| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L García, R de Miguel, J A Ramos, J J Fernàndez-Rui. Perinatal delta 9-tetrahydrocannabinol exposure in rats modifies the responsiveness of midbrain dopaminergic neurons in adulthood to a variety of challenges with dopaminergic drugs. Drug and alcohol dependence. vol 42. issue 3. 1997-01-16. PMID:8912798. |
in the third experiment, we evaluated the in vivo synthesis of da in midbrain dopaminergic neurons by analyzing the magnitude of l-3,4-dihydroxyphenylalanine (l-dopa) accumulation caused by the blockade of l-dopa decarboxylase with nsd 1015. |
1997-01-16 |
2023-08-12 |
rat |
| L García, R de Miguel, J A Ramos, J J Fernàndez-Rui. Perinatal delta 9-tetrahydrocannabinol exposure in rats modifies the responsiveness of midbrain dopaminergic neurons in adulthood to a variety of challenges with dopaminergic drugs. Drug and alcohol dependence. vol 42. issue 3. 1997-01-16. PMID:8912798. |
in summary, our results are consistent with the possible existence of subtle and sexually dimorphic changes in the sensitivity of midbrain dopaminergic neurons in adulthood caused by the exposure to thc during perinatal development. |
1997-01-16 |
2023-08-12 |
rat |
| K Unsicker, C Suter-Crazzalora, K Krieglstei. Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-beta. Ciba Foundation symposium. vol 196. 1997-01-13. PMID:8866128. |
growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for tgf-beta. |
1997-01-13 |
2023-08-12 |
Not clear |
| K Unsicker, C Suter-Crazzalora, K Krieglstei. Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-beta. Ciba Foundation symposium. vol 196. 1997-01-13. PMID:8866128. |
on the basis of their localization, putative sources and mechanisms of actions, such growth factors fall into several categories: (i) local factors within the midbrain influencing proliferation, transmitter phenotype, migration, positioning and neurite growth of stem cells and early neurons; (ii) factors acting retrogradely from the striatum, which are responsible for intrastriatal sprouting and navigation of newly arrived axons as well as life-long maintenance of the dopaminergic nigrostriatal connection; (iii) factors coming into play when the system is toxically impaired; (iv) factors directly acting on dopaminergic neurons; and (v) factors provided by cytokinestimulated astroglia, microglia and neurons affecting dopaminergic neurons anterogradely. |
1997-01-13 |
2023-08-12 |
Not clear |
| F Fukamauchi, M Ishimaru, T Hashimoto, K Obat. Neurochemical analysis of the tyrosine hydroxylase expression in methamphetamine-sensitized rats. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959049. |
in situ hybridization revealed that the signals of th mrna were localized to the dopaminergic perikarya of substantia nigra and ventral tegmental area in the midbrain, and northern blot analysis showed that the levels of th mrna in these areas decreased by 37% compared to that in the saline-treated controls. |
1997-01-08 |
2023-08-12 |
rat |
| T Takeshima, K Shimoda, J M Johnston, J W Commission. Standardized methods to bioassay neurotrophic factors for dopaminergic neurons. Journal of neuroscience methods. vol 67. issue 1. 1997-01-06. PMID:8844522. |
the search for specific neurotrophic factors that will eventually be used to reduce or arrest the rate of degeneration of dopaminergic neurons in parkinson's disease is being pursued by first testing the ability of putative compounds to increase the survival of dopaminergic neurons in primary cultures of the fetal, ventral mesencephalon. |
1997-01-06 |
2023-08-12 |
rat |
| T Takeshima, K Shimoda, J M Johnston, J W Commission. Standardized methods to bioassay neurotrophic factors for dopaminergic neurons. Journal of neuroscience methods. vol 67. issue 1. 1997-01-06. PMID:8844522. |
some important experimental variables include the age of the fetal tissue used; the dissection technique used to isolate the ventral mesencephalon; the percentage of dopaminergic neurons present in the culture initially; handling of the tissue during dissection; the technique used to disperse the cells; the use of serum; the technique of plating the cells; the attachment factors used; detachment and loss of cells during the staining procedure; the age of the cultures at the time of analysis; the uneven distribution of cells at the time of analysis and the use of imaging techniques in the analysis. |
1997-01-06 |
2023-08-12 |
rat |
