Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Gaia Scabia, Giovanna Testa, Manuela Scali, Serena Del Turco, Genni Desiato, Nicoletta Berardi, Alessandro Sale, Michela Matteoli, Lamberto Maffei, Margherita Maffei, Marco Mainard. Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34418501. |
interfering, in mice, with the ccl11 decrease induced by ee ablated the beneficial effects on long-term memory retention, hippocampal neurogenesis, activation of local microglia and of ribosomal protein s6. |
2021-12-09 |
2023-08-13 |
mouse |
Namkwon Kim, Seung Ho Jeon, In Gyoung Ju, Min Sung Gee, Jimin Do, Myung Sook Oh, Jong Kil Le. Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice. Brain, behavior, and immunity. vol 98. 2021-12-09. PMID:34500036. |
microglia in the hippocampus of the 5xfad-fmt mice were activated, which caused the elevation of pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β). |
2021-12-09 |
2023-08-13 |
mouse |
Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
we performed survival analysis, neurological deficit score, histological staining of hippocampus and cerebellum, immunofluorescence staining of microglia, detection of inflammatory and chemokine levels in the hippocampus and cerebellum in each group. |
2021-12-09 |
2023-08-13 |
rat |
Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
in addition, mscs treatment can significantly inhibit the over-activation of hippocampal microglia in heat stroke rats and the levels of pro-inflammatory factors and chemokines in the hippocampus. |
2021-12-09 |
2023-08-13 |
rat |
Lu Wang, Zihui Deng, Yan Zhao, Rui Yuan, Mengmeng Yang, Yu Zhang, Yun Li, Yuyan Liu, Feihu Zhou, Hongjun Kan. Mesenchymal stem cells regulate activation of microglia cells to improve hippocampal injury of heat stroke rats. Journal of thermal biology. vol 101. 2021-12-09. PMID:34879909. |
in conclusion, the application of mscs in the treatment of heat stroke in rats can significantly reduce mortality and neurological deficits and improve hippocampal damage, possibly by inhibiting the excessive activation of hippocampal microglia in heat stroke rats. |
2021-12-09 |
2023-08-13 |
rat |
Dimitrios Kleidonas, Andreas Vlacho. Scavenging Tumor Necrosis Factor α Does Not Affect Inhibition of Dentate Granule Cells Following In Vitro Entorhinal Cortex Lesion. Cells. vol 10. issue 11. 2021-12-07. PMID:34831454. |
these functional changes were accompanied by a recruitment of microglia in the denervated hippocampus, and experiments in tissue cultures prepared from tnf-reporter mice [ |
2021-12-07 |
2023-08-13 |
mouse |
Jian Shi, Huan Xu, María José Cavagnaro, Xingmei Li, Jia Fan. Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867376. |
reduced expression levels of tnf-α, il-1α, and c1qa were exhibited in the hippocampus of the berberine treatment group, and attenuated effect of declining neo-neuron, activation of microglia and astrocytes in the hippocampus of mice with sepsis were also found. |
2021-12-07 |
2023-08-13 |
mouse |
Ilia G Komoltsev, Liya V Tret'yakova, Stepan O Frankevich, Natalia I Shirobokova, Aleksandra A Volkova, Alexey V Butuzov, Margarita R Novikova, Alexey A Kvichansky, Yulia V Moiseeva, Mikhail V Onufriev, Alexey P Bolshakov, Natalia V Gulyaev. Neuroinflammatory Cytokine Response, Neuronal Death, and Microglial Proliferation in the Hippocampus of Rats During the Early Period After Lateral Fluid Percussion-Induced Traumatic Injury of the Neocortex. Molecular neurobiology. 2021-12-02. PMID:34855115. |
activation of microglia was observed from day 7 in different hippocampal areas of both hemispheres. |
2021-12-02 |
2023-08-13 |
rat |
Ilia G Komoltsev, Liya V Tret'yakova, Stepan O Frankevich, Natalia I Shirobokova, Aleksandra A Volkova, Alexey V Butuzov, Margarita R Novikova, Alexey A Kvichansky, Yulia V Moiseeva, Mikhail V Onufriev, Alexey P Bolshakov, Natalia V Gulyaev. Neuroinflammatory Cytokine Response, Neuronal Death, and Microglial Proliferation in the Hippocampus of Rats During the Early Period After Lateral Fluid Percussion-Induced Traumatic Injury of the Neocortex. Molecular neurobiology. 2021-12-02. PMID:34855115. |
