| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina E Mackey-Alfonso, Michael J Butler, Ashton M Taylor, Alberto R Williams-Medina, Stephanie M Muscat, Hongjun Fu, Ruth M Barriento. Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a mouse model of Alzheimer's disease. Brain, behavior, and immunity. 2024-07-23. PMID:39043341. |
synaptoneurosomes isolated from the hippocampus of 3xtg-ad mice fed chow or hfd were incubated with equal numbers of bv2 microglia. |
2024-07-23 |
2024-07-26 |
mouse |
| Junqi Yao, Liming Zhang, Chunkui Zhang, Xing Chen, Ke Bao, Shaojun Hou, Yongyu Yin, Kun Liu, Qing Wen, Xin Huang, Lun Son. Rhythmic gamma frequency light flickering ameliorates stress-related behaviors and cognitive deficits by modulating neuroinflammatory response through IL-12-Mediated cytokines production in chronic stress-induced mice. Brain, behavior, and immunity. 2024-07-23. PMID:39043349. |
rhythmic 40 hz lf exposure significantly decreased the number of iba1-positive microglia in the pfc and hippocampus, and the expression levels of the m1 markers of microglia inos and cd68 were reduced significantly in crs mice. |
2024-07-23 |
2024-07-26 |
mouse |
| Cheng-Fu Li, Qiu-Ping Zhang, Jie Cheng, Guang-Hui Xu, Ji-Xiao Zhu, Li-Tao Y. Role of ginsenoside Rb1 in attenuating depression-like symptoms through astrocytic and microglial complement C3 pathway. Metabolic brain disease. 2024-07-21. PMID:39034364. |
in conclusion, our results demonstrate that ginsenoside rb1 produces the antidepressant-like effects by inhibiting astrocyte tlr4/nf-κb/c3 signaling to covert microglia from a pro-inflammatory phenotype (amoeboid) towards an anti-inflammatory phenotype (ramified), which inhibit the synaptic pruning in the hippocampus. |
2024-07-21 |
2024-07-24 |
mouse |
| Xuan Li, Ziyu Kong, Ke Cai, Fujian Qi, Sen Zh. Neopterin mediates sleep deprivation-induced microglial activation resulting in neuronal damage by affecting YY1/HDAC1/TOP1/IL-6 signaling. Journal of advanced research. 2024-07-19. PMID:39029901. |
sd is accompanied by hippocampal microglia activation and a surge in inflammatory factors, but the precise mechanism remains unclear. |
2024-07-19 |
2024-07-22 |
mouse |
| Wai-Yin Cheng, Po-Lam Chan, Hang-Yin Ong, Ka-Hing Wong, Raymond Chuen-Chung Chan. Systemic Inflammation Disrupts Circadian Rhythms and Diurnal Neuroimmune Dynamics. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000563. |
furthermore, systemic inflammation induced by the lps could trigger neuroinflammation and perturb the diurnal dynamic behavior of microglia in the hippocampus. |
2024-07-13 |
2024-07-15 |
mouse |
| Olga Bakina, Thomas Conrad, Nina Mitic, Ramon Oliveira Vidal, Tessa Obrusnik, Somesh Sai, Christiane Nolte, Marcus Semtner, Helmut Kettenman. In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia. PloS one. vol 19. issue 7. 2024-07-11. PMID:38990806. |
on average, 4138 genes were detected in 113 cells from hippocampus, corpus callosum and cortex, including microglia markers such as tmem119, p2ry12 and siglec-h. |
2024-07-11 |
2024-07-14 |
mouse |
| Sin Ho Kweon, Hye Guk Ryu, Seung-Hwan Kwon, Hyeonwoo Park, Saebom Lee, Nam-Shik Kim, Shi-Xun Ma, Hee-Jung Jee, Sangjune Kim, Han Seok K. Gba1 E326K renders motor and non-motor symptoms with pathologic α-syn, tau and glial activation. Brain : a journal of neurology. 2024-07-08. PMID:38976650. |
gut inoculation of α-syn pff increased lewy body accumulation in the hippocampal dentate gyrus, with heightened microglia and astrocyte activation and worsened non-motor symptoms. |
2024-07-08 |
2024-07-12 |
mouse |
| Jiangong Zhang, Qinqin Zhu, Xun Shi, Yang Huang, Linlin Yan, Guozheng Zhang, Lei Pei, Jiahuan Liu, Xiaowei Han, Xisong Zh. NIR-II light therapy improves cognitive performance in MPTP induced Parkinson's disease rat models: A preliminary experimental study. Heliyon. vol 10. issue 12. 2024-07-08. PMID:38975234. |
the multiple fluorescence immunohistochemistry analysis trend plot showed that the activated microglia and astrocytes in the hippocampus were highest in mptp-induced pd untreated group, moderate in mptp-induced pd treatment group, and lowest in the control group. |
2024-07-08 |
2024-07-11 |
rat |
