| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Dalfó, J L Albasanz, M Martin, I Ferre. Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions. Brain pathology (Zurich, Switzerland). vol 14. issue 4. 2005-02-14. PMID:15605986. |
several neurotransmitter abnormalities have been reported including those of the nigrostriatal and mesocorticolimbic dopaminergic system, and central noradrenergic, serotoninergic and cholinergic pathways. |
2005-02-14 |
2023-08-12 |
Not clear |
| G Skuza, K Wedzon. Behavioral pharmacology of sigma-ligands. Pharmacopsychiatry. vol 37 Suppl 3. 2005-02-04. PMID:15547784. |
although the precise mechanism of the functional response of these receptors is still uncertain, it is accepted that sigma receptors can modulate a number of central neurotransmitter systems, including noradrenergic, glutamatergic and dopaminergic ones. |
2005-02-04 |
2023-08-12 |
human |
| C L Kuo, R B Wang, L J Shen, L L Lien, E J Lie. G-protein coupled receptors: SAR analyses of neurotransmitters and antagonists. Journal of clinical pharmacy and therapeutics. vol 29. issue 3. 2005-01-06. PMID:15153091. |
from the deductive point of view, neurotransmitter receptors can be divided into categories such as cholinergic (muscarinic, nicotinic), adrenergic (alpha- and beta-), dopaminergic, serotoninergic (5-ht1 approximately 5-ht5), and histaminergic (h1 and h2). |
2005-01-06 |
2023-08-12 |
Not clear |
| Yitzchak Frank, Robert G Pergolizzi, Mindy J Perill. Dopamine D4 receptor gene and attention deficit hyperactivity disorder. Pediatric neurology. vol 31. issue 5. 2005-01-03. PMID:15519116. |
its pathophysiology is thought to involve an abnormality of the brain's dopaminergic neurotransmitter system. |
2005-01-03 |
2023-08-12 |
human |
| Vandana Zaman, Matthew E Nelson, Greg A Gerhardt, Baerbel Rohre. Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice. Experimental neurology. vol 190. issue 2. 2004-12-29. PMID:15530873. |
these data suggest that elevated neurotransmitter and neurotrophic factor levels might be a compensatory mechanism following dopaminergic cell loss in the sn. |
2004-12-29 |
2023-08-12 |
mouse |
| Tomás González-Hernández, Pedro Barroso-Chinea, Manuel Rodrígue. Response of the GABAergic and dopaminergic mesostriatal projections to the lesion of the contralateral dopaminergic mesostriatal pathway in the rat. Movement disorders : official journal of the Movement Disorder Society. vol 19. issue 9. 2004-12-21. PMID:15372592. |
although dopamine is the main neurotransmitter in the mesostriatal system, recent studies indicate the existence of two nigrostriatal gabaergic projections: one arising from neurons immunoreactive for gaba, glutamic acid decarboxylase (gad67), and parvalbumin (pv) lying in the substantia nigra pars reticulata (nigrostriatal gaba cells) and the other arising from a subpopulation of dopaminergic neurons lying in the substantia nigra pars compacta and ventral tegmental area, which under normal conditions, contains mrna for gad65 (one of the two isoforms of glutamic acid decarboxylase), but which is not immunoreactive for gaba and gad65 (nigrostriatal dopaminergic [da]/gaba cells). |
2004-12-21 |
2023-08-12 |
rat |
| Shun Yu, Xiaohong Zuo, Yaohua Li, Chen Zhang, Ming Zhou, Yu Alex Zhang, Kenji Uéda, Piu Cha. Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308292. |
although the aberrant expression of alpha-synuclein (alpha-syn) is toxic to dopaminergic neurons, little is known about the correlation between the abnormality of alpha-syn and the expression of tyrosine hydroxylase (th), a rate-limiting enzyme for the synthesis of dopamine neurotransmitter. |
2004-11-24 |
2023-08-12 |
human |
| R Ceravolo, D Volterrani, G Gambaccini, S Bernardini, C Rossi, C Logi, G Tognoni, G Manca, G Mariani, U Bonuccelli, L Murr. Presynaptic nigro-striatal function in a group of Alzheimer's disease patients with parkinsonism: evidence from a dopamine transporter imaging study. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 8. 2004-11-19. PMID:15254794. |
the lack of dopamine transporter changes in our series of ad-p patients can indicate that dopaminergic presynaptic function is preserved in this population and that different dopaminergic changes such as postsynaptic ones, or different neurotransmitter alterations might underlie the extrapyramidal features in ad. |
2004-11-19 |
2023-08-12 |
Not clear |
| Ruth Reeves, Mona Thiruchelvam, Eric K Richfield, Deborah A Cory-Slecht. The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Toxicology and applied pharmacology. vol 200. issue 1. 2004-11-19. PMID:15451308. |
studies in this laboratory have found that repeated dosing with tdf in adult mice leads to the development and robust expression of behavioral sensitization, a response mediated by dopaminergic and glutamatergic neurotransmitter systems, and causing long-term changes in dopaminergic function. |
2004-11-19 |
2023-08-12 |
mouse |
