| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Travaglini, C Montanari, M Ballabio, R Elli, R C Scaperrotta, G Fagli. Effects of increased central dopaminergic tonus on gonadotropin secretion. Journal of endocrinological investigation. vol 4. issue 2. 1981-11-18. PMID:6792267. |
gonadotropin secretion was investigated in 10 healthy volunteers (5 men and 5 women in the early follicular phase of cycle) by the following procedures: i) infusion of saline over 4 1/2 h period; ii) infusion of dopamine (da) 4 microgram/kg bw/min over 4 h period; iii) oral administration of l-dopa (d) 100 mg plus carbidopa (c) 35 mg after 24 h pretreatment with c 50 mg every 6 h. this last pharmacological approach selectively enhances the central dopaminergic tonus. |
1981-11-18 |
2023-08-12 |
human |
| G E Hoffman, J R Slade. Age-related changes in dopamine, LHRH and somatostatin in the rat hypothalamus. Neurobiology of aging. vol 1. issue 1. 1981-10-25. PMID:6115324. |
comparative analysis or rats at 3, 12, 20, and 30 months of age revealed a general decrease in somatostatin and lhrh in the median eminence; dopamine fluorescence intensity also was depressed in the median eminence although dopaminergic perikarya of the arcuate nucleus of the hypothalamus appeared to increase in intensity with age. |
1981-10-25 |
2023-08-12 |
rat |
| R E Burke, S Fahn, R Mayeux, H Weinberg, K Louis, J H Willne. Neuroleptic malignant syndrome caused by dopamine-depleting drugs in a patient with Huntington disease. Neurology. vol 31. issue 8. 1981-10-25. PMID:6115336. |
central dopaminergic systems probably participate in thermoregulation, and dopamine depletion probably plays a pathogenetic role in this syndrome. |
1981-10-25 |
2023-08-12 |
Not clear |
| M L Barbaccia, A Reggiani, P F Spano, M Trabucch. Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors. Psychopharmacology. vol 74. issue 3. 1981-10-25. PMID:6267650. |
acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (c57 and albino) that are rich in enkephalinergic receptors upon nigrostriatal dopaminergic fibers. |
1981-10-25 |
2023-08-12 |
mouse |
| J T McDevitt, P E Setle. Differential effects of dopamine agonists in mature and immature rats. European journal of pharmacology. vol 72. issue 1. 1981-10-25. PMID:6973482. |
the ineffectiveness of apomorphine in the neonate, however, suggest that the neonatal syndrome may not be related exclusively to dopamine, or that the dopaminergic system involved with this behavior is not sensitive to apomorphine. |
1981-10-25 |
2023-08-12 |
rat |
| C Sumners, D Dijkstra, J B de Vries, A S Hor. Neurochemical and behavioural profiles of five dopamine analogues. Naunyn-Schmiedeberg's archives of pharmacology. vol 316. issue 4. 1981-10-25. PMID:7196506. |
the dopaminergic actions of five hydroxylated dopamine analogues have been examined for: i) ability to induce stereotypy, ii) effects upon dopamine metabolism, iii) ability to antagonise the rise in striatal dopamine caused by gammabutyrolactone. |
1981-10-25 |
2023-08-12 |
Not clear |
| A Agnoli, M Baldassarre, S Ruggieri, P Falaschi, R D Urso, A Rocc. Prolactin response as an index of dopaminergic receptor function in Parkinson's disease. Correlation with clinical findings and therapeutic response. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264625. |
the endocrine effects of dopaminergic drugs show a mild rise in comparison with controls suggesting an important alteration in the dopamine (da) control of growth hormone (gh). |
1981-10-25 |
2023-08-12 |
Not clear |
| U K Rinn. Treatment of Parkinson's disease: problems with a progressing disease. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264627. |
post-mortem brain studies have shown that in parkinson's disease there is not only a progressive loss of dopaminergic substantia nigra neurons but there are also significant changes in the striatal dopamine receptors. |
1981-10-25 |
2023-08-12 |
Not clear |
| K Fuxe, L F Agnati, C Köhler, D Kuonen, S O Ogren, K Andersson, T Hökfel. Characterization of normal and supersensitive dopamine receptors: effects of ergot drugs and neuropeptides. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264628. |
actions of dopaminergic ergot drugs have been evaluated at supersensitive dopamine receptors. |
1981-10-25 |
2023-08-12 |
rat |
| K Fuxe, L F Agnati, C Köhler, D Kuonen, S O Ogren, K Andersson, T Hökfel. Characterization of normal and supersensitive dopamine receptors: effects of ergot drugs and neuropeptides. Journal of neural transmission. vol 51. issue 1-2. 1981-10-25. PMID:7264628. |
in agreement with previous work, evidence have also been presented that prolonged treatment with a potent dopaminergic drug, pergolide, can produce a down regulation of normal dopamine receptors by reducing the density of such receptors. |
1981-10-25 |
2023-08-12 |
rat |
| L György, Z Orr, G Folly, M Dód. The influence of dopamine and dopaminergic agonists on the contractions of field stimulated rat vas deferens. Archives internationales de pharmacodynamie et de therapie. vol 250. issue 1. 1981-10-14. PMID:6268006. |
