Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Qinwen Mao, Dongyang Wang, Yanqing Li, Missia Kohler, Jayson Wilson, Zachary Parton, Bella Shmaltsuyeva, Demirkan Gursel, Rosa Rademakers, Sandra Weintraub, Marek-Marsel Mesulam, Haibin Xia, Eileen H Bigi. Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration. Journal of neuropathology and experimental neurology. vol 76. issue 11. 2017-10-27. PMID:29044416. |
in the hippocampus, grn immunopositivity in the ca1 and ca2 regions showed disease-specific changes in both neurons and microglia. |
2017-10-27 |
2023-08-13 |
Not clear |
Qinwen Mao, Dongyang Wang, Yanqing Li, Missia Kohler, Jayson Wilson, Zachary Parton, Bella Shmaltsuyeva, Demirkan Gursel, Rosa Rademakers, Sandra Weintraub, Marek-Marsel Mesulam, Haibin Xia, Eileen H Bigi. Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration. Journal of neuropathology and experimental neurology. vol 76. issue 11. 2017-10-27. PMID:29044416. |
most interestingly, in ftld-tdp type a with grn mutations, there is a 60% decrease in the density of grn-positive microglia in the hippocampal ca1, suggesting that haploinsufficiency of the grn mutations also extends to pgrn expression in microglia. |
2017-10-27 |
2023-08-13 |
Not clear |
Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayam. Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27769904. |
we noted significantly increased numbers of activated microglia in the granule cell layer, hilus, ca1, and ca3 regions of the hippocampi of lh rats. |
2017-08-31 |
2023-08-13 |
rat |
Tae-Kyeong Lee, Joon Ha Park, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Eun Joo Bae, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Le. Pretreated duloxetine protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury through decreases of glial activation and oxidative stress. Journal of the neurological sciences. vol 370. 2017-05-22. PMID:27772765. |
in addition, pre-treatment with dxt reduced ischemia-induced activations of microglia and astrocytes in the ischemic ca1 region. |
2017-05-22 |
2023-08-13 |
Not clear |
Ha-Jin Pak, Tae-Ryong Riew, Yoo-Jin Shin, Jeong-Heon Choi, Xuyan Jin, Mun-Yong Le. Enhanced expression of the calcium-sensing receptor in reactive astrocytes following ischemic injury in vivo and in vitro. Journal of the neurological sciences. vol 366. 2017-04-25. PMID:27288786. |
casr was constitutively expressed in neurons of the pyramidal and granule cell layers, whereas increased casr immunoreactivity was observed in reactive astrocytes, but not in activated microglia or macrophages, in the ca1 region of the post-ischemic hippocampus. |
2017-04-25 |
2023-08-13 |
rat |
Shuangxi Liu, Yan Gao, Xiaoli Yu, Baoming Zhao, Lu Liu, Yin Zhao, Zhenzhao Luo, Jing Sh. Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion. International journal of molecular sciences. vol 17. issue 10. 2017-03-23. PMID:27782092. |
in rat hippocampal slices, ogd/r treatment enhanced the anxa1 expression in neuron, the formyl peptide receptor (fprs) expression in microglia, and the microglial activation in the ca1 region (cornu ammonis 1). |
2017-03-23 |
2023-08-13 |
rat |
Eun Jeong Sohn, Min Jea Shin, Won Sik Eum, Dae Won Kim, Ji In Yong, Eun Ji Ryu, Jung Hwan Park, Su Bin Cho, Hyun Ju Cha, Sang Jin Kim, Hyeon Ji Yeo, Eun Ji Yeo, Yeon Joo Choi, Seung Kwon Im, Hae Young Kweon, Duk-Soo Kim, Yeon Hee Yu, Sung-Woo Cho, Meeyoung Park, Jinseu Park, Yong-Jun Cho, Soo Young Cho. Tat-NOL3 protects against hippocampal neuronal cell death induced by oxidative stress through the regulation of apoptotic pathways. International journal of molecular medicine. vol 38. issue 1. 2017-03-06. PMID:27221790. |
