| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Wang, Ya-Jin Shi, Ting-Yuan Niu, Ting-Ting Chen, Han-Bing Li, Su-Hui Wu, Gen-Lin L. Neuroprotective effect of 20 (S) - Protopanaxadiol (PPD) attenuates NLRP3 inflammasome-mediated microglial pyroptosis in vascular dementia rats. Neuroscience letters. 2023-08-14. PMID:37579868. |
ppd significantly reduced the cerebral infarction area and the activation of microglia in the cortex and hippocampal dg, ca1, and ca3 area. |
2023-08-14 |
2023-09-07 |
rat |
| Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhan. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction. Neurochemical research. 2023-07-25. PMID:37490197. |
ds also remarkably inhibited lps-induced neuroinflammation by suppressing microglia overactivation, pro-inflammatory cytok ine release (tnf-\xce\xb1 and il-1\xce\xb2) and reducing neuronal loss in the ca1 and dg regions of the hippocampus. |
2023-07-25 |
2023-08-14 |
rat |
| Gumaro Galindo-Paredes, Gonzalo Flores, Julio C\\xc3\\xa9sar Morales-Medin. Olfactory bulbectomy induces nociceptive alterations associated with gliosis in male rats. IBRO neuroscience reports. vol 14. 2023-06-30. PMID:37388490. |
in the bla, cea and ca1, obx caused significant changes in glial cells, such as hypertrophy and hypotrophy in gfap-positive astrocytes and iba1-positive microglia, respectively. |
2023-06-30 |
2023-08-14 |
rat |
| Ekaterina V Pershina, Irina Yu Chernomorets, Dmitry A Fedorov, Vladimir I Arkhipo. Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175959. |
in contrast to the hilus, microglia in the ca1 region had an increase in rod-like cells. |
2023-05-14 |
2023-08-14 |
rat |
| Kazuki Nakanishi, Kosuke Norimatsu, Akira Tani, Teruki Matsuoka, Ryoma Matsuzaki, Syogo Kakimoto, Nao Nojima, Yuta Tachibe, Yuki Kato, Masaki Inadome, Riho Kitazato, Shotaro Otsuka, Seiya Takada, Megumi Sumizono, Harutoshi Sakakim. Effects of early exercise intervention and exercise cessation on neuronal loss and neuroinflammation in a senescence-accelerated mouse prone 8. Neuroscience letters. 2023-05-14. PMID:37182575. |
however, the 2m-detraining group showed increased bdnf positive area in the ca1 region and the enhancement of anti-inflammatory m2 phenotype microglia. |
2023-05-14 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
sexually differentiated microglia and ca1 hippocampal synaptic connectivity. |
2023-05-12 |
2023-08-14 |
mouse |
| Tim M Prengel, Bianka Brunne, Moataz Habiballa, Gabriele M Run. Sexually differentiated microglia and CA1 hippocampal synaptic connectivity. Journal of neuroendocrinology. 2023-05-12. PMID:37170708. |
in this study, we tested whether sexual differentiation of microglia results in sex-dependent postnatal reorganization of ca1 synaptic connectivity in the hippocampus. |
2023-05-12 |
2023-08-14 |
mouse |
| Si-Jie Dai, Yu-Ying Shao, Yang Zheng, Jin-Yi Sun, Zhi-Sheng Li, Jia-Ying Shi, Meng-Qi Yan, Xiao-Yun Qiu, Ceng-Lin Xu, Wan-Sang Cho, Masahiro Nishibori, Sihyeong Yi, Seung Bum Park, Yi Wang, Zhong Che. Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation. Acta pharmacologica Sinica. 2023-04-19. PMID:37076634. |
notably, in ca1 region, the seizure focus, icm pretreatment mainly inhibited hmgb1 translocation in microglia. |
2023-04-19 |
2023-08-14 |
mouse |
| Naveen Nagarajan, Mario R Capecch. Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both. Molecular psychiatry. 2023-04-10. PMID:37037872. |
optogenetic stimulation of hoxb8 microglia in the ventral ca1 region of the hippocampus (vca1) induces both behaviors as well as freezing. |
2023-04-10 |
2023-08-14 |
mouse |
| Michael Nugent, Mark St Pierre, Ashley Brown, Salma Nassar, Pritika Parmar, Yuma Kitase, Sarah Ann Duck, Charles Pinto, Lauren Jantzie, Camille Fung, Raul Chavez-Valde. Sexual dimorphism in the closure of the hippocampal postnatal critical period of synaptic plasticity after intrauterine growth restriction - link to oligodendrocyte and glial dysregulation. Developmental neuroscience. 2023-04-05. PMID:37019088. |
lastly, activated microglia was only detected in iugr female ca1 and ca3 sub-regions. |
2023-04-05 |
2023-08-14 |
mouse |
| Peiyan Jiang, Lianyu Zhou, Zhulin Du, Linyang Zhao, Yexi Tang, Xinghang Fei, Lian Wang, Dabing Li, Song Li, Hui Yang, Xiaotang Fan, Huiling Lia. Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice. Behavioural brain research. 2023-03-08. PMID:36889463. |
furthermore, ica treatment inhibited neuroinflammation via decreasing microglia number and the soma size in the ca1 region of the hippocampus, as well as the protein levels of proinflammatory cytokines in the hippocampus of btbr mice. |
2023-03-08 |
2023-08-14 |
mouse |
