| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shane D McKeon, Maria I Perica, Finnegan J Calabro, Will Foran, Hoby Hetherington, Chan-Hong Moon, Beatriz Lun. Prefrontal Excitation/Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio. bioRxiv : the preprint server for biology. 2024-09-04. PMID:39229165. |
during adolescence, the maturation of pfc is proposed to be a critical period (cp) for executive function, driven by a break in balance between glutamatergic excitation and gabaergic inhibition (e/i) neurotransmission. |
2024-09-04 |
2024-09-06 |
human |
| Claire E Tume, Sophie L Chick, Peter A Holmans, Elliott Rees, Michael C O'Donovan, Darren Cameron, Nicholas J Bra. Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia. Biological psychiatry global open science. vol 4. issue 5. 2024-08-05. PMID:39099730. |
genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. |
2024-08-05 |
2024-08-07 |
human |
| Wenjing Shi, Minyu Li, Ting Zhang, Chunlong Yang, Dongdong Zhao, Jie Ba. GABA system in the prefrontal cortex involved in psychostimulant addiction. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 8. 2024-08-04. PMID:39098820. |
the pfc is made up of excitatory glutamatergic cells and gamma-aminobutyric acid (gabaergic) interneurons. |
2024-08-04 |
2024-08-07 |
Not clear |
| Sarah H Hayes, Salonee V Patel, Parinita Arora, Lin Zhao, Ashley L Schormans, Shawn N Whitehead, Brian L Allma. Neurophysiological, structural, and molecular alterations in the prefrontal and auditory cortices following noise-induced hearing loss. Neurobiology of disease. 2024-07-30. PMID:39079581. |
we show that following noise exposure, impaired gamma phase coherence within the prefrontal cortex is accompanied by alterations in pyramidal cell dendritic morphology and decreased expression of proteins involved in gabaergic (gad65) and glutamatergic (nr2b) neurotransmission; findings that were not observed in the auditory cortex, where gamma phase coherence remained unchanged post-noise exposure. |
2024-07-30 |
2024-08-02 |
Not clear |
| Joya Maser, Mary F Morrison, Helene Philogene Khalid, Ronan Cunningham, Daohai Yu, M Ingre Walters, Xiaoning Lu, Nicolas R Bol. Clavulanic Acid-Mediated Increases in Anterior Cingulate Glutamate Levels are Associated With Decreased Cocaine Craving and Brain Network Functional Connectivity Changes. Current therapeutic research, clinical and experimental. vol 101. 2024-07-24. PMID:39045086. |
glutamatergic transmission in the prefrontal cortex is affected by addictive behaviors. |
2024-07-24 |
2024-07-26 |
Not clear |
| Noemi Nicosia, Mattia Giovenzana, Paulina Misztak, Jessica Mingardi, Laura Musazz. Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders. International journal of molecular sciences. vol 25. issue 12. 2024-06-27. PMID:38928227. |
indeed, brain areas involved in memory formation and consolidation as well as in fear and emotional processing, such as the hippocampus, prefrontal cortex, and amygdala, are predominantly glutamatergic. |
2024-06-27 |
2024-06-29 |
Not clear |
| Michael P Sceniak, Shasta L Sab. Prefrontal cortical network dysfunction from acute neurotoxicant exposure. Journal of neurophysiology. 2024-06-12. PMID:38864824. |
neurons of the pfc are susceptible to glutamatergic excitotoxicity, an effect associated with cortical degeneration in frontotemporal disorders (ftd). |
2024-06-12 |
2024-06-14 |
Not clear |
| Caitlyn R Cody, Emilce Artur de la Villarmois, Anabel Miguelez Fernandez, Janelle Lardizabal, Chaney McKnight, Kuei Tseng, Heather C Brenhous. Effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and anxiety behaviors. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38853948. |
prior work has shown that early life adversity (ela) leads to hyperinnervation of glutamatergic basolateral amygdala (bla) projections to the prefrontal cortex (pfc) in adolescence. |
2024-06-10 |
2024-06-14 |
Not clear |
| Caitlyn R Cody, Emilce Artur de la Villarmois, Anabel Miguelez Fernandez, Janelle Lardizabal, Chaney McKnight, Kuei Tseng, Heather C Brenhous. Effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and anxiety behaviors. bioRxiv : the preprint server for biology. 2024-06-10. PMID:38853948. |
since ela increases activity of the early-developing bla, while the pfc exhibits protracted development, we further examined impacts of glutamatergic bla activity during early adolescence on later-life pfc innervation and heightened anxiety. |
2024-06-10 |
2024-06-14 |
Not clear |
| Francesca Mottarlini, Beatrice Rizzi, Giorgia Targa, Valeria Buzzelli, Melania Di Trapano, Laura Rullo, Sanzio Candeletti, Roberto Ciccocioppo, Liana Fattore, Patrizia Romualdi, Fabio Fumagalli, Viviana Trezza, Lucia Caffin. Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex. Frontiers in psychiatry. vol 15. 2024-06-05. PMID:38835543. |
communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex. |
2024-06-05 |
2024-06-07 |
rat |
| Dionnet L Bhatti, Junghee Jin, Jia Cheng, Kathryn McCabe, Ko-Woon Lee, Clara Berdasco, Yu Young Jeong, Subhash C Sinha, Yong Ki. Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice. Frontiers in molecular neuroscience. vol 17. 2024-06-03. PMID:38828281. |
conditional deletion of ahnak in the pfc or forebrain glutamatergic neurons facilitates stress susceptibility, suggesting that ahnak is required for behavioral resilience. |
2024-06-03 |
2024-06-05 |
mouse |
| Xue-Fen Zhang, Yi-Dan Li, Yue Li, Ying Li, Dan Xu, Lin-Lin Bi, Hai-Bo X. Ventral subiculum promotes wakefulness through several pathways in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-05-11. PMID:38734818. |
in addition, optogenetic stimulation of vsub glutamatergic terminals and retrograde-targeted chemogenetic activation of vsub glutamatergic neurons revealed that vsub promoted arousal by innervating the lateral hypothalamus (lh), nucleus accumbens (nac) shell, and prefrontal cortex (pfc). |
2024-05-11 |
2024-05-27 |
mouse |
| Marion Ponserre, Tudor M Ionescu, Alessa A Franz, Serena Deiana, Niklas Schuelert, Thorsten Lamla, Rhîannan H Williams, Carsten T Wotjak, Scott Hobson, Julien Dine, Azar Omran. Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction. Neuropharmacology. 2024-04-30. PMID:38685343. |
a decrease in the strength of optogenetically-evoked glutamatergic current at the ventral hippocampus (hpc) to pfc synapse was also demonstrated, along with a weaker shunt of excitatory transmission by local pfc interneurons. |
2024-04-30 |
2024-05-03 |
mouse |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
prefrontal cortex (pfc) maturation during adolescence is characterized by structural and functional changes, which involve the remodeling of gaba and glutamatergic synapses, as well as changes in the endocannabinoid system. |
2024-03-12 |
2024-03-14 |
rat |
| Hanna M Molla, Anabel M M Miguelez Fernández, Kuei Y Tsen. Late-adolescent onset of prefrontal endocannabinoid control of hippocampal and amygdalar inputs and its impact on trace-fear conditioning behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-12. PMID:38467844. |
yet, the way pfc endocannabinoid signaling interacts with local gaba and glutamatergic function to impact its processing of afferent transmission during the adolescent transition to adulthood remains unknown. |
2024-03-12 |
2024-03-14 |
rat |
| George Ntoulas, Charalampos Brakatselos, Gerasimos Nakas, Michail-Zois Asprogerakas, Foteini Delis, Leonidas J Leontiadis, George Trompoukis, Costas Papatheodoropoulos, Dimitrios Gkikas, Dimitrios Valakos, Giannis Vatsellas, Panagiotis K Politis, Alexia Polissidis, Katerina Antonio. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Translational psychiatry. vol 14. issue 1. 2024-02-20. PMID:38378836. |
we found that these rats exhibit hyperactivity and cognitive deficits, along with characteristic bidirectional glutamatergic and gabaergic alterations in the prefrontal cortex and the hippocampus. |
2024-02-20 |
2024-02-23 |
mouse |
| Sebastian A Pace, Ema Lukinic, Tyler Wallace, Carlie McCartney, Brent Myer. Cortical-brainstem circuitry attenuates physiological stress reactivity. The Journal of physiology. 2024-02-14. PMID:38353989. |
key points: glutamatergic efferents from the ventromedial prefrontal cortex target catecholaminergic neurons throughout the ventrolateral medulla. |
2024-02-14 |
2024-02-16 |
rat |
| Yu-Jie Su, Pei-Lu Yi, Fang-Chia Chan. Transcranial Direct Current Stimulation (tDCS) Ameliorates Stress-Induced Sleep Disruption via Activating Infralimbic-Ventrolateral Preoptic Projections. Brain sciences. vol 14. issue 1. 2024-01-26. PMID:38275525. |
we hypothesized that anodal prefrontal cortex stimulation activates glutamatergic projections from the infralimbic cortex (il) to the ventrolateral preoptic area (vlpo) to promote sleep. |
2024-01-26 |
2024-01-28 |
mouse |
| Maya O Nesbit, Soyon Ahn, Haiyan Zou, Stan B Floresco, Anthony G Phillip. Potentiation of prefrontal cortex dopamine function by the novel cognitive enhancer d-govadine. Neuropharmacology. 2024-01-20. PMID:38244888. |
we hypothesize that d-gov acts in the mpfc to engage the mesocortical feedback loop through which prefrontal glutamatergic projections activate a population of vta da neurons that specifically project back to the pfc. |
2024-01-20 |
2024-01-23 |
rat |
| Mahum T Siddiqi, Dhruba Podder, Amanda R Pahng, Alexandria C Athanason, Tali Nadav, Chelsea Cates-Gatto, Max Kreifeldt, Candice Contet, Amanda J Roberts, Scott Edwards, Marisa Roberto, Florence P Varodaya. Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. Addiction neuroscience. vol 9. 2023-12-28. PMID:38152067. |
prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder. |
2023-12-28 |
2023-12-30 |
mouse |