the influence of dopamine and dopaminergic agonists on the contractions of field stimulated rat vas deferens. |
1981-10-14 |
2023-08-12 |
rat |
| A L Gundlach, P M Bear. Differential effects of IV and IP muscimol on central dopamine metabolism. Psychopharmacology. vol 74. issue 1. 1981-10-14. PMID:6791208. |
the effect of iv and ip muscimol on the concentrations of dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) in both the nigrostriatal and mesolimbic dopaminergic pathways has been studied. |
1981-10-14 |
2023-08-12 |
Not clear |
| C Ferrari, P Rampini, A Malinverni, C Scarduelli, R Benco, R Caldara, C Barbieri, G Testori, P G Crosignan. Inhibition of luteinizing hormone release by dopamine infusion in healthy women and in various pathophysiological conditions. Acta endocrinologica. vol 97. issue 4. 1981-10-14. PMID:6791426. |
to investigate the effect of dopaminergic stimulation on gonadotrophin release, serum lh and fsh concentrations were measured during dopamine infusion (5 microgram/kg/min for 120 min) in 8 healthy women in the early follicular phase, in 12 patients with hyperprolactinaemic amenorrhoea, in 5 subjects with premature ovarian failure and in 8 with polycystic ovarian disease and raised serum lh levels. |
1981-10-14 |
2023-08-12 |
human |
| M J Kell. An analysis of the effects of apomorphine and haloperidol on the release of [3H]-dopamine and [3H]-noradrenaline from rabbit brain slices. Archives internationales de pharmacodynamie et de therapie. vol 250. issue 1. 1981-10-14. PMID:7271378. |
in low concentrations both compounds showed selectivity for dopaminergic receptor sites, apomorphine stimulating and haloperidol inhibiting pre-synaptic dopamine receptors. |
1981-10-14 |
2023-08-12 |
rabbit |
| A L Gundlach, P M Bear. Effect of GABAergic drugs on dopamine catabolism in the nigrostriatal and mesolimbic dopaminergic pathways of the rat. The Journal of pharmacy and pharmacology. vol 33. issue 1. 1981-09-25. PMID:6114152. |
effect of gabaergic drugs on dopamine catabolism in the nigrostriatal and mesolimbic dopaminergic pathways of the rat. |
1981-09-25 |
2023-08-12 |
rat |
| G R Hanson, L Alphs, W Wolf, R Levine, W Lovenber. Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems. The Journal of pharmacology and experimental therapeutics. vol 218. issue 2. 1981-09-25. PMID:6166743. |
data presented in this paper suggest that 1) blockade of dopamine postsynaptic receptors alters nigral spli levels associated with the substance p striatal-nigral loop, 2) destruction of the nigral-striatal dopaminergic pathway results in changes in nigral content of spli similar to that induced by haloperidol, 3) several weeks after nigral-striatal lesions, compensatory mechanisms mediate a return of nigral spli content to control levels and 4) substance p striatal-nigral circuits continue to respond to dopaminergic input after kainic acid lesions in the anterior striatum, whereas properly placed mechanical striatal-nigral lesions appear to be effective in preventing this interaction. |
1981-09-25 |
2023-08-12 |
Not clear |
| S Bansal, L A Lee, P D Wool. Dopaminergic regulation of growth hormone (GH) secretion in normal man: correlation of L-dopa and dopamine levels with the GH response. The Journal of clinical endocrinology and metabolism. vol 53. issue 2. 1981-09-25. PMID:7251816. |
dopaminergic regulation of growth hormone (gh) secretion in normal man: correlation of l-dopa and dopamine levels with the gh response. |
1981-09-25 |
2023-08-12 |
Not clear |
| P Demenge, P Mouchet, B Guerin, C Feuerstei. Identification and distribution of neuroleptic binding sites in the rat spinal cord. Journal of neurochemistry. vol 37. issue 1. 1981-09-22. PMID:6114137. |
the displacement of the labelled ligand by different dopaminergic and nondopaminergic drugs at various concentrations gave similar results in the whole striatum and the spinal cord, giving further support for the existence of a dopaminergic innervation of the spinal cord and showing that dopaminergic receptor sites are distributed through the different spinal horns, with a maximal density in the dorsal horn--as for dopamine levels. |
1981-09-22 |
2023-08-12 |
rat |
| K Anderson, A Kuruvilla, N Uretsky, D D Mille. Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists. Journal of medicinal chemistry. vol 24. issue 6. 1981-09-22. PMID:7252978. |
in order to test whether the nitrogen/ammonium moiety in the dopamine molecule is required for dopaminergic activity, we have synthesized two sulfonium analogues of dopamine and tested them for biological activity in an in vivo and in an in vitro system. |
1981-09-22 |
2023-08-12 |
rat |
| K Anderson, A Kuruvilla, N Uretsky, D D Mille. Synthesis and pharmacological evaluation of sulfonium analogues of dopamine: nonclassical dopamine agonists. Journal of medicinal chemistry. vol 24. issue 6. 1981-09-22. PMID:7252978. |
this study suggests that the nitrogen atom found in th dopamine molecule is not essential for dopaminergic activity, since the nitrogen can be replaced by a sulfonium functional group for this activity. |
1981-09-22 |
2023-08-12 |
rat |