| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi He, Lin Jiang, Yi Zhang, Hao Yang, Chun-Ni Zhou, Yu-Han Xie, Yan-Min Luo, Shan-Shan Zhang, Lin Zhu, Yi-Jing Guo, Yu-Hui Deng, Xin Liang, Qian Xiao, Lei Zhang, Jing Tang, Du-Juan Huang, Yu-Ning Zhou, Xiao-Yun Dou, Feng-Lei Chao, Yong Tan. Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice. Neurobiology of disease. vol 156. 2021-09-03. PMID:34044148. |
behavioral, stereology, immunohistochemistry and immunofluorescence analyses revealed that the anti-lingo-1 antibody significantly improved the cognitive abilities, promoted adult hippocampal neurogenesis (ahn), decreased the amyloid beta (aβ) deposition, enlarged the hippocampal volume, and increased the numbers of total neurons and gabaergic interneurons, including gabaergic and cck-gabaergic interneurons rich in cannabinoid type 1 receptor (cb1r), in the hippocampus of ad mice. |
2021-09-03 |
2023-08-13 |
mouse |
| Qi He, Lin Jiang, Yi Zhang, Hao Yang, Chun-Ni Zhou, Yu-Han Xie, Yan-Min Luo, Shan-Shan Zhang, Lin Zhu, Yi-Jing Guo, Yu-Hui Deng, Xin Liang, Qian Xiao, Lei Zhang, Jing Tang, Du-Juan Huang, Yu-Ning Zhou, Xiao-Yun Dou, Feng-Lei Chao, Yong Tan. Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice. Neurobiology of disease. vol 156. 2021-09-03. PMID:34044148. |
in contrast, this intervention significantly reduced the number of gabaergic interneurons expressing lingo-1 and cb1r in the hippocampus of ad mice. |
2021-09-03 |
2023-08-13 |
mouse |
| Qi He, Lin Jiang, Yi Zhang, Hao Yang, Chun-Ni Zhou, Yu-Han Xie, Yan-Min Luo, Shan-Shan Zhang, Lin Zhu, Yi-Jing Guo, Yu-Hui Deng, Xin Liang, Qian Xiao, Lei Zhang, Jing Tang, Du-Juan Huang, Yu-Ning Zhou, Xiao-Yun Dou, Feng-Lei Chao, Yong Tan. Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice. Neurobiology of disease. vol 156. 2021-09-03. PMID:34044148. |
more importantly, we also found a negative correlation between lingo-1 and cb1r on gabaergic interneurons in the hippocampus of ad mice, while the anti-lingo-1 antibody reversed this relationship. |
2021-09-03 |
2023-08-13 |
mouse |
| Qi He, Lin Jiang, Yi Zhang, Hao Yang, Chun-Ni Zhou, Yu-Han Xie, Yan-Min Luo, Shan-Shan Zhang, Lin Zhu, Yi-Jing Guo, Yu-Hui Deng, Xin Liang, Qian Xiao, Lei Zhang, Jing Tang, Du-Juan Huang, Yu-Ning Zhou, Xiao-Yun Dou, Feng-Lei Chao, Yong Tan. Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice. Neurobiology of disease. vol 156. 2021-09-03. PMID:34044148. |
the improvement in cognitive abilities may be attributed to the improvement in ahn, and in the numbers of gabaergic interneurons and cck-gabaergic interneurons rich in cb1rs in the hippocampus of ad mice induced by the anti-lingo-1 antibody. |
2021-09-03 |
2023-08-13 |
mouse |
| Anna S Berezovskaya, Sergey A Tyganov, Svetlana D Nikolaeva, Alexandra A Naumova, Natalia S Merkulyeva, Boris S Shenkman, Margarita V Glazov. Dynamic Foot Stimulations During Short-Term Hindlimb Unloading Prevent Dysregulation of the Neurotransmission in the Hippocampus of Rats. Cellular and molecular neurobiology. vol 41. issue 7. 2021-09-02. PMID:32683580. |
here we analyzed whether short-term simulated microgravity caused by 3-day hindlimb unloading (hu) will affect the glutamatergic and gabaergic systems of the hippocampus and how dynamic foot stimulation (dfs) to the plantar surface applied during hu can contribute in the regulation of hippocampus functioning. |
2021-09-02 |
2023-08-13 |
rat |
| Sachie Sasaki-Hamada, Yoshimichi Maeno, Mizuki Yabe, Hitoshi Ishibash. Neuromedin U modulates neuronal excitability in rat hippocampal slices. Neuropeptides. vol 89. 2021-08-30. PMID:34243110. |
