| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Gäddnäs, K Pietilä, T P Piepponen, L Ahte. Enhanced motor activity and brain dopamine turnover in mice during long-term nicotine administration in the drinking water. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796149. |
also, the striatal postmortem tissue concentrations and accumbal extracellular concentrations of dopamine (da) and its metabolites 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) were measured to study the role of dopaminergic systems in nicotine-induced hyperactivity in mice. |
2002-03-12 |
2023-08-12 |
mouse |
| S D Ugarte, G E Homanics, D L Hammon. Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse. Brain research. vol 904. issue 2. 2002-03-11. PMID:11406127. |
in contrast, the levels of serotonin, dopamine or their metabolites were unaffected, suggesting that the development of serotonergic and dopaminergic neurons may require activation of only a small fraction of gaba(a) receptors or may not be dependent on beta3 subunit-containing gaba(a) receptors. |
2002-03-11 |
2023-08-12 |
mouse |
| K Kashihara, Y Manabe, T Murakami, Koji Ab. Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions. Life sciences. vol 70. issue 9. 2002-03-08. PMID:11860157. |
effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-ohda lesions. |
2002-03-08 |
2023-08-12 |
rat |
| K Kashihara, Y Manabe, T Murakami, Koji Ab. Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions. Life sciences. vol 70. issue 9. 2002-03-08. PMID:11860157. |
the effects of short and long-acting dopamine agonists on sensitized dopaminergic transmission in an animal model of parkinson's disease were investigated. |
2002-03-08 |
2023-08-12 |
rat |
| K Kashihara, Y Manabe, T Murakami, Koji Ab. Effects of short- and long-acting dopamine agonists on sensitized dopaminergic neurotransmission in rats with unilateral 6-OHDA lesions. Life sciences. vol 70. issue 9. 2002-03-08. PMID:11860157. |
these findings suggest that the repeated administration of long-acting dopamine agonists may reduce sensitized dopaminergic transmission in dopamine-depleted rats, whereas short-acting ones may further enhance sensitization of the transmission process. |
2002-03-08 |
2023-08-12 |
rat |
| S Jiang, R Xin, S Lin, Y Qian, G Tang, D Wang, X W. Linkage studies between attention-deficit hyperactivity disorder and the monoamine oxidase genes. American journal of medical genetics. vol 105. issue 8. 2002-03-05. PMID:11803531. |
molecular genetic and pharmacological studies suggest the involvement of dopaminergic and noradrenergic neurotransmitter systems in adhd, e.g., several reports have found association between adhd and the dopamine receptor gene drd-4, the dopamine transporter gene dat1, and the catecholamine clearance enzyme catechol-o-methyltransferase. |
2002-03-05 |
2023-08-12 |
Not clear |
| Venkata S Mattay, Alessandro Tessitore, Joseph H Callicott, Alessandro Bertolino, Terry E Goldberg, Thomas N Chase, Thomas M Hyde, Daniel R Weinberge. Dopaminergic modulation of cortical function in patients with Parkinson's disease. Annals of neurology. vol 51. issue 2. 2002-03-01. PMID:11835371. |
these results support evidence from basic research that dopamine modulates cortical networks subserving working memory and motor function via two distinct mechanisms: nigrostriatal projections facilitate motor function indirectly via thalamic projections to motor cortices, whereas the mesocortical dopaminergic system facilitates working memory function via direct inputs to prefrontal cortex. |
2002-03-01 |
2023-08-12 |
Not clear |
| B Drukarch, F L van Muiswinke. Neuroprotection for Parkinson's disease: a new approach for a new millennium. Expert opinion on investigational drugs. vol 10. issue 10. 2002-02-28. PMID:11772291. |
efforts concentrated on understanding the mechanisms of dopaminergic cell death in parkinson's disease have led to identification of a large variety of pathogenetic factors, including excessive release of oxygen free radicals during enzymatic dopamine breakdown, impairment of mitochondrial function, production of inflammatory mediators, loss of trophic support, and apoptosis. |
2002-02-28 |
2023-08-12 |
Not clear |
| Vesna Sossi, Raúl de La Fuente-Fernández, James E Holden, Doris J Doudet, Jess McKenzie, A J Stoessl, T J Rut. Increase in dopamine turnover occurs early in Parkinson's disease: evidence from a new modeling approach to PET 18 F-fluorodopa data. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 2. 2002-02-28. PMID:11823721. |
an increase in dopamine turnover has been hypothesized to occur early in parkinson's disease (pd) as a compensatory mechanism for dopaminergic neuronal loss. |
2002-02-28 |
2023-08-12 |
human |
| Etsuro Matsubara, Mikio Shoji, Koji Ab. [The treatment of Parkinson's disease--adenosine A2A receptor antagonists]. Nihon rinsho. Japanese journal of clinical medicine. vol 60. issue 1. 2002-02-26. PMID:11808320. |
