| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kurt A Jellinge. The pathobiological basis of depression in Parkinson disease: challenges and outlooks. Journal of neural transmission (Vienna, Austria : 1996). 2022-11-02. PMID:36322206. |
although its diagnosis is based on standard criteria, due to overlap with other symptoms related to pd or to side effects of treatment, depression is frequently underdiagnosed and undertreated. dpd has been related to a variety of pathogenic mechanisms associated with the underlying neurodegenerative process, in particular dysfunction of neurotransmitter systems (dopaminergic, serotonergic and noradrenergic), as well as to disturbances of cortico-limbic, striato-thalamic-prefrontal, mediotemporal-limbic networks, with disruption in the topological organization of functional mood-related, motor and other essential brain network connections due to alterations in the blood-oxygen-level-dependent (bold) fluctuations in multiple brain areas. |
2022-11-02 |
2023-08-14 |
Not clear |
| Bo Zhang, Xijian Peng, Xiumei Sun, Yuanming Guo, Tiejun L. Environmentally-relevant concentrations of the antipsychotic drugs sulpiride and clozapine induce abnormal dopamine and serotonin signaling in zebrafish brain. Scientific reports. vol 12. issue 1. 2022-10-26. PMID:36289270. |
hence, the aim of this study was to investigate the effect of environmentally-relevant concentrations of the antipsychotic drugs, sulpiride and clozapine, on dopaminergic (daergic) and serotonergic (5-htergic) neurotransmitter systems in the brain of zebrafish. |
2022-10-26 |
2023-08-14 |
zebrafish |
| Ruiqing N. PET imaging in animal models of Parkinson's disease. Behavioural brain research. 2022-10-25. PMID:36283568. |
this review focuses on the development of new positron emission tomography tracers and studies of alpha-synuclein, synaptic vesicle glycoprotein 2a, neurotransmitter receptor deficits such as dopaminergic receptor, dopaminergic transporter, serotonergic receptor, vesicular monoamine transporter 2, hypometabolism, neuroinflammation, mitochondrial dysfunction and leucine rich repeat kinase 2 in animal models of parkinson's disease. |
2022-10-25 |
2023-08-14 |
Not clear |
| Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshah. The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson's disease. Frontiers in neuroscience. vol 16. 2022-10-24. PMID:36278000. |
furthermore, ample preclinical and clinical evidence indicates that dbs influences neurotransmitter dynamics in pd, particularly the effects of subthalamic nucleus (stn) dbs on striatal dopaminergic and glutamatergic systems; pallidum dbs on striatal dopaminergic and gabaergic systems; pedunculopontine nucleus dbs on cholinergic systems; and stn-dbs on locus coeruleus (lc) noradrenergic system. |
2022-10-24 |
2023-08-14 |
Not clear |
| Dmitry Troshev, Alyona Bannikova, Victor Blokhin, Anna Kolacheva, Tatiana Pronina, Michael Ugrumo. Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232359. |
in this study, it was shown that in transgenic mice expressing green fluorescent protein (gfp) under the tyrosine hydroxylase (th) gene promoter, (i) there are striatal neurons expressing only th, only aromatic l-amino acid decarboxylase (aadc), or both enzymes of dopamine synthesis; (ii) striatal neurons expressing dopamine-synthesizing enzymes are not dopaminergic since they lack a dopamine transporter; (iii) monoenzymatic neurons expressing individual complementary dopamine-synthesizing enzymes produce this neurotransmitter in cooperation; (iv) striatal nerve fibers containing only th, only aadc, or both enzymes project into the lateral ventricles, providing delivery pathways for l-3,4-dihydroxyphenylalanine and dopamine to the cerebrospinal fluid; and (v) striatal gfp neurons express receptor genes for various signaling molecules, i.e., classical neurotransmitters, neuropeptides, and steroids, indicating fine regulation of these neurons. |
2022-10-14 |
2023-08-14 |
mouse |
| Yuanyan Zi, Justin R Barker, Hugh J MacIsaac, Ruihan Zhang, Robin Gras, Ying-Chih Chiang, Yuan Zhou, Fangchi Lu, Wenwen Cai, Chunxiao Sun, Xuexiu Chan. Identification of neurotoxic compounds in cyanobacteria exudate mixtures. The Science of the total environment. 2022-10-08. PMID:36208737. |
cholinergic, dopaminergic and serotonergic neurotransmitter systems). |
2022-10-08 |
2023-08-14 |
Not clear |
| Angeliki Zarkali, Andrea I Luppi, Emmanuel A Stamatakis, Suzanne Reeves, Peter McColgan, Louise-Ann Leyland, Andrew J Lees, Rimona S Wei. Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease. Communications biology. vol 5. issue 1. 2022-09-08. PMID:36075964. |
the regional energy needed for this transition was correlated with regional neurotransmitter density and gene expression for serotoninergic, gabaergic, noradrenergic and cholinergic, but not dopaminergic, receptors. |
2022-09-08 |
2023-08-14 |
Not clear |
| Domiziana Rinaldi, Marika Alborghetti, Edoardo Bianchini, Michela Sforza, Silvia Galli, Francesco E Pontier. Monoamine-Oxidase type B- Inhibitors and Cognitive Functions in Parkinson's Disease: Beyond the Primary Mechanism of Action. Current neuropharmacology. 2022-09-06. PMID:36065929. |
worsening of cognitive symptoms in pd patients depends on the progression of subcortical dopaminergic damage as well as the involvement of other brain neurotransmitter systems in cortical and subcortical regions. |
2022-09-06 |
2023-08-14 |
human |
| Elena E Vaiman, Natalia A Shnayder, Aiperi K Khasanova, Anna I Strelnik, Arseny J Gayduk, Mustafa Al-Zamil, Margarita R Sapronova, Natalia G Zhukova, Daria A Smirnova, Regina F Nasyrov. Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009557. |
