| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Judith Leyh, Karsten Winter, Madlen Reinicke, Uta Ceglarek, Ingo Bechmann, Julia Landman. Long-term diet-induced obesity does not lead to learning and memory impairment in adult mice. PloS one. vol 16. issue 9. 2021-11-22. PMID:34587222. |
neurons and microglia were histologically analyzed within the mediobasal hypothalamus, hippocampus and frontal motor cortex after long-term hfd and change of diet. |
2021-11-22 |
2023-08-13 |
mouse |
| Xuan Li, You Cai, Jiao Luo, Jingyun Ding, Guojun Yao, Xiaohua Xiao, Yizhe Tang, Zhen Lian. Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice. Cell death discovery. vol 7. issue 1. 2021-11-20. PMID:34750365. |
diet-induced obesity is manifested by low-grade inflammation in the mediobasal hypothalamus (mbh), and microglia are implicated as critical responsive components for this process. |
2021-11-20 |
2023-08-13 |
mouse |
| Aisha Sati, Melanie Prescott, Sarah Holland, Christine L Jasoni, Elodie Desroziers, Rebecca E Campbel. Morphological evidence indicates a role for microglia in shaping the PCOS-like brain. Journal of neuroendocrinology. vol 33. issue 8. 2021-11-16. PMID:34216402. |
here, we tested the hypothesis that microglia play a role in the excessive gabaergic wiring that leads to pcos-like features in the pna brain. using specific immunolabelling, microglia number and morphology associated with activation states were analysed in pna and vehicle-treated controls across developmental timepoints, including embryonic day 17.5, p0, p25 and p60 (n = 7-14 per group), and in two regions of the hypothalamus implicated in fertility regulation. |
2021-11-16 |
2023-08-13 |
mouse |
| R L Moretti, E N Dias, S G Kiel, M C M Augusto, P S Rodrigues, A C S Sampaio, L S Medeiros, M F M Martins, I B Suffredini, C V Cardoso, E F Bonda. Behavioral and morphological effects of resveratrol and curcumin in rats submitted to doxorubicin-induced cognitive impairment. Research in veterinary science. vol 140. 2021-10-15. PMID:34536813. |
dox-injected rats presented short-term and long-term memory impairments as seen in the nort at 3 and 24 h after habituation and increased gfap and iba1 expression, respectively, in astrocytes and microglia of the frontal cortex, hypothalamus and hippocampus. |
2021-10-15 |
2023-08-13 |
rat |
| Jessica M Rosin, Sarthak Sinha, Jeff Biernaskie, Deborah M Kurrasc. A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Developmental cell. vol 56. issue 9. 2021-09-23. PMID:33887203. |
we asked if microglia in the embryonic hypothalamus were likewise stress responsive and, if so, whether their precocious activation perturbs nearby neural stem cell (nsc) programs. |
2021-09-23 |
2023-08-13 |
Not clear |
| Kevin G Burfeind, Xinxia Zhu, Mason A Norgard, Peter R Levasseur, Christian Huisman, Katherine A Michaelis, Brennan Olson, Daniel L Mark. Microglia in the hypothalamus respond to tumor-derived factors and are protective against cachexia during pancreatic cancer. Glia. vol 68. issue 7. 2021-08-18. PMID:32039522. |
microglia in the hypothalamus respond to tumor-derived factors and are protective against cachexia during pancreatic cancer. |
2021-08-18 |
2023-08-13 |
Not clear |
| Kevin G Burfeind, Xinxia Zhu, Mason A Norgard, Peter R Levasseur, Christian Huisman, Katherine A Michaelis, Brennan Olson, Daniel L Mark. Microglia in the hypothalamus respond to tumor-derived factors and are protective against cachexia during pancreatic cancer. Glia. vol 68. issue 7. 2021-08-18. PMID:32039522. |
microglia in the mediobasal hypothalamus (mbh) respond to inflammatory stimuli and metabolic perturbations to mediate body composition. |
2021-08-18 |
2023-08-13 |
Not clear |
| Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narit. Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus. Biochemical and biophysical research communications. vol 541. 2021-08-13. PMID:33461064. |
normal aging induces pd-1-enriched exhausted microglia and a1-like reactive astrocytes in the hypothalamus. |
2021-08-13 |
2023-08-13 |
mouse |
| Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narit. Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus. Biochemical and biophysical research communications. vol 541. 2021-08-13. PMID:33461064. |
in this study, we used normal aging mice and investigated aging-specific transcriptional identities of microglia and astrocytes in the hypothalamus. |
2021-08-13 |
2023-08-13 |
mouse |
| Yukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki, Minoru Narit. Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus. Biochemical and biophysical research communications. vol 541. 2021-08-13. PMID:33461064. |
to investigate the senescence of hypothalamic glial cells, we isolated cd11b-positive microglia and acsa-2-positive astrocytes from the hypothalamus of aged mice using magnetic-activated cell sorting (macs). |
2021-08-13 |
2023-08-13 |
mouse |
| Jian-Bo Xiu, Lan-Lan Li, Qi X. Minocycline Activates the Nucleus of the Solitary Tract-associated Network to Alleviate Lipopolysaccharide-induced Neuroinflammation. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 2021-07-15. PMID:34261577. |
results minocycline alleviated lps-induced neuroinflammation as evidenced by reduced activation of microglia in multiple brain regions, including the shell part of the nucleus accumbens (acbs), paraventricular nucleus of the hypothalamus (pvn), central nucleus of the amygdala (cea), locus coeruleus (lc), and nucleus tractus solitarius (nts). |