in addition, tat-nol3 protein transduced into the animal brains and significantly protected against neuronal cell death in the ca1 region of the hippocampus by regulating the activation of microglia and astrocytes. |
2017-03-06 |
2023-08-13 |
Not clear |
Miguel Ángel Ontiveros-Torres, María Luisa Labra-Barrios, Sofía Díaz-Cintra, Azucena Ruth Aguilar-Vázquez, Samadhi Moreno-Campuzano, Paola Flores-Rodríguez, Claudia Luna-Herrera, Raúl Mena, George Perry, Benjamín Florán-Garduño, José Luna-Muñoz, Juan Pedro Luna-Aria. Fibrillar Amyloid-β Accumulation Triggers an Inflammatory Mechanism Leading to Hyperphosphorylation of the Carboxyl-Terminal End of Tau Polypeptide in the Hippocampal Formation of the 3×Tg-AD Transgenic Mouse. Journal of Alzheimer's disease : JAD. vol 52. issue 1. 2017-01-27. PMID:27031470. |
our results indicate that the presence of fibrillar aβ deposits correlates with a significant activation of astrocytes and microglia in subiculum and ca1 regions of hippocampus. |
2017-01-27 |
2023-08-13 |
mouse |
K E Boschen, M J Ruggiero, A Y Klintsov. Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus. Neuroscience. vol 324. 2017-01-03. PMID:26996510. |
on pd10, microglial cell counts and area of cell territory were assessed using unbiased stereology in the hippocampal subfields ca1, ca3 and dentate gyrus (dg), and hippocampal expression of pro- and anti-inflammatory genes was analyzed. |
2017-01-03 |
2023-08-13 |
rat |
K E Boschen, M J Ruggiero, A Y Klintsov. Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus. Neuroscience. vol 324. 2017-01-03. PMID:26996510. |
a significant decrease in microglial cell counts in ca1 and dg was found in alcohol-exposed and sham-intubated (si) animals compared to undisturbed suckle controls (scs), suggesting overlapping effects of alcohol exposure and intubation alone on the neuroimmune response. |
2017-01-03 |
2023-08-13 |
rat |
K E Boschen, M J Ruggiero, A Y Klintsov. Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus. Neuroscience. vol 324. 2017-01-03. PMID:26996510. |
cell territory was decreased in alcohol-exposed animals in ca1, ca3, and dg compared to controls, suggesting the microglia have shifted to a more activated state following alcohol treatment. |
2017-01-03 |
2023-08-13 |
rat |
Joo-Hee Park, Ha-Jin Pak, Tae-Ryong Riew, Yoo-Jin Shin, Mun-Yong Le. Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia. Brain research. vol 1634. 2016-12-13. PMID:26764532. |
the ligand and receptors were constitutively expressed in hippocampal neurons in control animals; however, in animals with ischemic injury, their upregulation was detected in reactive astrocytes, but not in neurons or activated microglia, in the ca1 region. |
2016-12-13 |
2023-08-13 |
rat |
Kenji Hisamatsu, Masayuki Niwa, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akihiro Hirata, Yuichiro Hatano, Hiroyuki Tomita, Akira Har. Galectin-3 expression in hippocampal CA2 following transient forebrain ischemia and its inhibition by hypothermia or antiapoptotic agents. Neuroreport. vol 27. issue 5. 2016-12-13. PMID:26848998. |
we have also reported that galectin-3 was expressed in activated microglia in the ca1 region 96 h after transient ischemia. |
2016-12-13 |
2023-08-13 |
Not clear |
