| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kurt A Jellinge. Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203667. |
the heterogeneity of cognitive phenotypes suggests that a common neuropathological process, characterized by progressive degeneration of the dopaminergic striatonigral system and of many other neuronal systems, results not only in structural deficits but also extensive changes of functional neuronal network activities and neurotransmitter dysfunctions. |
2024-01-11 |
2024-01-13 |
Not clear |
| Ryu Mochizuki, Yasumitsu Ogr. Determination of intracellular dopamine by liquid chromatography-fluorescence detection with post-column derivatization using the König reaction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1232. 2023-12-21. PMID:38128164. |
dopamine is an important neurotransmitter, and the disruption of dopaminergic homeostasis causes various neurological diseases such as parkinson's disease. |
2023-12-21 |
2023-12-24 |
Not clear |
| Nikolai I Novikov, Elena S Brazhnik, Valentina F Kitchigin. Pathological Correlates of Cognitive Decline in Parkinson's Disease: From Molecules to Neural Networks. Biochemistry. Biokhimiia. vol 88. issue 11. 2023-12-19. PMID:38105206. |
these changes can lead to the death of dopaminergic cells in the substantia nigra and affect the functioning of other neurotransmitter systems, thus disturbing neuronal networks involved in the transmission of information related to the regulation of motor activity and cognitive functions. |
2023-12-19 |
2023-12-21 |
Not clear |
| Laura Kubens, Ann-Kathrin Weishaupt, Vivien Michaelis, Isabelle Rohn, Fabian Mohr, Julia Bornhors. Exposure to the environmentally relevant fungicide Maneb: Studying toxicity in the soil nematode Caenorhabditis elegans. Environment international. vol 183. 2023-12-10. PMID:38071851. |
nevertheless, an alteration in the neurotransmitter homeostasis of dopamine, acetylcholine, and gamma-butyric acid (gaba) was observed as well as morphological changes in the dopaminergic neurons upon maneb exposure, which underlines the assumption of the neurotoxic potential of maneb. |
2023-12-10 |
2023-12-17 |
caenorhabditis_elegans |
| Antonino Natalello, Stefania Brocca, Erika Ponzini, Carlo Santambrogio, Rita Grandor. Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919088. |
dopaminergic neurons are constantly threatened by the thin boundaries between functional α-synuclein (as) structural disorder and pathogenic aggregation, and between dopamine (da) neurotransmitter activity and accumulation of cytotoxic by-products. |
2023-11-02 |
2023-11-08 |
Not clear |
| Olga Abramova, Anna Morozova, Eugene Zubkov, Valeria Ushakova, Yana Zorkina, Andrey T Proshin, Zinaida Storozheva, Olga Gurina, Vladimir Chekhoni. Ultrasound-Induced Prenatal Stress: New Possibilities for Modeling Mental Disorders. Developmental neuroscience. 2023-10-19. PMID:37857257. |
we also determined the activity of the serotonergic, dopaminergic, and noradrenergic neurotransmitter systems in the hippocampus and frontal cortex by hplc-ed. |
2023-10-19 |
2023-11-08 |
rat |
| Olga Abramova, Anna Morozova, Eugene Zubkov, Valeria Ushakova, Yana Zorkina, Andrey T Proshin, Zinaida Storozheva, Olga Gurina, Vladimir Chekhoni. Ultrasound-Induced Prenatal Stress: New Possibilities for Modeling Mental Disorders. Developmental neuroscience. 2023-10-19. PMID:37857257. |
us ps activated the serotonergic, dopaminergic, and noradrenergic neurotransmitter systems of the rat frontal cortex and hippocampus. |
2023-10-19 |
2023-11-08 |
rat |
| Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Floriana Volpicelli, Rosa Maria Piscitelli, Luisa Speranza, Carla Perrone-Capano, Umberto di Porzio, Massimiliano Caiazzo, Alessandro Martini, Cecilia Giacomet, Diego Medina, Rajeshwar Awatramani, Davide Viggiano, Mauro Federici, Nicola B Mercuri, Ezia Guatteo, Gian Carlo Bellench. miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes network. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-10-10. PMID:37816598. |
mir-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes network. |
2023-10-10 |
2023-10-15 |
mouse |
| Ahmed Faraz Khan, Quadri Adewale, Sue-Jin Lin, Tobias R Baumeister, Yashar Zeighami, Felix Carbonell, Nicola Palomero-Gallagher, Yasser Iturria-Medin. Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease. Nature communications. vol 14. issue 1. 2023-09-26. PMID:37752107. |
parkinson's disease involves multiple neurotransmitter systems beyond the classical dopaminergic circuit, but their influence on structural and functional alterations is not well understood. |
2023-09-26 |
2023-10-07 |
Not clear |
| Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim, Eng King Ta. Role of dopamine in the pathophysiology of Parkinson's disease. Translational neurodegeneration. vol 12. issue 1. 2023-09-17. PMID:37718439. |
da is the neurotransmitter of dopaminergic neurons. |
2023-09-17 |
2023-10-07 |
Not clear |
| Francisco Nieto-Escamez, Esteban Obrero-Gaitán, Irene Cortés-Pére. Visual Dysfunction in Parkinson's Disease. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626529. |
similarly, although the involvement of different neurotransmitter systems is controversial, data about neurochemical alterations related to visual impairments are presented, especially dopaminergic, cholinergic, and serotoninergic systems. |
