| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Antonietta Casu, T P Wong, Yves De Koninck, Alfredo Ribeiro-da-Silva, A Claudio Cuell. Aging causes a preferential loss of cholinergic innervation of characterized neocortical pyramidal neurons. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 3. 2002-03-22. PMID:11839606. |
our results add important new evidence in support of the concept that the age-related learning and memory deficits are attributable, at least partially, to a decline in the functional integrity of the forebrain cholinergic systems. |
2002-03-22 |
2023-08-12 |
rat |
| Tania Vitalis, Coralie Fouquet, Chantal Alvarez, Isabelle Seif, David Price, Patricia Gaspar, Olivier Case. Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse. The Journal of comparative neurology. vol 442. issue 4. 2002-02-21. PMID:11793338. |
(3) maoa is transiently expressed in the cholinergic motor nuclei of the hindbrain, and maob is expressed in the forebrain cholinergic neurons. |
2002-02-21 |
2023-08-12 |
mouse |
| Glenn I Hatton, Qin Zhao Yan. Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 1. 2002-02-04. PMID:11756485. |
brain slice preparations preserving projections from nearby forebrain cholinergic neurons to the supraoptic nucleus (son) were used to study synaptic potentials mediated by nicotinic acetylcholine receptors (nachrs) in the hypothalamus. |
2002-02-04 |
2023-08-12 |
Not clear |
| U Gies, T J Görcs, J Mulder, O Planz, L Stitz, T Bilzer, P G Luiten, T Harkan. Cortical cholinergic decline parallels the progression of Borna virus encephalitis. Neuroreport. vol 12. issue 17. 2002-01-11. PMID:11726791. |
in summary, our data indicate progressive deterioration of forebrain cholinergic systems that parallels the progression of bdv encephalitis. |
2002-01-11 |
2023-08-12 |
rat |
| D Nakahara, Y Ishida, M Nakamura, N Furuno, T Nishimor. Intracranial self-stimulation induces Fos expression in GABAergic neurons in the rat mesopontine tegmentum. Neuroscience. vol 106. issue 3. 2001-12-07. PMID:11591463. |
therefore, using double immunostaining for fos as a marker of neuronal activity and choline acetyltransferase as a marker of cholinergic neurons, or for fos and gaba, we investigated whether self-stimulation of the medial forebrain bundle induces fos expression within cholinergic and gabaergic neurons in two regions of the mesopontine tegmentum, i.e., pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus. |
2001-12-07 |
2023-08-12 |
rat |
| D Nakahara, Y Ishida, M Nakamura, N Furuno, T Nishimor. Intracranial self-stimulation induces Fos expression in GABAergic neurons in the rat mesopontine tegmentum. Neuroscience. vol 106. issue 3. 2001-12-07. PMID:11591463. |
these results indicate that intracranial self-stimulation of the medial forebrain bundle may increase acetylcholine release without affecting expression of fos in cholinergic neurons, while the same stimulation may induce fos expression in gabaergic neurons of the mesopontine tegmentum. |
2001-12-07 |
2023-08-12 |
rat |
| D Nakahara, Y Ishida, M Nakamura, N Furuno, T Nishimor. Intracranial self-stimulation induces Fos expression in GABAergic neurons in the rat mesopontine tegmentum. Neuroscience. vol 106. issue 3. 2001-12-07. PMID:11591463. |
gabaergic as well as cholinergic neurons in this area appear to be activated by self-stimulation reward in the medial forebrain bundle. |
2001-12-07 |
2023-08-12 |
rat |
| J A Burk, M Sarte. Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons. Neuroscience. vol 105. issue 4. 2001-12-04. PMID:11530228. |
as basal forebrain lesions produced with ibotenic acid were previously observed to potently destroy non-cholinergic, particularly gabaergic neurons while producing only moderate decreases in the density of cortical cholinergic inputs, the present experiment examined the effects of such lesions on sustained attention performance and then compared these effects with the immunohistochemical and attentional consequences of selective cholinotoxic lesions produced by intra-basal forebrain infusions of 192 igg-saporin. |
2001-12-04 |
2023-08-12 |
rat |
| M G Giovannini, A Rakovska, R S Benton, M Pazzagli, L Bianchi, G Pepe. Effects of novelty and habituation on acetylcholine, GABA, and glutamate release from the frontal cortex and hippocampus of freely moving rats. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564415. |
the involvement of the forebrain cholinergic system in arousal, learning and memory has been well established. |
2001-12-04 |
2023-08-12 |
rat |
| M G Giovannini, A Rakovska, R S Benton, M Pazzagli, L Bianchi, G Pepe. Effects of novelty and habituation on acetylcholine, GABA, and glutamate release from the frontal cortex and hippocampus of freely moving rats. Neuroscience. vol 106. issue 1. 2001-12-04. PMID:11564415. |
