| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matt J N Brown, Quincy J Almeid. Evaluating dopaminergic system contributions to cued pattern switching during bimanual coordination. The European journal of neuroscience. vol 34. issue 4. 2011-12-07. PMID:21781190. |
it is concluded that although modulation of the dopaminergic system improves the slowness during switching, coordination deficits may be the result of secondary impairments (possibly attention-related) that cannot be improved with dopamine replacement. |
2011-12-07 |
2023-08-12 |
human |
| Ikuko Miyazaki, Masato Asanuma, Yuri Kikkawa, Mika Takeshima, Shinki Murakami, Ko Miyoshi, Norio Sogawa, Taizo Kit. Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia. vol 59. issue 3. 2011-12-06. PMID:21264950. |
astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. |
2011-12-06 |
2023-08-12 |
mouse |
| Ikuko Miyazaki, Masato Asanuma, Yuri Kikkawa, Mika Takeshima, Shinki Murakami, Ko Miyoshi, Norio Sogawa, Taizo Kit. Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia. vol 59. issue 3. 2011-12-06. PMID:21264950. |
we further reported that the cysteine-rich metal-binding metallothionein (mt) family of proteins protects dopaminergic neurons against dopamine (da) quinone neurotoxicity by its quinone-quenching property. |
2011-12-06 |
2023-08-12 |
mouse |
| Andrew J Thorpe, Andrew Clair, Shawn Hochman, Stefan Clemen. Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands. European neurology. vol 66. issue 1. 2011-12-06. PMID:21709418. |
the hypothalamic a11 dopaminergic circuit is used to explain the dopamine dysfunction in rls and the potential therapeutic actions of dopamine d(2) agonists. |
2011-12-06 |
2023-08-12 |
Not clear |
| Janusz Lipski, Robert Nistico, Nicola Berretta, Ezia Guatteo, Giorgio Bernardi, Nicola B Mercur. L-DOPA: a scapegoat for accelerated neurodegeneration in Parkinson's disease? Progress in neurobiology. vol 94. issue 4. 2011-12-06. PMID:21723913. |
however, this necessary therapeutic step is biased by an enduring belief that l-dopa is toxic to the remaining substantia nigra dopaminergic neurons by itself, or by specific metabolites such as dopamine. |
2011-12-06 |
2023-08-12 |
human |
| Anna Mané, Judith Gallego, Francisco Lomeña, Jose Javier Mateos, Emilio Fernandez-Egea, Guillermo Horga, Albert Cot, Javier Pavia, Miguel Bernardo, Eduard Parellad. A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients. Psychiatry research. vol 194. issue 1. 2011-12-06. PMID:21831607. |
a key component in dopaminergic neurotransmission is the striatal dopamine transporter (dat). |
2011-12-06 |
2023-08-12 |
Not clear |
| Pooja Jadiya, Asif Khan, Shreesh Raj Sammi, Supinder Kaur, Snober S Mir, Aamir Nazi. Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease. Biochemical and biophysical research communications. vol 413. issue 4. 2011-12-06. PMID:21925152. |
two different strains of c. elegans; a transgenic model expressing "human" alpha synuclein [nl5901 (p(unc-54)::alphasynuclein::yfp+unc-119)], and a pharmacological model expressing green fluorescent protein (gfp) specifically in the dopaminergic neurons [bz555 (p(dat-1)::gfp)] treated with selective catecholaminergic neurotoxin 6-hydroxy dopamine (6-ohda), were employed for the study. |
2011-12-06 |
2023-08-12 |
human |
| Jennifer Carrillo, Rueben A Gonzale. A single exposure to voluntary ethanol self-administration produces adaptations in ethanol consumption and accumbal dopamine signaling. Alcohol (Fayetteville, N.Y.). vol 45. issue 6. 2011-12-05. PMID:21827930. |
in well-trained animals, accumbal dopamine release is stimulated during operant ethanol self-administration, but the time course of development of this dopaminergic response, particularly during the acquisition of ethanol drinking behavior, remains unknown. |
2011-12-05 |
2023-08-12 |
rat |
| Pooja Jadiya, Manavi Chatterjee, Shreesh Raj Sammi, Supinder Kaur, Gautam Palit, Aamir Nazi. Sir-2.1 modulates 'calorie-restriction-mediated' prevention of neurodegeneration in Caenorhabditis elegans: implications for Parkinson's disease. Biochemical and biophysical research communications. vol 413. issue 2. 2011-12-05. PMID:21889494. |
selective degeneration of dopaminergic neurons was induced by treatment of worms with 6-hydroxy dopamine (6-ohda), a selective catecholaminergic neurotoxin, followed by studies on effect of calorie restriction on the neurodegeneration. |
2011-12-05 |
2023-08-12 |
caenorhabditis_elegans |
| Pooja Jadiya, Manavi Chatterjee, Shreesh Raj Sammi, Supinder Kaur, Gautam Palit, Aamir Nazi. Sir-2.1 modulates 'calorie-restriction-mediated' prevention of neurodegeneration in Caenorhabditis elegans: implications for Parkinson's disease. Biochemical and biophysical research communications. vol 413. issue 2. 2011-12-05. PMID:21889494. |