the primary pathology of parkinson's disease is the degeneration of dopaminergic neurons in the nigrostriatal pathway, resulting in a significant reduction in striatum dopamine concentration which is responsible for the altered motor functions. |
2002-02-26 |
2023-08-12 |
Not clear |
| Kengo Funakoshi, Masato Nakano, Yoshitoshi Atobe, Tetsuo Kadota, Richard C Goris, Reiji Kishid. Catecholaminergic innervation of the sympathetic preganglionic cell column of the filefish Stephanolepis cirrhifer. The Journal of comparative neurology. vol 442. issue 3. 2002-02-25. PMID:11774336. |
fluorescent double labeling distinguished noradrenergic nerve fibers immunoreactive for both tyrosine hydroxylase and dopamine beta hydroxylase, and dopaminergic fibers immunoreactive only for tyrosine hydroxylase. |
2002-02-25 |
2023-08-12 |
Not clear |
| Kengo Funakoshi, Masato Nakano, Yoshitoshi Atobe, Tetsuo Kadota, Richard C Goris, Reiji Kishid. Catecholaminergic innervation of the sympathetic preganglionic cell column of the filefish Stephanolepis cirrhifer. The Journal of comparative neurology. vol 442. issue 3. 2002-02-25. PMID:11774336. |
double labeling of tyrosine hydroxylase and dopamine beta hydroxylase showed that the neurons in the locus coeruleus were all noradrenergic, and those in the caudal dorsomedial medulla were mostly noradrenergic, whereas the area postrema contained both noradrenergic and dopaminergic neurons. |
2002-02-25 |
2023-08-12 |
Not clear |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
previous in vivo experiments using rats anesthetized with chloral hydrate have revealed that nicotine applied iontophoretically increased firing of striatal neurons receiving excitatory dopaminergic input from the substantia nigra, and nicotine-induced firing was inhibited by domperidone, a dopamine d2 antagonist. |
2002-02-22 |
2023-08-12 |
rat |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
the results suggest that nicotine increases release of dopamine from the terminals of dopaminergic neurons. |
2002-02-22 |
2023-08-12 |
rat |
| Y W Chung, A A Nunez, L G Clemen. Effects of neonatal polychlorinated biphenyl exposure on female sexual behavior. Physiology & behavior. vol 74. issue 3. 2002-02-22. PMID:11714501. |
since sexual behavior is affected by dopamine and since pcbs have been reported to alter dopamine content in the brain, we examined the effects of a1221 or a1254 on dopaminergic cells in the incertohypothalamic region of neonatally exposed rats. |
2002-02-22 |
2023-08-12 |
rat |
| Pawel Grieb, Robert Rejda. Pharmacodynamics of citicoline relevant to the treatment of glaucoma. Journal of neuroscience research. vol 67. issue 2. 2002-02-21. PMID:11782957. |
furthermore, citicoline stimulates some brain neurotransmitter systems, including the dopaminergic system, and dopamine is known as a major neurotransmitter in retina and postretinal visual pathways. |
2002-02-21 |
2023-08-12 |
Not clear |
| I G Sil'ki. [A possible mechanism of dopamine-induced synergistic disinhibition of thalamic cells via "direct" and "indirect" pathways in basal ganglia]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 51. issue 3. 2002-02-19. PMID:11550635. |
this effect can be responsible of a rise of inhibition of dopaminergic cells and decrease in dopamine release by these cells. |
2002-02-19 |
2023-08-12 |
Not clear |
| R E Yee, I Irwin, C Milonas, D B Stout, S C Huang, K Shoghi-Jadid, N Satyamurthy, L E Delanney, D M Togasaki, K F Farahani, K Delfani, A M Janson, M E Phelps, J W Langston, J R Barri. Novel observations with FDOPA-PET imaging after early nigrostriatal damage. Movement disorders : official journal of the Movement Disorder Society. vol 16. issue 5. 2002-02-13. PMID:11746613. |
after scanning, stereological counts of dopaminergic neurons were done in substantia nigra, and dopamine (da) and metabolite concentrations were determined in the caudate, putamen, and substantia nigra. |
2002-02-13 |
2023-08-12 |
monkey |
| A D Zurn, H R Widmer, P Aebische. Sustained delivery of GDNF: towards a treatment for Parkinson's disease. Brain research. Brain research reviews. vol 36. issue 2-3. 2002-02-08. PMID:11690619. |
although symptomatic therapies to substitute for the missing neurotransmitter dopamine are efficient at the early stages of the disease, the goal is to find alternative therapies which could protect dopaminergic neurons from the degenerative process. |
2002-02-08 |
2023-08-12 |
monkey |
| M Kitazawa, V Anantharam, A G Kanthasam. Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free radical biology & medicine. vol 31. issue 11. 2002-02-08. PMID:11728820. |
taken together, these results suggest that rapid release of dopamine and generation of ros are early cellular events that may account for dieldrin-induced apoptotic cell death in dopaminergic cells. |
2002-02-08 |
2023-08-12 |
Not clear |