| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Demenge, P Mouchet, B Guerin, C Feuerstei. Identification and distribution of neuroleptic binding sites in the rat spinal cord. Journal of neurochemistry. vol 37. issue 1. 1981-09-22. PMID:6114137. |
the displacement of the labelled ligand by different dopaminergic and nondopaminergic drugs at various concentrations gave similar results in the whole striatum and the spinal cord, giving further support for the existence of a dopaminergic innervation of the spinal cord and showing that dopaminergic receptor sites are distributed through the different spinal horns, with a maximal density in the dorsal horn--as for dopamine levels. |
1981-09-22 |
2023-08-12 |
rat |
| K Anderson, A Kuruvilla, N Uretsky, D D Mille. Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists. Journal of medicinal chemistry. vol 24. issue 6. 1981-09-22. PMID:7252978. |
in order to test whether the nitrogen/ammonium moiety in the dopamine molecule is required for dopaminergic activity, we have synthesized two sulfonium analogues of dopamine and tested them for biological activity in an in vivo and in an in vitro system. |
1981-09-22 |
2023-08-12 |
rat |
| K Anderson, A Kuruvilla, N Uretsky, D D Mille. Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists. Journal of medicinal chemistry. vol 24. issue 6. 1981-09-22. PMID:7252978. |
this study suggests that the nitrogen atom found in th dopamine molecule is not essential for dopaminergic activity, since the nitrogen can be replaced by a sulfonium functional group for this activity. |
1981-09-22 |
2023-08-12 |
rat |
| T E Robinson, D M Camp, J B Becke. Gonadectomy attenuates turning behavior produced by electrical stimulation of the nigrostriatal dopamine system in female but not male rats. Neuroscience letters. vol 23. issue 2. 1981-09-22. PMID:7254708. |
steroid hormones influence the metabolism of many dopaminergic drugs, and therefore this approach avoids the complications inherent in drug-induced behavior models of dopamine activity. |
1981-09-22 |
2023-08-12 |
rat |
| S Kaakkol. Effect of nicotinic and muscarinic drugs on amphetamine- and apomorphine-induced circling behaviour in rats. Acta pharmacologica et toxicologica. vol 48. issue 2. 1981-09-22. PMID:7257827. |
the presynaptic nicotinic cholinergic receptors on the terminals of the nigrostriatal dopaminergic neurones, stimulation of which may increase the release of dopamine, might be involved in the action of nicotinic drugs. |
1981-09-22 |
2023-08-12 |
rat |
| A A Megens, A R Cool. Presence of a particular subpopulation of dopamine receptors within the septal nuclei: a behavioural study on cats. European journal of pharmacology. vol 71. issue 2-3. 1981-09-15. PMID:6265235. |
the behavioural effects of intraseptal administration of dopaminergic drugs (apomorphine, haloperidol, (3,4-dihydroxy-phenylamino)-2-imidazoline (dpi), ergometrine and dopamine) and alpha-noradrenergic drugs (oxymetazoline, noradrenaline and phentolamine) were analysed in cats pretreated with morphine (5 mg/kg, i.p.). |
1981-09-15 |
2023-08-12 |
Not clear |
| J Nguyen-Legros, B Berger, C Alvare. High resolution radioautography of central dopaminergic fibers labelled in vitro with [3H]dopamine or [3H]norepinephrine. Brain research. vol 213. issue 2. 1981-09-15. PMID:7248758. |
high resolution radioautography of central dopaminergic fibers labelled in vitro with [3h]dopamine or [3h]norepinephrine. |
1981-09-15 |
2023-08-12 |
human |
| P G Guyenet, J K Cran. Non-dopaminergic nigrostriatal pathway. Brain research. vol 213. issue 2. 1981-09-15. PMID:7248760. |
despite a reduction of up to 85% in the number of dopaminergic cell bodies, the substantia nigra of these rats contained the same average number of eb-labelled neurons devoid of dopamine fluorescence. |
1981-09-15 |
2023-08-12 |
rat |
| K Dishovski, I Panova, P Uzuno. [Effect of the organophosphorus compound neguvon on the dopamine content in the rat brain]. Eksperimentalna meditsina i morfologiia. vol 20. issue 2. 1981-09-15. PMID:7250022. |
they discussed the connection between the changes in the content of dopamine and modulating role of presynaptic choline receptors of h- and m- types in the dopaminergic terminals of the striatum. |
1981-09-15 |
2023-08-12 |
rat |
| K Golombiowska-Nikitin, K H Sontag, N N Osborn. 3H-Spiroperidol binding to striatal membranes of mutant Han-Wistar rats which exhibit spastic paresis. Experientia. vol 37. issue 5. 1981-09-15. PMID:7250319. |
these findings indicate that the dopamine receptors of the mutants are affected and could explain some of the previous data; it has been suggested that some of the spasticity observed in the mutants may be due to an abnormal functioning of their dopaminergic neurones. |