other neurotransmitters such as gaba and glutamate may be involved in the mechanisms of memory by modulating the forebrain cholinergic pathways. |
2001-12-04 |
2023-08-12 |
rat |
| J Montplaisir, D Petit, S Gauthier, H Gaudreau, A Décar. Sleep disturbances and eeg slowing in alzheimer's disease. Sleep research online : SRO. vol 1. issue 4. 2001-10-18. PMID:11382871. |
these results are discussed with respect to the role of brainstem and forebrain cholinergic populations in rem sleep generation in humans. |
2001-10-18 |
2023-08-12 |
human |
| W L Inglis, M C Olmstead, T W Robbin. Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions. Behavioural brain research. vol 123. issue 2. 2001-10-11. PMID:11399325. |
the pptg may control attentional processes through its direct projections to the forebrain cholinergic system or, indirectly, through activation of thalamocortical projections. |
2001-10-11 |
2023-08-12 |
rat |
| M Solm. Dreaming and REM sleep are controlled by different brain mechanisms. The Behavioral and brain sciences. vol 23. issue 6. 2001-09-20. PMID:11515144. |
recent neuropsychological, radiological, and pharmacological findings suggest that the cholinergic brain stem mechanisms that control the rem state can only generate the psychological phenomena of dreaming through the mediation of a second, probably dopaminergic, forebrain mechanism. |
2001-09-20 |
2023-08-12 |
Not clear |
| M M Thakkar, V Ramesh, R E Strecker, R W McCarle. Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats. Archives italiennes de biologie. vol 139. issue 3. 2001-08-30. PMID:11330208. |
orexin-containing neurons project to both brainstem and forebrain regions that are known to regulate sleep and wakefulness, including the field of cholinergic neurons in the basal forebrain (bf) that is implicated in regulation of wakefulness, and includes, in the rat, the horizontal limb of the diagonal band, the substantia innominata, and the magnocellular preoptic region. |
2001-08-30 |
2023-08-12 |
rat |
| E Vaucher, N Aumont, D Pearson, W Rowe, J Poirier, S Ka. Amyloid beta peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats. Journal of chemical neuroanatomy. vol 21. issue 4. 2001-08-23. PMID:11429273. |
excessive extracellular deposition of amyloid beta (abeta) peptide in neuritic plaques and degeneration of forebrain cholinergic neurones, which innervate the hippocampus and the neocortex, are the invariant characteristic features of alzheimer's disease (ad). |
2001-08-23 |
2023-08-12 |
rat |
| M Hartlage-Rübsamen, R Schlieb. Sequential upregulation of cell adhesion molecules in degenerating rat basal forebrain cholinergic neurons and in phagocytotic microglial cells. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282354. |
however, 7 days after cholinergic lesion, only a few, shrunken neuronal somata were found to be immunoreactive for icam-1 and lfa-1, while activated microglial cells demonstrated strong immunoreactivity for icam-1 and lfa-1 in the lesioned forebrain areas, persisting up to 14 days after lesion while no immunoreactivity was observed in neurons at this time point. |
2001-06-21 |
2023-08-12 |
rat |
| S R Kopf, R S Benton, R Kalfin, M G Giovannini, G Pepe. NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response. Brain research. vol 894. issue 1. 2001-05-31. PMID:11245824. |
these results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system. |
2001-05-31 |
2023-08-12 |
rat |
| I Ferencz, G Leanza, A Nanobashvili, Z Kokaia, M Kokaia, O Lindval. Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons. Neuroscience. vol 102. issue 4. 2001-05-17. PMID:11182245. |
widespread lesions of forebrain cholinergic or noradrenergic projections by intraventricular administration of 192 igg-saporin or 6-hydroxydopamine, respectively, accelerate kindling epileptogenesis. |
2001-05-17 |
2023-08-12 |
rat |
| I Ferencz, G Leanza, A Nanobashvili, Z Kokaia, M Kokaia, O Lindval. Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons. Neuroscience. vol 102. issue 4. 2001-05-17. PMID:11182245. |
these results indicate that although both noradrenergic and cholinergic projections to the forebrain exert powerful inhibitory effects on hippocampal kindling epileptogenesis, the action of the cholinergic system is less pronounced and occurs specifically prior to seizure generalization. |
2001-05-17 |
2023-08-12 |
rat |
| M A Pombal, O Marín, A Gonzále. Distribution of choline acetyltransferase-immunoreactive structures in the lamprey brain. The Journal of comparative neurology. vol 431. issue 1. 2001-04-26. PMID:11169993. |
in the forebrain, cholinergic cells were present in the striatum, preoptic region, paraventricular nucleus, pineal and parapineal organs, habenula, and pretectum. |
2001-04-26 |
2023-08-12 |
Not clear |