one of the causes of dip is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, gabaergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. |
2022-08-26 |
2023-08-14 |
Not clear |
| Shahram Zarrabian, Shole Jamali, Soheila Fazli-Tabaei, Abbas Haghparas. Dopaminergic and nitric oxide systems interact to regulate the electrical activity of neurons in the medial septal nucleus in rats. Experimental brain research. 2022-08-17. PMID:35976391. |
these results contribute to our understanding of the complex neurotransmitter interactions in the m-sept and showed that both dopaminergic and no neurotransmission are involved in the modulation of the firing rate of neurons in the m-sept. |
2022-08-17 |
2023-08-14 |
rat |
| Ziqian Cheng, Jingyun Su, Kai Zhang, Huiyi Jiang, Bingjin L. Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems. Frontiers in cell and developmental biology. vol 10. 2022-07-22. PMID:35865627. |
many reports indicate that different types of els induce epigenetic modifications of genes involved in the neurotransmitter systems, such as the dopaminergic system, the serotonergic system, the gamma-aminobutyric acid (gaba)-ergic system, and the glutamatergic system, which further regulate gene expression and ultimately induce depression-like behaviors. |
2022-07-22 |
2023-08-14 |
Not clear |
| Natalia Juliá-Palacios, Cristina Molina-Anguita, María Sigatulina Bondarenko, Elisenda Cortès-Saladelafont, Javier Aparicio, Daniel Cuadras, Gabriella Horvath, Carmen Fons, Rafael Artuch, Àngels García-Cazorl. Monoamine neurotransmitters in early epileptic encephalopathies: New insights into pathophysiology and therapy. Developmental medicine and child neurology. vol 64. issue 7. 2022-07-14. PMID:35833444. |
to study neurotransmitter status in children with early epileptic and developmental and epileptic encephalopathy (dee) and to explore the clinical response to dopaminergic and serotoninergic therapies in a group of patients. |
2022-07-14 |
2023-08-14 |
Not clear |
| Dongyue Lin, Zhonghao Wang, Wei Chen, Tao Shen, Xuan Qiu, Kun Wei, Jiahui Li, Dongsheng Yang, Ping Wang, Xuri Li, Jianhua Yan, Zhongshu Tan. Regional Downregulation of Dopamine Receptor D1 in Bilateral Dorsal Lateral Geniculate Nucleus of Monocular Form-Deprived Amblyopia Models. Frontiers in neuroscience. vol 16. 2022-06-27. PMID:35757538. |
interestingly, a particular neurotransmitter pathway, the dopaminergic pathway, was identified. |
2022-06-27 |
2023-08-14 |
Not clear |
| R Goldberg Lisa, J Gould Thoma. "Genetic influences impacting nicotine use and abuse during adolescence: insights from human and rodent studies". Brain research bulletin. 2022-06-23. PMID:35738503. |
human adolescent studies have largely included candidate gene studies for genes identified in adult populations, such as genes involved in nicotine metabolism, nicotinic acetylcholine receptor signaling, dopaminergic signaling, and other neurotransmitter signaling systems. |
2022-06-23 |
2023-08-14 |
human |
| Jaromir Myslivece. Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors. Life (Basel, Switzerland). vol 12. issue 5. 2022-05-28. PMID:35629274. |
the dopaminergic system is one of the most important neurotransmitter systems in the central nervous system (cns). |
2022-05-28 |
2023-08-13 |
Not clear |
| Sofia Elizarova, Abed Alrahman Chouaib, Ali Shaib, Björn Hill, Florian Mann, Nils Brose, Sebastian Kruss, James A Danie. A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 22. 2022-05-25. PMID:35613050. |
significancethe neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. |
2022-05-25 |
2023-08-13 |
Not clear |
| Robert M Wadolowski, Irene C Solomo. Basal and Hypoxic Respiratory Behaviors in Aged 6-OHDA-Induced SN Lesion PD Rat Model: Effects of the 5-HT FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556437. |
while this model results in the loss of dopaminergic neurons and the subsequent changes in downstream neurotransmitter signaling that are characteristic of pd, it does not consider potential contributions of physical changes to the brain and neurotransmitter signaling that are part of normal aging on the progression of pd. |
2022-05-13 |
2023-08-13 |
rat |
| Frederic Sampedro, Saul Martínez-Horta, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsk. Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson's Disease. Journal of Parkinson's disease. 2022-05-02. PMID:35491803. |
among the multiple neurotransmitter alterations that have been associated with apathy, the involvement of extra-striatal dopaminergic degeneration remains to be fully explored. |
2022-05-02 |
2023-08-13 |
Not clear |
| Beth Fairfield, Caterina Padulo, Nicola Mammarella, Sara Fontanella, Annalina Sarra, Fani Konstantinidou, Liborio Stuppia, Valentina Gatt. Dopamine-related polymorphisms and Affective Working Memory in aging. Neurobiology of learning and memory. 2022-04-26. PMID:35472439. |
the neurotransmitter dopamine (da) is a key regulatory component of executive functioning and dysfunction in dopaminergic circuity has been shown to result in impaired working memory. |
2022-04-26 |
2023-08-13 |
human |
| Béla Kiss, Balázs Krámos, István Laszlovszk. Potential Mechanisms for Why Not All Antipsychotics Are Able to Occupy Dopamine D Frontiers in psychiatry. vol 13. 2022-04-11. PMID:35401257. |
the first line of treatment of schizophrenia are antipsychotics, a class of medications that targets several neurotransmitter receptors in the brain, including dopaminergic, serotonergic, adrenergic and/or muscarinic receptors, depending on the given agent. |
2022-04-11 |
2023-08-13 |
Not clear |