| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard M Meade, Kathryn J C Watt, Robert J Williams, Jody M Maso. A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding. Journal of molecular biology. vol 433. issue 24. 2021-11-30. PMID:34695381. |
importantly, our data demonstrate that the peptide does not directly disrupt αs lipid-binding, a desirable trait since antagonists of αs aggregation and toxicity should not impede association with small synaptic neurotransmitter vesicles, and thus not disrupt dopaminergic vesicle fusion and recycling. |
2021-11-30 |
2023-08-13 |
Not clear |
| Sanders A McDougall, Jasmine A M Robinson, Devon C Gleason, Laura L Cotte. Reciprocal cross-sensitization between cocaine and RU 24969 in male and female preweanling rats. Pharmacology, biochemistry, and behavior. vol 209. 2021-11-25. PMID:34437872. |
neuronal adaptations involving dopaminergic, glutamatergic, and serotonergic neurotransmitter systems are responsible for behavioral sensitization. |
2021-11-25 |
2023-08-13 |
rat |
| Tun-Wei Hsu, Jong-Ling Fuh, Da-Wei Wang, Li-Fen Chen, Chia-Jung Chang, Wen-Sheng Huang, Hsiu-Mei Wu, Wan-Yuo Gu. Disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686089. |
disrupted metabolic connectivity in dopaminergic and cholinergic networks at different stages of dementia from dementia is related to the cellular accumulation of β-amyloid plaques, tau aggregates, or α-synuclein aggregates, or to neurotransmitter deficiencies in the dopaminergic and cholinergic pathways. |
2021-11-22 |
2023-08-13 |
human |
| Nadine Huber, Sonja Korhonen, Dorit Hoffmann, Stina Leskelä, Hannah Rostalski, Anne M Remes, Paavo Honkakoski, Eino Solje, Annakaisa Haapasal. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches. Molecular psychiatry. 2021-11-20. PMID:34799692. |
changes in several neurotransmitter systems including the glutamatergic, gabaergic, dopaminergic, and serotonergic systems have been reported in ftld spectrum disease patients. |
2021-11-20 |
2023-08-13 |
Not clear |
| Aaron M Earley, Lena F Burbulla, Dimitri Krainc, Rajeshwar Awatraman. Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons. Scientific reports. vol 11. issue 1. 2021-11-19. PMID:34782629. |
ascl1 was identified as a necessary transcription factor for regulating dopaminergic neurotransmitter selection. |
2021-11-19 |
2023-08-13 |
human |
| Giuditta Pellino, Raffaella Faggioli, Anna Galuppi, Alberta Leon, Carlo Fusco, Valeria Tugnoli, Agnese Suppie. Mitofusin 2: The missing link between mtDNA maintenance defects and neurotransmitter disorders. Mitochondrion. vol 61. 2021-11-15. PMID:34600155. |
the relationship between mitochondrial dna (mtdna) maintenance defects and dopaminergic neurotransmitter disorders, governed by mfn2, is discussed. |
2021-11-15 |
2023-08-13 |
Not clear |
| Angela M Thomas, Kaley J Cargile, Jannelle A Lunn, Lisa E Bake. Characterization of 3,4-methylenedioxypyrovalerone discrimination in female Sprague-Dawley rats. Behavioural pharmacology. vol 32. issue 6. 2021-11-05. PMID:34397448. |
moreover, they confirm the contribution of dopaminergic mechanisms but do not rule out the possible contribution of other neurotransmitter actions to the interoceptive stimulus effects of mdpv. |
2021-11-05 |
2023-08-13 |
rat |
| Valentina Bashkatov. Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity. World journal of psychiatry. vol 11. issue 10. 2021-11-05. PMID:34733645. |
pd is primarily caused by dysfunction of dopaminergic neurons; however, other neurotransmitter systems are also involved. |
2021-11-05 |
2023-08-13 |
Not clear |
| Juan Pérez-Fernández, Marta Barandela, Cecilia Jiménez-Lópe. The Dopaminergic Control of Movement-Evolutionary Considerations. International journal of molecular sciences. vol 22. issue 20. 2021-10-26. PMID:34681941. |
dopamine is likely the most studied modulatory neurotransmitter, in great part due to characteristic motor deficits in parkinson's disease that arise after the degeneration of the dopaminergic neurons in the substantia nigra |
2021-10-26 |
2023-08-13 |
Not clear |
| Trevor Archer, Marlene Oscar-Berman, Kenneth Blum, Mark Gol. Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry. Journal of genetic syndromes & gene therapy. vol 3. issue 3. 2021-10-21. PMID:23264884. |
brain-derived neurotrophic factor (bdnf) affects the development and integrity of the noradrenergic, dopaminergic, serotonergic, glutamatergic, and cholinergic neurotransmitter systems, and plasma levels of the neurotrophin are associated with both cognitive and aggressive impulsiveness. |
2021-10-21 |
2023-08-12 |
Not clear |
| S De Bruyne, T L Boos, L Wyffels, J L Goeman, K C Rice, F De Vo. Synthesis, radiosynthesis and in vivo evaluation of [I]-4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(4-iodobenzyl)piperidine as a selective tracer for imaging the dopamine transporter. Journal of labelled compounds & radiopharmaceuticals. vol 52. issue 8. 2021-10-20. PMID:19746191. |