these results suggest that the activation of nmu receptors contributes to gabaergic neuronal activity in the ca1 region of the hippocampus. |
2021-08-30 |
2023-08-13 |
rat |
| Adam Hamed, Miron Bartosz Kurs. Social deprivation substantially changes multi-structural neurotransmitter signature of social interaction: Glutamate concentration in amygdala and VTA as a key factor in social encounter-induced 50-kHz ultrasonic vocalization. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 37. 2021-08-26. PMID:32651127. |
our behavioral and neurochemical analysis indicated that social encounter was a triggering factor of the glutamatergic neurotransmission in the ventral tegmental area (vta), hippocampus, and amygdala; serotonergic neurotransmission in the nacc, cpu, and amygdala; the dopaminergic neurotransmission in the caudate putamen (cpu) and hippocampus; gabaergic neurotransmission in the hippocampus and vta. |
2021-08-26 |
2023-08-13 |
rat |
| Joan Jiménez-Balado, Teal S Eic. GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease. Seminars in cell & developmental biology. vol 116. 2021-08-23. PMID:33573856. |
finally, we outline a model of gabaergic dysfunction based on the results of functional neuroimaging studies in humans, which have shown hippocampal hyperactivity to episodic memory tasks concurrent with and even preceding ad diagnosis, along with factors that may modulate this association. |
2021-08-23 |
2023-08-13 |
human |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
the gabaergic septohippocampal pathway, responsible for hippocampal rhythmic activity, is preserved in j20/vlw mice, in contrast to single mutants. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
moreover, they suggest that a differential tau phosphorylation pattern in hippocampal interneurons prevents the loss of gabaergic septohippocampal innervation and alterations in local field potentials, thereby avoiding cognitive deficits. |
2021-08-23 |
2023-08-13 |
mouse |
| Sven Wagner, ChoongKu Lee, Lucia Rojas, Christian G Specht, JeongSeop Rhee, Nils Brose, Theofilos Papadopoulo. The α3 subunit of GABA The Journal of biological chemistry. vol 296. 2021-08-19. PMID:33901490. |
collybistin (cb), a brain-specific guanine nucleotide exchange factor, is essential for the formation of γ-aminobutyric acidergic (gabaergic) postsynapses in defined regions of the mammalian forebrain, including the hippocampus and basolateral amygdala. |
2021-08-19 |
2023-08-13 |
Not clear |
| Shane Antrobus, Brandon Pressly, Atefeh Mousavi Nik, Heike Wulff, Isaac N Pessa. Structure-Activity Relationship of Neuroactive Steroids, Midazolam, and Perampanel Toward Mitigating Tetramine-Triggered Activity in Murine Hippocampal Neuronal Networks. Toxicological sciences : an official journal of the Society of Toxicology. vol 180. issue 2. 2021-08-18. PMID:33483729. |
murine hippocampal neuronal/glial cocultures develop extensive dendritic connectivity between glutamatergic and gabaergic inputs and display two distinct sco patterns when imaged with the ca2+ indicator fluo-4: low amplitude sco events (lase) and high amplitude sco events (hase) that are dependent on ttx-sensitive network electrical spike activity (esa). |
2021-08-18 |
2023-08-13 |
Not clear |
| Sang Hun Lee, Vadim Y Bolshakov, Jie She. Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34034776. |
in the current study, we investigate ps function in gabaergic neurons by performing whole-cell and field-potential electrophysiological recordings using acute hippocampal slices from inhibitory neuron-specific ps conditional double knockout (in-ps cdko) mice at 2 months of age, before the onset of age-dependent loss of interneurons. |
