| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David B O'Sullivan, Patrick T Harrison, Aideen M Sulliva. Effects of GDF5 overexpression on embryonic rat dopaminergic neurones in vitro and in vivo. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 5. 2010-07-29. PMID:20349094. |
the present study shows, using optimised lipid-mediated transfection procedures, that overexpression of gdf5 significantly improves the survival of dopaminergic neurones in cultures of embryonic day (e) 13 rat ventral mesencephalon (vm) and protects them against 6-hydroxydopamine (6-ohda)-induced toxicity. |
2010-07-29 |
2023-08-12 |
rat |
| Chee Yeun Chung, Pawel Licznerski, Kambiz N Alavian, Antonio Simeone, Zhicheng Lin, Eden Martin, Jeffery Vance, Ole Isacso. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology. vol 133. issue Pt 7. 2010-07-20. PMID:20573704. |
the transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. |
2010-07-20 |
2023-08-12 |
mouse |
| Chee Yeun Chung, Pawel Licznerski, Kambiz N Alavian, Antonio Simeone, Zhicheng Lin, Eden Martin, Jeffery Vance, Ole Isacso. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology. vol 133. issue Pt 7. 2010-07-20. PMID:20573704. |
two adjacent groups of midbrain dopaminergic neurons, a9 (substantia nigra pars compacta) and a10 (ventral tegmental area), have distinct projections and exhibit differential vulnerability in parkinson's disease. |
2010-07-20 |
2023-08-12 |
mouse |
| Chee Yeun Chung, Pawel Licznerski, Kambiz N Alavian, Antonio Simeone, Zhicheng Lin, Eden Martin, Jeffery Vance, Ole Isacso. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology. vol 133. issue Pt 7. 2010-07-20. PMID:20573704. |
little is known about transcription factors that influence midbrain dopaminergic subgroup phenotypes or their potential role in disease. |
2010-07-20 |
2023-08-12 |
mouse |
| Chee Yeun Chung, Pawel Licznerski, Kambiz N Alavian, Antonio Simeone, Zhicheng Lin, Eden Martin, Jeffery Vance, Ole Isacso. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology. vol 133. issue Pt 7. 2010-07-20. PMID:20573704. |
here, we demonstrate elevated expression of the transcription factor orthodenticle homeobox 2 in a10 dopaminergic neurons of embryonic and adult mouse, primate and human midbrain. |
2010-07-20 |
2023-08-12 |
mouse |
| Chee Yeun Chung, Pawel Licznerski, Kambiz N Alavian, Antonio Simeone, Zhicheng Lin, Eden Martin, Jeffery Vance, Ole Isacso. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology. vol 133. issue Pt 7. 2010-07-20. PMID:20573704. |
lack of orthodenticle homeobox 2 in the ventral mesencephalon of orthodenticle homeobox 2 conditional knockout mice caused a reduction of midbrain dopaminergic neurons and selective loss of a10 dopaminergic projections. |
2010-07-20 |
2023-08-12 |
mouse |
| Chee Yeun Chung, Pawel Licznerski, Kambiz N Alavian, Antonio Simeone, Zhicheng Lin, Eden Martin, Jeffery Vance, Ole Isacso. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain : a journal of neurology. vol 133. issue Pt 7. 2010-07-20. PMID:20573704. |
these results show that orthodenticle homeobox 2 is important for establishing subgroup phenotypes of post-mitotic midbrain dopaminergic neurons and may alter neuronal vulnerability. |
2010-07-20 |
2023-08-12 |
mouse |
| Li Lu, Fengqiao Li, Xiaomin Wan. Novel anti-inflammatory and neuroprotective agents for Parkinson's disease. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20015029. |
parkinson's disease (pd) is a type of motor system disorder that results from the progressive loss of dopaminergic (daergic) neurons in the substantia nigra (sn) of the midbrain. |
2010-07-12 |
2023-08-12 |
Not clear |
| Guillaume Drion, Maxime Bonjean, Olivier Waroux, Jacqueline Scuvée-Moreau, Jean-Françis Liégeois, Terrence J Sejnowski, Rodolphe Sepulchre, Vincent Seuti. M-type channels selectively control bursting in rat dopaminergic neurons. The European journal of neuroscience. vol 31. issue 5. 2010-07-12. PMID:20180842. |
midbrain dopaminergic neurons in the substantia nigra, pars compacta and ventral tegmental area are critically important in many physiological functions. |
2010-07-12 |
2023-08-12 |
rat |
| Guillaume Drion, Maxime Bonjean, Olivier Waroux, Jacqueline Scuvée-Moreau, Jean-Françis Liégeois, Terrence J Sejnowski, Rodolphe Sepulchre, Vincent Seuti. M-type channels selectively control bursting in rat dopaminergic neurons. The European journal of neuroscience. vol 31. issue 5. 2010-07-12. PMID:20180842. |
