| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanan Wu, Kaiyi Zhou, Baiyang Liu, Jindong Xu, Liming Lei, Jiaqi Hu, Xiao Cheng, Feng Zhong, Sheng Wan. Glial Activation, Mitochondrial Imbalance, and Akt/mTOR Signaling May Be Potential Mechanisms of Cognitive Impairment in Heart Failure Mice. Neurotoxicity research. 2023-09-05. PMID:37668877. |
hf group cued fear memory, spatial memory, and learning impairment, accompanied by activation of glial cells (astrocytes, microglia, and oligodendrocytes) in the hippocampus. |
2023-09-05 |
2023-09-07 |
mouse |
| Zhen Mei, Jiaqi Liu, Jason P Schroeder, David Weinshenker, Duc M Duong, Nicholas T Seyfried, Yujing Li, Peng Jin, Aliza P Wingo, Thomas S Wing. Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice. Research square. 2023-08-30. PMID:37645711. |
mir-29a sponge expression significantly reduced hippocampal beta-amyloid deposition in 5xfad mice and lowered astrocyte and microglia activation in both 5xfad and wt mice. |
2023-08-30 |
2023-09-07 |
mouse |
| Heying Zhong, Xiaojuan Ran, Bin Chen, Yiqiang Xiong, Xiangdi Y. Apamin, an SK2 Inhibitor, Attenuated Neonatal Sevoflurane Exposures Caused Cognitive Deficits in Mice through the Regulation of Hippocampal Neuroinflammation. ACS chemical neuroscience. 2023-08-30. PMID:37647501. |
apamin inhibited m1-type polarization but promoted m2-type polarization of microglia after neonatal sevoflurane exposures in the hippocampus. |
2023-08-30 |
2023-09-07 |
mouse |
| Ruizhuo Chen, Brandy N Routh, Jillian E Straetker, Cecily R Gibson, Aidan S Weitzner, Kiersten S Bell, Andrew D Gaudet, Laura K Fonke. Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erb\\xce\\xb1 knockout mice. Brain, behavior, and immunity. 2023-08-30. PMID:37648007. |
surprisingly, these increases were only fully reversed by microglia depletion in the male but not female rko hippocampus. |
2023-08-30 |
2023-09-07 |
mouse |
| Chen Chen, Tao Zhu, Lifen Gong, Zhe Hu, Hao Wei, Jianchen Fan, Donghui Lin, Xiaojun Wang, Junyu Xu, Xinyan Dong, Yifan Wang, Ningxiao Xia, Linghui Zeng, Peifang Jiang, Yicheng Xi. Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogensis by upregulating autophagy via the AMPK/mTOR pathway. Neurobiology of disease. 2023-08-30. PMID:37648036. |
trpm2 knockout in microglia attenuated kainic acid (ka)-induced glial activation, inflammatory cytokines production and hippocampal paroxysmal discharges, whereas trpm2 knockout in astrocytes exhibited no significant effects. |
2023-08-30 |
2023-09-07 |
Not clear |
| Sarah R Oca\\xc3\\xb1as, Kevin D Pham, Jillian E J Cox, Alex W Keck, Sunghwan Ko, Felix A Ampadu, Hunter L Porter, Victor A Ansere, Adam Kulpa, Collyn M Kellogg, Adeline H Machalinski, Manu A Thomas, Zsabre Wright, Ana J Chucair-Elliott, Willard M Freema. Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease. Journal of neuroinflammation. vol 20. issue 1. 2023-08-16. PMID:37587511. |
here, we examined and compared transcriptomic and translatomic sex effects in young and old murine hippocampal microglia. |
2023-08-16 |
2023-09-07 |
mouse |
| He Li, Tianyuan Ye, Xingyang Liu, Rui Guo, Xiuzhao Yang, Yangyi Li, Dongmei Qi, Yihua Wei, Yifan Zhu, Lei Wen, Xiaorui Chen. The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer's disease. Journal of pharmaceutical analysis. vol 13. issue 7. 2023-08-14. PMID:37577391. |
the role of signaling crosstalk of microglia in hippocampus on progression of ageing and alzheimer's disease. |
2023-08-14 |
2023-08-16 |
mouse |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd significantly reduced the cerebral infarction area and the activation of microglia in the cortex and hippocampal dg, ca1, and ca3 area. |
2023-08-14 |
2023-09-07 |
rat |
| M J Zhang, J H Zhong, X J Y. Effect of Curcumin on Cognitive Behavior and Pathological Characteristics of the Hippocampus in Mice with Inherent Alzheimer's Disease. Bulletin of experimental biology and medicine. 2023-08-11. PMID:37566247. |
the distribution and the quantity of amyloid plaques and the spread of microglia in the hippocampus were determined by immunofluorescence. |
2023-08-11 |
2023-08-16 |
mouse |
| M J Zhang, J H Zhong, X J Y. Effect of Curcumin on Cognitive Behavior and Pathological Characteristics of the Hippocampus in Mice with Inherent Alzheimer's Disease. Bulletin of experimental biology and medicine. 2023-08-11. PMID:37566247. |
in the hippocampus of app/ps1 mice, curcumin significantly diminished the elevated a\xce\xb2 levels and inhibited microglia proliferation. |
2023-08-11 |
2023-08-16 |
mouse |
