| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arantzazu Belloso-Iguerategui, Marta Zamarbide, Leyre Merino-Galan, Tatiana Rodríguez-Chinchilla, Belén Gago, Enrique Santamaria, Joaquín Fernández-Irigoyen, Carl W Cotman, G Aleph Prieto, Ana Quiroga-Varela, María Cruz Rodríguez-Oro. Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit. Brain : a journal of neurology. 2023-07-04. PMID:37403195. |
our results not only point to dopaminergic but also to glutamatergic and gabaergic dysfunction, highlighting the relevance of the three neurotransmitter systems in the ventral tegmental area-hippocampus interaction from the earliest stages of parkinsonism. |
2023-07-04 |
2023-08-14 |
human |
| Mallikarjuna Nimgampalle, Harshini Chakravarthy, Sapana Sharma, Shruti Shree, Anoop Ramachandra Bhat, Jangampalli Adi Pradeepkiran, Vasudharani Devanatha. Neurotransmitter Systems in the Etiology of Major Neurological Disorders: Emerging Insights and Therapeutic Implications. Ageing research reviews. 2023-06-29. PMID:37385351. |
neurotransmitter systems are classified as cholinergic, glutamatergic, gabaergic, dopaminergic, serotonergic, histaminergic, or aminergic systems, depending on the type of neurotransmitter secreted by the neuron, allowing effector organs to carry out specific functions by sending nerve impulses. |
2023-06-29 |
2023-08-14 |
Not clear |
| Artem Savchenko, Giorgia Targa, Zoia Fesenko, Damiana Leo, Raul R Gainetdinov, Ilya Sukhano. Dopamine Transporter Deficient Rodents: Perspectives and Limitations for Neuroscience. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238676. |
the administration of dopaminergic and pharmacological agents affecting other neurotransmitter systems can mitigate those abnormalities. |
2023-05-27 |
2023-08-14 |
Not clear |
| Ying Li, Chiao-Chun Chang, Chu Wang, Wen-Ti Wu, Chih-Min Wang, Hsiung-Lin T. Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection. ACS sensors. 2023-05-08. PMID:37155824. |
dopamine (da) is a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
| Joanne Ng, Serena Barral, Simon N Waddington, Manju A Kuria. Gene Therapy for Dopamine Dyshomeostasis: From Parkinson's to Primary Neurotransmitter Diseases. Movement disorders : official journal of the Movement Disorder Society. 2023-05-06. PMID:37147851. |
here, we review recent advances in gene therapy, focused on the targeted delivery of dopaminergic genes for parkinson's disease and the primary neurotransmitter disorders, aadc deficiency and dopamine transporter deficiency syndrome (dtds). |
2023-05-06 |
2023-08-14 |
Not clear |
| Toni Kühl, Maya G Georgieva, Harald Hübner, Maria Lazarova, Matthias Vogel, Bodo Haas, Martina I Peeva, Aneliya A Balacheva, Ivan P Bogdanov, Luigi Milella, Maria Ponticelli, Tsvetomir Garev, Immacolata Faraone, Roumyana Detcheva, Borislav Minchev, Polina Petkova-Kirova, Lyubka Tancheva, Reni Kalfin, Atanas G Atanasov, Liudmil Antonov, Tamara I Pajpanova, Kiril Kirilov, Marcus Gastreich, Peter Gmeiner, Diana Imhof, Nikolay T Tzvetko. Neurotensin(8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease. European journal of medicinal chemistry. vol 254. 2023-04-24. PMID:37094450. |
the modulatory interactions between neurotensin (nt) and the dopaminergic neurotransmitter system in the brain suggest that nt may be associated with the progression of parkinson's disease (pd). |
2023-04-24 |
2023-08-14 |
mouse |
| Marianne Oldehinkel, Jeggan Tiego, Kristina Sabaroedin, Sidhant Chopra, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Christos Pantelis, Stephen J Wood, Patrick McGorry, Mark A Bellgrove, Alex Fornit. Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy. Translational psychiatry. vol 13. issue 1. 2023-04-18. PMID:37072388. |
