| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Engele, H Rieck, D Choi-Lundberg, M C Boh. Evidence for a novel neurotrophic factor for dopaminergic neurons secreted from mesencephalic glial cell lines. Journal of neuroscience research. vol 43. issue 5. 1997-05-15. PMID:8833092. |
media conditioned by these cell lines were tested for survival-promoting effects on dopaminergic neurons in serum-free cultures of the dissociated e14.5 rat mesencephalon. |
1997-05-15 |
2023-08-12 |
rat |
| J Engele, H Rieck, D Choi-Lundberg, M C Boh. Evidence for a novel neurotrophic factor for dopaminergic neurons secreted from mesencephalic glial cell lines. Journal of neuroscience research. vol 43. issue 5. 1997-05-15. PMID:8833092. |
moreover, treatment of serum-free cultures of the dissociated e14.5 mesencephalon with glial cell line-cm conditioned medium (cm) delayed dopaminergic cell death in a dose-dependent manner, resulting in a maximal twofold to sixfold increase in the number of surviving tyrosine hydroxylase-ir neurons at various days in vitro. |
1997-05-15 |
2023-08-12 |
rat |
| M S Airaksinen, H Thoenen, M Meye. Vulnerability of midbrain dopaminergic neurons in calbindin-D28k-deficient mice: lack of evidence for a neuroprotective role of endogenous calbindin in MPTP-treated and weaver mice. The European journal of neuroscience. vol 9. issue 1. 1997-05-15. PMID:9042576. |
vulnerability of midbrain dopaminergic neurons in calbindin-d28k-deficient mice: lack of evidence for a neuroprotective role of endogenous calbindin in mptp-treated and weaver mice. |
1997-05-15 |
2023-08-12 |
mouse |
| R P Gaykema, L Zaborszk. Parvalbumin-containing neurons in the basal forebrain receive direct input from the substantia nigra-ventral tegmental area. Brain research. vol 747. issue 1. 1997-05-14. PMID:9042545. |
pv-containing neurons in pallidal and adjacent basal forebrain territories are thus directly targeted by presumably a9-a10 dopaminergic neurons and represent a novel aspect of midbrain dopaminergic control of basal forebrain neuronal activity. |
1997-05-14 |
2023-08-12 |
Not clear |
| Z Y Tong, P G Overton, D Clar. Antagonism of NMDA receptors but not AMPA/kainate receptors blocks bursting in dopaminergic neurons induced by electrical stimulation of the prefrontal cortex. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 8-9. 1997-05-12. PMID:9013383. |
evidence suggests that the prefrontal cortex (pfc) plays an important role in the burst activity of midbrain dopaminergic (da) neurons. |
1997-05-12 |
2023-08-12 |
Not clear |
| Z Y Tong, P G Overton, D Clar. Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132987. |
stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. |
1997-04-29 |
2023-08-12 |
rat |
| Z Y Tong, P G Overton, D Clar. Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events. Synapse (New York, N.Y.). vol 22. issue 3. 1997-04-29. PMID:9132987. |
evidence suggests that excitatory amino acid-containing afferents from the prefrontal cortex (pfc) play an important role in the induction of burst firing in midbrain dopaminergic (da) neurons. |
1997-04-29 |
2023-08-12 |
rat |
| R H Zetterström, L Solomin, L Jansson, B J Hoffer, L Olson, T Perlman. Dopamine neuron agenesis in Nurr1-deficient mice. Science (New York, N.Y.). vol 276. issue 5310. 1997-04-28. PMID:9092472. |
mice lacking nurr1 failed to generate midbrain dopaminergic neurons, were hypoactive, and died soon after birth. |
1997-04-28 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
the purpose of the present study was to determine whether mptp also causes degeneration of midbrain dopaminergic neurons in nuclei a8 and a10 in the mouse, as occurs in humans with parkinson's disease. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
seven days later, dopamine concentrations were measured in the striatum using high performance liquid chromatography, and midbrain dopaminergic neurons were identified using an antibody against tyrosine hydroxylase. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
