| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zeyi Huang, Sijie Ta. P2X7 Receptor as a Potential Target for Major Depressive Disorder. Current drug targets. vol 22. issue 10. 2021-11-26. PMID:33494675. |
chronic stress activates microglia in the hippocampus by secreting interleukin- 1β (il-1β) and other inflammatory cytokines, and increasing the bbb permeability, thus promoting the occurrence and development of mdd, which indicated that p2x7r might be a promising therapeutic target for mdd. |
2021-11-26 |
2023-08-13 |
Not clear |
| A V Morgun, E D Osipova, E B Boitsova, A N Shuvaev, N A Malinovskaya, A I Mosiagina, A B Salmin. Neurogenic Potential of Implanted Neurospheres Is Regulated by Optogenetic Stimulation of Hippocampal Astrocytes Ex Vivo. Bulletin of experimental biology and medicine. vol 170. issue 6. 2021-11-26. PMID:33893948. |
the electrophysiological characteristics of the hippocampus and expression of molecules involved in the mechanisms of activation of astrocytes and microglia (gfap, cd38, c3/c3b, cx43, cd11b, and cd18) were evaluated. |
2021-11-26 |
2023-08-13 |
mouse |
| Changming Tan, Feng Xu, Qiong Xie, Feng L. Deficiency of cGAS signaling protects against sepsis-associated encephalopathy. Biochemical and biophysical research communications. vol 577. 2021-11-26. PMID:34507063. |
the restoration may attribute to the recovery of neo-neuron decline that associated with the decrease of activated microglia and astrocytes in the hippocampus of cgas-deficient mice. |
2021-11-26 |
2023-08-13 |
mouse |
| Mariya Tsyglakova, Alisa M Huskey, Emily H Hurst, Natalie M Telep, Mary C Wilding, Meghan E Babington, Jennifer R Rainville, Georgia E Hode. Sex and region-specific effects of variable stress on microglia morphology. Brain, behavior, & immunity - health. vol 18. 2021-11-26. PMID:34820640. |
here we report changes in microglia morphology in the nucleus accumbens (nac) and subregions of the hippocampus (hpc) in both male and female mice following variable stress of 6 or 28 days in duration. |
2021-11-26 |
2023-08-13 |
mouse |
| Marina Estrázulas, Raquel D S Freitas, Eduarda T Käfer, Ana P A Dagnino, Maria M Campo. Central and peripheral effects of environmental enrichment in a mouse model of arthritis. International immunopharmacology. 2021-11-26. PMID:34824037. |
ee diminished the immunopositivity for the microglia marker iba1 in the pre-frontal cortex, with slight changes for hippocampal gfap-positive activated astrocytes. |
2021-11-26 |
2023-08-13 |
mouse |
| Federica Cordella, Caterina Sanchini, Maria Rosito, Laura Ferrucci, Natalia Pediconi, Barbara Cortese, Francesca Guerrieri, Giuseppe Rubens Pascucci, Fabrizio Antonangeli, Giovanna Peruzzi, Maria Giubettini, Bernadette Basilico, Francesca Pagani, Alfonso Grimaldi, Giuseppina D'Alessandro, Cristina Limatola, Davide Ragozzino, Silvia Di Angelantoni. Antibiotics Treatment Modulates Microglia-Synapses Interaction. Cells. vol 10. issue 10. 2021-11-25. PMID:34685628. |
hippocampal microglia from adult mice treated with oral antibiotics exhibited increased microglia density, altered basal patrolling activity, and impaired process rearrangement in response to damage. |
2021-11-25 |
2023-08-13 |
mouse |
| Yi Li, Lixia DU, Xiaofeng Guo, Xijing Zhan. [Cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nAChR) and the proportion of M1/M2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809734. |
[cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nachr) and the proportion of m1/m2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy]. |
2021-11-24 |
2023-08-13 |
mouse |
| Yi Li, Lixia DU, Xiaofeng Guo, Xijing Zhan. [Cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nAChR) and the proportion of M1/M2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809734. |
the expression and distribution of α7 nicotinic acetylcholinergic receptor (α7nachr) and the proportion of m2 microglia in hippocampus of sae mice were detected by immunofluorescence staining, and the level of α7nachr protein was detected by western blot. |
2021-11-24 |
2023-08-13 |
mouse |
| Yi Li, Lixia DU, Xiaofeng Guo, Xijing Zhan. [Cognitive impairments relate to the expression of α7 nicotinic acetylcholinergic receptor (α7nAChR) and the proportion of M1/M2 microglia in the hippocampus of male mice with sepsis-associated encephalopathy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 37. issue 11. 2021-11-24. PMID:34809734. |
conclusion the expression level of α7nachr protein in hippocampus of sae male mice is significantly lower than that of sae female mice, and the proportion of m2 microglia is relatively lower, which lead to the cognitive dysfunction of sae male mice. |