disruption of the presumed dopaminergic gradient was only noticeable in patients, suggesting that neurotransmitter dysfunction may be more apparent to clinical illness. |
2023-04-18 |
2023-08-14 |
Not clear |
| Peter Riederer, Toshiharu Nagatsu, Moussa B H Youdim, Max Wulf, Johannes M Dijkstra, Jeswinder Sian-Huelsman. Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-04-16. PMID:37062012. |
however, more recent pd research demonstrates that (i) lbs are detected not only in dopaminergic neurons and glia but in various neurotransmitter systems, (ii) sympathetic nerve fibres degenerate first, and (iii) at least in "brain-first" cases dopaminergic deficiency is evident before pathology induced by iron and nm. |
2023-04-16 |
2023-08-14 |
Not clear |
| Jiangbo Ying, Qian Hui Chew, Roger S McIntyre, Kang Si. Treatment-Resistant Schizophrenia, Clozapine Resistance, Genetic Associations, and Implications for Precision Psychiatry: A Scoping Review. Genes. vol 14. issue 3. 2023-03-29. PMID:36980961. |
extant evidence comprised associations between trs and clozapine resistance with genetic factors related to mainly dopaminergic and serotoninergic neurotransmitter systems, specifically, trs and rs4680, rs4818 within comt, and rs1799978 within drd2; clozapine resistance and drd3 polymorphisms, cyp1a2 polymorphisms; weight gain with lep and snap-25 genes; and agranulocytosis risk with hla-related polymorphisms. |
2023-03-29 |
2023-08-14 |
Not clear |
| Daniela Vázquez-González, Sonia Carreón-Trujillo, Lourdes Alvarez-Arellano, Daniela Melissa Abarca-Merlin, Pablo Domínguez-López, Marcela Salazar-García, Juan Carlos Coron. A Potential Role for Neuroinflammation in ADHD. Advances in experimental medicine and biology. vol 1411. 2023-03-23. PMID:36949317. |
although increases in oxidative stress and disturbances of neurotransmitter system such as the dopaminergic and abnormalities in several brain regions have been demonstrated, the pathophysiology of adhd is not fully understood. |
2023-03-23 |
2023-08-14 |
Not clear |
| Débora Dreher Nabinger, Stefani Altenhofen, Alexis Buatois, Amanda Facciol, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Diptendu Chatterjee, Gabriel Rübensam, Robert Gerlai, Carla Denise Bona. Acute administration of a dopamine D2/D3 receptor agonist alters behavioral and neural parameters in adult zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 2023-03-19. PMID:36934998. |
the dopaminergic neurotransmitter system is implicated in several brain functions and behavioral processes. |
2023-03-19 |
2023-08-14 |
human |
| Elisa Giunti, Roberto Collu, Simona Dedoni, M Paola Castelli, Maria Scherma, Paola Fadd. Food restriction and hyperactivity induce changes in corticolimbic brain dopamine and serotonin levels in female rats. Behavioural brain research. 2023-03-02. PMID:36863461. |
these results provide further proof of the impairment of the dopaminergic and serotoninergic systems in the brain of aba rats and support the knowledge of the involvement of these two important neurotransmitter systems in the development and progression of an. |
2023-03-02 |
2023-08-14 |
rat |
| Tong-Tong Guo, Zheng Zhang, Yan Sun, Rui-Yang Zhu, Fei-Xia Wang, Lian-Ju Ma, Lin Jiang, Han-Deng Li. Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's Disease. Nutrients. vol 15. issue 4. 2023-02-25. PMID:36839287. |
nab improved the motor functioning of pd mice, increased striatal neurotransmitter levels, and reduced the death of dopaminergic neurons. |
2023-02-25 |
2023-08-14 |
mouse |