2021-07-15 |
2023-08-13 |
mouse |
| Jihong Zhou, Haiyu Lin, Ping Xu, Liyun Yao, Qingyi Xie, Limin Mao, Yuefei Wan. Matcha green tea prevents obesity-induced hypothalamic inflammation Food & function. vol 11. issue 10. 2021-07-09. PMID:33001081. |
the results showed that dietary supplementation with matcha could effectively inhibit the weight gain, fat accumulation, glycemia and lipidemia increase, and excessive activation of microglia in the arcuate nucleus of the hypothalamus. |
2021-07-09 |
2023-08-13 |
mouse |
| E P G Vazi, F Holanda, N A Santos, C V Cardoso, M F M Martins, E F Bonda. Short-term systemic methotrexate administration in rats induces astrogliosis and microgliosis. Research in veterinary science. vol 138. 2021-07-08. PMID:34091228. |
on the 5th day, brain samples were collected for hematoxylin-eosin and luxol fast blue staining techniques, as well as for immunohistochemical staining for glial fibrillary acidic protein (gfap) expression in astrocytes and iba1 (ionized calcium binding adaptor molecule 1) for microglia in the frontal cortex, hippocampus, hypothalamus and molecular/granular layers of the cerebellum. |
2021-07-08 |
2023-08-13 |
rat |
| Kuan-Hui Ethan Chen, Nancy M Lainez, Meera G Nair, Djurdjica Cos. Visceral adipose tissue imparts peripheral macrophage influx into the hypothalamus. Journal of neuroinflammation. vol 18. issue 1. 2021-06-25. PMID:34154608. |
we previously demonstrated that high-fat diet (hfd)-fed male mice exhibited peripheral macrophage infiltration into the hypothalamus, in addition to activation of resident microglia. |
2021-06-25 |
2023-08-13 |
mouse |
| Dominik Pretz, Christelle Le Foll, Mohammed Z Rizwan, Thomas A Lutz, Alexander Tup. Hyperleptinemia as a contributing factor for the impairment of glucose intolerance in obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 2. 2021-06-24. PMID:33230896. |
in contrast, administration of a predetermined dose of a long-acting leptin antagonist (100 µg/kg/d, peslan) chosen to block excessive leptin signaling during diet-induced obesity (dio) showed the opposite effect and significantly improved glucose tolerance as well as decreased the total number of microglia and astrocytes in the hypothalamus of mice fed hfd. |
2021-06-24 |
2023-08-13 |
mouse |
| Martin Jt Kalsbeek, Samantha Ec Wolff, Nikita L Korpel, Susanne E la Fleur, Johannes A Romijn, Eric Fliers, Andries Kalsbeek, Dick F Swaab, Inge Huitinga, Elly M Hol, Chun-Xia Y. The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia. JCI insight. vol 5. issue 16. 2021-06-11. PMID:32814716. |
here, we characterized the proopiomelanocortin (pomc) immunoreactive (-ir) neurons, the neuropeptide-y-ir (npy-ir) neurons, the ionized calcium-binding adapter molecule 1-ir (iba1-ir) microglia, and the transmembrane protein 119-ir (tmem119-ir) microglia in the infundibular nucleus (ifn) of human postmortem hypothalamus of 32 t2dm subjects with different antidiabetic treatments and 17 matched nondiabetic control subjects. |
2021-06-11 |
2023-08-13 |
human |
| Mariko Sugiyama, Ryoichi Banno, Hiroshi Yaginuma, Keigo Taki, Akira Mizoguchi, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Okiru Komine, Koji Yamanaka, Hiroshi Arim. Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions. Neurochemistry international. vol 136. 2021-06-07. PMID:32222288. |
we used magnetic-activated cell sorting (macs) to isolate microglia and astrocytes from hypothalamus of mice fed hfd and examined changes in expression of inflammation-related cytokines and markers related to glial cell activation status. |
2021-06-07 |
2023-08-13 |
mouse |
| Mariko Sugiyama, Ryoichi Banno, Hiroshi Yaginuma, Keigo Taki, Akira Mizoguchi, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Okiru Komine, Koji Yamanaka, Hiroshi Arim. Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions. Neurochemistry international. vol 136. 2021-06-07. PMID:32222288. |
hypothalamus from male c57bl6 mice fed a chow diet (chow) or hfd for 1, 3, or 28 days were collected and microglia and astrocytes were isolated by macs. |
2021-06-07 |
2023-08-13 |
mouse |
| Theoharis C Theoharides, Christos Cholevas, Konstantinos Polyzoidis, Antonios Politi. Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue. BioFactors (Oxford, England). vol 47. issue 2. 2021-04-26. PMID:33847020. |
the pathogenesis of brain fog in these illnesses is presently unknown but may involve neuroinflammation via mast cells stimulated by pathogenic and stress stimuli to release mediators that activate microglia and lead to inflammation in the hypothalamus. |
2021-04-26 |
2023-08-13 |
Not clear |
| Ravindra K Sharma, Aline C Oliveira, Tao Yang, Marianthi M Karas, Jing Li, Gilberto O Lobaton, Victor P Aquino, Iñaki Robles-Vera, Annette D de Kloet, Eric G Krause, Andrew J Bryant, Amrisha Verma, Qiuhong Li, Elaine M Richards, Mohan K Raizad. Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension. Hypertension (Dallas, Tex. : 1979). vol 76. issue 1. 2021-04-13. PMID:32418496. |
hypoxia significantly increased right ventricular systolic pressure, sympathetic activity as well as the number and activation of microglia in the paraventricular nucleus of the hypothalamus in wt mice. |
2021-04-13 |
2023-08-13 |
mouse |