2021-08-12 |
2023-08-13 |
mouse |
| Pierre Lecouflet, Candice M Roux, Brigitte Potier, Marianne Leger, Elie Brunet, Jean-Marie Billard, Pascale Schumann-Bard, Thomas Frere. Interplay between 5-HT4 Receptors and GABAergic System within CA1 Hippocampal Synaptic Plasticity. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-08-11. PMID:32935845. |
interplay between 5-ht4 receptors and gabaergic system within ca1 hippocampal synaptic plasticity. |
2021-08-11 |
2023-08-13 |
Not clear |
| Raul Chavez-Valdez, Charles Lechner, Paul Emerson, Frances J Northington, Lee J Marti. Accumulation of PSA-NCAM marks nascent neurodegeneration in the dorsal hippocampus after neonatal hypoxic-ischemic brain injury in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 41. issue 5. 2021-07-29. PMID:32703109. |
neonatal hypoxia-ischemia (nhi) disrupts hippocampal gabaergic development leading to memory deficits in mice. |
2021-07-29 |
2023-08-13 |
mouse |
| Manana G Dashniani, Maia A Burjanadze, Nino C Chkhikvishvili, Revaz O Solomonia, Manana Kandashvili, Temur L Naneishvili, Gela V Beselia, Lali B Kruashvili, Mariam R Chighladz. Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32770352. |
modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and gabaergic neurons. |
2021-07-28 |
2023-08-13 |
rat |
| Manana G Dashniani, Maia A Burjanadze, Nino C Chkhikvishvili, Revaz O Solomonia, Manana Kandashvili, Temur L Naneishvili, Gela V Beselia, Lali B Kruashvili, Mariam R Chighladz. Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32770352. |
therefore, we investigated spatial memory and the expression level of cholinergic (α7 nach and m1), gabaergic (α1 subunit of gabaa) and glutamatergic (nr2b subunit of nmda and glur 1 subunit of ampa) receptors in the hippocampus following selective lesions of cholinergic and gabaergic septo-hippocampal projection. |
2021-07-28 |
2023-08-13 |
rat |
| Manana G Dashniani, Maia A Burjanadze, Nino C Chkhikvishvili, Revaz O Solomonia, Manana Kandashvili, Temur L Naneishvili, Gela V Beselia, Lali B Kruashvili, Mariam R Chighladz. Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32770352. |
western blot analyses revealed the ms cholinergic lesions have significant effect on the expression level of the m1 mach receptors, while ms gabaergic lesions induce dramatic modulations of hippocampal glutamatergic, cholinergic and gabaergic receptors expression. |
2021-07-28 |
2023-08-13 |
rat |
| Manana G Dashniani, Maia A Burjanadze, Nino C Chkhikvishvili, Revaz O Solomonia, Manana Kandashvili, Temur L Naneishvili, Gela V Beselia, Lali B Kruashvili, Mariam R Chighladz. Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32770352. |
these results for the first time demonstrated that selective lesions of ms cholinergic and gabaergic neurons differentially affect long-term spatial memory and the memory deficit after ms gabaergic lesion is paralleled with significant changes of hippocampal glutamate, gaba and acetylcholine receptors expression. |
2021-07-28 |
2023-08-13 |
rat |
| Yong Wang, Xiao-Yu Yin, Xue He, Chen-Mao Zhou, Jin-Chun Shen, Jian-Hua Ton. Parvalbumin interneuron-mediated neural disruption in an animal model of postintensive care syndrome: prevention by fluoxetine. Aging. vol 13. issue 6. 2021-07-22. PMID:33619236. |
accumulating evidence has demonstrated that hippocampal gabaergic interneuron dysfunction is implicated in various mood disorders induced by stress. |
2021-07-22 |
2023-08-13 |
human |