1981-09-15 |
2023-08-12 |
rat |
| S Chiu, C S Paulose, R K Mishr. Effect of L-prolyl-L-leucyl-glycinamide (PLG) on neuroleptic-induced catalepsy and dopamine/neuroleptic receptor bindings. Peptides. vol 2. issue 1. 1981-08-27. PMID:6113579. |
the behavioural and biochemical results obtained in the present study raise the possibility that plg may facilitate nigro-striatal dopaminergic neurotransmission through interacting with a unique plg receptor functionally coupled to the dopamine receptor-adenylate cyclase complex. |
1981-08-27 |
2023-08-12 |
rat |
| C Y Cheung, A C Neill, R I Weine. Stimulation of prolactin secretion by neuroleptics in rats with medial basal hypothalamic lesions. Neuroendocrinology. vol 32. issue 6. 1981-08-27. PMID:6165920. |
these data suggest that dopaminergic antagonists can further increase prolactin levels in medial basal hypothalamus-lesioned rats possibly by blocking the inhibitory action of dopamine from nonhypothalamic sources, or by releasing a substance which possesses prolactin-releasing activity. |
1981-08-27 |
2023-08-12 |
rat |
| A E Langley, J Kirlangitis, T Lehma. Stereotypy and striatal dopamine receptor changes with 1-alpha-acetylmethadol (LAAM). Pharmacology, biochemistry, and behavior. vol 14. issue 5. 1981-08-27. PMID:7195581. |
narcotics like morphine and methadone produce effects on striatal dopaminergic mechanisms as evidenced by changes in a stereotyped behavior induced by apomorphine and binding or radioactive ligands to dopamine (da) receptors. |
1981-08-27 |
2023-08-12 |
mouse |
| J P Wyse, F L Lorscheide. Low retinal dopamine and serum prolactin levels indicate an inherited dopaminergic abnormality in BW rats. Experimental eye research. vol 32. issue 5. 1981-08-27. PMID:7238636. |
low retinal dopamine and serum prolactin levels indicate an inherited dopaminergic abnormality in bw rats. |
1981-08-27 |
2023-08-12 |
rat |
| P D Wool. Resumption of prolactin secretion after dopaminergic inhibition: differential effects of dopamine and its agonists. The American journal of physiology. vol 240. issue 6. 1981-08-27. PMID:7246736. |
resumption of prolactin secretion after dopaminergic inhibition: differential effects of dopamine and its agonists. |
1981-08-27 |
2023-08-12 |
Not clear |
| C Sumners, J B De Vries, D Dijkstra, A S Hor. Involvement of both dopaminergic and alpha-adrenergic receptors in the hypomotility induced by dibenzoyl-6,7-ADTN. European journal of pharmacology. vol 70. issue 4. 1981-08-20. PMID:6113149. |
the dopaminergic prodrug dibenzoyl-6,7-adtn (db-6,7-adtn) can enter the brain following intraperitoneal injection and be hydrolysed to produce low concentrations of the dopamine agonist 6,7-adtn. |
1981-08-20 |
2023-08-12 |
Not clear |
| C Sumners, J B De Vries, D Dijkstra, A S Hor. Involvement of both dopaminergic and alpha-adrenergic receptors in the hypomotility induced by dibenzoyl-6,7-ADTN. European journal of pharmacology. vol 70. issue 4. 1981-08-20. PMID:6113149. |
inhibition of the effects of db-6,7-adtn on noradrenaline and dopamine turnover by yohimbine and sulpiride, respectively, suggests that 6,7-adtn (derived from the prodrug) has alpha adrenergic as well as dopaminergic activity. |
1981-08-20 |
2023-08-12 |
Not clear |
| R Deskin, F J Seidler, W L Whitmore, T A Slotki. Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain. Journal of neurochemistry. vol 36. issue 5. 1981-08-20. PMID:6264034. |
uptakes of [(3)h]dopamine or [(3)h]norepinephrine into dopaminergic and noradrenergic nerve terminals were low during the 1st week postpartum and increased rapidly during the 2nd week. |
1981-08-20 |
2023-08-12 |
rat |
| R Deskin, F J Seidler, W L Whitmore, T A Slotki. Development of alpha-noradrenergic and Dopaminergic receptor systems depends on maturation of their presynaptic nerve terminals in the rat brain. Journal of neurochemistry. vol 36. issue 5. 1981-08-20. PMID:6264034. |
stimulation of incorporation of (33)p(i) into brain phospholipids (elicited by intracisternal injection of dopamine), which is mediated by dopaminergic receptors, was shown to be highly correlated with the maturation of both receptor binding sites and presynaptic nerve terminal uptake. |
1981-08-20 |
2023-08-12 |
rat |
| B Kerdelhue, A S Weisman, R I Weine. A dopaminergic binding site in the high speed supernatant of steer anterior pituitary homogenates. Endocrinology. vol 109. issue 1. 1981-08-20. PMID:7238409. |
the rank order of potencies of dopaminergic agents to compete for binding was consistent with known dopamine (da) receptors. |
1981-08-20 |
2023-08-12 |
Not clear |