using both in-vivo recordings combined with microiontophoretic or intraperitoneal drug applications and in-vitro experiments, we have found that m-type channels, which are present in midbrain dopaminergic cells, modulate the firing during bursting without affecting the background low-frequency pacemaker firing. |
2010-07-12 |
2023-08-12 |
rat |
| Kevin J Skoblenick, Niran Argintaru, Yingtao Xu, Bailee A Dyck, Dipannita Basu, Mattea L Tan, Michael F Mazurek, Ram K Mishr. Role of AP-2alpha transcription factor in the regulation of synapsin II gene expression by dopamine D1 and D2 receptors. Journal of molecular neuroscience : MN. vol 41. issue 2. 2010-07-09. PMID:19842069. |
this study investigated the mechanistic pathway involved in synapsin ii regulation by dopaminergic drugs using primary midbrain neurons to determine which of several transcription factors regulates synapsin ii expression. |
2010-07-09 |
2023-08-12 |
Not clear |
| Olle Bergman, Anna Håkansson, Lars Westberg, Kajsa Nordenström, Andrea Carmine Belin, Olof Sydow, Lars Olson, Björn Holmberg, Elias Eriksson, Hans Nissbrand. PITX3 polymorphism is associated with early onset Parkinson's disease. Neurobiology of aging. vol 31. issue 1. 2010-07-08. PMID:18420308. |
pitx3 is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons, the gene of which is disrupted in a putative mouse model for parkinson's disease (pd). |
2010-07-08 |
2023-08-12 |
mouse |
| Aleksandra Glavaski-Joksimovic, Tamas Virag, Qin A Chang, Neva C West, Thomas A Mangatu, Michael P McGrogan, Millicent Dugich-Djordjevic, Martha C Boh. Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitors. Cell transplantation. vol 18. issue 7. 2010-07-08. PMID:19796495. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the selective loss of dopaminergic (da) neurons in the midbrain. |
2010-07-08 |
2023-08-12 |
human |
| Garret D Stuber, Thomas S Hnasko, Jonathan P Britt, Robert H Edwards, Antonello Bonc. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554874. |
here, we expressed the light-activated cation channel channelrhodopsin-2 (chr2) in genetically defined midbrain dopamine neurons to stimulate exocytosis specifically from dopaminergic terminals in both the nucleus accumbens (nac) shell and dorsal striatum of brain slices from adult mice. |
2010-07-02 |
2023-08-12 |
mouse |
| Elisa Tamariz, N Emmanuel Díaz-Martínez, Néstor F Díaz, Claudia M García-Peña, Iván Velasco, Alfredo Varela-Echavarrí. Axon responses of embryonic stem cell-derived dopaminergic neurons to semaphorins 3A and 3C. Journal of neuroscience research. vol 88. issue 5. 2010-06-24. PMID:19859963. |
class 3 semaphorins are a subfamily of chemotropic molecules implicated in the projection of dopaminergic neurons from the ventral mesencephalon and in the formation of the nigrostriatal pathway (nsp) during embryonic development. |
2010-06-24 |
2023-08-12 |
Not clear |
| Päivi Lindholm, Mart Saarm. Novel CDNF/MANF family of neurotrophic factors. Developmental neurobiology. vol 70. issue 5. 2010-06-23. PMID:20186704. |
parkinson's disease (pd) is a movement disorder with characteristic degeneration of dopaminergic neurons in the midbrain. |
2010-06-23 |
2023-08-12 |
rat |
| Päivi Lindholm, Mart Saarm. Novel CDNF/MANF family of neurotrophic factors. Developmental neurobiology. vol 70. issue 5. 2010-06-23. PMID:20186704. |
cdnf and manf protect midbrain dopaminergic neurons and restore motor function in 6-hydroxydopamine rat model of pd in vivo. |
2010-06-23 |
2023-08-12 |
rat |
| M L Johnson, A E Day, C C Ho, Q D Walker, R Francis, C M Kuh. Androgen decreases dopamine neurone survival in rat midbrain. Journal of neuroendocrinology. vol 22. issue 4. 2010-06-17. PMID:20136692. |
clinical studies show that men are more likely to develop disorders affecting midbrain dopaminergic pathways, such as drug addiction and parkinson's disease (pd). |
2010-06-17 |
2023-08-12 |
mouse |
| M L Johnson, A E Day, C C Ho, Q D Walker, R Francis, C M Kuh. Androgen decreases dopamine neurone survival in rat midbrain. Journal of neuroendocrinology. vol 22. issue 4. 2010-06-17. PMID:20136692. |
although a great deal of focus has been given to the role of oestrogen in the maintenance of midbrain dopaminergic pathways, little is known about how testosterone influences these pathways. |
2010-06-17 |
2023-08-12 |
mouse |
| M L Johnson, A E Day, C C Ho, Q D Walker, R Francis, C M Kuh. Androgen decreases dopamine neurone survival in rat midbrain. Journal of neuroendocrinology. vol 22. issue 4. 2010-06-17. PMID:20136692. |
these findings suggest that testosterone may play a suppressive role in midbrain dopaminergic pathways. |
2010-06-17 |
2023-08-12 |
mouse |