2021-11-24 |
2023-08-13 |
mouse |
| Min Li, Junwen Hu, Yucong Peng, Jingbo Li, Reng Re. CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-11-23. PMID:33952191. |
circptk2-mir-181c-5p-hmgb1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. |
2021-11-23 |
2023-08-13 |
mouse |
| Yun-Tao Zhao, Lulu Zhang, Haowen Yin, Ling Shen, Wenjing Zheng, Kun Zhang, Jian Zeng, Chuanyin Hu, You Li. Hydroxytyrosol alleviates oxidative stress and neuroinflammation and enhances hippocampal neurotrophic signaling to improve stress-induced depressive behaviors in mice. Food & function. vol 12. issue 12. 2021-11-23. PMID:33998633. |
ht administration significantly suppressed microglia activation and inhibited the expression of tumor necrosis factor alpha and interleukin 1 beta in the hippocampus versus the untreated group. |
2021-11-23 |
2023-08-13 |
mouse |
| Amy C Reichelt, Claire A Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J Bussey, Lisa M Saksid. Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33692414. |
age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. |
2021-11-22 |
2023-08-13 |
mouse |
| Amy C Reichelt, Claire A Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J Bussey, Lisa M Saksid. Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33692414. |
hfhs diet increased microgliosis in the adult cohort, and morphological changes to microglia were observed in the pfc and hippocampus of the adolescent cohort, with a shift to activated microglia phenotypes. |
2021-11-22 |
2023-08-13 |
mouse |
| Samuel B R Harley, Emily F Willis, Samreen N Shaikh, Daniel G Blackmore, Pankaj Sah, Marc J Ruitenberg, Perry F Bartlett, Jana Vukovi. Selective Ablation of BDNF from Microglia Reveals Novel Roles in Self-Renewal and Hippocampal Neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 19. 2021-11-22. PMID:33785644. |
selective ablation of bdnf from microglia reveals novel roles in self-renewal and hippocampal neurogenesis. |
2021-11-22 |
2023-08-13 |
Not clear |
| Judith Leyh, Karsten Winter, Madlen Reinicke, Uta Ceglarek, Ingo Bechmann, Julia Landman. Long-term diet-induced obesity does not lead to learning and memory impairment in adult mice. PloS one. vol 16. issue 9. 2021-11-22. PMID:34587222. |
neurons and microglia were histologically analyzed within the mediobasal hypothalamus, hippocampus and frontal motor cortex after long-term hfd and change of diet. |
2021-11-22 |
2023-08-13 |
mouse |
| Marta Celorrio, Miguel A Abellanas, James Rhodes, Victoria Goodwin, Jennie Moritz, Sangeetha Vadivelu, Leran Wang, Rachel Rodgers, Sophia Xiao, Ilakkia Anabayan, Camryn Payne, Alexandra M Perry, Megan T Baldridge, Maria S Aymerich, Ashley Steed, Stuart H Fries. Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta neuropathologica communications. vol 9. issue 1. 2021-11-18. PMID:33691793. |
antibiotic-induced gut microbial dysbiosis established prior to tbi significantly worsened neuronal loss and reduced microglia activation in the injured hippocampus with concomitant changes in fear memory response. |
2021-11-18 |
2023-08-13 |
Not clear |
| Hongzhi Chen, Haichao Chu, Qian Jiang, Cong Wang, Yue Tia. Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia. Brain research bulletin. vol 177. 2021-11-18. PMID:34536519. |
perioperative neurocognitive disorder (pnd) frequently occurs in elderly patients following anesthesia, and is associated with pro-inflammatory activation of microglia in hippocampus. |
2021-11-18 |
2023-08-13 |
rat |
| Hongzhi Chen, Haichao Chu, Qian Jiang, Cong Wang, Yue Tia. Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia. Brain research bulletin. vol 177. 2021-11-18. PMID:34536519. |
microglia preferred to polarizing towards pro-inflammatory m1 subtype (inos+iba-1 +) in rat hippocampus post sevoflurane exposure, but not anti-inflammatory m2 subtype (arg-1 +iba-1 +). |
2021-11-18 |
2023-08-13 |
rat |
| Hongzhi Chen, Haichao Chu, Qian Jiang, Cong Wang, Yue Tia. Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia. Brain research bulletin. vol 177. 2021-11-18. PMID:34536519. |
co-immunofluorescence data further illustrated that sevoflurane decreased irf6 expression in hippocampal microglia. |
2021-11-18 |
2023-08-13 |
rat |
| Hongzhi Chen, Haichao Chu, Qian Jiang, Cong Wang, Yue Tia. Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia. Brain research bulletin. vol 177. 2021-11-18. PMID:34536519. |
collectively, these findings suggest that irf6 downregulation in hippocampal microglia may be a compensatory mechanism against sevoflurane-induced pnd in the elderly. |
2021-11-18 |
2023-08-13 |
rat |