| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajun Zheng, Tingjie Li, Shuang Qi, Bing Qin, Jiandong Yu, Gong Che. Neuroregenerative gene therapy to treat temporal lobe epilepsy in a rat model. Progress in neurobiology. vol 208. 2021-12-09. PMID:34852273. |
here, we develop a novel gene therapy-mediated cell therapy that regenerates gabaergic neurons using internal hippocampal astrocytes to suppress seizure activity in a rat tle model. |
2021-12-09 |
2023-08-13 |
rat |
| Edem Ekpenyong Edem, Blessing Eghosa Ihaza, Adedamola Adediran Fafure, Azeez Olakunle Ishola, Kate Eberechukwu Nebo, Linus Anderson Enye, Elizabeth Toyin Akinluy. Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice. Drug metabolism and personalized therapy. 2021-12-09. PMID:34881837. |
virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, gabaergic and glutamatergic receptors in mice. |
2021-12-09 |
2023-08-13 |
mouse |
| Cosimo Prestigio, Daniele Ferrante, Antonella Marte, Alessandra Romei, Gabriele Lignani, Franco Onofri, Pierluigi Valente, Fabio Benfenati, Pietro Baldell. REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion. eLife. vol 10. 2021-12-08. PMID:34855580. |
here, we show that hyperactivity-induced rest/nrsf activation, triggers a homeostatic rearrangement of gabaergic inhibition, with increased frequency of miniature inhibitory postsynaptic currents (ipscs) and amplitude of evoked ipscs in mouse cultured hippocampal neurons. |
2021-12-08 |
2023-08-13 |
mouse |
| Célia Lentini, Marie d'Orange, Nicolás Marichal, Marie-Madeleine Trottmann, Rory Vignoles, Louis Foucault, Charlotte Verrier, Céline Massera, Olivier Raineteau, Karl-Klaus Conzelmann, Sylvie Rival-Gervier, Antoine Depaulis, Benedikt Berninger, Christophe Heinric. Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy. Cell stem cell. vol 28. issue 12. 2021-12-06. PMID:34592167. |
we addressed this question in the context of therapy-resistant mesial temporal lobe epilepsy (mtle), which is associated with hippocampal seizures and degeneration of hippocampal gabaergic interneurons. |
2021-12-06 |
2023-08-13 |
mouse |
| Célia Lentini, Marie d'Orange, Nicolás Marichal, Marie-Madeleine Trottmann, Rory Vignoles, Louis Foucault, Charlotte Verrier, Céline Massera, Olivier Raineteau, Karl-Klaus Conzelmann, Sylvie Rival-Gervier, Antoine Depaulis, Benedikt Berninger, Christophe Heinric. Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy. Cell stem cell. vol 28. issue 12. 2021-12-06. PMID:34592167. |
mtle mice with gabaergic ins show a significant reduction in both the number and cumulative duration of spontaneous recurrent hippocampal seizures. |
2021-12-06 |
2023-08-13 |
mouse |
| Melina Thetiot, Sean A Freeman, Thomas Roux, Anne-Laure Dubessy, Marie-Stéphane Aigrot, Quentin Rappeneau, François-Xavier Lejeune, Julien Tailleur, Nathalie Sol-Foulon, Catherine Lubetzki, Anne Desmaziere. An alternative mechanism of early nodal clustering and myelination onset in GABAergic neurons of the central nervous system. Glia. vol 68. issue 9. 2021-11-30. PMID:32119167. |
we previously described that node-like clusters can form prior to myelin deposition in hippocampal gabaergic neurons and are associated with increased conduction velocity. |
2021-11-30 |
2023-08-13 |
Not clear |
| Miquel Saumell-Esnaola, Sergio Barrondo, Gontzal García Del Caño, María Aranzazu Goicolea, Joan Sallés, Beat Lutz, Krisztina Monor. Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex. Molecules (Basel, Switzerland). vol 26. issue 22. 2021-11-30. PMID:34833992. |
