grondona, María D López-Ávalo. Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity. Glia. 2022-05-23. PMID:35603807. |
besides, na-treated mice had enhanced microgliosis (evidenced by increased number and reactive morphology of microglia) and a reduced population of pomc neurons in the basal hypothalamus. |
2022-05-23 |
2023-08-13 |
mouse |
| Zuri Ngozi, Jessica L Bolto. Microglia Don't Treat All Neurons the Same: The Importance of Neuronal Subtype in Microglia-Neuron Interactions in the Developing Hypothalamus. Frontiers in cellular neuroscience. vol 16. 2022-05-02. PMID:35496905. |
microglia don't treat all neurons the same: the importance of neuronal subtype in microglia-neuron interactions in the developing hypothalamus. |
2022-05-02 |
2023-08-13 |
Not clear |
| Zuri Ngozi, Jessica L Bolto. Microglia Don't Treat All Neurons the Same: The Importance of Neuronal Subtype in Microglia-Neuron Interactions in the Developing Hypothalamus. Frontiers in cellular neuroscience. vol 16. 2022-05-02. PMID:35496905. |
for example, microglia abutting corticotropin-releasing hormone (crh)-expressing neurons in the paraventricular nucleus of the hypothalamus (pvn) engulf fewer excitatory synapses than do microglia on the borders of the pvn that are not contacting crh+ neurons. |
2022-05-02 |
2023-08-13 |
Not clear |
| Jessica M Rosin, Nikol Tretiakov, Emily Hanniman, Kiana Hampton, Deborah M Kurrasc. Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups. Frontiers in neuroscience. vol 16. 2022-03-07. PMID:35250464. |
gestational bpa exposure from embryonic day 0.5 (e0.5) to e15.5 resulted in a significant increase in the number of microglia present in the hypothalamus of both male and female embryos. |
2022-03-07 |
2023-08-13 |
Not clear |
| Daiane F Engel, Licio A Vellos. The timeline of neuronal and glial alterations in experimental obesity. Neuropharmacology. 2022-02-10. PMID:35143850. |
early after the introduction of a high-fat diet, neurons, microglia, astrocytes and tanycytes of the mediobasal hypothalamus undergo structural and functional changes that impact caloric intake, energy expenditure and systemic glucose tolerance. |
2022-02-10 |
2023-08-13 |
Not clear |