| Priyanka Mishra, Alexander Silva, Jay Sharma, Jacqueline Nguyen, Donald P Pizzo, Denise Hinz, Debashis Sahoo, Stephanie Cherqu. Rescue of Alzheimer's disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells. Cell reports. vol 42. issue 8. 2023-08-10. PMID:37561625. |
transcriptomic analysis revealed a significant decrease in gene expression related to "disease-associated microglia" in the cortex and "neurodegeneration-associated endothelial cells" in the hippocampus of the wt hspc-transplanted 5xfad mice compared with diseased controls. |
2023-08-10 |
2023-08-16 |
mouse |
| Ya Lan Yang, Ted Weita La. Chronic Visual Stimulation with LED Light Flickering at 24, 40, or 80 Hz Failed to Reduce Amyloid \\xce\\xb2 Load in the 5XFAD Alzheimer's Disease Mouse Model. eNeuro. vol 10. issue 8. 2023-08-07. PMID:37550065. |
as expected, 33-week-old 5xfad mice but not control wild-type mice of the same age exhibited an abundance of swollen microglia and a\xce\xb2 plaques in the visual cortex and hippocampus. |
2023-08-07 |
2023-08-14 |
mouse |
| Seong Hye Kim, In Gyoung Ju, Jin Hee Kim, Hyeyoon Eo, So-Ri Son, Dae Sik Jang, Myung Sook O. Linderae Radix Ameliorates Cognitive Dysfunction by Inhibiting Neuroinflammation and Synaptic Damage in Alzheimer's Disease Models. Molecular neurobiology. 2023-08-05. PMID:37542650. |
furthermore, we found that microglia activation increased, and the expression of synaptic proteins decreased in the hippocampus of the a\xce\xb2o-injected group, which was alleviated in the lr-treated group. |
2023-08-05 |
2023-08-14 |
mouse |
| Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuk. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023-08-04. PMID:37540445. |
the expression of cd68, an m1 phenotypic marker of microglia, was significantly elevated in the prefrontal cortex and hippocampus of mrl/lpr mice, which was significantly suppressed by 2ccpa treatment. |
2023-08-04 |
2023-08-14 |
mouse |
| Tao Zhu, Bingran Chen, Han Han, Xu Lu, Zhuo Chen, Ting Ye, Hui Zhao, Meng Zheng, Chao Huan. Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. Behavioural pharmacology. vol 34. issue 6. 2023-08-02. PMID:37530136. |
zymosan a produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia. |
2023-08-02 |
2023-08-14 |
mouse |
| Nina E Baumgartner, Mandy C Biraud, Elizabeth K Luca. Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice. Neurobiology of aging. vol 130. 2023-07-31. PMID:37524006. |
to investigate potential neural mechanisms underlying these behavioral changes, we analyzed transcriptional neuropathology markers in the ventral hippocampus and found age-related changes in genes related to activated microglia, angiogenesis, and cytokines. |
2023-07-31 |
2023-08-14 |
mouse |
| Jemi Feiona Vergil Andrews, Divya Bharathi Selvaraj, Akshay Kumar, Syed Aasish Roshan, Muthuswamy Anusuyadevi, Mahesh Kandasam. A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice. Brain sciences. vol 13. issue 7. 2023-07-29. PMID:37509038. |
this study investigated the effect of aspirin on spatial memory in correlation with the regulation of hippocampal neurogenesis and microglia in the brains of ageing experimental mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D Shuboni-Mulligan, Olivier George, Larry D Sanford, Ming-Lei Gu. Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509440. |
to further characterize the effects of cocaine on microglia and neuroimmune signaling in vivo, we utilized the brains from both sexes of outbred rats with cocaine self-administration to explore the activation status of microglia, nod-, lrr-, and pyrin domain-containing protein 3 (nlrp3) inflammasome activity, corticotropin-releasing factor (crf) signaling, and nf-\xce\xbab levels in the striatum and hippocampus (hp). |
2023-07-29 |
2023-08-14 |
mouse |
| Keiichi Hiramoto, Masashi Imai, Shota Tanaka, Kazuya Oo. Dementia Is Induced via the AGEs/Iba1/iNOS Pathway in Aged KK-Ay/Tajcl Mice. Life (Basel, Switzerland). vol 13. issue 7. 2023-07-29. PMID:37511915. |
hippocampal levels of cc-chemokine receptor 7 and inducible nitric oxide synthase, which are from m1-type macrophages that shift from microglia, were higher in kk-ay/tajcl mice than in control mice. |
2023-07-29 |
2023-08-14 |
mouse |
| Lulu Xie, Jiaxin Qin, Tingting Wang, Shuai Zhang, Mingcui Luo, Xuelei Cheng, Xinrui Cao, Hui Wang, Baozhen Yao, Dan Xu, Biwen Pen. Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice. Molecular neurobiology. 2023-07-29. PMID:37516664. |
in addition, pace significantly decreased the expression of genes related to synaptic development in fetal hippocampal neurons and hippocampal astrocyte and microglia were also damaged to varying degrees. |
2023-07-29 |
2023-08-14 |
mouse |