| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A C Z Baso, F C Goulart, E Teodorov, L F Felício, M M Bernard. Effects of maternal exposure to picrotoxin during lactation on physical and reflex development, square crossing and sexual behavior of rat offspring. Pharmacology, biochemistry, and behavior. vol 75. issue 4. 2004-04-13. PMID:12957213. |
three hypotheses were proposed to explain the mechanisms underlying this effect: (1) the development of subsensitivity of gabaergic receptors, (2) an interference with early receptor development or (3) with neurotransmitter balance, mainly involving the dopaminergic system. |
2004-04-13 |
2023-08-12 |
rat |
| Amani E Khalif. Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 75. issue 4. 2004-04-13. PMID:12957216. |
the neurocognitive profile of zuclopenthixol, a thioxanthene dopaminergic antagonist and a conventional neuroleptic agent, has yet to be investigated despite the effect of the drug on a variety of neurotransmitter systems involved in mediation of learning and memory processes. |
2004-04-13 |
2023-08-12 |
rat |
| Klaus L Leender. Significance of non-presynaptic SPECT tracer methods in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 18 Suppl 7. 2004-03-29. PMID:14531045. |
tropane-related tracers for spect and pet scanning have shown their value in assessing the in vivo striatal presynaptic status of the dopaminergic neurotransmitter system in man. |
2004-03-29 |
2023-08-12 |
Not clear |
| Gesine Paul, Wassilios Meissner, Susanne Rein, Daniel Harnack, Christine Winter, Kai Hosmann, Rudolf Morgenstern, Andreas Kupsc. Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease. Experimental neurology. vol 185. issue 2. 2004-03-02. PMID:14736508. |
we conclude that subthalamic nucleus ablation exerts neuroprotective properties on the dopaminergic nigrostriatal pathway against 6-hydroxydopamine toxicity in terms of rescuing the neurotransmitter phenotype in the remaining neurons rather than enhancing the total number of nigral cells. |
2004-03-02 |
2023-08-12 |
rat |
| Uriel Heresco-Lev. Glutamatergic neurotransmission modulation and the mechanisms of antipsychotic atypicality. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 7. 2004-02-24. PMID:14642971. |
the neurotransmission mediated by the excitatory amino acids (eaa) glutamate (glu) and aspartate is of interest to the pharmacotherapy of psychosis due to its role in neurodevelopment and neurotoxicity, its complex interactions with dopaminergic and other neurotransmitter systems and its pivotal importance in recent models of schizophrenia. |
2004-02-24 |
2023-08-12 |
Not clear |
| Torgny H Svensso. Alpha-adrenoceptor modulation hypothesis of antipsychotic atypicality. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 7. 2004-02-24. PMID:14642973. |
clozapine, as well as several other atypicals, displays significant affinities also for several other neurotransmitter receptors, including other dopaminergic receptors, alpha-adrenergic receptors and different serotonergic and cholinergic receptors, which in several ways may contribute to the clinical effectiveness of the drugs. |
2004-02-24 |
2023-08-12 |
Not clear |
| M Keitz, C Martin-Soelch, K L Leender. Reward processing in the brain: a prerequisite for movement preparation? Neural plasticity. vol 10. issue 1-2. 2004-02-18. PMID:14640313. |
the cerebral dopaminergic neurotransmitter circuitry does play an important role in the organization of both the motor and motivational system. |
2004-02-18 |
2023-08-12 |
human |
| Sk Jamaluddin, Mrinal K Podda. Brain regional gamma-aminobutyric acid (GABA) and locomotor activity: effect of long-term aldrin exposure. Polish journal of pharmacology. vol 55. issue 3. 2004-02-06. PMID:14506316. |
moreover, the studies of the interaction between neurotransmitters (using agonist(s) and antagonist(s) of the respective neurotransmitter receptors) showed that long-term administration of aldrin restored the la to control value by upregulation of central gabaergic activity through the interaction with dopaminergic and cholinergic systems. |
2004-02-06 |
2023-08-12 |
rat |
| Masahisa Yamada, Anthony S Basile, Irina Fedorova, Weilie Zhang, Alokesh Duttaroy, Yinghong Cui, Kathryn G Lamping, Frank M Faraci, Chu Xia Deng, Jürgen Wes. Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology. Life sciences. vol 74. issue 2-3. 2004-01-05. PMID:14607263. |
in addition, in vitro neurotransmitter release experiments indicated that m(5) receptors located on dopaminergic nerve terminals play a role in facilitating muscarinic agonist-induced dopamine release in the striatum, consistent with the observation that the dopaminergic neurons innervating the striatum almost exclusively express the m(5) receptor subtype. |
2004-01-05 |
2023-08-12 |
mouse |
| Simone M Smits, Tiia Ponnio, Orla M Conneely, J Peter H Burbach, Marten P Smid. Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622207. |
