| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Wuerthele, N M Friedle, K E Moor. Effects of intranigral administration of dopamine agonists and antagonists and baclofen on concentrations of dopac and dopamine in the striatum and substantia nigra of the rat. Journal of neural transmission. vol 45. issue 2. 1979-10-24. PMID:469523. |
however, intranigral microinjections of high concentrations of several dopaminergic antagonists failed to mimic the biochemical effects resulting from systemic administration of these drugs; instead, they slightly increased the concentrations of both dopamine and dopac in the striatum and decreased dopamine in substantia nigra. |
1979-10-24 |
2023-08-11 |
rat |
| R Schwarcz, K Fuxe, L F Agnati, T Hökfelt, J T Coyl. Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain research. vol 170. issue 3. 1979-10-17. PMID:37986. |
since kainic acid treatment had previously been shown to reduce the number of dopamine receptors in the injected brain regions, ipsilateral turning behaviour elicited by dopaminergic drugs after these lesions seems to be due to intact receptors on the contralateral hemisphere. |
1979-10-17 |
2023-08-11 |
rat |
| R Schwarcz, K Fuxe, L F Agnati, T Hökfelt, J T Coyl. Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain research. vol 170. issue 3. 1979-10-17. PMID:37986. |
thus, the present report suggests: (a) that a behavioural model for studies of drugs acting at intact dopamine receptors can be obtained by unilateral neostriatal kainate injections and (b) that development of dopaminergic supersensitivity involves increased affinity of the receptors for dopamine receptor agonists and an increase in the coupling to its biological effector mechanism. |
1979-10-17 |
2023-08-11 |
rat |
| L C Tolbert, T N Thomas, L D Middaugh, J W Zem. Ascorbate blocks amphetamine-induced turning behavior in rats with unilateral nigro-striatal lesions. Brain research bulletin. vol 4. issue 1. 1979-10-17. PMID:572739. |
thus, ascorbic acid might have a role in regulating dopaminergic transmission and could be of therapeutic value in disorders involving functional dopamine excess. |
1979-10-17 |
2023-08-11 |
rat |
| A V Christensen, I M Nielse. Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia. Psychopharmacology. vol 62. issue 2. 1979-09-17. PMID:111273. |
dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia. |
1979-09-17 |
2023-08-11 |
Not clear |
| A J Zametkin, J R Stevens, R Pittma. Ontogeny of spontaneous blinking and of habituation of the blink reflex. Annals of neurology. vol 5. issue 5. 1979-09-17. PMID:223495. |
the inverse relationship of spontaneous blink rate and number of blink reflexes to habituation in early childhood and in disorders of dopamine transmission suggests that spontaneous blink rate and habituation of the blink reflex reflect maturation and integrity of dopaminergic circuits in the brain. |
1979-09-17 |
2023-08-11 |
Not clear |
| P Seeman, G N Woodruff, J A Poa. Similar binding of 3H-ADTN and 3H-apomorphine to calf brain dopamine receptors. European journal of pharmacology. vol 55. issue 2. 1979-09-17. PMID:456412. |
the ic50 values (nm concentrations inhibiting specific binding by 50%) were 0.9 for (+/-)-n-propyl-norapomorphine, 3.0 for dopamine, 7 for (--)-adrenaline, 60 for (--)-noradrenaline and 4000 for isoproterenol, a series of potencies compatible with properties for a dopaminergic site. |
1979-09-17 |
2023-08-11 |
Not clear |
| P Muller, P Seema. Presynaptic subsensitivity as a possible basis for sensitization by long-term dopamine mimetics. European journal of pharmacology. vol 55. issue 2. 1979-09-17. PMID:572299. |
a possible cellular basis for dopaminergic sensitization by long-term dopamine mimetics was examined in rat brain striatum. |
1979-09-17 |
2023-08-11 |
rat |
| P Muller, P Seema. Presynaptic subsensitivity as a possible basis for sensitization by long-term dopamine mimetics. European journal of pharmacology. vol 55. issue 2. 1979-09-17. PMID:572299. |
this permits less autoregulation and enhanced dopamine agonist action, possibly accounting for the dopaminergic sensitization by long-term agonists. |
1979-09-17 |
2023-08-11 |
rat |
| J M Loeb, M Vassall. Adrenergic mechanisms in postvagal tachycardia. The Journal of pharmacology and experimental therapeutics. vol 210. issue 1. 1979-09-01. PMID:448648. |
postvagal tachycardia: 1) is not affected by ventricular or atrial drive; 2) is enhanced by the application of either norepinephrine or dopamine on the sinus node area; 3) is increased in magnitude and duration by the catecholamine uptake blockers desipramine and phenoxybenzamine; 4) is significantly reduced by beta blockade with propranolol; 5) is not affected by alpha blockade with phentolamine or dopaminergic blockade with haloperidol; 6) is not affected by disulfiram, a drug which inhibits dopamine beta-hydroxylase and thereby increases endogenous dopamine; 7) rises more slowly to a smaller peak after bretylium; and 8) is enhanced by phenoxybenzamine, but not by desipramine, after destruction of sympathetic nerves by 6-hydroxydopamine. |