the data suggest that tbi results in distant hippocampal damage (delayed neurodegeneration in the dentate gyrus and microglia proliferation in both the ipsilateral and contralateral hippocampus), the time course of this damage being different from that of the neuroinflammatory response. |
2021-12-02 |
2023-08-13 |
rat |
Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged tupaia belangeri. |
2021-11-30 |
2023-08-13 |
Not clear |
Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
to further understand the process of microglia dysfunction during the aging process, we used hippocampal sections from tupaia belangeri (tree shrews). |
2021-11-30 |
2023-08-13 |
Not clear |
Juan D Rodriguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Increased oxidative stress, hyperphosphorylation of tau, and dystrophic microglia in the hippocampus of aged Tupaia belangeri. Glia. vol 68. issue 9. 2021-11-30. PMID:32096580. |
adult (mean age 3.8 years), old (mean age 6 years), and aged (mean age 7.5 years) tree shrews were used for histochemical and immunostaining techniques to determine ferritin and iba1 positive microglia, iron tissue content, tau hyperphosphorylation and oxidized-rna in dentate gyrus, subiculum, and ca1-ca3 hippocampal regions. |
2021-11-30 |
2023-08-13 |
Not clear |
Dan Luo, Lu Han, Shengqiao Gao, Zhiyong Xiao, Qingru Zhou, Xiaorui Cheng, Yongxiang Zhang, Wenxia Zho. LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827410. |
the results showed that dutasteride significantly reduced the levels of il-6 and tnf-α in the supernatants of lps-stimulated bv2 cells, and decreased the levels of il-6 in the hippocampus and plasma, and the number of activated microglia in the brain of lps administration mice. |
2021-11-30 |
2023-08-13 |
mouse |
Shiji Huo, Jiling Ren, Yunqing Ma, Ahsawle Ozathaley, Wenjian Yuan, Hong Ni, Dong Li, Zhaowei Li. Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice. Journal of neuroinflammation. vol 18. issue 1. 2021-11-30. PMID:34836549. |
upregulation of trpc5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout il-10 mice. |
2021-11-30 |
2023-08-13 |
mouse |
Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
stat3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. |
2021-11-29 |
2023-08-13 |
mouse |
Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
we also took advantage of mice lacking stat3 in microglia and demonstrated that depletion of microglial stat3 reduced neuronal apoptosis in the diabetic hippocampus. |
2021-11-29 |
2023-08-13 |
mouse |
Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Hye Sun Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia exacerbates hippocampal neuronal apoptosis in diabetic brains. Journal of cellular physiology. vol 236. issue 10. 2021-11-29. PMID:33754353. |
taken together, these results suggest that stat3 activation in microglia plays an important role in hyperglycemia-induced neuronal apoptosis in the diabetic hippocampus and provide a potential therapeutic benefit of stat3 inhibition in microglia for preventing diabetic neuronal lesions. |
2021-11-29 |
2023-08-13 |
mouse |
Ke Wang, Yongquan Shi, Wei Liu, Shuqing Liu, Ming-Zhong Su. Taurine improves neuron injuries and cognitive impairment in a mouse Parkinson's disease model through inhibition of microglial activation. Neurotoxicology. vol 83. 2021-11-26. PMID:33450328. |
clinical and experimental findings support the view that activation of hippocampus microglia through nadph oxidase contributes to cognitive impairment in parkinson's disease (pd). |
2021-11-26 |
2023-08-13 |
mouse |
Ke Wang, Yongquan Shi, Wei Liu, Shuqing Liu, Ming-Zhong Su. Taurine improves neuron injuries and cognitive impairment in a mouse Parkinson's disease model through inhibition of microglial activation. Neurotoxicology. vol 83. 2021-11-26. PMID:33450328. |
then the ability of learning and memory was observed by morris water maze, neuron loss was evaluated by immunohistochemistry in hippocampus, the level of postsynaptic density 95 (psd95) and microglia activation was assessed by immunostaining, the molecules (gp91 |
2021-11-26 |
2023-08-13 |
mouse |