employing confocal microscopy of the dopaminergic neurons and hplc analysis of dopamine levels in the nematodes, we found that calorie restriction has a preventive effect on dopaminergic neurodegeneration in the worm model. |
2011-12-05 |
2023-08-12 |
caenorhabditis_elegans |
| Zsofia Nemoda, Anna Szekely, Maria Sasvari-Szekel. Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neuroscience and biobehavioral reviews. vol 35. issue 8. 2011-12-01. PMID:21527290. |
dopamine hypotheses of several psychiatric disorders are based upon the clinical benefits of drugs affecting dopamine transporter or receptors, and have prompted intensive candidate gene research within the dopaminergic system during the last two decades. |
2011-12-01 |
2023-08-12 |
Not clear |
| Ahmed Hasbi, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance. Molecular brain. vol 4. 2011-11-30. PMID:21663703. |
dopamine d1 and d2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of d1-d2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. |
2011-11-30 |
2023-08-12 |
Not clear |
| Daniel O Claassen, Wery P M van den Wildenberg, K Richard Ridderinkhof, Charles K Jessup, Madaline B Harrison, G Frederick Wooten, Scott A Wyli. The risky business of dopamine agonists in Parkinson disease and impulse control disorders. Behavioral neuroscience. vol 125. issue 4. 2011-11-29. PMID:21604834. |
in patients with parkinson's disease (pd), impulse control disorder (icd) can result from dopaminergic medication use, particularly dopamine agonists (daa). |
2011-11-29 |
2023-08-12 |
Not clear |
| David W Anderson, Rebecca C Schray, Gregg Duester, Jay S Schneide. Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system. Brain research. vol 1408. 2011-11-29. PMID:21784415. |
in the brain, aldh1a1 participates in the metabolism of catecholamines including dopamine (da) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (daergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. |
2011-11-29 |
2023-08-12 |
mouse |
| M Suárez-Piñera, M L Prat, A Mestre-Fusco, J Fuertes, S Mojal, E Balague. [Interobserver agreement in the visual and semi-quantitative analysis of the 123I-FP-CIT SPECT images in the diagnosis of Parkinsonian syndrome]. Revista espanola de medicina nuclear. vol 30. issue 4. 2011-11-28. PMID:21524823. |
using (123)i-fp-cit spect images makes it possible to identify presynaptic deterioration of the dopaminergic pathway by studying the dopamine transporter (dat). |
2011-11-28 |
2023-08-12 |
Not clear |
| Anna R Moore, Wen-Liang Zhou, Evgeniy S Potapenko, Eun-Ji Kim, Srdjan D Anti. Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons. Brain research. vol 1370. 2011-11-23. PMID:21059342. |
in response to food reward and other pertinent events, midbrain dopaminergic neurons fire short bursts of action potentials causing a phasic release of dopamine in the prefrontal cortex (rapid and transient increases in cortical dopamine concentration). |
2011-11-23 |
2023-08-12 |
rat |
| Anna R Moore, Wen-Liang Zhou, Evgeniy S Potapenko, Eun-Ji Kim, Srdjan D Anti. Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons. Brain research. vol 1370. 2011-11-23. PMID:21059342. |
here we apply short (2s) iontophoretic pulses of glutamate, gaba, dopamine and dopaminergic agonists locally, onto layer 5 pyramidal neurons in brain slices of the rat medial prefrontal cortex (pfc). |
2011-11-23 |
2023-08-12 |
rat |
| Anna R Moore, Wen-Liang Zhou, Evgeniy S Potapenko, Eun-Ji Kim, Srdjan D Anti. Brief dopaminergic stimulations produce transient physiological changes in prefrontal pyramidal neurons. Brain research. vol 1370. 2011-11-23. PMID:21059342. |
our present data imply that one population of pfc pyramidal neurons receiving direct synaptic contacts from midbrain dopaminergic neurons would stall during the 0.5s of the phasic dopamine burst. |
2011-11-23 |
2023-08-12 |
rat |
| Sung-Man Jeon, Sang-Myung Cheon, Hye-Rahn Bae, Jae Woo Kim, Seung U Ki. Selective susceptibility of human dopaminergic neural stem cells to dopamine-induced apoptosis. Experimental neurobiology. vol 19. issue 3. 2011-11-23. PMID:22110355. |
dysfunctions of ubiquitin-proteasome system and toxicity of dopamine have been known as the key mechanisms in the pathogenesis of parkinson's disease (pd) and proteasome inhibitors are widely used in experimental models of pd to reproduce cell death of dopaminergic neurons. |
2011-11-23 |
2023-08-12 |
human |
| Sung-Man Jeon, Sang-Myung Cheon, Hye-Rahn Bae, Jae Woo Kim, Seung U Ki. Selective susceptibility of human dopaminergic neural stem cells to dopamine-induced apoptosis. Experimental neurobiology. vol 19. issue 3. 2011-11-23. PMID:22110355. |
in the present study, immortalized human neural stem cells (hb1.f3, f3) and those transfected with human aromatic acid decarboxylase gene (f3.aadc), were used to investigate the mechanism of selective dopaminergic neuronal cell death mediated by dopamine or proteasome inhibitors. |
2011-11-23 |
2023-08-12 |
human |