1979-09-01 |
2023-08-11 |
dog |
| V Leviel, A Chéramy, J Glowinsk. Role of the dendritic release of dopamine in the reciprocal control of the two nigro-striatal dopaminergic pathways. Nature. vol 280. issue 5719. 1979-09-01. PMID:450141. |
role of the dendritic release of dopamine in the reciprocal control of the two nigro-striatal dopaminergic pathways. |
1979-09-01 |
2023-08-11 |
Not clear |
| T J McKenna, D P Island, W E Nicholson, G W Liddl. Dopamine inhibits angiotensin-stimulated aldosterone biosynthesis in bovine adrenal cells. The Journal of clinical investigation. vol 64. issue 1. 1979-08-29. PMID:447857. |
the possibility that dopamine may play a role in the in vivo control of aldosterone production in man was suggested to us by reports from others; (a) that bromocriptine, a dopaminergic agonist, inhibits the aldosterone response to diuresis and to the infusion of angiotensin or acth; and (b) that metaclopramide, a dopamine blocking agent, causes elevations in plasma aldosterone levels. |
1979-08-29 |
2023-08-11 |
human |
| T J McKenna, D P Island, W E Nicholson, G W Liddl. Dopamine inhibits angiotensin-stimulated aldosterone biosynthesis in bovine adrenal cells. The Journal of clinical investigation. vol 64. issue 1. 1979-08-29. PMID:447857. |
these in vitro studies suggest a direct inhibitory role for dopamine on the late phase of aldosterone biosynthesis, which may account for the in vivo inhibition of the aldosterone response to angiotensin in subjects treated with a dopaminergic agent. |
1979-08-29 |
2023-08-11 |
human |
| J C Cheronis, L Erinoff, A Heller, P C Hoffman. Pharmacological analysis of the functional ontogeny of the nigrostriatal dopaminergic neurons. Brain research. vol 169. issue 3. 1979-08-16. PMID:36209. |
this axotomy-induced increase in striatal dopamine is believed to be a response of the dopaminergic terminals to cessation of impulse traffic and is secondary to a decrease in dopamine release and a concomitant increase in dopamine synthesis resulting from tyrosine hydroxylase activation. |
1979-08-16 |
2023-08-11 |
rat |
| R Horowsk. Hypothermic action of lisuride in rats and differences to bromocriptine in the antagonistic effect of neuroleptics. Naunyn-Schmiedeberg's archives of pharmacology. vol 306. issue 2. 1979-08-16. PMID:36572. |
the effect of both drugs could be reduced by pretreatment with the dopamine antagonist haloperidol, which indicated a dopaminergic action of both drugs. |
1979-08-16 |
2023-08-11 |
rat |
| R C Smith, J R Strong, P B Hicks, T Samorajsk. Behavioral evidence for supersensitivity after chronic bromocriptine administration. Psychopharmacology. vol 60. issue 3. 1979-07-25. PMID:108701. |
this behavioral evidence for dopaminergic supersensitivity after chronic brc administration may have relevance for the clinical use of brc in combination with l-dopa or other dopamine agonists. |
1979-07-25 |
2023-08-11 |
mouse |
| S Lavielle, J P Tassin, A M Thierry, G Blanc, D Herve, C Barthelemy, J Glowinsk. Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat. Brain research. vol 168. issue 3. 1979-07-25. PMID:435982. |
blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat. |
1979-07-25 |
2023-08-11 |
rat |
| M Lorenzi, J H Karam, E Tsalikian, N V Bohannon, J E Gerich, P H Forsha. Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects. The Journal of clinical investigation. vol 63. issue 2. 1979-06-29. PMID:34629. |
whereas some metabolic and cardiovascular effects of dopamine are mediated through adrenergic mechanisms, these observations indicate that this is not the case for the effects of this catecholamine on glucagon, insulin, and prolactin secretion, and thus provide further support for the theory of a specific dopaminergic sensitivity of these hormonal systems in man. |
1979-06-29 |
2023-08-11 |
human |
| R W Fuller, J A Clemens, E C Kornfeld, H D Snoddy, E B Smalstig, N J Bac. Effects of (8beta)-8-[methylthio)methyl]-6-propylergoline on dopaminergic function and brain dopamine turnover in rats. Life sciences. vol 24. issue 4. 1979-06-29. PMID:34767. |
effects of (8beta)-8-[methylthio)methyl]-6-propylergoline on dopaminergic function and brain dopamine turnover in rats. |
1979-06-29 |
2023-08-11 |
rat |
| J G Cannon, C Suarez-Gutierrez, T Lee, J P Long, B Costall, D H Fortune, R J Naylo. Rigid congeners of dopamine based on octahydrobenzo[f]quinoline: peripheral and central effects. Journal of medicinal chemistry. vol 22. issue 4. 1979-06-29. PMID:571020. |
the trans isomers include the dopamine moiety held rigidly in an antiperiplanar diposition which is believed to be necessary for certian central and peripheral dopaminergic effects. |
1979-06-29 |
2023-08-11 |
Not clear |