| Kevin R Duque, Joaquin A Vizcarra, Emily J Hill, Alberto J Espa. Disease-modifying vs symptomatic treatments: Splitting over lumping. Handbook of clinical neurology. vol 193. 2023-02-21. PMID:36803811. |
while this convergent approach has resulted in important successes in trials of symptomatic therapies, largely aimed at correcting common neurotransmitter deficiencies (e.g., cholinergic deficiency in alzheimer's disease or dopaminergic deficiency in parkinson's disease), it has been consistently futile in trials of neuroprotective or disease-modifying interventions. |
2023-02-21 |
2023-08-14 |
human |
| Ahmed Haider, Nehal H Elghazawy, Alyaa Dawood, Catherine Gebhard, Thomas Wichmann, Wolfgang Sippl, Marius Hoener, Ernest Arenas, Steven H Lian. Translational molecular imaging and drug development in Parkinson's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-02-10. PMID:36759912. |
in addition to dopaminergic imaging, serotonin transporter and n-methyl-d-aspartate (nmda) receptor probes are increasingly used as research tools to better understand the complexity of neurotransmitter dysregulation in pd. |
2023-02-10 |
2023-08-14 |
Not clear |
| Hu-Jiang Shi, Shuang Wang, Xin-Ping Wang, Rui-Xin Zhang, Li-Juan Zh. Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety. Neuroscience bulletin. 2023-01-21. PMID:36680709. |
studies of hippocampal neurotransmitter systems, including glutamatergic, gabaergic, cholinergic, dopaminergic, and serotonergic systems, have contributed to the interpretation of the underlying neural mechanisms of anxiety. |
2023-01-21 |
2023-08-14 |
Not clear |
| Enrico Premi, Juergen Dukart, Irene Mattioli, Ilenia Libri, Marta Pengo, Yasmine Gadola, Maria Cotelli, Rosa Manenti, Giuliano Binetti, Stefano Gazzina, Antonella Alberici, Mauro Magoni, Giacomo Koch, Roberto Gasparotti, Alessandro Padovani, Barbara Borron. Unravelling neurotransmitters impairment in primary progressive aphasias. Human brain mapping. 2023-01-17. PMID:36649260. |
in the present study, we applied juspace toolbox, which allowed for cross-modal correlation of magnetic resonance imaging (mri)-based measures with nuclear imaging derived estimates covering various neurotransmitter systems including dopaminergic, serotonergic, noradrenergic, gabaergic and glutamatergic neurotransmission. |
2023-01-17 |
2023-08-14 |
Not clear |
| Henrike Schol. From Natural Behavior to Drug Screening: Invertebrates as Models to Study Mechanisms Associated with Alcohol Use Disorders. Current topics in behavioral neurosciences. 2023-01-04. PMID:36598738. |
for example in drosophila melanogaster, the dopaminergic neurotransmitter system regulates the positive reinforcing properties of ethanol and in caenorhabditis elegans, serotonergic neurons regulate feeding behavior. |
2023-01-04 |
2023-08-14 |
caenorhabditis_elegans |
| Murad Al-Nusaif, Yushan Lin, Tianbai Li, Cheng Cheng, Weidong L. Advances in NURR1-Regulated Neuroinflammation Associated with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555826. |
in addition to playing a key role in developing and maintaining neurotransmitter phenotypes in dopaminergic neurons, nurr1 agonists have been shown to reverse behavioral and histological abnormalities in animal pd models. |
2022-12-23 |
2023-08-14 |
Not clear |
| Lisa Schwarz, Karan Sharma, Lorenzo D Dodi, Lara-Sophie Rieder, Petra Fallier-Becker, Nicolas Casadei, Julia C Fitzgeral. Miro1 R272Q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons. Frontiers in molecular neuroscience. vol 15. 2022-12-19. PMID:36533136. |
miro1 r272q disrupts mitochondrial calcium handling and neurotransmitter uptake in dopaminergic neurons. |
2022-12-19 |
2023-08-14 |
Not clear |