| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E C Wolter. Psychiatric complications in Parkinson's disease. Journal of neural transmission. Supplementum. issue 60. 2001-04-12. PMID:11205148. |
parkinson's disease (pd) is caused by an abnormal degeneration of the dopamine (da) producing cells in the substantia nigra (sn) and ventral tegmentum area (vta) in combination with a varying decay of the noradrenergic (locus coeruleus), cholinergic forebrain (nucleus basalis of meynert) and serotoninergic (dorsal raphe nuclei) systems, leading to a multitude of motor and non-motor behavioral disturbances, known as parkinsonism. |
2001-04-12 |
2023-08-12 |
Not clear |
| M Jucker, L Bondolfi, M E Calhoun, J M Long, D K Ingra. Structural brain aging in inbred mice: potential for genetic linkage. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113616. |
129sv/j mice have more pronounced age-related cognitive deficits, although hippocampal and basal cholinergic forebrain neuron number also appear unchanged with aging. |
2001-03-29 |
2023-08-12 |
mouse |
| N A Muma, J M Lee, L Gorman, B A Heidenreich, I Mitrovic, T C Napie. 6-hydroxydopamine-induced lesions of dopaminergic neurons alter the function of postsynaptic cholinergic neurons without changing cytoskeletal proteins. Experimental neurology. vol 168. issue 1. 2001-03-29. PMID:11170728. |
these results suggest that removal of dopaminergic inputs to the forebrain results in hyperactivity of the cholinergic systems but is not sufficient to induce postsynaptic perturbations in cytoskeletal proteins which occur in neurodegenerative diseases. |
2001-03-29 |
2023-08-12 |
rat |
| R Li, I Taniguchi, H Sakaguch. Auditory-vocal cholinergic pathway in the songbird brain. Canadian journal of physiology and pharmacology. vol 78. issue 12. 2001-03-01. PMID:11149383. |
the two main song control nuclei in the zebra finch forebrain, the higher vocal center (hvc) and the robust nucleus of the archistriatum (ra), receive cholinergic innervation from the ventral paleostriatum (vp) of the basal forebrain which may play a key role in song learning. |
2001-03-01 |
2023-08-12 |
Not clear |
| T Araki, H Tanji, K Fujihara, H Kato, Y Imai, M Mizugaki, Y Itoyam. Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041269. |
sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. |
2001-02-15 |
2023-08-12 |
rat |
| T Araki, H Tanji, K Fujihara, H Kato, Y Imai, M Mizugaki, Y Itoyam. Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041269. |
we studied sequential changes in muscarinic cholinergic receptors, high-affinity choline uptake sites and dopamine d2 receptors in the brain after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. |
2001-02-15 |
2023-08-12 |
rat |
| T Araki, H Tanji, K Fujihara, H Kato, Y Imai, M Mizugaki, Y Itoyam. Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 8-9. 2001-02-15. PMID:11041269. |
the present study indicates that 6-hydroxydopamine injection of medial forebrain bundle in rats can cause functional changes in high-affinity choline uptake site in the striatum, as compared with muscarinic cholinergic receptors. |
2001-02-15 |
2023-08-12 |
rat |
| M R Lamprea, F P Cardenas, R Silveira, S Morato, T J Wals. Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms. Behavioural brain research. vol 117. issue 1-2. 2001-02-08. PMID:11099762. |
dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms. |
2001-02-08 |
2023-08-12 |
rat |
| M R Lamprea, F P Cardenas, R Silveira, S Morato, T J Wals. Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms. Behavioural brain research. vol 117. issue 1-2. 2001-02-08. PMID:11099762. |
these results suggest that the cholinergic innervation of the hpc, the frontal cortex, or both forebrain structures, modulate the initiation of exploratory activity which, results in the acquisition and retention of spatial information, but does not affect the expression of anxiety in the elevated plus-maze. |
2001-02-08 |
2023-08-12 |
rat |
| R H Schmidt, K J Scholten, P H Maugha. Cognitive impairment and synaptosomal choline uptake in rats following impact acceleration injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186227. |
animal studies with fluid percussion or controlled cortical impact injury have identified transient disturbances in forebrain cholinergic innervation which may contribute to such cognitive problems. |