| Rebecca L Roberts, Suzanne E Luty, Roger T Mulder, Peter R Joyce, Martin A Kenned. Association between cytochrome P450 2D6 genotype and harm avoidance. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 127B. issue 1. 2004-11-02. PMID:15108188. |
genetic polymorphisms within the serotonergic and dopaminergic neurotransmitter systems may be associated with heightened harm avoidance and novelty seeking. |
2004-11-02 |
2023-08-12 |
Not clear |
| Chan-Hyung Kim, Min-Seong Koo, Keun-Ah Cheon, Young-Hoon Ryu, Jong-Doo Lee, Hong-Shick Le. Dopamine transporter density of basal ganglia assessed with [123I]IPT SPET in obsessive-compulsive disorder. European journal of nuclear medicine and molecular imaging. vol 30. issue 12. 2004-10-05. PMID:14513291. |
these findings suggest that the dopaminergic neurotransmitter system of the basal ganglia in patients with ocd could be involved in the pathophysiology of ocd. |
2004-10-05 |
2023-08-12 |
Not clear |
| Lavinia Albéri, Paola Sgadò, Horst H Simo. Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons. Development (Cambridge, England). vol 131. issue 13. 2004-08-30. PMID:15175251. |
despite a large mid-hindbrain deletion in double mutants null for both genes, mesencephalic dopaminergic (mda) neurons are induced, become postmitotic and acquire their neurotransmitter phenotype. |
2004-08-30 |
2023-08-12 |
mouse |
| Sarah M Clinton, James H Meador-Woodruf. Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 7. 2004-08-02. PMID:15054476. |
abnormalities of psd95-like molecules and other intracellular signaling machinery may contribute to dysregulated communication between multiple neurotransmitter systems (such as glutamatergic and dopaminergic systems) that are potentially involved in the neurobiology of schizophrenia and affective disorders. |
2004-08-02 |
2023-08-12 |
Not clear |
| Andreas Hermann, Manfred Gerlach, Johannes Schwarz, Alexander Storc. Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneration. Expert opinion on biological therapy. vol 4. issue 2. 2004-07-21. PMID:14998773. |
parkinson's disease (pd) is characterised by a continuous and selective loss of dopaminergic neurons in the substantia nigra pars compacta with a subsequent reduction of the neurotransmitter dopamine. |
2004-07-21 |
2023-08-12 |
Not clear |
| Valtteri Kaasinen, Sargo Aalto, Kjell Någren, Juha O Rinn. Expectation of caffeine induces dopaminergic responses in humans. The European journal of neuroscience. vol 19. issue 8. 2004-06-18. PMID:15090062. |
the present study aimed to investigate neurotransmitter function in psychostimulant expectation, with the focus on dopaminergic effects of placebo caffeine in healthy human subjects. |
2004-06-18 |
2023-08-12 |
human |
| Grazyna Skuz. Potential antidepressant activity of sigma ligands. Polish journal of pharmacology. vol 55. issue 6. 2004-06-15. PMID:14730086. |
moreover, sigma ligands are able to modulate the activity of the central neurotransmitter systems, including noradrenergic, serotonergic, dopaminergic and glutamatergic (nmda) ones, which are seemingly important for the mechanism of action of known ads. |
2004-06-15 |
2023-08-12 |
Not clear |
| Rose-Marie Marié, Gilles-Louis Defe. Working memory and dopamine: clinical and experimental clues. Current opinion in neurology. vol 16 Suppl 2. 2004-06-03. PMID:15129848. |
the involvement of monoaminergic neurotransmitter systems, and in particular of the dopaminergic system, in these complex cognitive functions has been suggested by numerous studies, both in humans and in non-human primates. |
2004-06-03 |
2023-08-12 |
Not clear |
| Wei Zhang, Tongguang Wang, Liya Qin, Hui-Ming Gao, Belinda Wilson, Syed F Ali, Wanqin Zhang, Jau-Shyong Hong, Bin Li. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 3. 2004-06-01. PMID:14734632. |
parkinson's disease (pd) is a neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra and depletion of the neurotransmitter dopamine in the striatum. |
2004-06-01 |
2023-08-12 |
mouse |
| Monsheel S K Sodhi, Elaine Sanders-Bus. Serotonin and brain development. International review of neurobiology. vol 59. 2004-05-10. PMID:15006487. |
the serotonergic system interacts with brain-derived neurotrophic factor (bdnf), s100beta, and other chemical messengers, in addition to ts cross talk with the gabaergic, glutamatergic, and dopaminergic neurotransmitter systems. |
2004-05-10 |
2023-08-12 |
Not clear |
| Tiziano Barberi, Peter Klivenyi, Noel Y Calingasan, Hyojin Lee, Hibiki Kawamata, Kathleen Loonam, Anselme L Perrier, Juan Bruses, Maria E Rubio, Norbert Topf, Viviane Tabar, Neil L Harrison, M Flint Beal, Malcolm A S Moore, Lorenz Stude. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nature biotechnology. vol 21. issue 10. 2004-04-28. PMID:14502203. |
neuronal function of es cell-derived dopaminergic neurons was shown in vitro by electron microscopy, measurement of neurotransmitter release and intracellular recording. |
2004-04-28 |
2023-08-12 |
mouse |