| Kyu Ri Hahn, Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, In Koo Hwang, Dae Won Kim, Yeo Sung Yoo. Cu,Zn-Superoxide Dismutase has Minimal Effects Against Cuprizone-Induced Demyelination, Microglial Activation, and Neurogenesis Defects in the C57BL/6 Mouse Hippocampus. Neurochemical research. 2023-02-22. PMID:36808020. |
eight weeks feeding of cuprizone-supplemented (0.2%) diets caused a significant decrease in myelin basic protein (mbp) expression in the stratum lacunosum-moleculare of the ca1 region, the polymorphic layer of the dentate gyrus, and the corpus callosum, while ionized calcium-binding adapter molecule 1 (iba-1)-immunoreactive microglia showed activated and phagocytic phenotypes. |
2023-02-22 |
2023-08-14 |
mouse |
| Iv\\xc3\\xa1n Ballasch, Esther Garc\\xc3\\xada-Garc\\xc3\\xada, Cristina Vila, Anna P\\xc3\\xa9rez-Gonz\\xc3\\xa1lez, Anna Sancho-Balsells, J\\xc3\\xa9ssica Fern\\xc3\\xa1ndez, David Soto, Mar Puigdell\\xc3\\xadvol, Xavier Gasull, Jordi Alberch, Manuel J Rodr\\xc3\\xadguez, Josep M Canals, Albert Giral. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain, behavior, and immunity. 2023-01-26. PMID:36702234. |
by characterizing the ikzf1 deficient mice, we observed that these mice displayed spatial learning deficits, impaired hippocampal ca3-ca1 long-term potentiation, and decreased spine density in pyramidal neurons of the ca1, which correlates with an increased expression of synaptic markers within microglia. |
2023-01-26 |
2023-08-14 |
mouse |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
cleaved gsdmd was detected in microglia, but also in astrocytes and in few pyramidal neurons in the first sector of the cornu ammonis (ca1) of the hippocampus and the temporal cortex of brodmann area 36. |
2022-12-09 |
2023-08-14 |
human |
| Sebastiaan Moonen, Marta J Koper, Evelien Van Schoor, Jolien M Schaeverbeke, Rik Vandenberghe, Christine A F von Arnim, Thomas Tousseyn, Bart De Strooper, Dietmar Rudolf Tha. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta neuropathologica. 2022-12-09. PMID:36481964. |
in ca1, nlrp3-positive microglia and cleaved gsdmd-positive neurons were associated with local neuronal loss, indicating a possible contribution of nlrp3 inflammasome and pyroptosis activation to ad-related neurodegeneration. |
2022-12-09 |
2023-08-14 |
human |
| E De Felice, E Gon\\xc3\\xa7alves de Andrade, M T Golia, F Gonz\\xc3\\xa1lez Ib\\xc3\\xa1\\xc3\\xb1ez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
we characterized in depth the features of microglia in the two hippocampal poles and investigated their contribution to ca1 plasticity under physiological conditions. |
2022-12-09 |
2023-08-14 |
mouse |
| E De Felice, E Gon\\xc3\\xa7alves de Andrade, M T Golia, F Gonz\\xc3\\xa1lez Ib\\xc3\\xa1\\xc3\\xb1ez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
this was recapitulated in cx3cr1 knockout mice, indicating that microglia have a key role in setting the conditions for plasticity processes in a region-specific manner, and that the cx3cl1-cx3cr1 pathway is a key element in determining the basal level of ca1 ltp in the two regions. |
2022-12-09 |
2023-08-14 |
mouse |
| E De Felice, E Gon\\xc3\\xa7alves de Andrade, M T Golia, F Gonz\\xc3\\xa1lez Ib\\xc3\\xa1\\xc3\\xb1ez, M Khakpour, M A Di Castro, S Garofalo, E Di Pietro, C Benatti, N Brunello, F Tascedda, B Kaminska, C Limatola, D Ragozzino, M E Tremblay, S Alboni, L Magg. Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions. Journal of neuroinflammation. vol 19. issue 1. 2022-12-09. PMID:36482444. |
furthermore, microglia in the ca1 sr region showed an increase in soma and a more extensive arborization, an increased prevalence of immature lysosomes accompanied by an elevation in mrna expression of phagocytic markers mertk and cd68 and a surge in the expression of microglial outward k |
2022-12-09 |
2023-08-14 |
mouse |
| Yingjuan Xu, Jiling Zhang, Zeman Fang, Handi Zhan. The effects of social defeat stress on hippocampal glial cells and interleukin-6 in adolescence and adulthood. Neuroreport. vol 33. issue 18. 2022-11-11. PMID:36367792. |
microglia activation characterized by increased ionized calcium-binding adapter molecule 1 positive cell numbers or staining area in the ca1 and ca3 regions of the hippocampus were observed 24 h after the end of stress, which did not last into the adulthood. |
2022-11-11 |
2023-08-14 |
mouse |
| Yi Tian, Meihui Li, Shanshan Zhang, Juntao Hu, Haoran Wu, Mitchell Wan, Jingxin Xue, Leilei Wang, Honglei Xiao, Guomin Zhou, Kaidi Wang, Qiong Li. Microglia activation in the hippocampus mediates retinal degeneration-induced depressive-like behaviors via the NLRP3/IL-1\\xce\\xb2 pathway. Brain research bulletin. 2022-11-04. PMID:36332880. |
microglial proliferation was first observed in the dentate gyrus on day 3, while the number of microglia in cornu ammonis 1 grew the most. |
2022-11-04 |
2023-08-14 |
mouse |