2001-02-08 |
2023-08-12 |
rat |
| R H Schmidt, K J Scholten, P H Maugha. Cognitive impairment and synaptosomal choline uptake in rats following impact acceleration injury. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186227. |
compared with those models, the impact acceleration model does not produce a similar disruption of forebrain cholinergic nerve terminals. |
2001-02-08 |
2023-08-12 |
rat |
| P H Maughan, K J Scholten, R H Schmid. Recovery of water maze performance in aged versus young rats after brain injury with the impact acceleration model. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186228. |
we have modeled injury in aged rats in an effort to elucidate the pathophysiology of this enhanced sensitivity and, in particular, to determine if there are susceptibility differences in forebrain cholinergic innervation in young versus aged rats. |
2001-02-08 |
2023-08-12 |
rat |
| P H Maughan, K J Scholten, R H Schmid. Recovery of water maze performance in aged versus young rats after brain injury with the impact acceleration model. Journal of neurotrauma. vol 17. issue 12. 2001-02-08. PMID:11186228. |
the neurophysiological basis for this difference is presently unknown, but the differences in cognitive dysfunction between young and aged rats appears to be much greater than would seem to be explained by the small differences in forebrain cholinergic innervation. |
2001-02-08 |
2023-08-12 |
rat |
| K A Jellinge. Morphological substrates of mental dysfunction in Lewy body disease: an update. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961431. |
dysfunction of subcorticocortical networks with neuron losses in a) the dopaminergic nigrostriatal loop, causing striato-(pre)frontal deafferentation and mesocortico-limbic system (medial substantia nigra, ventral tegmentum); b) noradrenergic (locus coeruleus), and serotonergic systems (dorsal raphe nuclei), c) cholinergic forebrain system (nucleus basalis of meynert, etc), and d) specific nuclei of amygdala and limbic system (thalamic nuclei, hippocampus); 2. |
2000-12-22 |
2023-08-12 |
Not clear |
| K A Jellinge. Morphological substrates of mental dysfunction in Lewy body disease: an update. Journal of neural transmission. Supplementum. vol 59. 2000-12-22. PMID:10961431. |
they predominantly affect the limbic system with less frequent isocortical braak stages, whereas the cholinergic forebrain system is more severely affected than in ad. |
2000-12-22 |
2023-08-12 |
Not clear |
| F Sohrabji, K W Peeples, O A Marroqui. Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen. Journal of neurobiology. vol 45. issue 2. 2000-12-07. PMID:11018768. |
collectively, these results indicate that neural injury to one limb of the forebrain cholinergic system may result in collateral damage to other limbs of this system, suggesting a mechanism for the progression of neurodegenerative diseases, such as alzheimer's disease, that involve the cholinergic system. |
2000-12-07 |
2023-08-12 |
Not clear |
| R F Butterwort. Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency. Metabolic brain disease. vol 15. issue 1. 2000-10-12. PMID:10885542. |
evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency. |
2000-10-12 |
2023-08-12 |
mouse |
| R F Butterwort. Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency. Metabolic brain disease. vol 15. issue 1. 2000-10-12. PMID:10885542. |
using an animal model of congenital otc deficiency, the sparse fur (spf) mouse, studies reveal convincing evidence of a loss of forebrain cholinergic neurons in this condition. |
2000-10-12 |
2023-08-12 |
mouse |
| R F Butterwort. Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency. Metabolic brain disease. vol 15. issue 1. 2000-10-12. PMID:10885542. |
loss of forebrain cholinergic neurons is consistent with the severe cognitive impairment characteristic of congenital otc deficiency. |
2000-10-12 |
2023-08-12 |
mouse |
| G L Wenk, K McGann, A Mencarelli, B Hauss-Wegrzyniak, P Del Soldato, S Fiorucc. Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. European journal of pharmacology. vol 402. issue 1-2. 2000-10-11. PMID:10940360. |
mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. |
2000-10-11 |
2023-08-12 |
rat |