dopamine transporter (dat) neuroimaging is a useful tool in parkinson's disease diagnosis, staging and follow-up providing information on the integrity of the dopaminergic neurotransmitter system in vivo. |
2021-10-20 |
2023-08-12 |
mouse |
| Ramani S Durvasula, Charles H Hinki. Neuropsychological Dysfunction among HIV Infected Drug Abusers. American journal of infectious diseases. vol 2. issue 2. 2021-10-20. PMID:20467580. |
damage to neurotransmitter systems including the dopaminergic, serotonergic and glutamatergic systems which are affected by both stimulant use and hiv is an alternate explanation. |
2021-10-20 |
2023-08-12 |
human |
| Paulina Gonzalez-Latapi, Nicolas Marotta, Niccolò E Mencacc. Emerging and converging molecular mechanisms in dystonia. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 4. 2021-10-15. PMID:33386558. |
examples of these advances are the recognition that multiple dyt-genes are involved in (1) endoplasmic reticulum function and regulation of the integrated stress response (isr) through eukaryotic initiation factor 2 alpha signaling; (2) gene transcription modulation during neurodevelopment; (3) pre-and post-synaptic nigrostriatal dopaminergic signaling; and (4) presynaptic neurotransmitter vesicle release. |
2021-10-15 |
2023-08-13 |
Not clear |
| Banashree Chetia Phukan, Ankumoni Dutta, Satarupa Deb, Rubul Saikia, Muhammed Khairujjaman Mazumder, Rajib Paul, Pallab Bhattacharya, Rajat Sandhir, Anupom Bora. Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson's disease: involvement of anti-inflammatory response. Experimental brain research. 2021-10-11. PMID:34633467. |
although the etiology of parkinson's disease (pd) is poorly understood, studies in animal models revealed loss of dopamine and the dopaminergic neurons harbouring the neurotransmitter to be the principal cause behind this neuro-motor disorder. |
2021-10-11 |
2023-08-13 |
mouse |
| Pavel A Markin, Alex Brito, Natalia E Moskaleva, Franco Tagliaro, Vadim V Tarasov, Michael R La Frano, Mark V Savitskii, Svetlana A Appolonov. Short- and medium-term exposures of diazepam induce metabolomic alterations associated with the serotonergic, dopaminergic, adrenergic and aspartic acid neurotransmitter systems in zebrafish (Danio rerio) embryos/larvae. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 38. 2021-10-04. PMID:33610025. |
short- and medium-term exposures of diazepam induce metabolomic alterations associated with the serotonergic, dopaminergic, adrenergic and aspartic acid neurotransmitter systems in zebrafish (danio rerio) embryos/larvae. |
2021-10-04 |
2023-08-13 |
zebrafish |
| Sara Dominguez, Eugene Varfolomeev, Robert Brendza, Kim Stark, Joy Tea, Jose Imperio, Hai Ngu, Timothy Earr, Oded Foreman, Joshua D Webster, Amy Easton, Domagoj Vucic, Baris Bingo. Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS. Cell death and differentiation. vol 28. issue 3. 2021-10-01. PMID:32994544. |
on the other hand, genetic inactivation of rip1 kinase activity ameliorated the depletion of the neurotransmitter dopamine in a toxin model of dopaminergic neurodegeneration. |
2021-10-01 |
2023-08-13 |
mouse |
| Miranda L Fisher, James R Pauly, Brett Froeliger, Jill R Turne. Translational Research in Nicotine Addiction. Cold Spring Harbor perspectives in medicine. vol 11. issue 6. 2021-09-29. PMID:32513669. |
likewise, translational studies investigating single-nucleotide polymorphisms (snps) within the cholinergic, dopaminergic, and opioid systems have found high levels of involvement of these neurotransmitter systems in regulating the reinforcing aspects of nicotine in both humans and mouse models. |
2021-09-29 |
2023-08-13 |
mouse |
| Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selen. Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical science. vol 12. issue 33. 2021-09-16. PMID:34522296. |
in this work, we combine molecular dynamics simulations, live-cell biosensor and electrophysiological assays to investigate the action of the neurotransmitter dopamine at the dopaminergic d |
2021-09-16 |
2023-08-13 |
Not clear |
| Débora Dreher Nabinger, Stefani Altenhofen, Júlia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Robert Gerlai, Carla Denise Bona. Feeding status alters exploratory and anxiety-like behaviors in zebrafish larvae exposed to quinpirole. Progress in neuro-psychopharmacology & biological psychiatry. vol 108. 2021-09-02. PMID:33212194. |
they showed that consumption of food, a naturally rewarding stimulus known to engage the dopaminergic system, made this neurotransmitter system more susceptible to quinpirole's effects. |
2021-09-02 |
2023-08-13 |
human |
| Auxiliadora Mena, Sandra López, Juan C Ruiz-Salas, Aarón Fernández, Francisco J Pérez-Díaz, Juan C Lópe. Sensitivity to amphetamine in prepulse inhibition response requires a mature medial prefrontal cortex. Behavioral neuroscience. vol 135. issue 1. 2021-09-02. PMID:33734732. |
nevertheless, this neurotransmitter could not be involved in the expression of ppi because the administration of a dopaminergic agonist was ineffective in pnd-28 period. |
2021-09-02 |
2023-08-13 |
rat |