Joon Ha Park, Bich Na Shin, Bai Hui Chen, In Hye Kim, Ji Hyeon Ahn, Jeong-Hwi Cho, Hyun-Jin Tae, Jae-Chul Lee, Choong-Hyun Lee, Young-Myeong Kim, Yun Lyul Lee, Sung Koo Kim, Moo-Ho Wo. Neuroprotection and reduced gliosis by atomoxetine pretreatment in a gerbil model of transient cerebral ischemia. Journal of the neurological sciences. vol 359. issue 1-2. 2016-09-29. PMID:26671145. |
in addition, pre-treatment with 30 mg/kg atx, which had neuroprotective effect against ischemic damage, distinctly attenuated the activation of astrocytes and microglia in the ischemic ca1 region compared with the vehicle-treated ischemia group by glial fibrillary acidic protein (for astrocytes) and ionized calcium-binding adapter molecule 1 (for microglia) immunohistochemistry. |
2016-09-29 |
2023-08-13 |
Not clear |
Y Li, J Ki. Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus. Neuroscience. vol 311. 2016-09-14. PMID:26515747. |
cb2r mrnas were mostly expressed in a subset of excitatory and inhibitory neurons in the ca1, ca3 and dentate gyrus areas, but rarely in microglia. |
2016-09-14 |
2023-08-13 |
mouse |
G Keilhoff, M Titze, T Esser, K Langnaese, U Ebmeye. Constitutive and functional expression of YB-1 in microglial cells. Neuroscience. vol 301. 2016-04-18. PMID:26102006. |
this model is characterized by massive neurodegeneration of the hippocampal ca1 region and the subsequent long-lasting activation of microglia. |
2016-04-18 |
2023-08-13 |
Not clear |
So Mi Kim, In Koo Hwang, Dae Young Yoo, Won Sik Eum, Dae Won Kim, Min Jea Shin, Eun Hee Ahn, Hyo Sang Jo, Eun Ji Ryu, Ji In Yong, Sung-Woo Cho, Oh-Shin Kwon, Keun Wook Lee, Yoon Shin Cho, Kyu Hyung Han, Jinseu Park, Soo Young Cho. Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischaemic insult in animal model. Journal of cellular and molecular medicine. vol 19. issue 6. 2016-04-01. PMID:25781353. |
in addition, tat-atox1 significantly decreased the activation of astrocytes and microglia as well as lipid peroxidation in the ca1 region after ischaemic insult. |
2016-04-01 |
2023-08-13 |
Not clear |
Philip K-Y Chang, Armen Khatchadourian, Rebecca Anne McKinney, Dusica Maysinge. Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology. Journal of neuroinflammation. vol 12. 2016-03-09. PMID:25889069. |
here we investigated direct effects of dha on synaptic integrity and its indirect effects via microglia in the hippocampal ca1 region. |
2016-03-09 |
2023-08-13 |
Not clear |
Yan-Zhong Guan, Xiu-Dong Jin, Li-Xin Guan, Hua-Cheng Yan, Pu Wang, Zhi Gong, Shu-Ji Li, Xiong Cao, Yan-Li Xing, Tian-Ming Ga. Nicotine inhibits microglial proliferation and is neuroprotective in global ischemia rats. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25095782. |
this effect was accompanied by a significant reduction in the increase of microglia rather than astrocytes, as well as a significant reduction of enhanced expression of tumor necrosis factor-alpha (tnf-α) and interleukin-1beta (il-1β) in ca1 induced by ischemia/reperfusion. |
2016-03-08 |
2023-08-13 |
rat |
Catrinel Girbovan, Hélène Plamondo. Resveratrol downregulates type-1 glutamate transporter expression and microglia activation in the hippocampus following cerebral ischemia reperfusion in rats. Brain research. vol 1608. 2015-12-24. PMID:25727173. |
on microglia and astrocyte activation and characterized glt-1 expression in the dentate gyrus (dg), ca1 and ca3 layers of the hippocampus 7 days following 10min global ischemia. |
2015-12-24 |
2023-08-13 |
rat |