involvement of nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. |
2003-12-19 |
2023-08-12 |
mouse |
| Jenice D'Costa, Judith Harvey-White, Pankaj Qasba, Advait Limaye, Christine R Kaneski, Alberta Davis-Warren, Roscoe O Brady, Krys S Bankiewicz, Eugene O Major, Suresh K Ary. HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro. Journal of medical virology. vol 71. issue 2. 2003-11-25. PMID:12938190. |
parkinson's disease is a focal degeneration of dopaminergic neurons in the brain with progressive loss of ability to produce the neurotransmitter dopamine. |
2003-11-25 |
2023-08-12 |
Not clear |
| M Gruss, J Bock, K Brau. Haloperidol impairs auditory filial imprinting and modulates monoaminergic neurotransmission in an imprinting-relevant forebrain area of the domestic chick. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535951. |
these results indicate that the modulation of dopaminergic function and its interaction with other neurotransmitter systems in a higher associative forebrain region of the juvenile avian brain displays similar neurochemical characteristics as the adult mammalian prefrontal cortex. |
2003-11-24 |
2023-08-12 |
chicken |
| Francesco Benedetti, Alessandro Serretti, Cristina Colombo, Roberta Lilli, Cristina Lorenzi, Enrico Smerald. Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression. Psychiatry research. vol 118. issue 3. 2003-11-12. PMID:12834818. |
total sleep deprivation (tsd) is an effective treatment for mood disorders that is thought to act through an enhancement in several neurotransmitter pathways including dopaminergic transmission. |
2003-11-12 |
2023-08-12 |
Not clear |
| Mona Boules, Paul Fredrickson, Elliott Richelso. Current topics: brain penetrating neurotensin analog. Life sciences. vol 73. issue 22. 2003-10-23. PMID:14511764. |
it is closely associated with dopaminergic and other neurotransmitter systems, and evidence supports a role for nt in various neuropsychiatric disorders. |
2003-10-23 |
2023-08-12 |
Not clear |
| Keun-Ah Cheon, Young Hoon Ryu, Young-Kee Kim, Kee Namkoong, Chan-Hyung Kim, Jong Doo Le. Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 2. 2003-09-26. PMID:12552351. |
our findings support the complex dysregulation of the dopaminergic neurotransmitter system in children with adhd. |
2003-09-26 |
2023-08-12 |
Not clear |
| Cristina Bäckman, Zhi Bing You, Thomas Perlmann, Barry J Hoffe. Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine. Behavioural brain research. vol 143. issue 1. 2003-09-09. PMID:12842300. |
gene targeting experiments, in which both alleles of the nurr1 gene were deleted, have shown that this molecule plays an essential role in the development of midbrain dopaminergic neurons, as shown by the loss of dopaminergic markers and the neurotransmitter dopamine (da) in the ventral mesencephalon of nurr1 null mutant mice. |
2003-09-09 |
2023-08-12 |
mouse |
| Hung Fang, Joanne Chartier, Caroline Sodja, Angele Desbois, Maria Ribecco-Lutkiewicz, P Roy Walker, Marianna Sikorsk. Transcriptional activation of the human brain-derived neurotrophic factor gene promoter III by dopamine signaling in NT2/N neurons. The Journal of biological chemistry. vol 278. issue 29. 2003-08-27. PMID:12738784. |
this ability of da to regulate the expression of the bdnf survival factor has a profound significance for the nigrostriatal pathway, because it indicates the existence of a feedback loop between the neutrophin, which promotes both the maturation and survival of dopaminergic neurons, and the neurotransmitter, which the mature neurons ultimately produce and release. |
2003-08-27 |
2023-08-12 |
human |
| M Hansenne, E Pinto, G Scantamburlo, A Couvreur, J Reggers, S Fuchs, W Pitchot, M Anssea. Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects. Human psychopharmacology. vol 18. issue 3. 2003-08-22. PMID:12672172. |
however, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the mmn. |
2003-08-22 |
2023-08-12 |
human |
| b' Horst H Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgad\\xc3\\xb3, Lavinia Alber\\xc3\\xa. Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors. Annals of the New York Academy of Sciences. vol 991. 2003-08-04. PMID:12846972.' |
this requirement is specific to the midbrain dopaminergic neurons, since other populations of the same neurotransmitter phenotype develop normally in absence of the gene. |
2003-08-04 |
2023-08-12 |
human |
| M D Julian, A B Martin, B Cuellar, F Rodriguez De Fonseca, M Navarro, R Moratalla, L M Garcia-Segur. Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763090. |
our data suggest that the majority of the striatal cb1 receptors are located presynaptically on inhibitory gabaergic terminals, in a position to modulate neurotransmitter release and influence the activity of substantia nigra dopaminergic neurons. |
2003-07-28 |
2023-08-12 |
rat |