although the highest dose (300 mg/kg) caused an 86% reduction in striatal dopamine concentrations, there was only a moderate and non-significant loss of midbrain dopaminergic neurons. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
in the c57bl/6 strain, however, a high dose of mptp (240 mg/kg) caused a significant reduction in both striatal dopamine concentrations (95%), and midbrain dopaminergic cells; 69% loss of nucleus a8 cells, 75% loss of nucleus a9 cells, and in nucleus a10 subnuclei there was 42% loss of ventral tegmental area cells, 55% loss of interfascicular nucleus cells, and no loss of cells in the central linear nucleus. |
1997-04-24 |
2023-08-12 |
mouse |
| D C German, E L Nelson, C L Liang, S G Speciale, C M Sinton, P K Sonsall. The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117541. |
these data (1) provide further evidence for differential susceptibility to mptp toxicity among different mouse strains, (2) indicate that a significant depletion of striatal dopamine is not necessarily due to degeneration of midbrain dopaminergic neurons, (3) provide the precise locations of midbrain dopaminergic cells that are vulnerable to mptp, which will aid future studies that seek to determine the mechanism/s by which-mptp selectively destroys only certain midbrain dopaminergic neurons, and (4) indicate that mptp produces midbrain dopaminergic neuronal degeneration in the same nuclei in the c57bl16 mouse that degenerate in humans with parkinson's disease. |
1997-04-24 |
2023-08-12 |
mouse |
| C L Liang, C M Sinton, P K Sonsalla, D C Germa. Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117542. |
midbrain dopaminergic neurons in the mouse that contain calbindin-d28k exhibit reduced vulnerability to mptp-induced neurodegeneration. |
1997-04-24 |
2023-08-12 |
mouse |
| C L Liang, C M Sinton, P K Sonsalla, D C Germa. Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 5. issue 4. 1997-04-24. PMID:9117542. |
the calcium-binding protein calbindin-d28k (cb) is located in midbrain dopaminergic (da) neurons that are less vulnerable to degeneration in parkinson's disease and in an animal model of the disorder, the mptp-treated monkey. |
1997-04-24 |
2023-08-12 |
mouse |
| V Kostic, M E Gurney, H X Deng, T Siddique, C J Epstein, S Przedborsk. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124807. |
midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. |
1997-04-24 |
2023-08-12 |
mouse |
| V Kostic, M E Gurney, H X Deng, T Siddique, C J Epstein, S Przedborsk. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124807. |
we used a transgenic mouse model of familial amyotrophic lateral sclerosis (transgenic g1h mice) based on expression of mutant human cu/zn-sod to examine the influence of the transgene expression on midbrain dopaminergic neurons, cells that contain conspicuous amounts of this enzyme. |
1997-04-24 |
2023-08-12 |
mouse |
| V Kostic, M E Gurney, H X Deng, T Siddique, C J Epstein, S Przedborsk. Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis. Annals of neurology. vol 41. issue 4. 1997-04-24. PMID:9124807. |
these findings indicate that overexpression of the mutated cu/zn-sod protein caused a significant loss of midbrain dopaminergic neurons in addition to the loss of spinal motor neurons. |
1997-04-24 |
2023-08-12 |
mouse |
| M Rufer, S B Wirth, A Hofer, R Dermietzel, A Pastor, H Kettenmann, K Unsicke. Regulation of connexin-43, GFAP, and FGF-2 is not accompanied by changes in astroglial coupling in MPTP-lesioned, FGF-2-treated parkinsonian mice. Journal of neuroscience research. vol 46. issue 5. 1997-04-14. PMID:8951672. |
basic fibroblast growth factor (bfgf; fgf-2) has potent trophic effects on developing and toxically impaired midbrain dopaminergic (daergic) neurons which are crucially affected in parkinson's disease. |
1997-04-14 |
2023-08-12 |
mouse |
| B A Morrow, R H Rot. Serotonergic lesions alter cocaine-induced locomotor behavior and stress-activation of the mesocorticolimbic dopamine system. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807745. |
the aim of this study was to examine the effects of serotonergic lesions to the dorsal raphe on midbrain dopaminergic systems. |
1997-03-24 |
2023-08-12 |
rat |