the extent of the canonical gαi/o protein-dependent cb1 receptor signalling correlated with the abundance of cb1 receptor in the respective cell type (glutamatergic versus gabaergic neurons) both in frontal cortical and hippocampal synaptosomes. |
2021-11-30 |
2023-08-13 |
mouse |
| Olga Netsyk, Hayma Hammoud, Sergiy V Korol, Zhe Jin, Atieh S Tafreshiha, Bryndis Birni. Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis. Hippocampus. vol 30. issue 11. 2021-11-26. PMID:32533811. |
the results indicate that the tonic gabaergic inhibition is particularly strong in the ventral hippocampal dg granule cells and enhanced in the dorsal as compared to the ventral hippocampal ca3 pyramidal neurons. |
2021-11-26 |
2023-08-13 |
mouse |
| Yuki Kajita, Hajime Mushiak. Heterogeneous GAD65 Expression in Subtypes of GABAergic Neurons Across Layers of the Cerebral Cortex and Hippocampus. Frontiers in behavioral neuroscience. vol 15. 2021-11-23. PMID:34803625. |
heterogeneous gad65 expression in subtypes of gabaergic neurons across layers of the cerebral cortex and hippocampus. |
2021-11-23 |
2023-08-13 |
Not clear |
| b' Eda S\\xc3\\xbcnnet\\xc3\\xa7i, Volkan Solmaz, Oytun Erba\\xc5\\x9. Chronic Oxytocin treatment has long lasting therapeutic potential in a rat model of neonatal hypercapnic-hypoxia injury, through enhanced GABAergic signaling and by reducing hippocampal gliosis with its anti-inflammatory feature. Peptides. vol 135. 2021-11-19. PMID:33022295.' |
chronic oxytocin treatment has long lasting therapeutic potential in a rat model of neonatal hypercapnic-hypoxia injury, through enhanced gabaergic signaling and by reducing hippocampal gliosis with its anti-inflammatory feature. |
2021-11-19 |
2023-08-13 |
rat |
| Gulcan Semra Sahin, Jose Luis Rodriguez-Llamas, Crystal Dillon, Igor Medina, Suzanne M Appleyard, Jean-Luc Gaiarsa, Gary A Wayma. Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons. Science signaling. vol 14. issue 683. 2021-11-19. PMID:34006608. |
leptin increases gabaergic synaptogenesis through the rho guanine exchange factor β-pix in developing hippocampal neurons. |
2021-11-19 |
2023-08-13 |
Not clear |
| Gulcan Semra Sahin, Jose Luis Rodriguez-Llamas, Crystal Dillon, Igor Medina, Suzanne M Appleyard, Jean-Luc Gaiarsa, Gary A Wayma. Leptin increases GABAergic synaptogenesis through the Rho guanine exchange factor β-PIX in developing hippocampal neurons. Science signaling. vol 14. issue 683. 2021-11-19. PMID:34006608. |
the adipokine leptin is a satiety factor with neurotrophic actions, which potentiates both glutamatergic and gabaergic synaptogenesis in the hippocampus during neonatal development. |
2021-11-19 |
2023-08-13 |
Not clear |
| Laura B Tucker, Amanda H Fu, Joseph T McCab. Hippocampal-Dependent Cognitive Dysfunction following Repeated Diffuse Rotational Brain Injury in Male and Female Mice. Journal of neurotrauma. vol 38. issue 11. 2021-11-18. PMID:33622092. |
no changes in the density of gabaergic parvalbumin-expressing cells in the hippocampus, amygdala, or parietal cortex were found. |
2021-11-18 |
2023-08-13 |
mouse |
| Aliza T Ehrlich, Meriem Semache, Pierre Couvineau, Stefan Wojcik, Hiroyuki Kobayashi, Marcus Thelen, Florence Gross, Mireille Hogue, Christian Le Gouill, Emmanuel Darcq, Michel Bouvier, Brigitte L Kieffe. Ackr3-Venus knock-in mouse lights up brain vasculature. Molecular brain. vol 14. issue 1. 2021-11-18. PMID:34583741. |