| U Schmidt, C Beyer, A B Oestreicher, I Reisert, K Schilling, C Pilgri. Activation of dopaminergic D1 receptors promotes morphogenesis of developing striatal neurons. Neuroscience. vol 74. issue 2. 1997-01-06. PMID:8865196. |
the early dopaminergic input from the midbrain may play an important role in the development of the basal ganglia. |
1997-01-06 |
2023-08-12 |
rat |
| C Rouillard, A S Freema. Effects of electrical stimulation of the central nucleus of the amygdala on the in vivo electrophysiological activity of rat nigral dopaminergic neurons. Synapse (New York, N.Y.). vol 21. issue 4. 1997-01-03. PMID:8869165. |
the central nucleus of the amygdala (cea) receives a dopaminergic (da) innervation from the midbrain. |
1997-01-03 |
2023-08-12 |
rat |
| Y Wang, L T Tien, P A Lapchak, B J Hoffe. GDNF triggers fiber outgrowth of fetal ventral mesencephalic grafts from nigra to striatum in 6-OHDA-lesioned rats. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854891. |
these results indicate that fetal nigral transplantation and gdnf injection restore the nigrostriatal dopaminergic pathway in parkinsonian animals and support the hypothesis of trophic activity of gdnf on midbrain dopaminergic neurons. |
1996-12-17 |
2023-08-12 |
rat |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
glial cell line-derived neurotrophic factor (gdnf) is a highly selective neurotrophic factor for midbrain dopaminergic neurons and might thus be of potential use in the therapy of parkinson's disease. |
1996-12-17 |
2023-08-12 |
Not clear |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
in serum-free low density cultures of the dissociated embryonic day 15 mesencephalon, dopaminergic neurons undergo constant cell death as evidenced by a 90% reduction in tyrosine hydroxylase-immunoreactive (th-ir) cell numbers between days 1 and 9 of cultivation. |
1996-12-17 |
2023-08-12 |
Not clear |
| J Engele, B Frank. Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways. Cell and tissue research. vol 286. issue 2. 1996-12-17. PMID:8854892. |
taken together, our findings suggest that the action of gdnf on midbrain dopaminergic neurons is modulated by other extracellular signals. |
1996-12-17 |
2023-08-12 |
Not clear |
| H Sawada, S Shimohama, Y Tamura, T Kawamura, A Akaike, J Kimur. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of neuroscience research. vol 43. issue 1. 1996-12-16. PMID:8838574. |
methylphenylpyridium ion (mpp+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. |
1996-12-16 |
2023-08-12 |
rat |
| H Sawada, S Shimohama, Y Tamura, T Kawamura, A Akaike, J Kimur. Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon. Journal of neuroscience research. vol 43. issue 1. 1996-12-16. PMID:8838574. |
using primary culture of the rat mesencephalon, we investigated glutamate-induced cytotoxicity against dopaminergic and non-dopaminergic neurons with or without the pretreatment with mpp+. |
1996-12-16 |
2023-08-12 |
rat |
| C Perrone-Capano, U di Porzi. Epigenetic factors and midbrain dopaminergic neurone development. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 18. issue 10. 1996-12-16. PMID:8885719. |
epigenetic factors and midbrain dopaminergic neurone development. |
1996-12-16 |
2023-08-12 |
Not clear |
| C Perrone-Capano, U di Porzi. Epigenetic factors and midbrain dopaminergic neurone development. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 18. issue 10. 1996-12-16. PMID:8885719. |
in particular we will focus on three major issues: (1) the differentiation of dopaminergic neurones triggered by direct contact with the midbrain floor plate cells through the action of sonic hedgehog; (2) the neurotrophic factors acting on dopaminergic neurones; and (3) the role of target striatal cells on the survival and the axonal growth of developing or grafted dopaminergic neurones. |
1996-12-16 |
2023-08-12 |
Not clear |
| T S Chen, E Koutsilieri, W D Rausc. MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/Bl6 mice. Journal of neural transmission. General section. vol 100. issue 2. 1996-12-16. PMID:8962685. |
primary cell cultures of mesencephalon from c57/bl6 mice were used to investigate the effects of various dopaminergic neurotoxins on the intracellular calcium metabolism. |
1996-12-16 |
2023-08-12 |
mouse |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. |
1996-12-13 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
midbrain dopaminergic neurons are known to release dopamine from somata and/or dendrites located in the substantia nigra (sn) and the ventral tegmental area (vta). |
1996-12-13 |
2023-08-12 |
rat |