2023-08-26 |
2023-09-07 |
Not clear |
| Ann-Kathrin Weishaupt, Laura Kubens, Lysann Ruecker, Tanja Schwerdtle, Michael Aschner, Julia Bornhors. A Reliable Method Based on Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Quantification of Neurotransmitters in Molecules (Basel, Switzerland). vol 28. issue 14. 2023-07-29. PMID:37513246. |
balance in neurotransmitter homeostasis is essential, and altered neurotransmitter levels are associated with various neurological disorders, e.g., loss of dopaminergic neurons (parkinson's disease) or altered ach synthesis (alzheimer's disease). |
2023-07-29 |
2023-08-14 |
Not clear |
| Kurt A Jellinge. Depression in dementia with Lewy bodies: a critical update. Journal of neural transmission (Vienna, Austria : 1996). 2023-07-07. PMID:37418037. |
depression in dlb that is frequently underdiagnosed and undertreated, has been related to a variety of pathogenic mechanisms associated with the basic neurodegenerative process, in particular dysfunctions of neurotransmitter systems (decreased monoaminergic/serotonergic, noradrenergic and dopaminergic metabolism), α-synuclein pathology, synaptic zinc dysregulation, proteasome inhibition, gray matter volume loss in prefrontal and temporal areas as well as dysfunction of neuronal circuits with decreased functional connectivity of specific brain networks. |
2023-07-07 |
2023-08-14 |
Not clear |
| Kurt A Jellinge. Mild cognitive impairment in dementia with Lewy bodies: an update and outlook. Journal of neural transmission (Vienna, Austria : 1996). 2023-07-07. PMID:37418039. |
biomarkers are slowing of the eeg rhythms, atrophy of hippocampus and nucleus basalis of meynert, temporoparietal hypoperfusion, signs of degeneration of the nigrostriatal dopaminergic, cholinergic and other neurotransmitter systems, and inflammation. |
2023-07-07 |
2023-08-14 |
Not clear |
| Arantzazu Belloso-Iguerategui, Marta Zamarbide, Leyre Merino-Galan, Tatiana Rodríguez-Chinchilla, Belén Gago, Enrique Santamaria, Joaquín Fernández-Irigoyen, Carl W Cotman, G Aleph Prieto, Ana Quiroga-Varela, María Cruz Rodríguez-Oro. Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit. Brain : a journal of neurology. 2023-07-04. PMID:37403195. |
our results not only point to dopaminergic but also to glutamatergic and gabaergic dysfunction, highlighting the relevance of the three neurotransmitter systems in the ventral tegmental area-hippocampus interaction from the earliest stages of parkinsonism. |
2023-07-04 |
2023-08-14 |
human |
| Mallikarjuna Nimgampalle, Harshini Chakravarthy, Sapana Sharma, Shruti Shree, Anoop Ramachandra Bhat, Jangampalli Adi Pradeepkiran, Vasudharani Devanatha. Neurotransmitter Systems in the Etiology of Major Neurological Disorders: Emerging Insights and Therapeutic Implications. Ageing research reviews. 2023-06-29. PMID:37385351. |
neurotransmitter systems are classified as cholinergic, glutamatergic, gabaergic, dopaminergic, serotonergic, histaminergic, or aminergic systems, depending on the type of neurotransmitter secreted by the neuron, allowing effector organs to carry out specific functions by sending nerve impulses. |
2023-06-29 |
2023-08-14 |
Not clear |
| Artem Savchenko, Giorgia Targa, Zoia Fesenko, Damiana Leo, Raul R Gainetdinov, Ilya Sukhano. Dopamine Transporter Deficient Rodents: Perspectives and Limitations for Neuroscience. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238676. |
the administration of dopaminergic and pharmacological agents affecting other neurotransmitter systems can mitigate those abnormalities. |
2023-05-27 |
2023-08-14 |
Not clear |
| Ying Li, Chiao-Chun Chang, Chu Wang, Wen-Ti Wu, Chih-Min Wang, Hsiung-Lin T. Microfluidic Biosensor Decorated with an Indium Phosphate Nanointerface for Attomolar Dopamine Detection. ACS sensors. 2023-05-08. PMID:37155824. |
dopamine (da) is a major neurotransmitter released by dopaminergic neurons and has huge implications in neurodegenerative diseases. |
2023-05-08 |
2023-08-14 |
Not clear |
| Joanne Ng, Serena Barral, Simon N Waddington, Manju A Kuria. Gene Therapy for Dopamine Dyshomeostasis: From Parkinson's to Primary Neurotransmitter Diseases. Movement disorders : official journal of the Movement Disorder Society. 2023-05-06. PMID:37147851. |
here, we review recent advances in gene therapy, focused on the targeted delivery of dopaminergic genes for parkinson's disease and the primary neurotransmitter disorders, aadc deficiency and dopamine transporter deficiency syndrome (dtds). |
2023-05-06 |
2023-08-14 |
Not clear |
| Toni Kühl, Maya G Georgieva, Harald Hübner, Maria Lazarova, Matthias Vogel, Bodo Haas, Martina I Peeva, Aneliya A Balacheva, Ivan P Bogdanov, Luigi Milella, Maria Ponticelli, Tsvetomir Garev, Immacolata Faraone, Roumyana Detcheva, Borislav Minchev, Polina Petkova-Kirova, Lyubka Tancheva, Reni Kalfin, Atanas G Atanasov, Liudmil Antonov, Tamara I Pajpanova, Kiril Kirilov, Marcus Gastreich, Peter Gmeiner, Diana Imhof, Nikolay T Tzvetko. Neurotensin(8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease. European journal of medicinal chemistry. vol 254. 2023-04-24. PMID:37094450. |
the modulatory interactions between neurotensin (nt) and the dopaminergic neurotransmitter system in the brain suggest that nt may be associated with the progression of parkinson's disease (pd). |
2023-04-24 |
2023-08-14 |
mouse |