in the brain there is notable ackr3 expression in endothelial vascular cells, hippocampal gabaergic interneurons and neuroblast neighboring cells. |
2021-11-18 |
2023-08-13 |
mouse |
| b' D Cunha-Reis, A Caulino-Rocha, P Correia-de-S\\xc3\\xa. VIPergic neuroprotection in epileptogenesis: challenges and opportunities. Pharmacological research. vol 164. 2021-11-12. PMID:33338622.' |
in the hippocampus, a brain area implicated in learning and memory, vip released from basket cells and/or interneuron-selective interneurons controls gabaergic transmission and pyramidal cell activity influencing hippocampal-dependent synaptic plasticity (long-term potentiation and long-term depression) and cognition. |
2021-11-12 |
2023-08-13 |
Not clear |
| Kayla M Shumate, Sadik T Tas, Ege T Kavalali, Ronald B Emeso. RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33894004. |
using mutant mouse lines engineered to solely express caps1 protein isoforms encoded by either the non-edited or edited cadps transcript, primary neuronal cultures from mouse hippocampus were used to explore the effect of cadps editing on neurotransmission and caps1 synaptic localization at both glutamatergic and gabaergic synapses. |
2021-11-12 |
2023-08-13 |
mouse |
| Juan Chen, Xiao-Lin Ma, Hui Zhao, Xiao-Yu Wang, Min-Xin Xu, Hua Wang, Tian-Qi Yang, Cheng Peng, Shuang-Shuang Liu, Man Huang, Yu-Dong Zhou, Yi She. Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission. Glia. vol 70. issue 1. 2021-11-11. PMID:34498776. |
here, we report that increasing hippocampal astrogenesis during development induces autistic-like behavior in mice and a concurrent decreased e/i ratio in the hippocampus that results from enhanced gabaergic transmission in ca1 pyramidal neurons. |
2021-11-11 |
2023-08-13 |
mouse |
| Amanda Kiemes, Felipe V Gomes, Diana Cash, Daniela L Uliana, Camilla Simmons, Nisha Singh, Anthony C Vernon, Federico Turkheimer, Cathy Davies, James M Stone, Anthony A Grace, Gemma Modino. GABA Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-11-07. PMID:34743200. |
gaba hippocampal hyperactivity driven by gabaergic interneuron deficits and nmda receptor hypofunction is associated with the hyperdopaminergic state often observed in schizophrenia. |
2021-11-07 |
2023-08-13 |
rat |
| Devon L Graham, Heather H Durai, Taylor S Trammell, Brenda L Noble, Douglas P Mortlock, Aurelio Galli, Gregg D Stanwoo. A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain. The Journal of comparative neurology. vol 528. issue 14. 2021-11-05. PMID:32170734. |
in most regions, glp-1r primarily colocalized with gabaergic neurons, except within some regions such as the hippocampus, where it was co-expressed in glutamatergic neurons. |
2021-11-05 |
2023-08-13 |
mouse |
| Jing Zhang, Lanyan Lin, Xiaoman Dai, Nai'an Xiao, Qinyong Ye, Xiaochun Che. ApoE4 increases susceptibility to stress-induced age-dependent depression-like behavior and cognitive impairment. Journal of psychiatric research. vol 143. 2021-11-02. PMID:34530340. |
stress induced a loss of gabaergic neurons and decline of reelin level in the prefrontal cortex (pfc) and in the dentate gyrus (dg) of the hippocampus in both 3-month-old and 8-month-old apoe-tr mice, which were more pronounced in the 8-month-old apoe4-tr mice. |
2021-11-02 |
2023-08-13 |
mouse |