| Jiangong Zhang, Qinqin Zhu, Xun Shi, Yang Huang, Linlin Yan, Guozheng Zhang, Lei Pei, Jiahuan Liu, Xiaowei Han, Xisong Zh. NIR-II light therapy improves cognitive performance in MPTP induced Parkinson's disease rat models: A preliminary experimental study. Heliyon. vol 10. issue 12. 2024-07-08. PMID:38975234. |
our data indicates that nir-ii illumination improves learning and cognitive impairment as well as coordination and balance abilities in pd rats by downregulating the activation of microglia and astrocytes in the hippocampus. |
2024-07-08 |
2024-07-11 |
rat |
| Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. |
electroacupuncture improves the learning and memory abilities of rats with psci by attenuating the tlr4/nf-κb/nlrp3 signaling pathway on the hippocampal microglia. |
2024-06-27 |
2024-06-29 |
rat |
| Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. |
this study aims to investigate how electroacupuncture regulates the learning and memory abilities of poststroke cognitive impairment (psci) rats through the tlr4/nf-κb/nlrp3 signaling pathway on the hippocampal microglia. |
2024-06-27 |
2024-06-29 |
rat |
| Jing Bian, Chunxu Liu, Xiang Li, Xiaoye Qin, Feng Wang, Lina Xuan, Weimin Zhan. Electroacupuncture improves the learning and memory abilities of rats with PSCI by attenuating the TLR4/NF-κB/NLRP3 signaling pathway on the hippocampal microglia. Neuroreport. 2024-06-27. PMID:38935074. |
its mechanism was related to inhibiting the expression of the tlr4/nf-κb/nlrp3 signaling pathway, attenuating the release of inflammatory factors, and regulating the activation of hippocampal microglia in the brain. |
2024-06-27 |
2024-06-29 |
rat |
| Jia-Rui Zhang, Shi-Yu Shen, Zu-Qi Shen, Shu-Yuan Yin, Ke Ye, Wei Li, Hao-Yuan Li, Ling-Feng Liang, Yan-Qing Wang, Xiao-Yun Guo, Jin Y. Role of mitochondria-associated membranes in the hippocampus in the pathogenesis of depression. Journal of affective disorders. 2024-06-24. PMID:38914161. |
pathological changes, such as microglia activation in the hippocampus frequently occur in individuals with animal models of depression; however, they may share a common cellular mechanism, such as endoplasmic reticulum (er) stress and mitochondrial dysfunction. |
2024-06-24 |
2024-06-27 |
Not clear |
| Hooman Hatami, Vahid Reza Askari, Vafa Baradaran Rahimi, Md Saquib Hasnain, Amit Kumar Naya. The Dilemma of Insulin Delivery into the Brain: A Comprehensive Review. Current drug delivery. 2024-06-24. PMID:38910469. |
the ubiquitous distribution of insulin receptors on various brain cells, such as neurons, microglia, astrocytes, and oligodendrocytes, and their differential localization across various brain regions, including the hippocampus, hypothalamus, and olfactory bulb, collectively underscore the crucial involvement of insulin in the modulation of cerebral functions. |
2024-06-24 |
2024-06-26 |
human |
| D K Avrova, L V Bayunova, N F Avrova, I O Zakharov. The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury. Bulletin of experimental biology and medicine. 2024-06-21. PMID:38907060. |
the immunohistochemical reaction of specific antibodies to marker proteins of activated microglia (iba1) and astrocytes (gfap) in hippocampal slices revealed the neuroprotective effect of exogenous gangliosides which can be mostly explained by their ability to suppress neuroinflammation and gliosis. |
2024-06-21 |
2024-06-24 |
rat |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
one mechanism for the promotion of depression by chronic stress in adulthood is the loss of hippocampal microglia. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
since deleterious stress in adolescence also activates microglia, we investigated the dynamic changes of microglia in the hippocampus in mice exposed to chronic unpredictable stress (cus) in adolescence. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
our results showed that 12 days of cus stimulation in adolescence induced typical depression-like behaviors in adult mice, which were accompanied by a significant decrease and dystrophy of microglia in the dentate gyrus of the hippocampus. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
further analysis showed that this decrease in microglia was mediated by the initial response of microglia to unpredictable stress in the dentate gyrus of the hippocampus and their subsequent apoptosis. |
2024-06-21 |
2024-06-24 |
mouse |